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Elaine C. Wirrell, M.D.

  1. Neurologist
  2. Pediatrician
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Publicaciones

  1. Vanderwiel SL, Jones B, Nickels KC, Wong-Kisiel LC, Fine A, Mandrekar J, Wirrell EC. Risk of ADHD in children with childhood absence epilepsy versus controls: A population-based study. Epilepsy Behav. 2024 Nov 7; 161:110143 Epub 2024 Nov 07
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  2. Padilla H, Pinto E Vairo F, Wirrell EC, Wong-Kisiel LC, Fine AL, Lanpher BC, Smith KM. CHD2-related epilepsy with eyelid myoclonia: Report of three cases. Epileptic Disord. 2024 Nov 6 Epub 2024 Nov 06
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  3. Valente KD, Reilly C, Carvalho RM, Smith ML, Mula M, Wirrell EC, Wilmshurst JM, Jette N, Brigo F, Kariuki SM, Fong CY, Wang YP, Polanczyk GV, Castanho V, Demarchi IG, Auvin S, Kerr M. Consensus-based recommendations for the diagnosis and treatment of anxiety and depression in children and adolescents with epilepsy: A report from the Psychiatric Pediatric Issues Task Force of the International League Against Epilepsy. Epilepsia. 2024 Nov; 65 (11):3155-3185 Epub 2024 Sept 25
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  4. Ramantani G, Wirrell E. Epilepsy surgery in developmental and epileptic encephalopathies. Epilepsy Behav. 2024 Oct; 159:109985 Epub 2024 Aug 24
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  5. Wirrell EC. Overview of clinical and physiologic aspects of status epilepticus in the developmental and epileptic encephalopathies. Epilepsy Behav. 2024 Oct; 159:109950 Epub 2024 July 27
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  6. Wirrell EC, Lagae L, Scheffer IE, Cross JH, Specchio N, Strzelczyk A. Practical considerations for the use of fenfluramine to manage patients with Dravet syndrome or Lennox-Gastaut syndrome in clinical practice. Epilepsia Open. 2024 Oct; 9 (5):1643-1657 Epub 2024 July 04
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  7. Conecker G, Xia MY, Hecker J, Achkar C, Cukiert C, Devries S, Donner E, Fitzgerald M, Gardella E, Hammer M, Hegde A, Hu C, Kato M, Luo T, Schreiber JM, Wang Y, Kooistra T, Oudin M, Waldrop K, Youngquist JT, Zhang D, Wirrell E, Perry MS. Global modified-Delphi consensus on comorbidities and prognosis of SCN8A-related epilepsy and/or neurodevelopmental disorders. Epilepsia. 2024 Aug; 65 (8):2308-2321 Epub 2024 May 27
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  8. Conecker G, Xia MY, Hecker J, Achkar C, Cukiert C, Devries S, Donner E, Fitzgerald MP, Gardella E, Hammer M, Hegde A, Hu C, Kato M, Luo T, Schreiber JM, Wang Y, Kooistra T, Oudin M, Waldrop K, Youngquist JT, Zhang D, Wirrell E, Perry MS. Global modified Delphi consensus on diagnosis, phenotypes, and treatment of SCN8A-related epilepsy and/or neurodevelopmental disorders. Epilepsia. 2024 Aug; 65 (8):2322-2338 Epub 2024 May 27
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  9. Bacq A, Depaulis A, Castagne V, Le Guern ME, Wirrell EC, Verleye M. An Update on Stiripentol Mechanisms of Action: A Narrative Review. Adv Ther. 2024 Apr; 41 (4):1351-1371 Epub 2024 Mar 05
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  10. Reed L, Ciliberto M, Fong SL, Nickels K, Kossoff E, Wirrell E, Joshi C. Efficacy of felbamate in a cohort of patients with epilepsy with myoclonic atonic seizures (EMAtS). Epilepsy Res. 2024 Mar; 201:107314 Epub 2024 Feb 02
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  11. Perucca E, French JA, Aljandeel G, Balestrini S, Braga P, Burneo JG, Felli AC, Cross JH, Galanopoulou AS, Jain S, Jiang Y, Kalviainen R, Lim SH, Meador KJ, Mogal Z, Nabbout R, Sofia F, Somerville E, Sperling MR, Triki C, Trinka E, Walker MC, Wiebe S, Wilmshurst JM, Wirrell E, Yacubian EM, Kapur J. Which terms should be used to describe medications used in the treatment of seizure disorders? An ILAE position paper. Epilepsia. 2024 Mar; 65 (3):533-541 Epub 2024 Jan 27
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  12. Katyal R, Sheikh IS, Hadjinicolaou A, Abath CB, Wirrell EC, Reddy SB, Beniczky S, Nascimento FA. Education Research: EEG Education in Child Neurology and Neurodevelopmental Disabilities Residencies: A Survey of US and Canadian Program Directors. Neurol Educ. 2024 Mar; 3 (1):e200112 Epub 2024 Jan 05
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  13. Stefanos-Yakoub I, Wingeier K, Held U, Latal B, Wirrell E, Smith ML, Ramantani G. Long-term intellectual and developmental outcomes after pediatric epilepsy surgery: A systematic review and meta-analysis. Epilepsia. 2024 Feb; 65 (2):251-265 Epub 2023 Dec 09
