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Shannon P. Fortin Ensign, M.D., Ph.D.

  1. Oncologist

Shannon Fortin Ensign, M.D., Ph.D., is an Oncologist and Physician-Scientist with Mayo Clinic Arizona, with a special interest and expertise in Neuro-Oncology.

Dr. Fortin Ensign received her bachelor's degree in Biochemistry at Arizona State University during which time she was awarded a national Goldwater Scholarship and international Fulbright Fellowship for her work in cancer research. She subsequently earned her dual MD, PhD degree from the University of Arizona College of Medicine Phoenix in collaboration with the Translational Genomics Research Institute. Her PhD thesis focused on molecular signaling in glioblastoma tumors. She completed Internal Medicine residency and served as chief resident at Scripps Clinic in La Jolla, CA while also a concurrent KL2 scholar under the American Board of Internal Medicine Physician Scientist training track. She then completed a Hematology & Oncology fellowship with Mayo Clinic Arizona, where she was chief fellow.

Dr. Fortin Ensign's clinical practice focuses on diagnosing and treating patients with primary brain tumors and brain metastases. She also oversees a translational brain tumor research lab at Mayo Clinic with a primary focus on understanding the biology and genomics of gliomas in order to identify tumor vulnerabilities and advance new treatments for brain cancer.

  1. Intrathecal chemotherapy
  • Treatment of primary brain tumors, brain metastases & leptomeningeal disease
  • Clinical trials for brain tumors
  • Translational research on the biology and genomics of brain tumors
  • Identification of novel drug targets for personalized medicine in CNS malignancies
  1. 2022
    Chief FellowHematology/Oncology Fellowship, Internal Medicine, Programs in Arizona, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  2. 2022
    FellowHematology/Oncology Fellowship, Internal Medicine, Programs in Arizona, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  3. 2019
    Chief Resident - Internal MedicineDepartment of Internal Medicine, Scripps Green Hospital Graduate Medical Education
  4. 2019
    Residency - Internal MedicineDepartment of Internal Medicine, Scripps Green Hospital Graduate Medical Education
  5. 2015
    MD - MedicineUniversity of Arizona College of Medicine - Phoenix
  6. 2013
    Ph.D. - Cancer BiologyUniversity of Arizona/Translational Genomics Research Institute
  7. 2008
    Fulbright Scholar - FellowshipUniversité Libre de Bruxelles
  8. 2007
    BS - BiochemistryArizona State University

Certifications

  1. 2022
    HematologyAmerican Board of Internal Medicine
  2. 2022
    Medical OncologyAmerican Board of Internal Medicine
  3. 2019
    Internal MedicineAmerican Board of Internal Medicine

Awards and honors

  1. 2022
    Dinah Armstrong Kukes Memorial Grant Fund for Cancer ResearchPhi Mu Foundation
  2. 2022
    Mayo Brothers Distinguished Fellowship AwardMayo Clinic School of Graduate Medical Education, Department of Education Administration
  3. 2021
    Outstanding Fellow AwardThe Arizona Clinical Oncology Society
  4. 2021
    Clinical Trials WorkshopSociety for Neuro-Oncology
  5. 2016
    First Place in Region, Poster CompetitionAmerican College of Physicians Southern Chapter
  6. 2013
    Apogee ScholarshipMedical School
  7. 2013
    American Association for Cancer Research Travel AwardArizona Cancer Center
  8. 2012
    Travel AwardHerb Carter Graduate Interdisciplinary Program
  9. 2011
    Doctoral ScholarshipAchievement Rewards for College Scientists
  10. 2011
    American Association for Cancer Research Travel AwardArizona Cancer Center
  11. 2011
    Travel AwardHerb Carter Graduate Interdisciplinary Program
  12. 2010
    Doctoral ScholarshipArizona Science Foundation
  13. 2008
    Apogee ScholarshipMedical School
  14. 2007
    Fulbright Fellowship to study at Université Libre de Bruxelles, Brussels, Belgium US Department of State
  15. 2007
    Travel AwardBarrett Honors College, Arizona State University
  16. 2007
    Honorable MentionAmerican Association for the Advancement of Science
  17. 2006
    National Goldwater ScholarArizona State University
  18. 2006
    Thomas J. Bardos Science Education Award/ScholarshipAmerican Association for Cancer Research
  19. 2006
    Travel AwardBarrett Honors College, Arizona State University
  20. 2006
    Third PlaceAmerican Association for the Advancement of Science
  21. 2006
    Bachelor of Science Merit AwardDepartment of Chemistry and Biochemistry, Arizona State University
  22. 2005
    Therald Moeller AwardDepartment of Chemistry and Biochemistry, Arizona State University
  23. 2003
    AZ Flinn Finalist ScholarshipArizona State University
  24. 2003
    Presidential ScholarshipArizona State University
  25. 2003
    Robert C. Byrd Honors ScholarshipArizona State University
  26. 2003
    Dean's ListArizona State University

Professional memberships

  1. 2024 - present
    Track ChairCNS Rare Tumors Track, Society for Neuro-Oncology
  2. 2023 - 2024
    Faculty InterviewerPhD Candidate Selection, Clinical and Translational Science (CTS) Track, Mayo Clinic Graduate School of Biomedical Sciences
  3. 2023 - present
    MemberItem Writing Task Force, Self-Evaluation Program (ASCO-SEP), American Society for Clinical Oncology
  4. 2019 - present
    MemberSociety for Neuro-Oncology
  5. 2019 - present
    MemberAmerican Society for Clinical Oncology
  6. 2005 - present
    MemberAmerican Association for Cancer Research

Publications

Research activities

See a description of research activities.