News Oct. 26, 2024 Continent ileostomy: A life-changing option Restorative proctocolectomy with ileal pouch-anal anastomosis (RPC-IPAA) and continent ileostomy are surgical options to treat patients who are not candidates for ileal J-pouch-anal anastomosis. Oct. 22, 2024 Assessing the effectiveness and safety of virtual reality in treating functional dyspepsia This first-ever, randomized, controlled pilot study assessed participants' symptoms and quality of life over a two-week period. Oct. 22, 2024 Examining the prevalence of low vitamin D levels in patients with gastroparesis and its relationship to symptoms Study data from a group of 513 patients also showed that low vitamin D levels are associated with nausea, vomiting and gastric neuromuscular dysfunction. Oct. 22, 2024 Examining the prevalence of FI and its relationship with age, sex and geographic location in adults The systematic review and meta-analysis sheds light on the prevalence of FI and its relationship with age, sex and geographic location in adults. Oct. 22, 2024 An updated appraisal of the SIBO hypothesis and the limits of breath testing Review article authors assert that breath testing for small intestinal bacterial overgrowth in patients with irritable bowel syndrome yields a high number of false positives. Aug. 27, 2024 Parastomal hernia repair: Helping patients return to their everyday activities A specialized Mayo Clinic team repairs parastomal hernias, complications arising in 50% of patients postostomy. The team has substantial training and experience in this surgery and assists patients with their entire sto[...] Aug. 22, 2024 Examining the efficacy of recombinant zoster vaccination in patients with IBD The study also examined the incidence of herpes zoster-related complications, and the impact of IBD medications and comorbidities on infection risks. Aug. 22, 2024 J-pouch disorders: Classification and management In an American Journal of Gastroenterology publication, Mayo Clinic gastroenterologists discuss the most common disorders of the pouch, and recent research findings related to their evaluation and management. Aug. 22, 2024 Fecal calprotectin assay performs well as biomarker for measurement of ulcerative colitis disease activity FC levels can accurately identify endoscopic and clinical remission and may reduce the need for frequent colonoscopies and associated risks. June 26, 2024 Continued type 2 diabetes mellitus remission independent of weight loss observed in patients after Roux-en-Y gastric bypass Data from a retrospective study of 224 patients suggest that roux-en-Y gastric bypass can help patients sustain type 2 diabetes mellitus remission even when significant weight recurrence occurs. June 26, 2024 The role of endoscopic techniques in addressing postbariatric surgery complications Mayo Clinic researchers share a comprehensive overview of the most common postoperative complications and the techniques and devices available to help manage them. June 26, 2024 Association between individualized metabolic surgery scores and weight-loss outcomes in patients treated with semaglutide Retrospective study examines associations between individualized metabolic surgery scores and weight-loss outcomes in patients treated with semaglutide for obesity and type 2 diabetes mellitus. June 26, 2024 Assessing the prevalence and impact of obesity among individuals with Crohn's disease In a population-based study of individuals with newly diagnosed Crohn's disease (CD), researchers analyzed the prevalence of obesity and whether it affects disease phenotype and CD-related outcomes. May 08, 2024 Kefir may improve gut health of patients in the ICU Gut microbiome derangement is frequent in the ICU, potentially leading to a heightened risk of infections, organ failure, septic shock and mortality. A recent study assessed the safety, feasibility and impact of kefir a[...] April 13, 2024 Using machine learning algorithms to differentiate between acute cholangitis and alcohol-associated hepatitis Mayo Clinic researchers used data from 10 routinely available laboratory values to develop and train MLAs to help clinicians differentiate between the two conditions. April 13, 2024 Use of smartphone-enabled mood assessments and sensor data to predict alcohol craving in patients with alcohol-associated liver disease and alcohol use disorder Researchers identified specific patterns in smartphone-enabled mood assessments and sensor data that were associated with increased alcohol craving among patients with alcohol-associated liver disease and alcohol use di[...] Feb. 24, 2024 Researchers study novel endoscopic therapy for type 2 diabetes Mayo Clinic gastroenterologist Andrew C. Storm, M.D., answers questions about the use of endoscopic re-cellularization via electroporation therapy (ReCET) in individuals with difficult-to-control type 2 diabetes. Feb. 24, 2024 Small bowel endoluminal bariatric and metabolic therapies Mayo Clinic gastroenterologist Dilhana S. Badurdeen, M.B.B.S., M.D., discusses the duodenojejunal bypass sleeve, duodenal mucosal resurfacing, pharmacological duodenal exclusion therapy, duodenal mucosal electroporation[...] Feb. 24, 2024 Profiling the human gastric muscle immunome in patients with idiopathic gastroparesis By profiling the human gastric muscle immunome in patients with idiopathic gastroparesis, researchers observed macrophage-driven changes and distinct patterns of human gastric muscle immune cells. Jan. 11, 2024 Transnasal endoscopy offers sedative-free alternative Eosinophilic esophagitis is a chronic immune system disease where eosinophils build up in the lining of the esophagus. Mayo Clinic Children's Center offers a multidisciplinary approach, which includes an alternative to [...] Dec. 12, 2023 Endoluminal bariatric and metabolic