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  14. Perry MS, Scheffer IE, Sullivan J, Brunklaus A, Boronat S, Wheless JW, Laux L, Patel AD, Roberts CM, Dlugos D, Holder D, Knupp KG, Lallas M, Phillips S, Segal E, Smeyers P, Lal D, Wirrell E, Zuberi S, Brunger T, Wojnaroski M, Maru B, O'Donnell P, Morton M, James E, Vila MC, Huang N, Gofshteyn JS, Rico S. Severe communication delays are independent of seizure burden and persist despite contemporary treatments in SCN1A+ Dravet syndrome: Insights from the ENVISION natural history study. Epilepsia. 2024 Feb; 65 (2):322-337 Epub 2023 Dec 22
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  15. Sullivan J, Wirrell E, Knupp KG, Chen D, Flamini R, Zafar M, Ventola P, Avendano J, Wang F, Parkerson KA, Ticho B. Adaptive functioning and neurodevelopment in patients with Dravet syndrome: 12-month interim analysis of the BUTTERFLY observational study. Epilepsy Behav. 2024 Feb; 151:109604 Epub 2024 Jan 13
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  16. Reilly C, Jette N, Johnson EC, Kariuki SM, Meredith F, Wirrell E, Mula M, Smith ML, Walsh S, Fong CY, Wilmshurst JM, Kerr M, Valente K, Auvin S. Scoping review and expert-based consensus recommendations for assessment and management of psychogenic non-epileptic (functional) seizures (PNES) in children: A report from the Pediatric Psychiatric Issues Task Force of the International League Against Epilepsy. Epilepsia. 2023 Dec; 64 (12):3160-3195 Epub 2023 Oct 07
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  17. Vasquez A, Wirrell E. Optimizing therapy in Dravet syndrome: Why the wait? Dev Med Child Neurol 2023 Dec; 65 (12):1545-1546 Epub 2023 May 17
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  18. Vasquez A, Hilliker DR, Wirrell EC. Pediatric psychogenic non-epileptic seizures: A retrospective observational cohort study at a quaternary center. Epilepsy Behav. 2023 Sep; 146:109359 Epub 2023 July 25
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  19. Smith KM, Wirrell EC, Andrade DM, Choi H, Trenite DK, Jones H, Knupp KG, Mugar J, Nordli DR Jr, Riva A, Stern JM, Striano P, Thiele EA, Zawar I. Management of epilepsy with eyelid myoclonia: Results of an international expert consensus panel. Epilepsia. 2023 Sep; 64 (9):2342-2350 Epub 2023 June 23
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  20. Smith KM, Wirrell EC, Andrade DM, Choi H, Trenite DK, Jones H, Knupp KG, Mugar J, Nordli DR Jr, Riva A, Stern JM, Striano P, Thiele EA, Zawar I. Clinical presentation and evaluation of epilepsy with eyelid myoclonia: Results of an international expert consensus panel. Epilepsia. 2023 Sep; 64 (9):2330-2341 Epub 2023 June 29
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  21. Perucca E, Perucca P, White HS, Wirrell EC. Drug resistance in epilepsy. Lancet Neurol. 2023 Aug; 22 (8):723-734 Epub 2023 June 20
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  22. Wirrell EC, Riney K, Specchio N, Zuberi SM. How have the recent updated epilepsy classifications impacted on diagnosis and treatment? Expert Rev Neurother. 2023 Jul-Dec; 23 (11):969-980 Epub 2023 Sept 07
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  23. Smith KM, Starnes DK, Brinkmann BH, So E, Cox BC, Marsh WR, Van Gompel JJ, Wirrell E, Britton JW, Burkholder DB, Wong-Kisiel LC. Stereo-EEG localization of midline onset seizures on scalp EEG. Epilepsy Res. 2023 Jul; 193:107162 Epub 2023 May 05
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  24. Smith KM, Wirrell EC, Andrade DM, Choi H, Trenite DK, Knupp KG, Nordli DR Jr, Riva A, Stern JM, Striano P, Thiele EA, Zawar I. A comprehensive narrative review of epilepsy with eyelid myoclonia. Epilepsy Res. 2023 Jul; 193:107147 Epub 2023 Apr 26
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  25. Buraniqi E, Guerin JB, Miller KJ, Van Gompel JJ, Krecke K, Wirrell EC, Nickels KC, Payne ET, Wong-Kisiel L. Temporal Encephalocele: A Treatable Etiology of Drug-Resistant Pediatric Temporal Lobe Epilepsy. Pediatr Neurol. 2023 May; 142:32-38 Epub 2022 Dec 31
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  26. Agashe S, Worrell G, Britton J, Noe K, Ritaccio A, Wirrell EC, Nickels KC, Cascino GD, Burkholder D. Cenobamate in Generalized Epilepsy and Combined Generalized and Focal Epilepsy. Neurol Clin Pract. 2023 Apr; 13 (2):e200133 Epub 2023 Feb 15
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  27. Vasquez A, Wirrell EC, Youssef PE. Stiripentol for the treatment of seizures associated with Dravet syndrome in patients 6 months and older and taking clobazam. Expert Rev Neurother. 2023 Apr; 23(4):297-309. Epub 2023 Mar 28.
