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Tim Leiner, M.D., Ph.D.

  1. Radiologist
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Publicaciones

  1. Zhang H, Leng S, Gao F, Kovalik JP, Tan RS, Wee HN, Chua KV, Ching J, Zhao X, Allen J, Wu Q, Leiner T, Zhong L, Koh AS. Longitudinal aortic strain, ventriculo-arterial coupling and fatty acid oxidation: novel insights into human cardiovascular aging. Geroscience. 2024 Dec; 46 (6):5459-5471 Epub 2024 Mar 22
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  2. Dobrolinska MM, Koetzier LR, Greuter MJW, Vliegenthart R, van der Bie J, Prakken NHJ, Slart RHJA, Leiner T, Budde RPJ, Mastrodicasa D, Booij R, Fleischmann D, Willemink MJ, van Straten M, van der Werf NR. Feasibility of virtual non-iodine coronary calcium scoring on dual source photon-counting coronary CT angiography: a dynamic phantom study. Eur Radiol. 2024 Nov; 34 (11):7429-7437 Epub 2024 May 24
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  3. Woodworth CF, Yee RC, Leiner T. First reported Intra-cavitary right-to-left coronary artery collateral in the context of D-TGA. J Cardiovasc Comput Tomogr. 2024 Nov-Dec; 18 (6):e18-e20 Epub 2024 Sept 27
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  4. van Herten RLM, Lagogiannis I, Leiner T, Isgum I. The role of artificial intelligence in coronary CT angiography. Neth Heart J. 2024 Nov; 32 (11):417-425 Epub 2024 Oct 10
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  5. Abu Rmilah A, Adham A, Ikram-Ul H, Alzu'bi H, Nandan A, Jouni H, Hirashi S, Owen D, Deswal A, Lin SH, Abe JI, Chao TC, Browne J, Leiner T, Laack N, Herrmann J. Novel risk score for predicting acute cardiovascular and cerebrovascular events after chest radiotherapy in patients with breast or lung cancer. Eur J Prev Cardiol. 2024 Oct 25 [Epub ahead of print]
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  6. Dobrolinska MM, Tetteroo PM, Greuter MJW, van Hamersvelt RW, Prakken NHJ, Slart RHJA, Vembar M, Grass M, Leiner T, Velthuis BK, Sucha D, van der Werf NR. The influence of motion-compensated reconstruction on coronary artery analysis for a dual-layer detector CT system: a dynamic phantom study. Eur Radiol. 2024 Aug; 34 (8):4874-4882 Epub 2024 Jan 04
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  7. Raisi-Estabragh Z, Szabo L, McCracken C, Bulow R, Aquaro GD, Andre F, Le TT, Sucha D, Condurache DG, Salih AM, Chadalavada S, Aung N, Lee AM, Harvey NC, Leiner T, Chin CWL, Friedrich MG, Barison A, Dorr M, Petersen SE. Cardiovascular Magnetic Resonance Reference Ranges From the Healthy Hearts Consortium. JACC Cardiovasc Imaging. 2024 Jul; 17 (7):746-762 Epub 2024 Apr 10
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  8. van Duin IAJ, Verheijden RJ, van Diest PJ, Blokx WAM, El-Sharouni MA, Verhoeff JJC, Leiner T, van den Eertwegh AJM, de Groot JWB, van Not OJ, Aarts MJB, van den Berkmortel FWPJ, Blank CU, Haanen JBAG, Hospers GAP, Piersma D, van Rijn RS, van der Veldt AAM, Vreugdenhil G, Wouters MWJM, Stevense-den Boer MAM, Boers-Sonderen MJ, Kapiteijn E, Suijkerbuijk KPM, Elias SG. A prediction model for response to immune checkpoint inhibition in advanced melanoma. Int J Cancer. 2024 May 15; 154 (10):1760-1771 Epub 2024 Jan 31
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  9. Liu LP, Shapira N, Halliburton SS, Meyer S, Perkins A, Litt HI, Kauczor HU, Leiner T, Stiller W, Noel PB. Spectral performance evaluation of a second-generation spectral detector CT. J Appl Clin Med Phys. 2024 Apr; 25 (4):e14300 Epub 2024 Feb 22
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  10. van Herten RLM, Hampe N, Takx RAP, Franssen KJ, Wang YN, Henriques JP, Leiner T, Planken RN, Isgum I. Automatic coronary artery plaque quantification and cad-rads prediction using mesh priors. Ieee Transactions on Medical Imaging. 2024 Apr; 43 (4):1272-83
  11. Zhang H, Leng S, Gao F, Kovalik JP, Wee HN, Chua KV, Ching J, Allen JC, Zhao X, Tan RS, Wu Q, Leiner T, Koh AS, Zhong L. Characteristics of pulmonary artery strain assessed by cardiovascular magnetic resonance imaging and associations with metabolomic pathways in human ageing. Front Cardiovasc Med. 2024; 11:1346443 Epub 2024 Feb 29
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  12. Verpalen VA, Ververs FA, Slieker M, Nuboer R, Swart JF, van der Ent CK, Fejzic Z, Westenberg JJM, Leiner T, Grotenhuis HB, Schipper HS. Enhanced aortic stiffness in adolescents with chronic disease is associated with decreased left ventricular global longitudinal strain. IJC Heart and Vasculature. 2024; 52:101385
  13. van der Werf NR, Dobrolinska MM, Greuter MJW, Willemink MJ, Fleischmann D, Bos D, Slart RHJA, Budoff M, Leiner T. Vendor Independent Coronary Calcium Scoring Improves Individual Risk Assessment: MESA (Multi-Ethnic Study of Atherosclerosis). JACC Cardiovasc Imaging. 2023 Dec; 16 (12):1552-1564 Epub 2023 June 14
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  14. Boonen PT, Buls N, van Gompel G, Devos H, de Brucker Y, Leiner T, Aerden D, de Mey J, Vandemeulebroucke J. Quantitative hemodynamic assessment of stenotic below-the-knee arteries using spatio-temporal bolus tracking on 4D-CT angiography. Med Phys. 2023 Nov; 50 (11):6844-6856 Epub 2023 Sept 26
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  15. Naaktgeboren WR, Stuiver MM, van Harten WH, Aaronson NK, Scott JM, Sonke G, van der Wall E, Velthuis M, Leiner T, Teske AJ, May AM, Groen WG. Effects of exercise during chemotherapy for breast cancer on long-term cardiovascular toxicity. Open Heart. 2023 Oct; 10 (2)