therapies: Part 1 — Endoscopic sleeve gastroplasty Researchers document the current state of EBMTs and clinical outcomes associated with these approaches. Dec. 12, 2023 Use of machine learning models to predict Barrett esophagus and esophageal adenocarcinoma risk Researchers are hopeful that this model may enable effective implementation of minimally invasive screening technology for Barrett esophagus (BE) and esophageal adenocarcinoma (EAC). Dec. 12, 2023 Management of obesity within hepatology clinics Researchers discuss the role of dietary supplements, glucagon-like peptide 1 receptor agonists, sodium-glucose cotransporter-2 inhibitors and bariatric surgery in patients with gastrointestinal and liver diseases. Oct. 31, 2023 Examining the efficacy and safety of CBD in patients with idiopathic and diabetic gastroparesis Mayo Clinic researchers observed that patients who received twice-daily doses of cannabidiol (CBD) had favorable outcomes in a placebo-controlled clinical trial with 44 participants. Oct. 31, 2023 Isolated bulb celiac disease in children Separating biopsies from the duodenal bulb and the distal duodenum enhances diagnostic sensitivity, especially in patients with lower celiac serology levels and disease isolated to the duodenal bulb. Oct. 31, 2023 Does pre-procedure knowledge of a positive multitarget stool DNA test improve polyp diagnosis rates? Pre-procedure knowledge of a positive multitarget stool DNA test improves polyp detection rates in follow-up colonoscopies. Oct. 31, 2023 Analysis of patient outcomes after flexible endoscopic Zenker diverticulotomy Mayo Clinic researchers analyzed data from 84 procedures, noting patient demographics, clinical features, procedural characteristics, adverse events and outcomes. Oct. 04, 2023 Pediatric metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD) Although MASLD is the primary cause of pediatric liver disease, not all children with MASLD have obesity, which makes it critical to diagnose and treat the root cause. Sept. 20, 2023 New gene markers detect Lynch syndrome-associated colorectal cancer, Mayo Clinic study ROCHESTER, Minn. — Researchers from Mayo Clinic Comprehensive Cancer Center and Mayo Clinic Center for Individualized Medicine have discovered new genetic markers to identify Lynch syndrome-associated colorectal cancer wit[...] Aug. 19, 2023 Examining interobserver agreement among endoscopists grading morphology and predicting histopathology of colorectal lesions in patients with inflammatory bowel disease Results show low interobserver agreement and low accuracy among endoscopists determining Paris and modified Paris classifications, lesion borders, and histopathology predictions. Aug. 19, 2023 Esophageal endoscopic submucosal dissection In this Q&A, Mayo Clinic gastroenterologist Norio Fukami, M.D., describes techniques and benefits associated with esophageal endoscopic submucosal dissection (ESD). Aug. 19, 2023 Scientific and clinical advances aid in diagnosis, staging and treatment of cholangiocarcinoma Sumera I. Ilyas, M.B.B.S., and colleagues highlight key areas of research that are helping clinicians better understand and treat cholangiocarcinoma. Aug. 19, 2023 Prior authorization process can have multiple negative impacts for gastroenterologists and patients with inflammatory bowel disease In a published letter to the editor, Mayo Clinic physicians discuss the impact of the prior authorization process and advocate for change that prioritizes evidence-based treatment decisions. June 16, 2023 Why gastroenterologists and hepatologists should be involved in treating obesity Mayo Clinic gastroenterologist Michael Camilleri, M.D., D.Sc., discusses the interplay between gastrointestinal and liver diseases and obesity, and the role of gastroenterologists in addressing these conditions. June 16, 2023 Analyzing the impact of EHR use on gastroenterology providers A retrospective study examined electronic health record (EHR) use among gastroenterology specialists and whether provider sex, clinical subspecialty or training level was associated with increased EHR related burdens. June 16, 2023 Examining HBV vaccine efficacy and durability in individuals with IBD and celiac disease Low hepatitis B surface antigen antibody titers in fully vaccinated patients may not indicate a lack of immunity. April 21, 2023 Optimizing surveillance in patients with dysplastic Barrett esophagus after endoscopic eradication Study results suggest that lengthening surveillance intervals would reduce the burden of endoscopic procedures without increasing rate of recurrence. April 21, 2023 Examining the use of endoscopic bariatric therapy in patients with IBD Five individuals with inflammatory bowel disease (IBD) and obesity experienced effective weight loss after endoscopic bariatric therapy (EBT). April 21, 2023 Assessing the performance of multitarget stool DNA testing in individuals with history of radiation therapy Researchers conclude that prior radiation treatment does not appear to adversely affect mt-sDNA test performance in colorectal cancer screening. March 02, 2023 Early Mayo Clinic research finds hope in stem cell therapy for perianal fistulas in patients with Crohn’s disease Mayo Clinic researchers documented healing and few side effects in patients with single-tract fistulas who were treated with the bioabsorbable, surgically implanted plug. Feb. 28, 2023 Mayo Clinic Healthcare expert: Artificial intelligence improves colonoscopy accuracy LONDON — James East, M.D., spends his days skillfully examining people’s colons, searching for and snaring away suspicious polyps that might one day turn into cancer. A gastroenterologist at Mayo Clinic Healthcare in Londo[...] Feb. 11, 2023 Impact of ESG on weight loss, gastric emptying, gastric motility, obesity-related