News Nov. 12, 2024 Asherman syndrome: A rare collection of symptoms that can profoundly affect patients A Mayo Clinic investigator is researching causes of Asherman syndrome and seeks to determine a standardized classification system. He also is pursuing multicenter research on treatment outcomes, especially regarding pos[...] Nov. 12, 2024 Are isolated tumor cells significant for prognosis? Isolated tumor cells (ITCs), tiny malignant cells in the sentinel lymph nodes, can arise in patients with low-risk endometrial cancer. A Mayo Clinic gynecologic oncologist addresses research questions about prognosis an[...] Nov. 12, 2024 Multisite study finds FETO associated with reduced postbirth ECMO for fetuses with CDH A multisite study found a potential morbidity reduction — lowered need for extracorporeal membrane oxygenation (ECMO) — in a subpopulation of infants with severe, left-sided congenital diaphragmatic hernia t[...] Nov. 12, 2024 Defining successful SUI treatment: A look at patient perceptions of success A study published in the American Journal of Obstetrics and Gynecology found that patients' expectations for stress urinary incontinence (SUI) success were lower than the stringent medical definition of success. July 27, 2024 Discovery of a healthy embryo clue will improve selection for in vitro fertilization transfer Investigators at Mayo Clinic have found patterns to identify the best embryos for IVF. Reproductive Sciences published the paper about the findings. July 27, 2024 Mayo Clinic investigators discover a surprisingly high number of women have experienced premature or early menopause Mayo Clinic investigators were surprised to find higher numbers of premature menopause and early menopause than they anticipated. July 27, 2024 Increased risk of cardiovascular disease associated with tubal ligation, hysterectomy alone or hysterectomy with oophorectomy A multicenter study indicated that hysterectomy — alone or combined with oophorectomy — and tubal ligation may increase cardiovascular disease risk. The Journal of Women's Health published these findings. July 27, 2024 Mayo Clinic investigators discover new clues to early ovarian cancer detection and treatment response prediction A study published in Scientific Reports describes the finding of a distinct ovarian cancer microbiome. This discovery may benefit earlier disease diagnosis and prediction of treatment effectiveness. July 27, 2024 Modified Mohs surgery reduces recurrence of extramammary Paget's disease A Mayo Clinic study found that a multidisciplinary surgical approach using modified Mohs surgery lowered recurrence for patients with female EMPD compared with traditional WLE. May 30, 2024 Advancing care for childbirth-related pelvic floor disorders Nikki J. Ron, P.T., D.P.T., WCS-ABPTS, explains the evolving role of Mayo Clinic physical therapists in pregnancy and postpartum care. April 10, 2024 Ovarian tissue vitrification potentially demonstrates superiority over slow freezing A Mayo Clinic research team found some superiority in ovarian tissue vitrification versus slow freezing due to stromal cell viability. The researchers call for a multicenter study to confirm these findings. April 10, 2024 Mayo Clinic pilot study pinpoints resectable high-grade serous ovarian cancer A pilot study assessing CT plus molecular subtyping provided useful information for patients and surgeons indicating which patients have low likelihood of successful disease resection. April 10, 2024 Management of deep bowel endometriosis Patients with bowel endometriosis spend on average six years with symptoms before diagnosis. Detection and surgical excision of this disease are challenging, yet Mayo Clinic GYN surgeons take it on. April 10, 2024 Mayo Clinic investigators surprised: Fetal surgery not associated with increased placental pathologies Findings published by Mayo Clinic investigators in Prenatal Diagnosis indicate that fetal surgery does not elevate abnormal findings in placental pathology assessment, contradicting the researchers' first hypothesis yet[...] Jan. 09, 2024 Minimally invasive versus open abdominal sacrocolpopexy Q&A A Q&A provides a Mayo Clinic urogynecologic surgeon's responses regarding two sacrocolpopexy techniques. He and a colleague published an invited commentary in Journal of Gynecologic Surgery. Jan. 09, 2024 Mayo Clinic GYN surgeon urges consideration of nonsurgical options for symptomatic uterine fibroids Contrary to what might be expected, a Mayo Clinic GYN surgeon is