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  16. de Koning MLY, van Dorp P, Assa S, Pundziute-Do Prado G, Voskuil M, Anthonio RL, Veen D, Leiner T, Sibeijn-Kuiper AJ, van Goor H, van Veldhuisen DJ, van der Meer P, Nijveldt R, Lipsic E, van der Harst P. Sodium Thiosulfate in Acute Myocardial Infarction: A Randomized Clinical Trial. JACC Basic Transl Sci. 2023 Oct; 8 (10):1285-1294 Epub 2023 Aug 23
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  17. Bartholomeus GA, van Amsterdam WAC, Harder AMD, Willemink MJ, van Hamersvelt RW, de Jong PA, Leiner T. Robustness of pulmonary nodule radiomic features on computed tomography as a function of varying radiation dose levels-a multi-dose in vivo patient study. Eur Radiol. 2023 Oct; 33 (10):7044-7055 Epub 2023 Apr 19
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  18. Dey D, Arnaout R, Antani S, Badano A, Jacques L, Li H, Leiner T, Margerrison E, Samala R, Sengupta PP, Shah SJ, Slomka P, Williams MC, Bandettini WP, Sachdev V. Proceedings of the NHLBI Workshop on Artificial Intelligence in Cardiovascular Imaging: Translation to Patient Care. JACC Cardiovasc Imaging. 2023 Sep; 16 (9):1209-1223 Epub 2023 July 19
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  19. Sander J, de Vos BD, Bruns S, Planken N, Viergever MA, Leiner T, Isgum I. Reconstruction and completion of high-resolution 3D cardiac shapes using anisotropic CMRI segmentations and continuous implicit neural representations. Comput Biol Med. 2023 Sep; 164:107266 Epub 2023 July 19
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  20. Panda A, Francois CJ, Bookwalter CA, Chaturvedi A, Collins JD, Leiner T, Rajiah PS. Non-Contrast Magnetic Resonance Angiography: Techniques, Principles, and Applications. Magn Reson Imaging Clin N Am. 2023 Aug; 31(3):337-360. Epub 2023 Jun 07.
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  21. Becker LM, Peper J, Verhappen BJLA, Swart LA, Dedic A, van Dockum WG, van der Ent M, Royaards KJ, Niezen A, Hensen JJ, van Kuijk JP, Mohamed Hoesein FAA, Leiner T, Bruning TA, Swaans MJ. Real world impact of added FFR-CT to coronary CT angiography on clinical decision-making and patient prognosis - IMPACT FFR study. Eur Radiol. 2023 Aug; 33 (8):5465-5475 Epub 2023 Mar 15
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  22. Boonen PT, Buls N, Vandemeulebroucke J, Van Gompel G, Van Den Bergh F, Leiner T, Aerden D, de Mey J. Combined evaluation of blood flow and tissue perfusion in diabetic feet by intra-arterial dynamic 4DCT imaging. Eur Radiol Exp. 2023 Jul 26; 7 (1):44 Epub 2023 July 26
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  23. van Duin IAJ, Elias SG, van den Eertwegh AJM, de Groot JWB, Blokx WAM, van Diest PJ, Leiner T, Verhoeff JJC, Verheijden RJ, van Not OJ, Aarts MJB, van den Berkmortel FWPJ, Blank CU, Haanen JBAG, Hospers GAP, Kamphuis AM, Piersma D, van Rijn RS, van der Veldt AAM, Vreugdenhil G, Wouters MWJM, Stevense-den Boer MAM, Boers-Sonderen MJ, Kapiteijn E, Suijkerbuijk KPM. Time interval from primary melanoma to first distant recurrence in relation to patient outcomes in advanced melanoma. Int J Cancer. 2023 Jun 15; 152 (12):2493-2502 Epub 2023 Mar 04
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  24. Rajiah PS, François CJ, Leiner T. Cardiac MRI: State of the Art. Radiology. 2023 May; 307(3):e223008. Epub 2023 Apr 11.
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  25. Singh Y, Farrelly CM, Hathaway QA, Leiner T, Jagtap J, Carlsson GE, Erickson BJ. Topological data analysis in medical imaging: current state of the art. Insights Imaging. 2023 Apr 1; 14 (1):58 Epub 2023 Apr 01
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  26. Peper J, Becker LM, Bruning TA, Budde RPJ, van Dockum WG, Frederix GWJ, Habets J, Henriques JPS, Houthuizen P, Mohamed Hoesein FAA, Planken RN, Voskuil M, Bots ML, Leiner T, Swaans MJ. Rationale and design of the iCORONARY trial: improving the cost-effectiveness of coronary artery disease diagnosis. Neth Heart J. 2023 Apr; 31 (4):150-156 Epub 2023 Jan 31
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  27. Baessler B, Gotz M, Antoniades C, Heidenreich JF, Leiner T, Beer M. Artificial intelligence in coronary computed tomography angiography: Demands and solutions from a clinical perspective. Front Cardiovasc Med. 2023; 10:1120361 Epub 2023 Feb 16
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  28. Vos JL, Leiner T, van Dijk APJ, Pedrizzetti G, Alenezi F, Rodwell L, van der Wegen CTPM, Post MC, Driessen MMP, Nijveldt R. Cardiovascular magnetic resonance-derived left ventricular intraventricular pressure gradients among patients with precapillary pulmonary hypertension. Eur Heart J Cardiovasc Imaging. 2022 Dec 19; 24 (1):78-87
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  29. van Amsterdam WAC, Harlianto NI, Verhoeff JJC, Moeskops P, de Jong PA, Leiner T. The Association between Muscle Quantity and Overall Survival Depends on Muscle Radiodensity: A Cohort Study in Non-Small-Cell Lung Cancer Patients. J Pers Med. 2022 Jul 21; 12 (7) Epub 2022 July 21
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  30. Ververs FA, Eikendal ALM, Kofink D, Nuboer R, Westenberg JJM, Hovenkamp GT, Kemps JJA, Coenen ICJ, Daems JJN, Claus LR, Ju Y, Wulffraat NM, van der Ent CK, Monaco C, Boes M, Leiner T, Grotenhuis HB, Schipper HS. Preclinical Aortic Atherosclerosis in Adolescents With Chronic Disease. J Am Heart Assoc. 2022 Jul 19; 11 (14):e024675 Epub 2022 July 13