hormones and eating behaviors Study results suggest that ESG can lead to greater weight loss, while preserving gastric motility and favorable changes in gastric emptying and obesity-related hormones. Feb. 11, 2023 Endoscopic retrograde cholangiography versus percutaneous transhepatic biliary drainage in liver transplant recipients with a Roux-en-Y biliary-enteric anastomosis Study data suggest that endoscopic retrograde cholangiography (ERC) and percutaneous transhepatic biliary drainage (PTBD) have comparable effectiveness in this patient population. Feb. 11, 2023 Research using latent class analysis reveals distinct patient clusters based on clinical, dietary, lifestyle and psychosocial factors associated with IBS The seven unique disease subsets identified among patients diagnosed with irritable bowel syndrome (IBS) suggest that variables beyond predominant bowel habits affect clinical course and outcomes. Dec. 15, 2022 Gastrointestinal manifestations of common variable immunodeficiency Mayo Clinic gastroenterologists discuss clinical presentations, diagnostic considerations and therapeutic options for the GI manifestations of common variable immunodeficiency (CVID). Dec. 15, 2022 Treatment of recurrent CDI: Examining the efficacy and safety of standardized live biotherapeutics as microbiota restoration therapies Mayo Clinic gastroenterologist Sahil Khanna, M.B.B.S., M.S., discusses two microbiota restoration therapies for treatment of recurrent Clostridioides difficile infection. Dec. 15, 2022 Understanding the needs and burdens of patients with CIC and IBS-C Identifying these issues helps clinicians understand patients' experiences and develop effective treatment strategies. Dec. 15, 2022 Addressing the rising incidence of early-onset colorectal cancer Mayo Clinic gastroenterologist Frank A. Sinicrope, M.D., analyzes current evidence related to the phenotype and diagnosis of early-onset colorectal cancer and strategies to address the increasing incidence of this disea[...] Nov. 03, 2022 Hepatic artery infusion pump chemotherapy spares livers and saves lives Mayo Clinic in Minnesota has begun treating liver metastases using hepatic artery infusion pump chemotherapy. This intensified, targeted chemotherapy provides potentially curative options for patients where they did not[...] Oct. 20, 2022 Large, multicenter randomized clinical trial examines the safety and efficacy of ESG Endoscopic sleeve gastroplasty (ESG), combined with lifestyle modifications, is a safe intervention that can help patients achieve and maintain significant weight loss and improvements in metabolic comorbidities. Oct. 20, 2022 Examining the efficacy of CBD in patients with functional dyspepsia and normal gastric emptying A randomized, double-blind, controlled trial showed that symptom relief associated with cannabidiol (CBD) and placebo were not significantly different. Oct. 20, 2022 Exploring the use of MRE and liver stiffness measurement to guide treatment and predict outcomes in patients with NAFLD Study suggests that liver stiffness measurement obtained through magnetic resonance elastography (MRE) can help individualize care and predict outcomes in patients with nonalcoholic fatty liver disease. Aug. 19, 2022 Factors related to jaundice and transplant-free survival in patients with PSC who receive endoscopic treatment The likelihood of resolution is affected by demographic, hepatic and biliary variables and can be predicted using noninvasive data. Aug. 19, 2022 Management of short bowel syndrome in adult patients Adult patients diagnosed with this complex condition can benefit from nutritional support, fluid and electrolyte management, pharmacologic therapies, and surgery provided by an experienced team. Aug. 19, 2022 Procedural and anthropometric factors associated with musculoskeletal injuries among gastroenterology endoscopists Findings reveal increasing rates of musculoskeletal symptoms and injury among endoscopists, many of which are significant enough to affect their daily function. Aug. 19, 2022 Health care maintenance in patients with IBD Following preventive care recommendations is extremely important in the management of patients with inflammatory bowel disease. Aug. 12, 2022 AI-assisted colonoscopies reduce miss rate by 50 percent In a multicenter, multicountry study, Mayo Clinic Gastroenterology and Hepatology joined a global collaboration to analyze the use of artificial intelligence (AI) in colorectal cancer screening. AI support reduced adeno[...] July 23, 2022 Expanding insights into autoimmune GI dysmotility Mayo Clinic has expertise and experience with this debilitating dysautonomia. Autoimmune neurologists work closely with GI specialists to provide care. July 14, 2022 Novel stem cell therapy for perianal fistula in pediatric patients with Crohn's disease Pediatric onset of Crohn's disease is associated with more-aggressive perianal fistula development. New therapy derives stem cells from patients' fat cells to create a plug to close the opening. June 17, 2022 Convolutional neural network detects and estimates severity of cirrhosis using ECG findings A deep learning-based artificial intelligence model using convolutional neural networks to analyze 12-lead electrocardiograms (ECGs) performed well in detecting the presence and severity of hepatic cirrhosis. June 17, 2022 Use of comprehensive multigene panel testing for patients with HBC Data from Mayo Clinic's INTERCEPT trial suggests that germline testing should be considered in all patients with hepatobiliary cancer (HBC). June 17, 2022 Examining the use of ETO gas sterilization and high-level disinfection on EUS imaging equipment Addition of ethylene oxide (ETO) gas sterilization to the disinfection process for endoscopic ultrasound (EUS) equipment does