Sarosh R. Irani, B.M.B.Ch., D.Phil.

Summary. I have extensive experiences and expertise in diagnosing and treating a broad range of patients with neurological diseases caused by dysfunction of the immune system.

Background. I graduated in medicine (BMBCh) from the University of Oxford, UK, and, from 2003-2006, completed my internal medicine training in both Oxford and London. Next, I completed a PhD in Clinical Neurology at Oxford University (DPhil) and, subsequently, undertook clinical residency training in neurology, in London and Oxford followed by a Fulbright Fellowship in multiple sclerosis and autoimmune neurology in UCSF, USA. Since 2014, I have practiced as a Consultant Neurologist in Oxford both caring for patients with general neurological conditions, and with a special focus on patients with autoimmune neurological illnesses. I founded the Oxford Autoimmune Neurology clinic and was promoted to full Professor of Autoimmune Neurology at the University of Oxford in 2021. I joined Mayo Clinic Florida in 2023 and am Professor of Neurology and Neurosciences.

Focus. I have extensive experience in diagnosing and managing a variety of autoimmune neurological conditions, including autoimmune encephalitis, neuromyelitis optica, stiff person syndrome and paraneoplastic syndromes. I discovered LGI1 and CASPR2 antibodies, and have cared for over 300 patients with LGI1, CASPR2, NMDA, AQP4, MOG and GABA receptor-antibodies and seronegative forms of encephalitis and neuromyelitis optica, and am one of the world's most experienced clinicians in this area.

Also, I help advise the Encephalitis Society and Autoimmune Encephalitis Alliance, two of the major foundations providing patient support in this field. In addition, I lead an internationally-recognized research group which has made several landmark discoveries including the detection of LGI1 and CASPR2 antibodies and their associated presentations, and published >200 scientific papers about autoimmune neurological diseases. I have been awarded multiple international prizes in recognition of my clinical and research observations.