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  31. van Vuren A, Kerkhoffs JL, Schols S, Rijneveld A, Nur E, Peereboom D, Gandon Y, Welsing P, van Wijk R, Schutgens R, van Solinge W, Marx J, Leiner T, Biemond B, van Beers E. Proton pump inhibition for secondary hemochromatosis in hereditary anemia: a phase III placebo-controlled randomized cross-over clinical trial. Am J Hematol. 2022 Jul; 97 (7):924-932 Epub 2022 May 10
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  32. Peper J, Becker LM, van den Berg H, Bor WL, Brouwer J, Nijenhuis VJ, van Ginkel DJ, Rensing BJMW, Ten Berg JM, Timmers L, Leiner T, Swaans MJ. Diagnostic Performance of CCTA and CT-FFR for the Detection of CAD in TAVR Work-Up. JACC Cardiovasc Interv. 2022 Jun 13; 15 (11):1140-1149 Epub 2022 May 11
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  33. Collins JD, Rowley H, Leiner T, Reeder S, Hood M, Dekkers I, Tha K, Gulani V, Kopanoglu E, ISMRM MR Safety Committee. Magnetic Resonance Imaging During a Pandemic: Recommendations by the ISMRM Safety Committee. J Magn Reson Imaging. 2022 May; 55 (5):1322-1339 Epub 2021 Dec 20
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  34. Petersen SE, Friedrich MG, Leiner T, Elias MD, Ferreira VM, Fenski M, Flamm SD, Fogel M, Garg R, Halushka MK, Hays AG, Kawel-Boehm N, Kramer CM, Nagel E, Ntusi NAB, Ostenfeld E, Pennell DJ, Raisi-Estabragh Z, Reeder SB, Rochitte CE, Starekova J, Sucha D, Tao Q, Schulz-Menger J, Bluemke DA. Cardiovascular Magnetic Resonance for Patients With COVID-19. JACC Cardiovasc Imaging. 2022 Apr; 15 (4):685-699 Epub 2021 Oct 13
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  35. van der Velden J, Asselbergs FW, Bakkers J, Batkai S, Bertrand L, Bezzina CR, Bot I, Brundel B, Carrier L, Chamuleau S, Ciccarelli M, Dawson D, Davidson SM, Dendorfer A, Duncker DJ, Eschenhagen T, Fabritz L, Falcao-Pires I, Ferdinandy P, Giacca M, Girao H, Gollmann-Tepekoylu C, Gyongyosi M, Guzik TJ, Hamdani N, Heymans S, Hilfiker A, Hilfiker-Kleiner D, Hoekstra AG, Hulot JS, Kuster DWD, van Laake LW, Lecour S, Leiner T, Linke WA, Lumens J, Lutgens E, Madonna R, Maegdefessel L, Mayr M, van der Meer P, Passier R, Perbellini F, Perrino C, Pesce M, Priori S, Remme CA, Rosenhahn B, Schotten U, Schulz R, Sipido K, Sluijter JPG, van Steenbeek F, Steffens S, Terracciano CM, Tocchetti CG, Vlasman P, Yeung KK, Zacchigna S, Zwaagman D, Thum T. Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart. Cardiovasc Res. 2022 Jan 6 Epub 2022 Jan 06
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  36. Henningsson M, Malik S, Botnar R, Castellanos D, Hussain T, Leiner T. Black-Blood Contrast in Cardiovascular MRI. J Magn Reson Imaging. 2022 Jan; 55 (1):61-80 Epub 2020 Oct 19
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  37. van Praagh GD, Wang J, van der Werf NR, Greuter MJW, Mastrodicasa D, Nieman K, van Hamersvelt RW, Oostveen LJ, de Lange F, Slart RHJA, Leiner T, Fleischmann D, Willemink MJ. Coronary Artery Calcium Scoring: Toward a New Standard. Invest Radiol. 2022 Jan 1; 57 (1):13-22
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  38. Hampe N, van Velzen SGM, Planken RN, Henriques JPS, Collet C, Aben JP, Voskuil M, Leiner T, Isgum I. Deep learning-based detection of functionally significant stenosis in coronary CT angiography. Front Cardiovasc Med. 2022; 9:964355 Epub 2022 Nov 15
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  39. Zhai Z, van Velzen SGM, Lessmann N, Planken N, Leiner T, Isgum I. Learning coronary artery calcium scoring in coronary CTA from non-contrast CT using unsupervised domain adaptation. Front Cardiovasc Med. 2022; 9:981901 Epub 2022 Sept 12
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  40. ter Maat LS, van Duin IAJ, Elias SG, van Diest PJ, Pluim JPW, Verhoeff JJC, de Jong PA, Leiner T, Veta M, Suijkerbuijk KPM. Imaging to predict checkpoint inhibitor outcomes in cancer. A systematic review. European Journal of Cancer. 2022; 175:60-76
  41. van der Werf NR, Booij R, Schmidt B, Flohr TG, Leiner T, de Groen JJ, Bos D, Budde RPJ, Willemink MJ, Greuter MJW. Evaluating a calcium-aware kernel for CT CAC scoring with varying surrounding materials and heart rates: a dynamic phantom study. Eur Radiol. 2021 Dec; 31 (12):9211-9220 Epub 2021 May 28
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  42. Huisman M, Ranschaert E, Parker W, Mastrodicasa D, Koci M, Pinto de Santos D, Coppola F, Morozov S, Zins M, Bohyn C, Koc U, Wu J, Veean S, Fleischmann D, Leiner T, Willemink MJ. An international survey on AI in radiology in 1041 radiologists and radiology residents part 2: expectations, hurdles to implementation, and education. Eur Radiol. 2021 Nov; 31 (11):8797-8806 Epub 2021 May 11
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  43. Woudstra OI, Alban FTE, Bijvoet GP, de Bruin-Bon RHACM, Planken RN, Leiner T, Boekholdt SM, Warmerdam EG, Sieswerda GT, Mulder BJM, Bouma BJ, Meijboom FJ. Baffle Complications in Adults After Atrial Switch for Transposition of the Great Arteries. Can J Cardiol. 2021 Oct 9 Epub 2021 Oct 09
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  44. van Velzen SGM, Bruns S, Wolterink JM, Leiner T, Viergever MA, Verkooijen HM, Isgum I. AI-Based Quantification of Planned Radiation Therapy Dose to Cardiac Structures and Coronary Arteries in Patients With Breast Cancer. Int J Radiat Oncol Biol Phys. 2021 Sep 20 Epub 2021 Sept 20