not appear to degrade image and video quality. June 09, 2022 Artificial intelligence informs solutions for gastric cancer challenges For gastric cancer, most patients are currently treated with surgery and chemotherapy. This new 32-gene signature can further stratify patients' diagnoses for a more tailored treatment plan. April 19, 2022 Vaccine efficacy and antibody response among patients with IBD and recipients of immunosuppressive agents Studies explore vaccine efficacy, antibody response and other outcomes in individuals with inflammatory bowel disease and patients receiving immune-modifying therapies. April 19, 2022 Use of prophylactic clip placement to reduce post-EMR bleeding In this Q&A, Mayo Clinic gastroenterologist Norio Fukami, M.D., discusses the role of prophylactic clip placement in reducing clinically significant post-EMR bleeding. April 19, 2022 Evaluation and management of small bowel bleeding Mayo Clinic gastroenterologists discuss the various etiologies of small bowel bleeding and a stepwise guide for diagnosing and managing this condition. Feb. 12, 2022 Researchers evaluate endoscopic through-the-scope tack and suture system A multicenter study led by Mayo Clinic physicians demonstrated that the endoscopic through-the-scope tack and suture system is safe and efficient. Feb. 12, 2022 Intrinsic tactile sensitivity within the GI tract linked to the activity of specialized sensory enteroendocrine cells Research demonstrates that specialized sensory cells within the gastrointestinal tract have a lot in common with the way the skin feels the sensation of touch. Feb. 12, 2022 Survey examines attitudes about ESG from providers around the world A Mayo Clinic survey assessed ESG-related practice trends and preferences of bariatric endoscopists who perform this weight-loss procedure. Feb. 12, 2022 Role of gut microbiota in obesity and the future of microbiota therapeutics for obesity Mayo Clinic researchers summarize the pathogenesis of obesity, the relationship between gut microbiota and obesity, and the future of microbiota-based therapies in obesity management. Jan. 25, 2022 Examining the clinical presentation and imaging characteristics of cryptogenic multifocal ulcerous stenosing enteritis Research supports that differential diagnosis of short, multifocal small bowel strictures should always include Crohn's disease, NSAID-induced enteropathy and cryptogenic multifocal ulcerous stenosing enteritis (CMUSE).[...] Jan. 25, 2022 Use of antispasmodics for the treatment of abdominal pain Data supporting the use of antispasmodics for the treatment of chronic abdominal pain in patients with disorders of gut-brain interaction (DGBI), including irritable bowel symptom and functional dyspepsia, are limited. Jan. 25, 2022 The role of capsule endoscopy in diagnosis and management of inflammatory bowel disease Mayo Clinic gastroenterologists discuss the indications, strengths and limitations of capsule endoscopy in the diagnosis and management of inflammatory bowel disease (IBD). Jan. 25, 2022 Diagnosis and management of patients with gastroparesis In commentary published in Neurogastroenterology & Motility in 2021, Mayo Clinic gastroenterology researchers identify five high-priority areas that require the attention of researchers in gastroparesis to advance t[...] Dec. 20, 2021 Improving implementation of best practice guidelines for colorectal cancer screening A web-based survey tool to assess factors shaping clinician beliefs and behaviors surrounding average-risk colorectal cancer screening strategies provides valid and consistent information about respondents. Nov. 20, 2021 Liver transplantation for colorectal liver metastases at Mayo Clinic in Jacksonville, Florida Mayo Clinic in Jacksonville, Florida, is one of only a few centers in the U.S. offering liver transplant as a treatment option for highly selected patients with colorectal liver metastases. Oct. 20, 2021 Learning to assess and manage eating disorders In this Q and A, gastroenterologist Brian E. Lacy, M.D., Ph.D., discusses maladaptive eating behaviors and provides useful tools to help clinicians identify and treat these illnesses. Oct. 20, 2021 Understanding lean NAFLD: Results from a population-based study A population-based, longitudinal study compares the trajectory of nonalcoholic fatty liver disease (NAFLD) in lean, overweight and obese individuals. Oct. 20, 2021 Examining the role of fatty acid ethyl esters in diagnosing alcoholic pancreatitis In a blinded, prospective study, investigators studied whether fatty acid ethyl esters, nonoxidative ethanol metabolites that are elevated during intoxication, can help in diagnosing alcoholic pancreatitis. Aug. 17, 2021 Use of weight-loss pharmacotherapy in patients with cirrhosis and in liver transplant recipients More data is needed to establish the safety and efficacy of these agents in the pretransplant and post-transplant settings. Aug. 17, 2021 Endoscopic retrograde cholangiopancreatography-guided transpapillary gallbladder drainage (ERGD): A minimally invasive treatment for acute cholecystitis When performed using a double-pigtail stent, endoscopic retrograde cholangiopancreatography-guided transpapillary gallbladder drainage (ERGD) can help maintain biliary anatomy and provide durable drainage. Aug. 17, 2021 Treatment response and management of biologics in patients with ECD Mayo Clinic researchers describe the clinical features and response to biologic treatment in patients with esophageal Crohn's disease (ECD), a rare Crohn's disease phenotype. June 18, 2021 Using a phenotype-guided approach for the treatment of obesity Actionable phenotypes of obesity based on pathophysiology and behavior can help individualize pharmacotherapy and enhance outcomes. June 18, 2021 Assessing the performance of