طب الأعصاب

بالأسفل التجارب السريرية الحالية.

غربل قائمة الدراسات هذه بالموقع والحالة وغيرها.

1. Phase 2 Study of TAK-341 for Multiple System Atrophy

   Rochester, Minn.

   The purpose of this study is to evaluate the effectiveness of TAK-341 versus placebo, as measured by the change from baseline to Week 52 on l Unified Multiple System Atrophy Rating Scale (UMSARS) Part I, minus the sexual function item, with collapse of the normal and mild ratings on each item.

2. A Study to Evaluate Caregiver Connections via Technology for Patients with Alzheimer's and Other Types of Dementia

   Rochester, Minn.

   The purpose of this study is to optimize profile questionnaire and matching algorithm developed in Phase I and implement in final website design, and to determine if algorithmically matched participants have statistically significant increase in match satisfaction and self-reported sense of resiliency and quality of life over randomly matched caregivers.

3. Ado-trastuzumab emtansine (T-DM1)-Induced Peripheral Neuropathy in HER2-positive Breast Cancer Patients

   Rochester, Minn.

   The purpose of this study is to prospectively evaluate the patient-reported outcomes data of T-DM1 induced peripheral neuropathy like prior research focused on paclitaxel-, paclitaxel/CBDCA-, oxaliplatin-, and cisplatin-induced peripheral neuropathy, to better understand the similarities and differences of chemotherapy-induced peripheral neuropathy (CIPN) symptoms caused by different agents, their pathogenesis, and impacts.

4. The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech

   Rochester, Minn.

   The purpose of this study is to identify and distinguish two different types of Progressive Apraxia of Speech through clinical imaging and testing.

5. A Study to Evaluate fMRI of Active Deep Brain Stimulation in Epilepsy

   Jacksonville, Fla.

   The purpose of this study is to to use functional imaging to study the mechanisms of anterior thalamic nucleus (ANT) Deep Brain Stimulation (DBS).

6. Breast Cancer, Reasoning, and Activity Intervention

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to test the effectiveness of aerobic exercise training, delivered in a community-based setting, for improving cognitive function in post-menopausal Breast Cancer Survivors (BCS).

7. HEALEY ALS Platform Trial

   Rochester, Minn., Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

   The purpose of this study is to evaluate the safety and effectiveness of investigational products for the treatment of ALS.

8. Posterior Fossa Decompression with or without Duraplasty for Chiari Type I Malformation with Syringomyelia

   Rochester, Minn.

   The purpose of this study is to determine whether a posterior fossa decompression or a posterior fossa decompression with duraplasty results in better patient outcomes with fewer complications and improved quality of life in those who have Chiari malformation type I and syringomyelia.

9. Submandibular Gland Needle Core Biopsy and Skin Punch Biopsy as Tissue Biomarkers for the Diagnosis and Monitoring of Disease Progression of Parkinson’s Disease and REM Sleep Behavior Disorder

   Scottsdale/Phoenix, Ariz.

   Determine 1) the magnitude of SMG and skin a-syn density change over time, 2) the

   improvement in adequate tissue acquisition doing bilateral SMG biopsies, 3) any laterality differences between

   SMG gland a-syn density, 4) correlate a-syn density and changes in density between SMG and skin biopsies

   Specific Aim 1. Determine, with bilateral submandibular gland (SMG) biopsies in 30 clinically

   diagnosed subjects with Parkinson’s disease (PD) and 20 clinically probable REM sleep behavior

   disorder (RBD) subjects whether bilateral biopsies improve the rate of acquisition of adequate

   glandular tissue, whether alpha-synuclein (a-syn) SMG pathology correlates with clinical severity

   and/or disease duration, and whether there is a left-right difference in the density of a-syn pathology.

   Specific Aim 2. Determine, with a second SMG biopsy in previously biopsied PD and RBD subjects,

   whether a-syn pathology density increases, decreases, or remains the same after a 1.5-2 year time

   interval and whether there is a correlation between a-syn SMG pathology and clinical and/or disease

   progression.

   Specific Aim 3. Determine whether a-syn pathology density in skin punch biopsies correlates

   with clinical measures and increases, decreases, or remains the same after a 1.5-2 year time

   interval, and whether the density and changes over time correlate with those found in SMG

   biopsies.

10. Immune Phenotyping in Amyotrophic Lateral Sclerosis

    Rochester, Minn.

    The goals of this study are to identify biomarkers that allow improved staging or prognosis of the disease, and through the discovery of previously unrecognized immune abnormalities in ALS we aim to eventually identify immune therapies that may provide benefit in ALS.