室管膜瘤

室管膜瘤是一种在脑或脊髓中形成的细胞生长物。这些细胞会形成一个肿块,称为肿瘤。室管膜瘤始于室管膜细胞。这些细胞构成了脑脊液流动通道的内衬层。脑脊液包围并保护着脑和脊髓。

室管膜瘤有多种不同的类型。有的生长缓慢,不被认为是癌性肿瘤。非癌性肿瘤也称为良性肿瘤。良性室管膜瘤的生长可能会压迫邻近的组织。有时室管膜瘤生长更为迅速,被认为是癌性肿瘤。癌性肿瘤也称为恶性肿瘤。恶性室管膜瘤的生长可能会侵袭并破坏邻近组织。癌细胞可能会脱落并在脑或脊髓内扩散。

室管膜瘤可能发生在任何年龄段,但在幼儿中最为常见。患有室管膜瘤的儿童可能会出现头痛和癫痫发作。发生在成人体内的室管膜瘤更有可能在脊髓中形成。这可能导致受肿瘤影响的神经所控制的身体部位无力。

外科手术是室管膜瘤的主要治疗方法。对于生长迅速的肿瘤或手术无法完全切除的肿瘤,可能建议采取其他治疗方法。其中可能包括放射疗法、放射外科手术、化疗或靶向治疗。

症状

Ependymoma signs and symptoms may depend on where it happens. This tumor can form in the brain or spinal cord.

Symptoms of ependymoma in the brain include:

  • Blurry vision.
  • Confusion.
  • Headaches.
  • Irritability.
  • Nausea.
  • Seizures.
  • Vomiting.

Symptoms of ependymoma in the spinal cord include:

  • Bowel changes.
  • Loss of balance.
  • Pain in the neck or back.
  • Trouble walking.
  • Weakness in the legs.

When to see a doctor

Make an appointment with a doctor or other healthcare professional if you have any symptoms that worry you.

病因

It's not clear what causes ependymoma. This tumor starts as a growth of cells in the brain or spinal cord.

Ependymoma happens when cells in the brain or spinal cord develop changes in their DNA. A cell's DNA holds the instructions that tell the cell what to do. In healthy cells, the DNA gives instructions to grow and multiply at a set rate. The instructions tell the cells to die at a set time. In tumor cells, the DNA changes give different instructions. The changes tell the tumor cells to grow and multiply quickly. Tumor cells can keep living when healthy cells would die. This causes too many cells.

风险因素

Factors that increase the risk of ependymoma include:

  • Young age. Ependymoma can happen at any age. This cancer happens most often in children.
  • Inherited syndromes. Some ependymomas are linked to genetic conditions passed down in families, such as with neurofibromatosis type 2 and Li-Fraumeni syndrome.

Dec. 19, 2024

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  1. Winn HR, ed. Ependymomas. In: Youmans and Winn Neurological Surgery. 8th ed. Elsevier; 2023. https://www.clinicalkey.com. Accessed Sept. 22, 2023.
  2. Upadhyaya SA, et al. Intracranial ependymoma and other ependymal tumors. https://www.uptodate.com/contents/search. Accessed Sept 22, 2023.
  3. Childhood ependymoma treatment (PDQ) — Patient version. National Cancer Institute. https://www.cancer.gov/types/brain/patient/child-ependymoma-treatment-pdq. Accessed Sept. 22, 2023.
  4. Central nervous system cancers. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1425. Accessed Sept. 22, 2023.