methylated DNA markers in blood for detection of pancreatic ductal adenocarcinoma A blood test combining methylated DNA markers with carbohydrate antigen 19-9 detects pancreatic ductal adenocarcinoma with high accuracy. June 18, 2021 Assessing the prevalence of Barrett's esophagus in patients with scleroderma Study results suggest that women with scleroderma should be included in the screening recommendations for Barrett's esophagus and treated accordingly if dysplasia is found. June 11, 2021 Where we are with gastric and esophageal cancers A Mayo Clinic medical oncologist answers questions about diagnosis and screening and discusses treatment advances in recent years for gastric and esophageal cancers. April 17, 2021 Understanding and managing chronic abdominal bloating and distension Mayo Clinic gastroenterologists review the epidemiology, effects and pathophysiology of chronic bloating and distension and describe diagnostic strategies and available treatment options. April 17, 2021 Encouraging innovation in gastroenterology and endoscopy Mayo Clinic gastroenterologist Elizabeth Rajan, M.D., answers questions about the skills and processes that guide physician-investigators working on device and technology innovation. April 17, 2021 Young-onset esophageal adenocarcinoma: Results from a population-based study Mayo Clinic research examining the incidence, stage distribution and survival outcomes associated with esophageal adenocarcinoma (EAC) in a large population-based study yields some surprising results about young-onset E[...] March 05, 2021 mt-sDNA test shows high specificity for colorectal cancer screening in average-risk 45- to 49-year-olds The multitarget stool DNA (mt-sDNA) test showed more than 95% specificity in a cross-sectional study of 45- to 49-year-old patients at average risk for colorectal cancer. Feb. 13, 2021 Esophageal dysfunction after bariatric surgery Esophageal dysmotility disorders, including an achalasia-like condition referred to as post-obesity surgery esophageal dysfunction (POSED), may be an underrecognized bariatric surgery complication. Feb. 13, 2021 Updates from trials of microbiome restoration products Multiple trials are examining alternatives to fecal microbiota transplantation, including capsule- and enema-based therapies, for treatment of recurrent Clostridioides difficile infection. Feb. 13, 2021 Screening strategies for prevalent esophageal adenocarcinoma may be different from those recommended for Barrett's esophagus Researchers find evidence that a second phenotype of esophageal adenocarcinoma is not associated with chronic gastroesophageal reflux and other Barrett's esophagus risk factors. Feb. 13, 2021 Convolutional neural network trained to distinguish autoimmune pancreatitis from pancreatic ductal adenocarcinoma and benign pancreas conditions Using an extensive endoscopic ultrasound image and video database, researchers developed and validated a convolutional neural network trained to distinguish autoimmune pancreatitis from pancreatic ductal adenocarcinoma [...] Feb. 05, 2021 The use of transoral outlet reduction endoscopy to manage weight regain after gastric bypass: A comparison of 2 endoscopic techniques Meta-analysis supports that full-thickness suturing plus argon plasma mucosal coagulation and argon plasma mucosal coagulation both offer safe, sustained weight-loss outcomes for patients who regain weight following Rou[...] Feb. 05, 2021 How obesity affects IBD management and patient outcomes: Q&A with Amanda M. Johnson, M.D. Prospective disease evaluation, improved control of confounding factors, and obesity measures that reflect visceral adipose tissue are needed to understand obesity's role in the pathogenesis and management of inflammato[...] Feb. 05, 2021 Understanding post-infection irritable bowel syndrome: A large population-based study Using Minnesota Department of Health surveillance data, researchers confirmed that 1 in 5 patients diagnosed with campylobacter infection may develop post-infection irritable bowel syndrome (PI-IBS). Feb. 05, 2021 Management of recurrent Clostridioides difficile infection and use of fecal microbiota transplantation during the COVID-19 pandemic Testing and COVID-19 status matching of both stool donors and fecal microbiota transplantation (FMT) recipients must occur to prevent transmitting COVID-19 via FMT using donor stool. Jan. 19, 2021 Mayo Clinic's Pediatric Liver Clinic provides exceptional care for patients requiring transplant Mayo Clinic Pediatric Liver Clinic specialists deliver an extensive evaluation to provide a comprehensive assessment and treatment plan for pediatric patients with liver disease. Nov. 02, 2020 Mayo Clinic study finds 1 in 8 patients with cancer harbor inherited genetic mutations The Interrogating Cancer Etiology Using Proactive Genetic Testing (INTERCEPT) study represents the largest known multicenter study of universal testing of patients with cancer. Aug. 28, 2020 Identification of actionable alterations in colorectal cancer are leading to the development of novel treatment strategies Daniel H. Ahn, D.O., talks about the latest advancements and research in colorectal cancer treatment. Aug. 15, 2020 Comparing modalities for detecting dysplasia in patients with IBD A one-year cross-sectional IBD surveillance colonoscopy cohort compares high-definition white light endoscopy and chromoendoscopy. Aug. 15, 2020 Avoiding a drainage tube through the skin for patients with postoperative abdominal fluid collections The study results suggest endoscopic ultrasound-guided drainage of postoperative fluid collections is a safe, effective alternative to percutaneous drain placement. Aug. 15, 2020 Studying bowel prep for capsule endoscopy A Mayo Clinic study investigates the use of comprehensive purgative