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Shannon P. Fortin Ensign, M.D., Ph.D.

  1. Oncologist

Shannon Fortin Ensign, M.D., Ph.D., is an Oncologist and Physician-Scientist with Mayo Clinic Arizona, with a special interest and expertise in Neuro-Oncology.

Dr. Fortin Ensign received her bachelor's degree in Biochemistry at Arizona State University during which time she was awarded a national Goldwater Scholarship and international Fulbright Fellowship for her work in cancer research. She subsequently earned her dual MD, PhD degree from the University of Arizona College of Medicine Phoenix in collaboration with the Translational Genomics Research Institute. Her PhD thesis focused on molecular signaling in glioblastoma tumors. She completed Internal Medicine residency and served as chief resident at Scripps Clinic in La Jolla, CA while also a concurrent KL2 scholar under the American Board of Internal Medicine Physician Scientist training track. She then completed a Hematology & Oncology fellowship with Mayo Clinic Arizona, where she was chief fellow.

Dr. Fortin Ensign's clinical practice focuses on diagnosing and treating patients with primary brain tumors and brain metastases. She also oversees a translational brain tumor research lab at Mayo Clinic with a primary focus on understanding the biology and genomics of gliomas in order to identify tumor vulnerabilities and advance new treatments for brain cancer.

  1. Acoustic neuroma
  2. Astrocytoma
  3. Brain metastasis
  4. Brain tumor
  5. Chordoma
  6. Craniopharyngioma
  7. Ependymoma
  8. Glioblastoma
  9. Glioma
  10. Leptomeningeal metastases
  11. Medulloblastoma
  12. Meningioma
  13. Neurofibroma
  14. Oligodendroglioma
  15. Peripheral nerve tumor
  16. Pituitary tumor
  17. Primary CNS lymphoma
  18. Spinal cord tumor
  1. Intrathecal chemotherapy
  • Treatment of primary brain tumors, brain metastases & leptomeningeal disease
  • Clinical trials for brain tumors
  • Translational research on the biology and genomics of brain tumors
  • Identification of novel drug targets for personalized medicine in CNS malignancies
  1. 2022
    Chief FellowHematology/Oncology Fellowship, Internal Medicine, Programs in Arizona, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  2. 2022
    FellowHematology/Oncology Fellowship, Internal Medicine, Programs in Arizona, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  3. 2019
    Chief Resident - Internal MedicineDepartment of Internal Medicine, Scripps Green Hospital Graduate Medical Education
  4. 2019
    Residency - Internal MedicineDepartment of Internal Medicine, Scripps Green Hospital Graduate Medical Education
  5. 2015
    MD - MedicineUniversity of Arizona College of Medicine - Phoenix
  6. 2013
    Ph.D. - Cancer BiologyUniversity of Arizona/Translational Genomics Research Institute
  7. 2008
    Fulbright Scholar - FellowshipUniversité Libre de Bruxelles
  8. 2007
    BS - BiochemistryArizona State University