urging healthcare professionals to consider not only hysterectomy but also nonsurgical options for patients with symptomatic uterine fibroids. Jan. 09, 2024 OB-GYN hospitalists associated with lower severe maternal morbidity A multicenter study led by a Mayo Clinic physician and published in the Journal of Patient Safety indicated lower severe maternal morbidity rates in medical centers using OB-GYN hospitalists. Jan. 09, 2024 Mayo Clinic investigates persistent pelvic pain following endometriosis surgery Despite surgery for bothersome endometriosis, some women continue to experience debilitating pain. A Mayo Clinic minimally invasive gynecologic surgeon delves into the problem and potential solutions. Jan. 09, 2024 A substantial step toward earlier endometrial cancer detection A Mayo Clinic study discovers methylated DNA markers present in malignant endometrium and not present in benign tissue using vaginal fluid self-collected with an over-the-counter tampon. Aug. 03, 2023 Fluorescence-guided surgical advancements for patients with ovarian cancer In a 2022 study, Mayo Clinic researchers reported advanced tumor detection and resection in epithelial ovarian cancer using fluorescence-guided surgery. Applying this technique for ovarian cancer opens up more options f[...] July 11, 2023 Study finds outcomes comparable between minimally invasive and open surgery for patients with high-risk endometrial cancer Due to equivalent surgical and oncologic outcomes of minimally invasive surgery compared with open surgery for high-risk endometrial cancer, investigators recommend minimally invasive surgery. July 11, 2023 Hypothesis disproved on uterine fibroids and elevated nerve activity, other fibroid relationships uncovered Contrary to their hypothesis, investigators did not find high nerve activity in women with uterine fibroids. They did find vascular distinctions between those with and without fibroids. July 11, 2023 Link discovered between primary infertility and subsequent bilateral oophorectomy A Mayo Clinic study finds an association between primary infertility and later bilateral oophorectomy. An author and reproductive endocrinology and fertility specialist explains the findings and their applications[...] May 13, 2023 Challenging search for ovarian cancer early detection assay appears hopeful In a clinical pilot study, an 11-MDM ovarian cancer panel, developed at Mayo Clinic, distinguished cancer and noncancer in plasma and identified all five early-stage, high-grade serous ovarian cancers included. May 13, 2023 A promising abdominal wall endometriosis treatment emerges at Mayo Clinic through teamwork A multidisciplinary research team at Mayo Clinic found that cryoablation has multiple advantages for patients with abdominal wall endometriosis compared with surgery. May 13, 2023 New customizable mold created for vaginoplasty postoperative period Mayo Clinic Urogynecology and Radiology anatomic modeling experts collaborated to create a 3D-printed, anatomically customizable, temporary vaginal mold from dental resin for use after neovagina creation. April 25, 2023 Diabetic ketoacidosis in pregnancy poses mortality risk A retrospective, multidisciplinary Mayo Clinic study shows that timely recognition and management of diabetic ketoacidosis (DKA) in pregnancy are crucial for maternal and fetal health. Jan. 13, 2023 Q&A: Mayo Clinic in Minnesota adds autotransplantation to ovarian tissue cryopreservation services Building on a history of pediatric ovarian tissue cryopreservation, Mayo Clinic has broadened this service to include more adults. Now, Mayo Clinic also offers ovarian tissue autotransplant. Jan. 13, 2023 Quantifying status of labor progression through machine learning Mayo Clinic investigators published a paper in a 2022 issue of PLOS ONE detailing how they use machine learning to quantify whether a patient's labor is progressing well or needs intervention. Jan. 13, 2023 Mayo Clinic and Universite de Montreal scientists discover distinct inflammatory profiles between preterm and term births Mayo Clinic and Universite de Montreal scientists found new genes and inflammatory biological processes abnormally expressed at the maternal-fetal interface in preterm births. Sept. 30, 2022 Pessary use and surgery improve prolapse symptoms, yet patients favor surgical outcomes A self-controlled, prospective Mayo Clinic study found that participants who trialed pessaries before surgery found that both therapies helped symptoms, but they preferred