preparation combined with right lateral positioning. Aug. 15, 2020 Examining COVID-19 polymerase chain reaction testing before endoscopy A Mayo Clinic study used computer modeling to compare different approaches for COVID-19 testing in patients requiring semi-urgent and elective endoscopies. June 16, 2020 Mayo Clinic, NASA team up to test AI algorithm on colorectal cancer A Center for Individualized Medicine algorithm shows potential in detecting spatio-temporal patterns of colorectal cancer progression from tumor snapshots to predict the cancer's evolutionary trajectory. April 18, 2020 Examining the role of visceral fat in worsening inflammation, organ failure and reduced survival in patients with acute pancreatitis A Mayo Clinic study describes the progression of visceral adipose injury, rapid fat necrosis, worsening inflammation and organ failure that can occur during acute pancreatitis. April 18, 2020 Understanding the role of proteolytic activity in mediating irritable bowel syndrome symptoms and disruption of intestinal barrier function Mayo Clinic researchers examined fecal proteolytic activity in individuals with post-infection and constipation-predominant irritable bowel syndrome, and its association with clinical symptoms and microbiota composition[...] April 18, 2020 Diagnosis and management of patients with chronic constipation Adil E. Bharucha, M.B.B.S, M.D., answers key questions about the diagnosis and management of patients with this common condition. April 18, 2020 Understanding the clinical significance of disease detected by imaging but not by ileoscopy or biopsy Researchers conclude that patients with evidence of ileal inflammation on enterography are likely to have active inflammatory disease, even when results of ileoscopy and biopsy appear normal. Feb. 14, 2020 Role of AI in detection and management of colorectal polyps and cancer Up to 25% of polyps can be missed during colonoscopy, due to factors such as withdrawal time, preparation quality and the endoscopist's ability to recognize flat polyps. Feb. 14, 2020 Head-to-head comparison between vedolizumab and adalimumab for treatment of moderately to severely active ulcerative colitis A head-to-head comparison suggests that vedolizumab is slightly superior to adalimumab for moderately to severely active ulcerative colitis and should be considered a first line biologic for this disease. Feb. 14, 2020 Novel approaches to the diagnosis of bile acid diarrhea In this Q and A, Mayo Clinic gastroenterologist Michael Camilleri, M.D., discusses the available and developing approaches to the diagnosis of bile acid diarrhea. Feb. 14, 2020 Prepless colon capsule technology: New research examines this less invasive approach to colorectal cancer screening Mayo gastroenterologists are collaborating in the first U.S. study evaluating the safety and compliance of a prepless capsule imaging system for colorectal cancer (CRC) screening. Feb. 14, 2020 Detection of esophageal cancer via assay of novel methylated DNA markers in plasma In the largest plasma-based pilot of esophageal cancer biomarkers to date, Mayo Clinic researchers identified five methylated DNA markers (MDMs) that achieved high discrimination for cancer. Feb. 14, 2020 Reducing post-polypectomy bleeding events in patients who require antithrombotic agents Mayo Clinic gastroenterologist Neena S. Abraham, M.D., M.S., reviews research findings related to the use of antithrombotic agents, polypectomy techniques and prophylactic placement of hemostatic clips, and their impact[...] Feb. 14, 2020 Update on hereditary gastrointestinal cancers: Lynch syndrome and familial adenomatous polyposis syndromes A primer on Lynch syndrome, familial adenomatous polyposis (FAP) and attenuated FAP provides clinicians with tools to understand the genetic bases of these conditions and appropriate diagnosis and management. Oct. 22, 2019 Panel of methylated DNA markers provides improved accuracy in detecting advanced neoplasia and other lesions that may require resection Researchers identified and validated a panel of DNA methylation markers that can detect advanced neoplasia and help determine which cysts require surgery. Oct. 22, 2019 The emerging role of AI in medicine, gastroenterology and hepatology In this Q & A, Mayo Clinic gastroenterologist Shounak Majumder, M.D., discusses this tool's potential impact within health care and within ongoing research, clinical practice and education efforts. Oct. 22, 2019 Assessing the timeline, location and patterns of recurrence in patients achieving complete remission after radiofrequency ablation Researchers assessed the timeline, location and patterns of recurrence in patients who achieved remission after radiofrequency ablation in a multicenter cohort study. Oct. 22, 2019 Evaluating the safety and diagnostic accuracy of endoscopic fine-needle aspiration for detection of extravascular migratory metastases in the pancreas In a retrospective review, researchers demonstrated that cytology analysis of pancreatic samples collected by endoscopic ultrasound fine-needle aspiration (EUS-FNA) can detect extravascular migratory metastases often mi[...] Aug. 16, 2019 Examining clinical and genetic factors that impact response to anti-TNF agents in patients with IBD Researchers developed and validated a model that predicts the influence of clinical and genetic factors on an individual's responsiveness to anti-TNF therapy. Aug. 16, 2019 Research establishes strong association between family history and increased risk of colorectal cancer in patients with inflammatory bowel diseases A large study demonstrates an elevated risk of colorectal cancer in individuals with inflammatory bowel disease (IBD) and in individuals with IBD who have a close relative with colorectal cancer. Aug. 16, 2019 EMR Scar