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  28. Nabbout R, Kuchenbuch M, Tinuper P, Cross JH, Wirrell E. 3D figure of epilepsy syndromes. Epilepsia Open. 2023 Mar; 8 (1):217-220 Epub 2022 Nov 10
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  29. Nascimento FA, Friedman D, Peters JM, Bensalem-Owen MK, Cendes F, Rampp S, Wirrell E, Blumcke I, Tatum W, Beniczky S. Focal epilepsies: Update on diagnosis and classification. Epileptic Disord. 2023 Feb; 25 (1):1-17 Epub 2023 Apr 17
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  30. Sullivan J, Wirrell EC. Dravet Syndrome as an Example of Precision Medicine in Epilepsy. Epilepsy Curr. 2023 Jan-Feb; 23 (1):4-7 Epub 2022 June 03
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  31. Ho ML, Wirrell EC, Petropoulou K, Sakonju A, Chu D, Seratti G, Palasis S. Role of Electroencephalogram (EEG) and Magnetic Resonance Imaging (MRI) Findings in Early Recognition and Diagnosis of Neuronal Ceroid Lipofuscinosis Type 2 Disease. J Child Neurol. 2022 Dec; 37 (12-14):984-991 Epub 2022 Oct 03
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  32. Sullivan J, Wirrell E, Knupp KG, Chen D, Zafar M, Flamini R, Stutely J, Brathwaite C, Ventola P, Avendano J, Parkerson KA, Wyant N, Ticho B. Interim results of adaptive functioning and neurodevelopment in BUTTERFLY - An observational study of children and adolescents with Dravet syndrome. Epilepsy Behav. 2022 Dec; 137 (Pt A):108955 Epub 2022 Nov 01
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  33. Brunklaus A, Brunger T, Feng T, Fons C, Lehikoinen A, Panagiotakaki E, Vintan MA, Symonds J, Andrew J, Arzimanoglou A, Delima S, Gallois J, Hanrahan D, Lesca G, MacLeod S, Marjanovic D, McTague A, Nunez-Enamorado N, Perez-Palma E, Scott Perry M, Pysden K, Russ-Hall SJ, Scheffer IE, Sully K, Syrbe S, Vaher U, Velayutham M, Vogt J, Weiss S, Wirrell E, Zuberi SM, Lal D, Moller RS, Mantegazza M, Cestele S. The gain of function SCN1A disorder spectrum: novel epilepsy phenotypes and therapeutic implications. Brain. 2022 Nov 21; 145 (11):3816-3831
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  34. Kwon CS, Wirrell EC, Jette N. Autism Spectrum Disorder and Epilepsy. Neurol Clin. 2022 Nov; 40 (4):831-847 Epub 2022 Sept 28
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  35. French J, Cleary E, Dlugos D, Farfel G, Farrell K, Gidal B, Grzeskowiak CL, Gurrell R, Harden C, Stalvey TJ, Tsai J, Wirrell EC, Blum D, Fountain N. Considerations for determining the efficacy of new antiseizure medications in children age 1 month to younger than 2 years. Epilepsia. 2022 Oct; 63 (10):2664-2670 Epub 2022 Aug 12
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  36. Nascimento FA, Jing J, Strowd R, Sheikh IS, Weber D, Gavvala JR, Maheshwari A, Tanner A, Ng M, Vinayan KP, Sinha SR, Yacubian EM, Rao VR, Perry MS, Fountain NB, Karakis I, Wirrell E, Yuan F, Friedman D, Tankisi H, Rampp S, Fasano R, Wilmshurst JM, O'Donovan C, Schomer D, Kaplan PW, Sperling MR, Benbadis S, Westover MB, Beniczky S. Competency-based EEG education: a list of "must-know" EEG findings for adult and child neurology residents. Epileptic Disord. 2022 Oct 1; 24 (5):979-982
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  37. Leal-Pardinas F, Truty R, McKnight DA, Johnson B, Morales A, Bristow SL, Yar Pang T, Cohen-Pfeffer J, Izzo E, Sankar R, Koh S, Wirrell EC, Millichap JJ, Aradhya S. Value of genetic testing for pediatric epilepsy: Driving earlier diagnosis of ceroid lipofuscinosis type 2 Batten disease. Epilepsia. 2022 Jul; 63 (7):e68-e73 Epub 2022 May 10
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  38. Wirrell EC, Hood V, Knupp KG, Meskis MA, Nabbout R, Scheffer IE, Wilmshurst J, Sullivan J. International consensus on diagnosis and management of Dravet syndrome. Epilepsia. 2022 Jul; 63 (7):1761-1777 Epub 2022 May 12
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  39. Hood V, Berg AT, Knupp KG, Koh S, Laux L, Meskis MA, Zulfiqar-Ali Q, Perry MS, Scheffer IE, Sullivan J, Wirrell E, Andrade DM. COVID-19 vaccine in patients with Dravet syndrome: Observations and real-world experiences. Epilepsia. 2022 Jul; 63 (7):1778-1786 Epub 2022 Apr 20
