Kristina A. Butler, M.D., M.S.

In addition to her clinical care, Dr. Butler is active in research and education, providing mentorship to trainees. She is currently involved in multiple clinical trials for patients:

• MIRASOL: A Randomized, Open-label, Phase 3 Study of Mirvetuximab Soravtansine vs. Investigator's Choice of Chemotherapy in Advanced High-Grade Epithelial Ovarian, Peritoneal, or Fallopian Tube Cancers with High Folate Receptor-Alpha Expression
• MC1371: Targeted Complex Therapy for Advanced Melanoma and Gynecologic Cancers: Nab-paclitaxel (Abraxane)/Bevacizumab Complex (AB-complex) - includes epithelial cervical / endometrial / ovarian / fallopian tube / primary peritoneal cancers
• T Cells and the tumor microenvironment for Ovarian Cancer
• MC1365, A Randomized Phase 2 Trial of a Genetically Engineered NIS-Expressing Strain of Measles Virus Versus Investigator's Choice Chemotherapy for Patients with Platinum-Resistant Ovarian, Fallopian, or Peritoneal Cancer
• A Phase 3, Randomized, Single Dose, Open-Label Study to Investigate the Safety and Efficacy of OTL38 Injection (OTL38) for Intra-operative Imaging of Folate Receptor Positive Ovarian Cancer. (data being analyzed, closed to new enrollment)
• TG4050.01 Neoantigen vaccine trial for newly diagnosed ovarian cancer - A phase I trial evaluating a mutanome-directed immunotherapy in patients with high grade serous carcinoma (HGSC) of the ovary, fallopian tube or peritoneum who experience an asymptomatic relapse (first recurrence)

She has also recently published best practice research for cancer and surgical outcomes:

• Surgical management in the pelvis for patients with advanced ovarian cancer. A Giannini, KA Butler Eur. J. Gynaecol. Oncol 1, 16. 2022

• Techniques for Robotic Adnexal Surgery KA Butler, JF Magrina Atlas of Robotic, Conventional, and Single-Port Laparoscopy, 225-234. 2022

• Radical Extirpation With Intraoperative Radiotherapy for Locally Recurrent Gynecologic Cancer: An Institutional Review R Delara, J Yang, E Suárez-Salvador, S Vora, J Magriña, K Butler, Mayo Clinic Proceedings: Innovations, Quality & Outcomes 5 (6), 1081-1088. 2022

• Survival outcomes in patients with cervical cancer treated with open versus robotic radical hysterectomy: Our surgical pathology interrogation. Gynecol Oncol. 2020 Nov; 159 (2):373-380 Epub 2020 Sept 03. Yang J, Butler K, Magrina J. (et al)
• Management and outcomes of primary vaginal Cancer. Gynecol Oncol. 2020 Nov; 159 (2):456-463 Epub 2020 Sept 22. Yang J, Butler K.
• Implementing robotic surgery for uterine cancer in the United States: Better outcomes without increased costs. Gynecol Oncol. 2020 Feb; 156 (2):451-458 Epub 2019 Nov 25. Casarin J, Butler KA, Mariani A, et al.
• Comparing survival outcomes between surgical and radiographic lymph node assessment in locally advanced cervical cancer: A propensity score-matched analysis. Gynecol Oncol. 2020 Feb; 156 (2):320-327 Epub 2019 Dec. Yang J, Butler K, et al.
• Adoption of Minimally Invasive Surgery and Decrease in Surgical Morbidity for Endometrial Cancer Treatment in the United States. Obstet Gynecol. 2018 Feb. Casarin J, Butler KA, Mariani A, et al.