Assessment Project for Endoscope (ESCAPE) trial helps determine when biopsy is necessary Researchers seek to determine which tools can help clinicians maximize the accuracy of optical diagnosis and avoid unnecessary biopsy. Aug. 16, 2019 Use of interventional endoscopy in management of gastrointestinal disorders and post-surgical complications in high-risk patients New endoscopic strategies can obviate the need for invasive surgeries, as well as mitigate the complications of gastrointestinal surgeries in high-risk patients. June 11, 2019 Update on IBS treatments: Examining the efficacy of antidepressants, psychological therapies, prebiotics, probiotics, synbiotics and antibiotics Researchers share new information about efficacy of antidepressants, psychological therapies, prebiotics, probiotics, synbiotics and antibiotics in treating individuals with irritable bowel syndrome (IBS). June 11, 2019 The microbiome, fecal microbiota transplants and inflammatory bowel disease Understanding dysbiosis — the disruption in the bacterial communities that populate the intestinal tract — may lead to a new role for fecal microbiota transplants in treating inflammatory bowel disease. June 11, 2019 3 factors associated with improved outcomes for individuals with pancreatic ductal adenocarcinoma A Mayo Clinic study finds that a pre-surgery treatment plan focused on three factors can extend life years beyond the average survival time. April 13, 2019 New vein of research focuses on inducing pancreatic hypothermia to reduce injury associated with mild and severe acute pancreatitis In an article published in Gastroenterology, researchers share findings that they hope will improve the understanding of how best to manage this condition in humans. April 13, 2019 Use of endoscopic submucosal dissection for treatment of gastrointestinal lesions Although its adoption in Western countries has been slow, experienced endoscopists are now using endoscopic submucosal dissection (ESD) to treat premalignant and early-stage malignant lesions within the stomach, esophag[...] April 13, 2019 Positive patient outcomes associated with liver transplant plus sleeve gastrectomy combination Study participants undergoing simultaneous liver transplant and sleeve gastrectomy had a more effective and more durable weight loss, as well as fewer metabolic complications. Feb. 16, 2019 Examining the role of gut microbial composition and function in weight loss Mayo Clinic researchers compared clinical characteristics and gut microbial composition and function in 26 adult study participants. Feb. 16, 2019 Transoral endoscopic incisionless fundoplication Barham K. Abu Dayyeh, M.D., M.P.H., answers key questions about transoral incisionless fundoplication and provides an overview of recent research findings evaluating the efficacy of this approach. Feb. 16, 2019 A closer look at sarcopenia and the role of exercise in liver transplant candidates Results from two multicenter studies help address the problem of progressive loss muscle mass and associated outcomes in liver transplant patients. Feb. 09, 2019 Advanced imaging and endoscopic tools enhance diagnosis and treatment of PSC and cancer surveillance Mayo specialists employ highly specialized magnetic resonance cholangiopancreatography (MRCP) to diagnose and manage primary sclerosing cholangitis (PSC) in a large cohort of patients. Feb. 09, 2019 Advances in the treatment of Crohn's disease and ulcerative colitis When used in a treat-to-target approach, therapies for mucosal healing may favorably modify the natural history of inflammatory bowel disease (IBD), reducing the need for steroids and risk of hospitalization. Feb. 09, 2019 Nonpharmacological approaches to management of functional gastrointestinal disorders — Where are we now? Gastroenterologists discuss the Mayo Clinic experience and research in the use of dietary interventions and other nonpharmacological measures to manage irritable bowel syndrome and other functional gastrointestinal diso[...] Oct. 23, 2018 Updated IDSA guideline for treatment of Clostridium difficile infection Mayo Clinic gastroenterologists discuss new Clostridium difficile infection (CDI) treatment recommendations developed by the Infectious Diseases Society of America and Society for Healthcare Epidemiology of America, add[...] Oct. 23, 2018 Esophageal cancers: Recent advances and challenges associated with early detection Because early diagnosis is associated with improved survival rates for both esophageal adenocarcinoma and squamous cell carcinoma, the search for accurate, cost-effective and widely accepted screening tools remains a pr[...] Oct. 23, 2018 Evaluating the role of peroral endoscopic myotomy in the treatment of achalasia Available study data suggest that in the hands of a well-trained endoscopist, peroral endoscopic myotomy (POEM) can combine the performance of surgical myotomy with the safety profile of an endoscopic procedure. Oct. 18, 2018 Endoscopic mucosal resection for management of large colorectal polyps Aug. 18, 2018 Pancreatic cancer screening in high-risk individuals Because pancreatic cancer and precursor lesions detected early are potentially curable with surgery, there is growing interest in evaluating whether screening of high-risk individuals is effective. Aug. 18, 2018 ACS announces new guideline for colorectal cancer screening for adults at average risk In an announcement published in late May, the American Cancer Society released a new guideline recommending that regular screening for colorectal cancer should begin at age 45 for adults at average risk. Aug. 18, 2018 Tofacitinib is first oral medication approved for use in treating moderate to severe ulcerative colitis Tofacitinib, a Janus kinase (JAK) inhibitor, is the first oral medication approved