surgical outcomes. Sept. 30, 2022 Hysterectomy for endometrial cancer shifts significantly toward outpatient approach Hysterectomy for endometrial cancer has shifted from the inpatient setting to minimally invasive surgery in the outpatient setting according to a study published in International Journal of Gynecological Cancer. Sept. 30, 2022 Fertility unaffected by myomectomy route Investigators found that patients treated using any of three myomectomy routes had similar fertility postsurgically, allowing surgeons and their patients to select any route appropriate for the patient. July 01, 2022 Women with cardiovascular disease in pregnancy receive multidisciplinary care Women with all types of cardiovascular disease receive comprehensive care during pregnancy, from preconception counseling to postpartum follow-up and risk factor assessment. June 21, 2022 Postpartum hemorrhage, risks and current management A Mayo Clinic obstetrician discusses postpartum hemorrhage (PPH) measurement, risk factors, treatment and prevention. She presents how Mayo Clinic has managed PPH and when physicians might consider referral. June 21, 2022 Live birth rate similar for frozen donor egg IVF with fresh or frozen sperm Investigators found no statistically significant live birth rate differences between fresh versus frozen ejaculated sperm for intracytoplasmic sperm injection in a frozen donor egg IVF cycle study. June 21, 2022 The ethics of maternal-fetal medicine surgery Mayo Clinic investigators conducted a review study of 37 peer-reviewed, maternal-fetal surgery papers with ethics discussions published between January 1999 and October 2020. The researchers published findings in a 2022[...] June 21, 2022 Q&A: Caring for patients with genetic mutations predisposed to ovarian cancer A Mayo Clinic Obstetrics and Gynecology physician assistant responds to frequent questions from medical professionals about working with patients found to have a hereditary ovarian cancer risk gene. March 15, 2022 Mayo Clinic offers fertility preservation for transgender individuals At Mayo Clinic's campus in Rochester, Minnesota, reproductive endocrinology and infertility specialists provide services to help transgender individuals preserve fertility for later use. Jan. 03, 2022 Link between preterm labor, fetal DNA supported by cell culture research Researchers studying the role cell-free fetal DNA plays in labor report data demonstrate that the concentration of cell-free fetal DNA in blood controls the timing of labor initiation. Dec. 22, 2021 A view from the bench: Perspectives on COVID-19 and pregnancy from an immunologist A reproductive immunologist discusses topics such as SARS-CoV-2 targets and elevated severe infection risk in pregnancy, action of mRNA vaccines, and COVID-19 fetal vaccination effects. Dec. 22, 2021 MiST IVF offers less expensive, easier treatment for motivated parents A reduced-cost, mostly oral medication in vitro fertilization method used in the 1990s with low success now has favorable outcomes for motivated parents due to a new methodology. Dec. 22, 2021 HIPEC and cytoreductive surgery do not improve outcomes over cytoreductive surgery alone in patients with platinum-sensitive recurrent ovarian cancer Secondary cytoreductive surgery (CRS) plus HIPEC followed by carboplatin cycles didn't demonstrate greater benefit compared with CRS followed by carboplatin cycles for patients with platinum-sensitive recurrent ovarian [...] Oct. 08, 2021 A modern approach to endometrial cancer care: molecular risk stratification, targeted therapy and team science The field of endometrial cancer is evolving rapidly, moving toward molecular risk stratification and targeted therapy using a team science approach. A Mayo Clinic gynecologic oncologist and a medical oncologist explain.[...] Oct. 08, 2021 One-size-fits-all treatment not ideal for patients with endometriosis A Mayo Clinic minimally invasive gynecologic surgeon talks about the customized approach needed — rather than automatic hysterectomy plus fallopian tube and ovary removal — for optimal endometriosis care. Oct. 08, 2021 Mayo Clinic offers round-the-clock acute OB care consult to small medical facilities Noting obstetrics (OB) care shortages, particularly in rural areas, Mayo Clinic Obstetrics started an acute teleOB program, offering virtual Mayo Clinic OB specialist access round-the-clock to hospitals and emergency de[...] July 16, 2021 Safety and efficacy of automated insulin delivery systems for pregnant