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  45. Huisman M, Ranschaert E, Parker W, Mastrodicasa D, Koci M, Pinto de Santos D, Coppola F, Morozov S, Zins M, Bohyn C, Koc U, Wu J, Veean S, Fleischmann D, Leiner T, Willemink MJ. An international survey on AI in radiology in 1,041 radiologists and radiology residents part 1: fear of replacement, knowledge, and attitude. Eur Radiol. 2021 Sep; 31 (9):7058-7066 Epub 2021 Mar 20
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  46. Xu C, Yi Y, Han Y, Xie H, Lu X, Vembar M, Leiner T, Jin Z, Wang Y. Incremental improvement of diagnostic performance of coronary CT angiography for the assessment of coronary stenosis in the presence of calcium using a dual-layer spectral detector CT: validation by invasive coronary angiography. Int J Cardiovasc Imaging. 2021 Aug; 37 (8):2561-2572 Epub 2021 June 27
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  47. van Praagh GD, van der Werf NR, Wang J, van Ommen F, Poelhekken K, Slart RHJA, Fleischmann D, Greuter MJW, Leiner T, Willemink MJ. Fully automated quantification method (FQM) of coronary calcium in an anthropomorphic phantom. Med Phys. 2021 Jul; 48 (7):3730-3740 Epub 2021 May 17
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  48. Gal R, van Velzen SGM, Hooning MJ, Emaus MJ, van der Leij F, Gregorowitsch ML, Blezer ELA, Gernaat SAM, Lessmann N, Sattler MGA, Leiner T, de Jong PA, Teske AJ, Verloop J, Penninkhof JJ, Vaartjes I, Meijer H, van Tol-Geerdink JJ, Pignol JP, van den Bongard DHJG, Isgum I, Verkooijen HM. Identification of Risk of Cardiovascular Disease by Automatic Quantification of Coronary Artery Calcifications on Radiotherapy Planning CT Scans in Patients With Breast Cancer. JAMA Oncol. 2021 Jul 1; 7 (7):1024-1032
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  49. Weikert T, Francone M, Abbara S, Baessler B, Choi BW, Gutberlet M, Hecht EM, Loewe C, Mousseaux E, Natale L, Nikolaou K, Ordovas KG, Peebles C, Prieto C, Salgado R, Velthuis B, Vliegenthart R, Bremerich J, Leiner T. Machine learning in cardiovascular radiology: ESCR position statement on design requirements, quality assessment, current applications, opportunities, and challenges. Eur Radiol. 2021 Jun; 31(6):3909-3922. Epub 2020 Nov 19.
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  50. de Boer A, Pieters TT, Harteveld AA, Blankestijn PJ, Bos C, Froeling M, Goldschmeding R, Hoogduin HJM, Joles JA, Petri BJ, Verhaar MC, Leiner T, Nguyen TQ, van Zuilen AD. Validation of multiparametric MRI by histopathology after nephrectomy: a case study. MAGMA. 2021 Jun; 34 (3):377-387 Epub 2020 Sept 20
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  51. van 't Klooster CC, van der Graaf Y, Nathoe HM, Bots ML, de Borst GJ, Visseren FLJ, Leiner T, UCC-SMART-study group. Added value of cardiovascular calcifications for prediction of recurrent cardiovascular events and cardiovascular interventions in patients with established cardiovascular disease. Int J Cardiovasc Imaging. 2021 Jun; 37 (6):2051-2061 Epub 2021 Feb 12
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  52. Vigen KK, Reeder SB, Hood MN, Steckner M, Leiner T, Dombroski DA, Gulani V, ISMRM Safety Committee. Recommendations for Imaging Patients With Cardiac Implantable Electronic Devices (CIEDs). J Magn Reson Imaging. 2021 May; 53 (5):1311-1317 Epub 2020 Aug 17
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  53. Wolterink JM, Mukhopadhyay A, Leiner T, Vogl TJ, Bucher AM, Isgum I. Generative Adversarial Networks: A Primer for Radiologists. Radiographics. 2021 May-Jun; 41 (3):840-857 Epub 2021 Apr 23
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  54. Jansz TT, Go MHY, Hartkamp NS, Stoger JL, Celeng C, Leiner T, de Jong PA, Visseren FJL, Verhaar MC, van Jaarsveld BC. Coronary Artery Calcification as a Marker for Coronary Artery Stenosis: Comparing Kidney Failure to the General Population. Kidney Med. 2021 May-Jun; 3 (3):386-394.e1 Epub 2021 Apr 20
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  55. de Baat EC, Naaktgeboren WR, Leiner T, Teske AJ, Habets J, Grotenhuis HB. Update in imaging of cancer therapy-related cardiac toxicity in adults. Open Heart. 2021 Apr; 8 (1)
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  56. Rijnberg FM, van Assen HC, Juffermans JF, Kroft LJM, van den Boogaard PJ, de Koning PJH, Hazekamp MG, van der Woude SFS, Warmerdam EG, Leiner T, Grotenhuis HB, Goeman JJ, Lamb HJ, Roest AAW, Westenberg JJM. Reduced scan time and superior image quality with 3D flow MRI compared to 4D flow MRI for hemodynamic evaluation of the Fontan pathway. Sci Rep. 2021 Mar 22; 11 (1):6507
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  57. Peper J, van Hamersvelt RW, Rensing BJWM, van Kuijk JP, Voskuil M, Berg JMT, Schaap J, Kelder JC, Grobbee DE, Leiner T, Swaans MJ. Diagnostic performance and clinical implications for enhancing a hybrid quantitative flow ratio-FFR revascularization decision-making strategy. Sci Rep. 2021 Mar 19; 11 (1):6425
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  58. de Boer A, Harteveld AA, Stemkens B, Blankestijn PJ, Bos C, Franklin SL, Froeling M, Joles JA, Verhaar MC, van den Berg N, Hoogduin H, Leiner T. Multiparametric Renal MRI: An Intrasubject Test-Retest Repeatability Study. J Magn Reson Imaging. 2021 Mar; 53 (3):859-873 Epub 2020 Apr 16
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  59. Leiner T, Bennink E, Mol CP, Kuijf HJ, Veldhuis WB. Bringing AI to the clinic: blueprint for a vendor-neutral AI deployment infrastructure. Insights Imaging. 2021 Feb 2; 12 (1):11 Epub 2021 Feb 02