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  40. Baumer FM, Mytinger JR, Neville K, Briscoe Abath C, Gutierrez CA, Numis AL, Harini C, He Z, Hussain SA, Berg AT, Chu CJ, Gaillard WD, Loddenkemper T, Pasupuleti A, Samanta D, Singh RK, Singhal NS, Wusthoff CJ, Wirrell EC, Yozawitz E, Knupp KG, Shellhaas RA, Grinspan ZM, Pediatric Epilepsy Research Consortium//National Infantile Spasms Consortium. Inequities in Therapy for Infantile Spasms: A Call to Action. Ann Neurol. 2022 Jul; 92 (1):32-44 Epub 2022 Apr 28
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  41. Buraniqi E, Dabaja H, Wirrell EC. Impact of Antiseizure Medications on Appetite and Weight in Children. Paediatr Drugs. 2022 Jul; 24 (4):335-363 Epub 2022 May 21
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  42. Wirrell E, Tinuper P, Perucca E, Moshe SL. Introduction to the epilepsy syndrome papers. Epilepsia. 2022 Jun; 63 (6):1330-1332 Epub 2022 May 03
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  43. Zuberi SM, Wirrell E, Yozawitz E, Wilmshurst JM, Specchio N, Riney K, Pressler R, Auvin S, Samia P, Hirsch E, Galicchio S, Triki C, Snead OC, Wiebe S, Cross JH, Tinuper P, Scheffer IE, Perucca E, Moshe SL, Nabbout R. ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia. 2022 Jun; 63 (6):1349-1397 Epub 2022 May 03
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  44. Wirrell EC, Nabbout R, Scheffer IE, Alsaadi T, Bogacz A, French JA, Hirsch E, Jain S, Kaneko S, Riney K, Samia P, Snead OC, Somerville E, Specchio N, Trinka E, Zuberi SM, Balestrini S, Wiebe S, Cross JH, Perucca E, Moshe SL, Tinuper P. Methodology for classification and definition of epilepsy syndromes with list of syndromes: Report of the ILAE Task Force on Nosology and Definitions. Epilepsia. 2022 Jun; 63 (6):1333-1348 Epub 2022 May 03
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  45. Hirsch E, French J, Scheffer IE, Bogacz A, Alsaadi T, Sperling MR, Abdulla F, Zuberi SM, Trinka E, Specchio N, Somerville E, Samia P, Riney K, Nabbout R, Jain S, Wilmshurst JM, Auvin S, Wiebe S, Perucca E, Moshe SL, Tinuper P, Wirrell EC. ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia. 2022 Jun; 63 (6):1475-1499 Epub 2022 May 03
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  46. Specchio N, Wirrell EC, Scheffer IE, Nabbout R, Riney K, Samia P, Guerreiro M, Gwer S, Zuberi SM, Wilmshurst JM, Yozawitz E, Pressler R, Hirsch E, Wiebe S, Cross HJ, Perucca E, Moshe SL, Tinuper P, Auvin S. International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions. Epilepsia. 2022 Jun; 63 (6):1398-1442 Epub 2022 May 03
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  47. Riney K, Bogacz A, Somerville E, Hirsch E, Nabbout R, Scheffer IE, Zuberi SM, Alsaadi T, Jain S, French J, Specchio N, Trinka E, Wiebe S, Auvin S, Cabral-Lim L, Naidoo A, Perucca E, Moshe SL, Wirrell EC, Tinuper P. International League Against Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia. 2022 Jun; 63 (6):1443-1474 Epub 2022 May 03
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  48. Triplet EM, Nickels K, Wong-Kisiel L, Fine A, Wirrell EC. A tale of two cohorts: Differing outcomes in infantile-onset focal epilepsy. Epilepsia. 2022 Apr; 63 (4):950-960 Epub 2022 Feb 10
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  49. Vasquez A, Buraniqi E, Wirrell EC. New and emerging pharmacologic treatments for developmental and epileptic encephalopathies. Curr Opin Neurol. 2022 Apr 1; 35 (2):145-154
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  50. Kerezoudis P, Gyftopoulos A, Alexander AY, Keith Starnes D, Nickels KC, Worrell GA, Wirrell EC, Lundstrom BN, Van Gompel JJ, Miller KJ. Safety and efficacy of responsive neurostimulation in the pediatric population: Evidence from institutional review and patient-level meta-analysis. Epilepsy Behav. 2022 Apr; 129:108646. Epub 2022 Mar 14.