patients with T1DM Researchers at Mayo Clinic in Rochester, Minnesota, are studying automated insulin delivery systems with continuous glucose monitoring in pregnant patients with type 1 diabetes mellitus (T1DM). June 26, 2021 Sentinel lymph node biopsy decreases lymphedema for patients with endometrial cancer Unlike use of lymphadenectomy, with a 49.4% rate of lower extremity lymphedema, using sentinel lymph node biopsy to stage patients with endometrial cancer led to a 26.0% rate of this type of lymphedema. June 26, 2021 Appropriate evidence-based triage is vital to outcomes in advanced epithelial ovarian cancer Two studies indicate the importance of triaging patients with advanced epithelial ovarian cancer by frailty and sarcopenia status for best survival and fewer complications. June 26, 2021 No specific characteristics associated with poor response to elagolix with add-back therapy in patients with uterine fibroids Further multisite research shows no characteristics predicting a lack of response to elagolix with add-back therapy for patients with uterine fibroids and heavy menstrual bleeding. June 19, 2021 Prenatal repair can improve hindbrain herniation About 90% of prenatal myelomeningocele repairs performed at Mayo Clinic reverse brain malformations before birth. The procedure requires multidisciplinary neurological, pediatric and radiologic expertise. May 22, 2021 National patterns of filled prescriptions and third line treatment use for privately insured women with overactive bladder Referral to specialists may close a gap in care for women who do not have success with oral therapies for overactive bladder. March 19, 2021 OB Nest: A new vision for prenatal care A Mayo Clinic obstetrician explains a novel program for women with low-risk pregnancies, including self-monitoring and 40% to 50% of prenatal visits from the patient's home. March 19, 2021 Laser therapy for twin-twin transfusion syndrome offers best outcomes The new Mayo Clinic division chair for Maternal and Fetal Medicine discusses the rare twin-twin transfusion syndrome and how it can be addressed in utero to prevent fetal loss. March 19, 2021 Villitis of unknown etiology found to be distinct placental condition negatively impacting the fetus, requiring screening and treatment A paper published by a Mayo Clinic immunologist highlights the differences between villitis of unknown etiology and infectious villitis, a key distinction for potential future screening and intervention for this placent[...] Dec. 17, 2020 Promoting fetal survival and lung development for severe congenital diaphragmatic hernia Fetoscopic endotracheal occlusion (FETO) transforms lung to head ratio and reduces extracorporeal membrane oxygenation use for fetuses diagnosed with congenital diaphragmatic hernia. Learn about risks, survival rates an[...] Dec. 17, 2020 Pelvic exenteration: Radical but positive for carefully selected patients with pelvic cancer A Mayo Clinic gynecologic surgeon discusses how pelvic exenteration, though radical, can benefit carefully selected patients and how complications can be predicted. April 11, 2020 Research focus: Spina bifida surgery before birth restores brain structure Mayo Clinic researchers have discovered that the benefit from spina bifida repair performed on a fetus in the womb works beyond the spine to improve the brain structure. March 20, 2020 Complex gynecological surgery for recurrent cancer: Navigating challenges when communicating with patients and their families Pelvic exenteration is used to treat cancer in the pelvic organs that has recurred after other treatment. Providers' empathy and understanding is vital to successful patient-centered care. March 20, 2020 Managing congenital anomalies with fetoscopic therapy Mayo Clinic multidisciplinary teams employ fetal endoscopic tracheal occlusion to promote lung growth in utero. The early intervention helps manage severe congenital diaphragmatic hernia successfully. March 20, 2020 Alternative, innovative method of delivering chemotherapy shows promising results, retrospective review says Hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to decrease the risk of recurrence and improve the survival of patients with peritoneal-based malignancies, with minimal side effects. Jan. 17, 2020 Importance of pre-pregnancy care for women with diabetes: A case from the endocrine teaching clinics Aoife M. Egan, M.B., B.Ch., Ph.D., and Adrian Vella, M.D., discuss the care program for a patient with type 1 diabetes mellitus