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  60. Groepenhoff F, Eikendal ALM, Bots SH, van Ommen AM, Overmars LM, Kapteijn D, Pasterkamp G, Reiber JHC, Hautemann D, Menken R, Wittekoek ME, Hofstra L, Onland-Moret NC, Haitjema S, Hoefer I, Leiner T, den Ruijter HM. Cardiovascular imaging of women and men visiting the outpatient clinic with chest pain or discomfort: design and rationale of the ARGUS Study. BMJ Open. 2020 Dec 15; 10 (12):e040712
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  61. Noothout JMH, De Vos BD, Wolterink JM, Postma EM, Smeets PAM, Takx RAP, Leiner T, Viergever MA, Isgum I. Deep Learning-Based Regression and Classification for Automatic Landmark Localization in Medical Images. IEEE Trans Med Imaging. 2020 Dec; 39 (12):4011-4022 Epub 2020 Nov 30
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  62. Dweck MR, Maurovich-Horvat P, Leiner T, Cosyns B, Fayad ZA, Gijsen FJH, Van der Heiden K, Kooi ME, Maehara A, Muller JE, Newby DE, Narula J, Pontone G, Regar E, Serruys PW, van der Steen AFW, Stone PH, Waltenberger JL, Yuan C, Evans PC, Lutgens E, Wentzel JJ, Back M. Contemporary rationale for non-invasive imaging of adverse coronary plaque features to identify the vulnerable patient: a Position Paper from the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2020 Oct 20; 21 (11):1177-1183
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  63. Bruns S, Wolterink JM, Takx RAP, van Hamersvelt RW, Sucha D, Viergever MA, Leiner T, Isgum I. Deep learning from dual-energy information for whole-heart segmentation in dual-energy and single-energy non-contrast-enhanced cardiac CT. Med Phys. 2020 Oct; 47 (10):5048-5060 Epub 2020 Aug 27
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  64. Blanken CPS, Westenberg JJM, Aben JP, Bijvoet GP, Chamuleau SAJ, Boekholdt SM, Nederveen AJ, Leiner T, van Ooij P, Planken RN. Quantification of Mitral Valve Regurgitation from 4D Flow MRI Using Semiautomated Flow Tracking. Radiol Cardiothorac Imaging. 2020 Oct; 2 (5):e200004 Epub 2020 Oct 15
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  65. Warmerdam EG, Magni F, Leiner T, Doevendans PA, Sieswerda GT, van Wijk SW, Breur HM, Driesen BW, Grotenhuis HB, Takken T. Echocardiography and MRI parameters associated with exercise capacity in patients after the arterial switch operation. J Cardiol. 2020 Sep; 76 (3):280-286 Epub 2020 May 10
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  66. Peper J, Sucha D, Swaans M, Leiner T. Functional cardiac CT-Going beyond Anatomical Evaluation of Coronary Artery Disease with Cine CT, CT-FFR, CT Perfusion and Machine Learning. Br J Radiol. 2020 Sep 1; 93 (1113):20200349 Epub 2020 Aug 12
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  67. de Boer A, Harteveld AA, Pieters TT, Blankestijn PJ, Bos C, Froeling M, Joles JA, Verhaar MC, Leiner T, Hoogduin H. Decreased native renal T1 up to one week after gadobutrol administration in healthy volunteers. J Magn Reson Imaging. 2020 Aug; 52 (2):622-631 Epub 2019 Dec 04
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  68. Zreik M, van Hamersvelt RW, Khalili N, Wolterink JM, Voskuil M, Viergever MA, Leiner T, Isgum I. Deep Learning Analysis of Coronary Arteries in Cardiac CT Angiography for Detection of Patients Requiring Invasive Coronary Angiography. IEEE Trans Med Imaging. 2020 May; 39 (5):1545-1557 Epub 2019 Nov 12
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  69. van 't Klooster CC, Nathoe HM, Hjortnaes J, Bots ML, Isgum I, Lessmann N, van der Graaf Y, Leiner T, Visseren FLJ, UCC-SMART-study group. Multifocal cardiovascular calcification in patients with established cardiovascular disease; prevalence, risk factors, and relation with recurrent cardiovascular disease. Int J Cardiol Heart Vasc. 2020 Apr; 27:100499 Epub 2020 Mar 17
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  70. van Velzen SGM, Lessmann N, Velthuis BK, Bank IEM, van den Bongard DHJG, Leiner T, de Jong PA, Veldhuis WB, Correa A, Terry JG, Carr JJ, Viergever MA, Verkooijen HM, Isgum I. Deep Learning for Automatic Calcium Scoring in CT: Validation Using Multiple Cardiac CT and Chest CT Protocols. Radiology. 2020 Apr; 295 (1):66-79 Epub 2020 Feb 11
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  71. Warmerdam E, Krings GJ, Leiner T, Grotenhuis HB. Three-dimensional and four-dimensional flow assessment in congenital heart disease. Heart. 2020 Mar; 106 (6):421-426 Epub 2019 Dec 19
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  72. van Laarhoven CJHCM, Rots ML, Pourier VEC, Jorritsma NKN, Leiner T, Hendrikse J, Vergouwen MDI, de Borst GJ. Gadolinium Enhancement of the Aneurysm Wall in Extracranial Carotid Artery Aneurysms. AJNR Am J Neuroradiol. 2020 Mar; 41 (3):501-507 Epub 2020 Feb 27
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  92. van den Elshout-den Uyl D, Spoto CPE, de Boer M, Leiner T, Leavis HL, Leguit RJ. First Report of IgG4 Related Disease Primary Presenting as Vertebral Bone Marrow Lesions. Front Immunol. 2019; 10:1910 Epub 2019 Aug 13
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  127. Smulders MW, Jaarsma C, Nelemans PJ, Bekkers SCAM, Bucerius J, Leiner T, Crijns HJGM, Wildberger JE, Schalla S. Comparison of the prognostic value of negative non-invasive cardiac investigations in patients with suspected or known coronary artery disease-a meta-analysis. Eur Heart J Cardiovasc Imaging. 2017 Sep 1; 18 (9):980-987
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  137. van Eijs MJM, van Zuilen AD, de Boer A, Froeling M, Nguyen TQ, Joles JA, Leiner T, Verhaar MC. Innovative Perspective: Gadolinium-Free Magnetic Resonance Imaging in Long-Term Follow-Up after Kidney Transplantation. Front Physiol. 2017; 8:296 Epub 2017 May 16