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  51. Fine AL, Wong-Kisiel LC, Nickels KC, Wirrell EC. Masking for School-Age Children With Epilepsy: We Do Have Consensus! J Child Neurol. 2022 Feb; 37 (2):127-132 Epub 2022 Jan 05
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  52. Cross JH, Galer BS, Gil-Nagel A, Devinsky O, Ceulemans B, Lagae L, Schoonjans AS, Donner E, Wirrell E, Kothare S, Agarwal A, Lock M, Gammaitoni AR. Impact of fenfluramine on the expected SUDEP mortality rates in patients with Dravet syndrome. Seizure. 2021 Dec; 93:154-159 Epub 2021 Nov 02
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  53. Johannesen KM, Gardella E, Gjerulfsen CE, Bayat A, Rouhl RPW, Reijnders M, Whalen S, Keren B, Buratti J, Courtin T, Wierenga KJ, Isidor B, Piton A, Faivre L, Garde A, Moutton S, Tran-Mau-Them F, Denomme-Pichon AS, Coubes C, Larson A, Esser MJ, Appendino JP, Al-Hertani W, Gamboni B, Mampel A, Mayorga L, Orsini A, Bonuccelli A, Suppiej A, Van-Gils J, Vogt J, Damioli S, Giordano L, Moortgat S, Wirrell E, Hicks S, Kini U, Noble N, Stewart H, Asakar S, Cohen JS, Naidu SR, Collier A, Brilstra EH, Li MH, Brew C, Bigoni S, Ognibene D, Ballardini E, Ruivenkamp C, Faggioli R, Afenjar A, Rodriguez D, Bick D, Segal D, Coman D, Gunning B, Devinsky O, Demmer LA, Grebe T, Pruna D, Cursio I, Greenhalgh L, Graziano C, Singh RR, Cantalupo G, Willems M, Yoganathan S, Goes F, Leventer RJ, Colavito D, Olivotto S, Scelsa B, Andrade AV, Ratke K, Tokarz F, Khan AS, Ormieres C, Benko W, Keough K, Keros S, Hussain S, Franques A, Varsalone F, Gronborg S, Mignot C, Heron D, Nava C, Isapof A, Borlot F, Whitney R, Ronan A, Foulds N, Somorai M, Brandsema J, Helbig KL, Helbig I, Ortiz-Gonzalez XR, Dubbs H, Vitobello A, Anderson M, Spadafore D, Hunt D, Moller RS, Rubboli G, PURA study group. PURA-Related Developmental and Epileptic Encephalopathy: Phenotypic and Genotypic Spectrum. Neurol Genet. 2021 Dec; 7 (6):e613 Epub 2021 Nov 15
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  54. Andrade DM, Berg AT, Hood V, Knupp KG, Koh S, Laux L, Meskis MA, Miller I, Perry MS, Scheffer IE, Sullivan J, Villas N, Wirrell E. Dravet syndrome: A quick transition guide for the adult neurologist. Epilepsy Res. 2021 Nov; 177:106743 Epub 2021 Aug 18
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  55. Guerrini R, Balestrini S, Wirrell EC, Walker MC. Monogenic Epilepsies: Disease Mechanisms, Clinical Phenotypes, and Targeted Therapies. Neurology. 2021 Oct 26; 97 (17):817-831 Epub 2021 Sept 07
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  56. Desnous B, Lenoir M, Bitton JY, Arbour M, Villeneuve N, Whiting S, Mohammed I, Wirrell EC, Bello-Espinosa L, Ronen GM, Lortie A, Birca A. What is the optimal duration for vigabatrin monotherapy in patients with infantile spasms: 6 months or longer? Seizure. 2021 Oct; 91:503-506 Epub 2021 Aug 02
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  57. Grinspan ZM, Knupp KG, Patel AD, Yozawitz EG, Wusthoff CJ, Wirrell EC, Valencia I, Singhal NS, Nordli DR, Mytinger JR, Mitchell WG, Keator CG, Loddenkemper T, Hussain SA, Harini C, Gaillard WD, Fernandez IS, Coryell J, Chu CJ, Berg AT, Shellhaas RA. Comparative Effectiveness of Initial Treatment for Infantile Spasms in a Contemporary US Cohort. Neurology. 2021 Sep 20; 97 (12):e1217-e1228 Epub 2021 Sept 20
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  58. Juando-Prats C, James E, Bilder DA, McNair L, Kenneally N, Helfer J, Huang N, Vila MC, Sullivan J, Wirrell E, Rico S. DRAVET ENGAGE. Parent caregivers of children with Dravet syndrome: Perspectives, needs, and opportunities for clinical research. Epilepsy Behav. 2021 Sep; 122:108198 Epub 2021 July 17