who wished to become pregnant. Dec. 21, 2019 Hysterectomy associated with an increased risk of cardiovascular disease, study says Research supports that with or without ovarian conservation, women age 35 and younger who undergo hysterectomy have an increased long-term risk of cardiovascular and metabolic conditions. Dec. 21, 2019 Study finds same-day discharge after hysterectomy safe and feasible Research indicates that same-day discharge after vaginal hysterectomy with pelvic floor reconstruction does not result in a higher number of emergency department or outpatient office evaluations. Dec. 21, 2019 Robotic surgery and sentinel lymph node biopsy improve perioperative outcomes in endometrial cancer treatment Researchers found that patients who received robot-assisted surgery with sentinel node biopsy had fewer postoperative complications and lower readmission rates than patients who received open abdominal surgery. Dec. 21, 2019 Clinic redesign increases efficiency and teamwork, shortens patient wait time Mayo Clinic's collaborative hysteroscopy clinic has streamlined appointment scheduling to incorporate needed hysteroscopy and eliminated duplicated effort to improve both patient and staff satisfaction. Dec. 21, 2019 A review of mortality rates in minimally invasive surgery adds insight, importance to perioperative counseling A systemic review of mortality in minimally invasive gynecological surgery showed that that the odds of death for laparoscopic and robotic gynecological surgery appear to be similar. April 23, 2019 Mayo Clinic offers comprehensive care for women with pelvic floor disorders such as pelvic organ prolapse and urinary incontinence Mayo Clinic's unique, multidisciplinary approach to managing sensitive female pelvic floor disorders allows for individualized decision-making and broad access to a multitude of treatment options. Feb. 19, 2019 Top-of-the-line treatment for Wilms' tumor Mayo Clinic's Fertility Preservation Program, 3D modeling, minimally invasive surgery techniques and proton beam therapy improve survival rates for children with Wilms' tumor. Feb. 01, 2019 Evaluation and management of abnormal uterine bleeding Mayo specialists discuss the systematic evaluation of abnormal uterine bleeding using PALM-COEIN etiology in a study published in Mayo Clinic Proceedings. Jan. 18, 2019 Fetal surgery: Early intervention to improve outcomes Rare, congenital anomalies — including pulmonary hypoplasia in congenital diaphragmatic hernia and fetal lower urinary tract obstruction — carry significant risk of mortality and disability. New surgical met[...] Dec. 20, 2018 Brian J. Linder, M.D., female pelvic medicine and reconstructive surgery specialist, joins Mayo Clinic Urology Brian J. Linder, M.D., a specialist in the management of overactive bladder, including advanced treatment options such as bladder Botox injection, sacral neuromodulation and noninvasive percutaneous tibial nerve stimula[...] Sept. 15, 2018 Steroid cell tumor of the ovary causing renin-mediated hypertension: A case from the endocrine teaching clinics Endocrinologists Oksana Hamidi, D.O., and Todd B. Nippoldt, M.D., discuss the diagnosis and treatment of a 37-year-old woman with a steroid cell tumor — an exceedingly rare sex cord-stromal tumor of the ovary. Feb. 15, 2018 Cytoreductive surgery and HIPEC offers effective treatment for selected patients with peritoneal carcinomatosis A retrospective study of intermediate-term outcomes for patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) indicates the treatment was most successful for patients with res[...] Oct. 06, 2017 Trauma in pregnancy: A unique challenge Trauma is the leading cause of nonobstetric death in expectant mothers. Trauma surgeon Erica A. Loomis, M.D., discusses pitfalls to avoid when managing a case of trauma in a patient who is pregnant. Nov. 18, 2016 Fertility preservation: Efforts to improve quality of life in children facing gonadotoxic therapy Recent advances in reproductive endocrinology allow cryopreservation of prepubertal boys' testicular tissue and girls' ovarian tissue before they begin cancer therapy known to impact fertility adversely. May 22, 2014 Treating patients with pelvic floor dysfunction Mayo Clinic gastroenterologists address chronic constipation through an integrated, multidisciplinary approach that can include constipation education classes, intensive pelvic floor retraining exercises, behavior modif[...] Medical Professionals Obstetrics & Gynecology News