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  146. Celeng C, Maurovich-Horvat P, Ghoshhajra BB, Merkely B, Leiner T, Takx RA. Prognostic Value of Coronary Computed Tomography Angiography in Patients With Diabetes: A Meta-analysis. Diabetes Care. 2016 Jul; 39 (7):1274-80
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  147. den Harder AM, Willemink MJ, van Hamersvelt RW, Vonken EP, Schilham AM, Lammers JW, Luijk B, Budde RP, Leiner T, de Jong PA. Pulmonary Nodule Volumetry at Different Low Computed Tomography Radiation Dose Levels With Hybrid and Model-Based Iterative Reconstruction: A Within Patient Analysis. J Comput Assist Tomogr. 2016 Jul-Aug; 40 (4):578-83
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  152. Willemink MJ, Leiner T, Maurovich-Horvat P. Cardiac CT Imaging of Plaque Vulnerability: Hype or Hope? Curr Cardiol Rep. 2016 Apr; 18 (4):37
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  168. Baggen VJ, Driessen MM, Meijboom FJ, Sieswerda GT, Jansen NJ, van Wijk SW, Doevendans PA, Leiner T, Schoof PH, Takken T, Breur JM. Main pulmonary artery area limits exercise capacity in patients long-term after arterial switch operation. J Thorac Cardiovasc Surg. 2015 Oct; 150 (4):918-25 Epub 2015 Aug 06
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  170. Wolterink JM, Leiner T, Takx RA, Viergever MA, Isgum I. Automatic Coronary Calcium Scoring in Non-Contrast-Enhanced ECG-Triggered Cardiac CT With Ambiguity Detection. IEEE Trans Med Imaging. 2015 Sep; 34 (9):1867-78 Epub 2015 Mar 16
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  171. Willemink MJ, Abramiuc B, den Harder AM, van der Werf NR, de Jong PA, Budde RP, Wildberger JE, Vliegenthart R, Willems TP, Greuter MJ, Leiner T. Coronary calcium scores are systematically underestimated at a large chest size: A multivendor phantom study. J Cardiovasc Comput Tomogr. 2015 Sep-Oct; 9 (5):415-21 Epub 2015 Apr 02
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  172. Willemink MJ, Takx RA, Isgum I, de Koning HJ, Oudkerk M, Mali WP, Budde RP, Leiner T, Vliegenthart R, de Jong PA. Prognostic value of heart valve calcifications for cardiovascular events in a lung cancer screening population. Int J Cardiovasc Imaging. 2015 Aug; 31 (6):1243-9 Epub 2015 May 12
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  174. Driessen MM, Breur JM, Budde RP, van Oorschot JW, van Kimmenade RR, Sieswerda GT, Meijboom FJ, Leiner T. Advances in cardiac magnetic resonance imaging of congenital heart disease. Pediatr Radiol. 2015 Jan; 45 (1):5-19 Epub 2015 Jan 01
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  175. Takx RA, Blomberg BA, El Aidi H, Habets J, de Jong PA, Nagel E, Hoffmann U, Leiner T. Diagnostic accuracy of stress myocardial perfusion imaging compared to invasive coronary angiography with fractional flow reserve meta-analysis. Circ Cardiovasc Imaging. 2015 Jan; 8 (1)
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  176. Takx RA, Vliegenthart R, Mohamed Hoesein FA, Isgum I, de Koning HJ, Mali WP, van der Aalst CM, Zanen P, Lammers JW, Groen HJ, van Rikxoort EM, Schmidt M, van Ginneken B, Oudkerk M, Leiner T, de Jong PA. Pulmonary function and CT biomarkers as risk factors for cardiovascular events in male lung cancer screening participants: the NELSON study. Eur Radiol. 2015 Jan; 25 (1):65-71 Epub 2014 Sept 03
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  177. Takx RA, Zanen P, Leiner T, van der Graaf Y, de Jong PA, SMART study group. The interdependence between cardiovascular calcifications in different arterial beds and vascular risk factors in patients at high cardiovascular risk. Atherosclerosis. 2015 Jan; 238 (1):140-6 Epub 2014 Nov 29
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  179. Jansen of Lorkeers SJ, Gho JM, Koudstaal S, van Hout GP, Zwetsloot PP, van Oorschot JW, van Eeuwijk EC, Leiner T, Hoefer IE, Goumans MJ, Doevendans PA, Sluijter JP, Chamuleau SA. Xenotransplantation of Human Cardiomyocyte Progenitor Cells Does Not Improve Cardiac Function in a Porcine Model of Chronic Ischemic Heart Failure. Results from a Randomized, Blinded, Placebo Controlled Trial. PLoS One. 2015; 10 (12):e0143953 Epub 2015 Dec 17
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  183. Salgado RA, Budde RP, Leiner T, Shivalkar B, Van Herck PL, Op de Beeck BJ, Vrints C, Buijsrogge MP, Stella PR, Rodrigus I, Bosmans J, Parizel PM. Transcatheter aortic valve replacement: postoperative CT findings of Sapien and CoreValve transcatheter heart valves. Radiographics. 2014 Oct; 34 (6):1517-36
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  186. Schrover IM, Leiner T, Klomp DW, Wijnen JP, Uiterwaal CS, Spiering W, Visseren FL. Feasibility and reproducibility of free fatty acid profiling in abdominal adipose tissue with 1H-magnetic resonance spectroscopy at 3 T: differences between lean and obese individuals. J Magn Reson Imaging. 2014 Aug; 40 (2):423-31 Epub 2013 Sept 23
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  188. van Hamersvelt RW, Willemink MJ, Takx RA, Eikendal AL, Budde RP, Leiner T, Mol CP, Isgum I, de Jong PA. Cardiac valve calcifications on low-dose unenhanced ungated chest computed tomography: inter-observer and inter-examination reliability, agreement and variability. Eur Radiol. 2014 Jul; 24 (7):1557-64 Epub 2014 May 10
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  189. Nguyen VL, Backes WH, Kooi ME, Wishaupt MC, Hellenthal FA, Bosboom EM, van der Geest RJ, Schurink GW, Leiner T. Quantification of abdominal aortic aneurysm wall enhancement with dynamic contrast-enhanced MRI: feasibility, reproducibility, and initial experience. J Magn Reson Imaging. 2014 Jun; 39 (6):1449-56 Epub 2013 Oct 22