for chronic use in this indication. June 13, 2018 Transoral outlet reduction with full thickness endoscopic suturing addresses weight regain after gastric bypass Transoral outlet reduction endoscopy (TORe) is a novel approach to reducing the stoma diameter that can be performed on an outpatient basis. June 12, 2018 Inflammatory bowel disease biobank research update Researchers from Mayo Clinic's inflammatory bowel disease (IBD) biobank are hopeful that serologic and genetic markers will help them develop therapeutic approaches tailored to an individual's unique genetic or molecula[...] June 12, 2018 Opioid-induced esophageal dysfunction Opioid-induced esophageal dysfunction is the subject of multiple studies conducted by Mayo Clinic researchers and colleagues. April 14, 2018 Laparoscopic gastrectomy for gastric cancer The minimally invasive procedure offers faster recovery, less blood loss and pain, and a return to eating and normal bowel function more quickly. The hospital stay is shorter and the patient is less likely to need a fee[...] April 13, 2018 Transforming noninvasive liver disease detection by MRE: the hepatogram Mayo researchers recently studied the use of magnetic resonance elastography (MRE) to detect nonalcoholic steatohepatitis (NASH) in its earlier stages, before the onset of fibrosis. April 13, 2018 Assessing the risk of tumoremia after endoscopic ultrasound-guided fine-needle aspiration of pancreatic adenocarcinoma Although endoscopic ultrasound-guided fine-needle aspiration is thought to be safe, some experts question whether tumor manipulation during this procedure causes tumors to shed cells into the bloodstream. April 13, 2018 Clip-assisted endoscopic full-thickness resection and biopsy techniques Clip-assisted endoscopic full-thickness resection (EFTR) and endoscopic full-thickness biopsy (EFTB) provide an alternative to surgery in the management of epithelial and subepithelial lesions and diagnosis of neuromusc[...] Feb. 27, 2018 Diagnosis and management of small bowel bleeding: Update on diagnostic and therapeutic tools Important issues to consider in the diagnosis and management of small bowel bleeding include appropriate selection of patients for evaluation, optimal selection and timing of tests, and an understanding of when a conser[...] Feb. 27, 2018 Inherited cancers clinic seeks to advance understanding, diagnosis and management of hereditary colorectal cancers Use of a simple questionnaire of personal and family history of cancer in outpatient settings helps improve the identification of high-risk patients and families, detect cancers earlier, and formulate more-effective ind[...] Feb. 27, 2018 Role of novel DNA methylation markers in detection of advanced neoplasia in pancreatic cysts Researchers successfully identified and validated novel methylated DNA markers in pancreatic tissue that discriminate — more accurately than currently available cyst fluid markers — high-grade precursor lesi[...] Feb. 20, 2018 NAFLD and NASH research update Mayo Clinic researchers are exploring several new treatment options for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Feb. 20, 2018 Understanding HCV and evolving treatment guidelines Hugo E. Vargas, M.D., a gastroenterologist and hepatologist specializing in viral hepatitis and liver transplantation at Mayo Clinic's campus in Arizona, answers several key questions about hepatitis C virus (HCV) infec[...] Feb. 20, 2018 Identifying diarrhea caused by bile acid malabsorption Bile acid malabsorption occurs in about one-third of patients diagnosed with irritable bowel syndrome with diarrhea. The serum 7αC4 test and the fecal bile acid excretion test help identify these patients so that [...] Feb. 20, 2018 Targeted DNA next-generation sequencing aids the molecular assessment of pancreatic neuroendocrine tumors A recent Mayo Clinic study demonstrated that endoscopic ultrasound-acquired cytology-based tumor genotyping can reveal a spectrum of genetic variants, which may help guide biomarker-driven, individualized, targeted trea[...] Nov. 17, 2017 Use of dietary strategies in treating eosinophilic esophagitis Mayo Clinic gastroenterologist Jeffrey A. Alexander, M.D., explains current research findings and clinical experience related to the use of elimination diets in the treatment of eosinophilic esophagitis. March 28, 2017 The role of lifestyle-related treatments for IBS Therapeutic options for irritable bowel syndrome (IBS) focus on alleviating symptoms. This article addresses the role of diet, exercise and sleep modifications in the treatment of IBS. March 28, 2017 Treatment of Zenker's diverticulum Mayo Clinic experience and recently published data suggest that one or two treatments using a flexible endoscopic approach can provide a high rate of symptom relief and a low rate of diverticular recurrence or persisten[...] Nov. 12, 2016 Food sensitivities may affect gut barrier function Despite growing evidence implicating dietary factors in dysregulated gut barrier function, much about these interactions isn't clear, especially in the absence of food sensitivity biomarkers and validated assays for int[...] May 13, 2016 Hemorrhoidal disease: Diagnosis and management Rubber band ligation has been shown to be a safe, effective and painless therapy for grade I and grade II hemorrhoids. Although less durable than surgical excision, it is also less costly, has fewer complications and ze[...] Sept. 05, 2015 Current and future treatments for irritable bowel syndrome associated with diarrhea Better agents needed for IBS-D - Pharmacological treatments for diarrhea-predominant irritable bowel syndrome (IBS-D) are limited and often fail to relieve pain or the full spectrum of associated symptoms. An expert dis[...] Medical Professionals Digestive Diseases News