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  59. Gil-Nagel A, Sullivan J, Ceulemans B, Wirrell E, Devinsky O, Nabbout R, Knupp KG, Scott Perry M, Polster T, Davis R, Lock M, Cortes RM, Gammaiton AR, Farfel G, Galer BS, Agarwal A. Treatment with fenfluramine in patients with Dravet syndrome has no long-term effects on weight and growth. Epilepsy Behav. 2021 Sep; 122:108212 Epub 2021 Aug 02
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  60. Bishop KI, Isquith PK, Gioia GA, Gammaitoni AR, Farfel G, Galer BS, Nabbout R, Wirrell EC, Polster T, Sullivan J. Improved everyday executive functioning following profound reduction in seizure frequency with fenfluramine: Analysis from a phase 3 long-term extension study in children/young adults with Dravet syndrome. Epilepsy Behav. 2021 Aug; 121 (Pt A):108024 Epub 2021 May 20
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  61. Augustine EF, Adams HR, de Los Reyes E, Drago K, Frazier M, Guelbert N, Laine M, Levin T, Mink JW, Nickel M, Peifer D, Schulz A, Simonati A, Topcu M, Turunen JA, Williams R, Wirrell EC, King S. Management of CLN1 Disease: International Clinical Consensus. Pediatr Neurol. 2021 Jul; 120:38-51 Epub 2021 Apr 09
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  62. Bitton JY, Desnous B, Sauerwein HC, Connolly M, Weiss SK, Donner EJ, Whiting S, Mohamed IS, Wirrell EC, Ronen GM, Lortie A, CPEN. Cognitive outcome in children with infantile spasms using a standardized treatment protocol. A five-year longitudinal study. Seizure. 2021 Jul; 89:73-80 Epub 2021 May 11
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  63. Payne ET, Wirrell EC. Discontinuing Antiseizure Medication in Neonates With Acute Symptomatic Seizures-Primum non nocere. JAMA Neurol 2021 Jul 1; 78 (7):797-799
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  64. Privitera M, Bhathal H, Wong M, Cross JH, Wirrell E, Marsh ED, Mazurkiewicz-Beldzinska M, Villanueva V, Checketts D, Knappertz V, VanLandingham K. Time to onset of cannabidiol (CBD) treatment effect in Lennox-Gastaut syndrome: Analysis from two randomized controlled trials. Epilepsia. 2021 May; 62 (5):1130-1140 Epub 2021 Apr 02
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  65. Johannessen Landmark C, Potschka H, Auvin S, Wilmshurst JM, Johannessen SI, Kasteleijn-Nolst Trenite D, Wirrell EC. The role of new medical treatments for the management of developmental and epileptic encephalopathies: Novel concepts and results. Epilepsia. 2021 Apr; 62 (4):857-873 Epub 2021 Feb 27
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  66. Koh S, Wirrell E, Vezzani A, Nabbout R, Muscal E, Kaliakatsos M, Wickstrom R, Riviello JJ, Brunklaus A, Payne E, Valentin A, Wells E, Carpenter JL, Lee K, Lai YC, Eschbach K, Press CA, Gorman M, Stredny CM, Roche W, Mangum T. Proposal to optimize evaluation and treatment of Febrile infection-related epilepsy syndrome (FIRES): A Report from FIRES workshop. Epilepsia Open. 2021 Mar; 6 (1):62-72 Epub 2021 Jan 13
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  67. Joshi C, Nickels K, Demarest S, Eltze C, Cross JH, Wirrell E. Results of an international Delphi consensus in epilepsy with myoclonic atonic seizures/ Doose syndrome. Seizure. 2021 Feb; 85:12-18 Epub 2020 Dec 28
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  68. Alcala-Zermeno JL, Gregg NM, Wirrell EC, Stead M, Worrell GA, Van Gompel JJ, Lundstrom BN. Centromedian thalamic nucleus with or without anterior thalamic nucleus deep brain stimulation for epilepsy in children and adults: A retrospective case series. Seizure. 2021 Jan; 84:101-107 Epub 2020 Nov 26
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  69. Lai YC, Muscal E, Wells E, Shukla N, Eschbach K, Hyeong Lee K, Kaliakatsos M, Desai N, Wickstrom R, Viri M, Freri E, Granata T, Nangia S, Dilena R, Brunklaus A, Wainwright MS, Gorman MP, Stredny CM, Asiri A, Hundallah K, Doja A, Payne E, Wirrell E, Koh S, Carpenter JL, Riviello J. Anakinra usage in febrile infection related epilepsy syndrome: an international cohort. Ann Clin Transl Neurol. 2020 Dec; 7 (12):2467-2474 Epub 2020 Dec 04