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  190. Sucha D, Willemink MJ, de Jong PA, Schilham AM, Leiner T, Symersky P, Budde RP. The impact of a new model-based iterative reconstruction algorithm on prosthetic heart valve related artifacts at reduced radiation dose MDCT. Int J Cardiovasc Imaging. 2014 Apr; 30 (4):785-93 Epub 2014 Jan 29
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  191. El Aidi H, Adams A, Moons KG, Den Ruijter HM, Mali WP, Doevendans PA, Nagel E, Schalla S, Bots ML, Leiner T. Cardiac magnetic resonance imaging findings and the risk of cardiovascular events in patients with recent myocardial infarction or suspected or known coronary artery disease: a systematic review of prognostic studies. J Am Coll Cardiol. 2014 Mar 25; 63 (11):1031-45 Epub 2014 Jan 30
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  192. Driessen MM, Baggen VJ, Freling HG, Pieper PG, van Dijk AP, Doevendans PA, Snijder RJ, Post MC, Meijboom FJ, Sieswerda GT, Leiner T, Willems TP. Pressure overloaded right ventricles: a multicenter study on the importance of trabeculae in RV function measured by CMR. Int J Cardiovasc Imaging. 2014 Mar; 30 (3):599-608 Epub 2014 Jan 20
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  195. Versluis B, Nelemans PJ, Brans R, Wildberger JE, Schurink GW, Leiner T, Backes WH. Functional MRI in peripheral arterial disease: arterial peak flow versus ankle-brachial index. PLoS One. 2014; 9 (2):e88471 Epub 2014 Feb 05
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  205. Willemink MJ, Borstlap J, Takx RA, Schilham AM, Leiner T, Budde RP, de Jong PA. The effects of computed tomography with iterative reconstruction on solid pulmonary nodule volume quantification. PLoS One. 2013; 8 (2):e58053 Epub 2013 Feb 27
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  206. Versluis B, Tuinder S, Boetes C, Van Der Hulst R, Lataster A, Van Mulken T, Wildberger J, de Haan M, Leiner T. Equilibrium-phase high spatial resolution contrast-enhanced MR angiography at 1.5T in preoperative imaging for perforator flap breast reconstruction. PLoS One. 2013; 8 (8):e71286 Epub 2013 Aug 29
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  207. Nguyen VL, Kooi ME, Backes WH, van Hoof RH, Saris AE, Wishaupt MC, Hellenthal FA, van der Geest RJ, Kessels AG, Schurink GW, Leiner T. Suitability of pharmacokinetic models for dynamic contrast-enhanced MRI of abdominal aortic aneurysm vessel wall: a comparison. PLoS One. 2013; 8 (10):e75173 Epub 2013 Oct 02
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  214. Versteylen MO, Takx RA, Joosen IA, Nelemans PJ, Das M, Crijns HJ, Hofstra L, Leiner T. Epicardial adipose tissue volume as a predictor for coronary artery disease in diabetic, impaired fasting glucose, and non-diabetic patients presenting with chest pain. Eur Heart J Cardiovasc Imaging. 2012 Jun; 13 (6):517-23 Epub 2012 Feb 05
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  217. Versteylen MO, Bekkers SC, Smulders MW, Winkens B, Mihl C, Winkens MH, Leiner T, Waltenberger JL, Kim RJ, Gorgels AP. Performance of angiographic, electrocardiographic and MRI methods to assess the area at risk in acute myocardial infarction. Heart. 2012 Jan; 98 (2):109-15 Epub 2011 Sept 19
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  218. Versluis B, Dremmen MH, Nelemans PJ, Wildberger JE, Schurink GW, Leiner T, Backes WH. MRI of arterial flow reserve in patients with intermittent claudication: feasibility and initial experience. PLoS One. 2012; 7 (3):e31514 Epub 2012 Mar 08
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  219. Versluis B, Dremmen MH, Nelemans PJ, Wildberger JE, Schurink GW, Leiner T, Backes WH. Dynamic contrast-enhanced MRI assessment of hyperemic fractional microvascular blood plasma volume in peripheral arterial disease: initial findings. PLoS One. 2012; 7 (5):e37756 Epub 2012 May 25
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  220. Joosen IA, Schiphof F, Versteylen MO, Laufer EM, Winkens MH, Nelemans PJ, Kooman JP, Hofstra L, Wildberger JE, Leiner T. Relation between mild to moderate chronic kidney disease and coronary artery disease determined with coronary CT angiography. PLoS One. 2012; 7 (10):e47267 Epub 2012 Oct 10
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  221. Schrauwen-Hinderling VB, Meex RC, Hesselink MK, van de Weijer T, Leiner T, Schar M, Lamb HJ, Wildberger JE, Glatz JF, Schrauwen P, Kooi ME. Cardiac lipid content is unresponsive to a physical activity training intervention in type 2 diabetic patients, despite improved ejection fraction. Cardiovasc Diabetol. 2011 May 26; 10:47
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  222. Budde RP, Krings GJ, Leiner T. Prospectively ECG-triggered 256-slice computed tomography findings in a patient with dextrocardia, stent-treated coarctation, and infracardial right-sided pulmonary vein deviation. Eur Heart J. 2011 May; 32 (10):1213 Epub 2010 Dec 23
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  223. Lambregts DM, Beets GL, Maas M, Kessels AG, Bakers FC, Cappendijk VC, Engelen SM, Lahaye MJ, de Bruine AP, Lammering G, Leiner T, Verwoerd JL, Wildberger JE, Beets-Tan RG. Accuracy of gadofosveset-enhanced MRI for nodal staging and restaging in rectal cancer. Ann Surg. 2011 Mar; 253 (3):539-45