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  70. Wirrell EC, Grinspan ZM, Knupp KG, Jiang Y, Hammeed B, Mytinger JR, Patel AD, Nabbout R, Specchio N, Cross JH, Shellhaas RA. Care Delivery for Children With Epilepsy During the COVID-19 Pandemic: An International Survey of Clinicians. J Child Neurol. 2020 Nov; 35 (13):924-933 Epub 2020 July 15
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  71. Kuchenbuch M, D'Onofrio G, Wirrell E, Jiang Y, Dupont S, Grinspan ZM, Auvin S, Wilmshurst JM, Arzimanoglou A, Cross JH, Specchio N, Nabbout R. An accelerated shift in the use of remote systems in epilepsy due to the COVID-19 pandemic. Epilepsy Behav. 2020 Nov; 112:107376 Epub 2020 Aug 31
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  72. Wirrell EC, Bieber ED, Vanderwiel A, Kreps S, Weaver AL. Self-injurious and suicidal behavior in young adults, teens, and children with epilepsy: A population-based study. Epilepsia. 2020 Sep; 61 (9):1919-1930 Epub 2020 July 22
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  73. Fine A, Wirrell EC. Seizures in Children. Pediatr Rev. 2020 Jul; 41 (7):321-347
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  74. Payne ET, Koh S, Wirrell EC. Extinguishing Febrile Infection-Related Epilepsy Syndrome: Pipe Dream or Reality? Semin Neurol. 2020 Apr; 40 (2):263-272 Epub 2020 Mar 17
    View PubMed
  75. Nabbout R, Mistry A, Zuberi S, Villeneuve N, Gil-Nagel A, Sanchez-Carpintero R, Stephani U, Laux L, Wirrell E, Knupp K, Chiron C, Farfel G, Galer BS, Morrison G, Lock M, Agarwal A, Auvin S, FAiRE, DS Study Group. Fenfluramine for Treatment-Resistant Seizures in Patients With Dravet Syndrome Receiving Stiripentol-Inclusive Regimens: A Randomized Clinical Trial. JAMA Neurol. 2020 Mar 1; 77 (3):300-308
    View PubMed
  76. Kerezoudis P, Wirrell E, Miller K. Post-placement Lead Deformation Secondary to Cerebrospinal Fluid Loss in Transventricular Trajectory During Responsive Neurostimulation Surgery. Cureus. 2020 Jan 30; 12 (1):e6823
    View PubMed
  77. Wallace A, Wirrell E, Payne E. Seizure Rescue Medication Use among US Pediatric Epilepsy Providers: A Survey of the Pediatric Epilepsy Research Consortium. J Pediatr. 2019 Sep; 212:111-116 Epub 2019 June 14
    View PubMed
  78. Lukmanji S, Manji SA, Kadhim S, Sauro KM, Wirrell EC, Kwon CS, Jette N. The co-occurrence of epilepsy and autism: A systematic review. Epilepsy Behav. 2019 Sep; 98 (Pt A):238-248 Epub 2019 Aug 06
    View PubMed
  79. Wirrell EC, Nabbout R. Recent Advances in the Drug Treatment of Dravet Syndrome. CNS Drugs. 2019 Sep; 33 (9):867-881
    View PubMed
  80. Berg AT, Wusthoff C, Shellhaas RA, Loddenkemper T, Grinspan ZM, Saneto RP, Knupp KG, Patel A, Sullivan JE, Kossoff EH, Chu CJ, Massey S, Valencia I, Keator C, Wirrell EC, Coryell J, Millichap JJ, Gaillard WD. Immediate outcomes in early life epilepsy: A contemporary account. Epilepsy Behav. 2019 Aug; 97:44-50 Epub 2019 June 07
    View PubMed
  81. Jagadish S, Payne ET, Wong-Kisiel L, Nickels KC, Eckert S, Wirrell EC. The Ketogenic and Modified Atkins Diet Therapy for Children With Refractory Epilepsy of Genetic Etiology. Pediatr Neurol. 2019 May; 94:32-37 Epub 2018 Dec 29
    View PubMed
  82. Camfield PR, Andrade D, Camfield CS, Carrizosa-Moog J, Appleton R, Baulac M, Brown L, Menachem EB, Cross H, Desguerre I, Grant C, Hosny H, Jurasek L, Mula M, Pfafflin M, Rheims S, Ring H, Shellhaas RA, Vinayan KP, Wirrell E, Nabbout R. How can transition to adult care be best orchestrated for adolescents with epilepsy? Epilepsy Behav. 2019 Apr; 93:138-147 Epub 2019 Jan 12
    View PubMed