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  224. Jaspers K, Versluis B, Leiner T, Dijkstra P, Oostendorp M, van Golde JM, Post MJ, Backes WH. MR angiography of collateral arteries in a hind limb ischemia model: comparison between blood pool agent Gadomer and small contrast agent Gd-DTPA. PLoS One. 2011 Jan 26; 6 (1):e16159
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  226. Wang J, Gerretsen SC, Maki JH, Jaarsma C, Kooi ME, Herzka D, Chu B, Yarnykh VL, Yuan C, Leiner T. Time-efficient black blood RCA wall imaging at 3T using improved motion sensitized driven equilibrium (iMSDE): feasibility and reproducibility. PLoS One. 2011; 6 (10):e26567 Epub 2011 Oct 20
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  227. Bekkers SC, Smulders MW, Passos VL, Leiner T, Waltenberger J, Gorgels AP, Schalla S. Clinical implications of microvascular obstruction and intramyocardial haemorrhage in acute myocardial infarction using cardiovascular magnetic resonance imaging. Eur Radiol. 2010 Nov; 20 (11):2572-8 Epub 2010 June 26
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  228. Jaspers K, Leiner T, Dijkstra P, Oostendorp M, van Golde JM, Post MJ, Backes WH. Optimized pharmacokinetic modeling for the detection of perfusion differences in skeletal muscle with DCE-MRI: effect of contrast agent size. Med Phys. 2010 Nov; 37 (11):5746-55
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  229. Gerretsen SC, Kooi ME, Kessels AG, Schalla S, Katoh M, van der Geest RJ, Manning WJ, Waltenberger J, van Engelshoven JM, Botnar RM, Leiner T. Visualization of coronary wall atherosclerosis in asymptomatic subjects and patients with coronary artery disease using magnetic resonance imaging. PLoS One. 2010 Sep 29; 5 (9) Epub 2010 Sept 29
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  230. Rennenberg RJ, van Varik BJ, Schurgers LJ, Hamulyak K, Ten Cate H, Leiner T, Vermeer C, de Leeuw PW, Kroon AA. Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans. Blood. 2010 Jun 17; 115 (24):5121-3 Epub 2010 Mar 30
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  231. Laufer EM, Mingels AM, Winkens MH, Joosen IA, Schellings MW, Leiner T, Wildberger JE, Narula J, Van Dieijen-Visser MP, Hofstra L. The extent of coronary atherosclerosis is associated with increasing circulating levels of high sensitive cardiac troponin T. Arterioscler Thromb Vasc Biol. 2010 Jun; 30 (6):1269-75 Epub 2010 Mar 18
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  233. Lobbes MB, Heeneman S, Passos VL, Welten R, Kwee RM, van der Geest RJ, Wiethoff AJ, Caravan P, Misselwitz B, Daemen MJ, van Engelshoven JM, Leiner T, Kooi ME. Gadofosveset-enhanced magnetic resonance imaging of human carotid atherosclerotic plaques: a proof-of-concept study. Invest Radiol. 2010 May; 45 (5):275-81
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  234. Schalla S, Bekkers SC, Dennert R, van Suylen RJ, Waltenberger J, Leiner T, Wildberger J, Crijns HJ, Heymans S. Replacement and reactive myocardial fibrosis in idiopathic dilated cardiomyopathy: comparison of magnetic resonance imaging with right ventricular biopsy. Eur J Heart Fail. 2010 Mar; 12 (3):227-31
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  235. Attenberger UI, Sourbron SP, Schoenberg SO, Morelli J, Leiner T, Schoeppler GM, Samtleben W, Birkemeier KL, Glaser C, Reiser MF, Michaely HJ. Comprehensive MR evaluation of renal disease: added clinical value of quantified renal perfusion values over single MR angiography. J Magn Reson Imaging. 2010 Jan; 31 (1):125-33
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  236. Prince MR, Zhang HL, Roditi GH, Leiner T, Kucharczyk W. Risk factors for NSF: a literature review. J Magn Reson Imaging. 2009 Dec; 30 (6):1298-308
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  237. Leiner T, Kucharczyk W. NSF prevention in clinical practice: summary of recommendations and guidelines in the United States, Canada, and Europe. J Magn Reson Imaging. 2009 Dec; 30 (6):1357-63
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  238. Maki JH, Wang M, Wilson GJ, Shutske MG, Leiner T. Highly accelerated first-pass contrast-enhanced magnetic resonance angiography of the peripheral vasculature: comparison of gadofosveset trisodium with gadopentetate dimeglumine contrast agents. J Magn Reson Imaging. 2009 Nov; 30 (5):1085-92
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  239. Jaspers K, Aerts HJ, Leiner T, Oostendorp M, van Riel NA, Post MJ, Backes WH. Reliability of pharmacokinetic parameters: small vs. medium-sized contrast agents. Magn Reson Med. 2009 Sep; 62 (3):779-87
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  240. Lobbes MB, Miserus RJ, Heeneman S, Passos VL, Mutsaers PH, Debernardi N, Misselwitz B, Post M, Daemen MJ, van Engelshoven JM, Leiner T, Kooi ME. Atherosclerosis: contrast-enhanced MR imaging of vessel wall in rabbit model--comparison of gadofosveset and gadopentetate dimeglumine. Radiology. 2009 Mar; 250 (3):682-91
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  241. Leiner T, Michaely H. Advances in contrast-enhanced MR angiography of the renal arteries. Magn Reson Imaging Clin N Am. 2008 Nov; 16 (4):561-72, vii
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  242. Cappendijk VC, Heeneman S, Kessels AG, Cleutjens KB, Schurink GW, Welten RJ, Mess WH, van Suylen RJ, Leiner T, Daemen MJ, van Engelshoven JM, Kooi ME. Comparison of single-sequence T1w TFE MRI with multisequence MRI for the quantification of lipid-rich necrotic core in atherosclerotic plaque. J Magn Reson Imaging. 2008 Jun; 27 (6):1347-55
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