  83. Auvin S, Wirrell E, Donald KA, Berl M, Hartmann H, Valente KD, Van Bogaert P, Cross JH, Osawa M, Kanemura H, Aihara M, Guerreiro MM, Samia P, Vinayan KP, Smith ML, Carmant L, Kerr M, Hermann B, Dunn D, Wilmshurst JM. Systematic review of the screening, diagnosis, and management of ADHD in children with epilepsy. Consensus paper of the Task Force on Comorbidities of the ILAE Pediatric Commission. Epilepsia. 2018 Oct; 59 (10):1867-1880 Epub 2018 Sept 03
    View PubMed
  84. Coryell J, Gaillard WD, Shellhaas RA, Grinspan ZM, Wirrell EC, Knupp KG, Wusthoff CJ, Keator C, Sullivan JE, Loddenkemper T, Patel A, Chu CJ, Massey S, Novotny EJ Jr, Saneto RP, Berg AT. Neuroimaging of Early Life Epilepsy. Pediatrics. 2018 Sep; 142 (3) Epub 2018 Aug 08
    View PubMed
  85. Lopez-Chiriboga AS, Klein C, Zekeridou A, McKeon A, Dubey D, Flanagan EP, Lennon VA, Tillema JM, Wirrell EC, Patterson MC, Gadoth A, Aaen JG, Brenton JN, Bui JD, Moen A, Otten C, Piquet A, Pittock SJ. LGI1 and CASPR2 neurological autoimmunity in children. Ann Neurol. 2018 Sep; 84 (3):473-480
    View PubMed
  86. Smith KM, Youssef PE, Wirrell EC, Nickels KC, Payne ET, Britton JW, Shin C, Cascino GD, Patterson MC, Wong-Kisiel LC. Jeavons Syndrome: Clinical Features and Response to Treatment. Pediatr Neurol. 2018 Sep; 86:46-51 Epub 2018 July 10
    View PubMed
  87. Ryan CS, Fine AL, Cohen AL, Schiltz BM, Renaud DL, Wirrell EC, Patterson MC, Boczek NJ, Liu R, Babovic-Vuksanovic D, Chan DC, Payne ET. De Novo DNM1L Variant in a Teenager With Progressive Paroxysmal Dystonia and Lethal Super-refractory Myoclonic Status Epilepticus. J Child Neurol. 2018 Sep; 33 (10):651-658 Epub 2018 June 07
    View PubMed
  88. Wong-Kisiel LC, Blauwblomme T, Ho ML, Boddaert N, Parisi J, Wirrell E, Nabbout R. Challenges in managing epilepsy associated with focal cortical dysplasia in children. Epilepsy Res. 2018 Sep; 145:1-17 Epub 2018 May 14
    View PubMed
  89. Knupp KG, Wirrell EC. Correction to: Treatment Strategies for Dravet Syndrome. CNS Drugs. 2018 Aug; 32 (8):783
    View PubMed
  90. Nickels K, Thibert R, Rau S, Demarest S, Wirrell E, Kossoff EH, Joshi C, Nangia S, Shellhaas R, Pediatric Epilepsy Research Consortium. How do we diagnose and treat epilepsy with myoclonic-atonic seizures (Doose syndrome)? Results of the Pediatric Epilepsy Research Consortium survey. Epilepsy Res. 2018 Aug; 144:14-19 Epub 2018 Apr 25
    View PubMed
  91. Fine AL, Wong-Kisiel LC, Wirrell EC. A Novel Phenotype in a Previously Described Epilepsy-Aphasia Disorder. Semin Pediatr Neurol. 2018 Jul; 26:21-24
    View PubMed
  92. Kossoff EH, Zupec-Kania BA, Auvin S, Ballaban-Gil KR, Christina Bergqvist AG, Blackford R, Buchhalter JR, Caraballo RH, Cross JH, Dahlin MG, Donner EJ, Guzel O, Jehle RS, Klepper J, Kang HC, Lambrechts DA, Liu YMC, Nathan JK, Nordli DR Jr, Pfeifer HH, Rho JM, Scheffer IE, Sharma S, Stafstrom CE, Thiele EA, Turner Z, Vaccarezza MM, van der Louw EJTM, Veggiotti P, Wheless JW, Wirrell EC, Charlie Foundation//Matthew's Friends//Practice Committee of the Child Neurology Society. Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group. Epilepsia Open. 2018 Jun; 3 (2):175-192 Epub 2018 May 21
    View PubMed
  93. Wirrell EC, Vanderwiel AJ, Nickels L, Vanderwiel SL, Nickels KC. Impact of Prior Authorization of Antiepileptic Drugs in Children With Epilepsy. Pediatr Neurol. 2018 Jun; 83:38-41 Epub 2018 Apr 03
    View PubMed
  94. Devinsky O, Patel AD, Cross JH, Villanueva V, Wirrell EC, Privitera M, Greenwood SM, Roberts C, Checketts D, VanLandingham KE, Zuberi SM, GWPCARE3 Study Group. Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome. N Engl J Med. 2018 May 17; 378 (20):1888-1897
    View PubMed
  95. Wirrell E, Eckert S, Wong-Kisiel L, Payne E, Nickels K. Ketogenic Diet Therapy in Infants: Efficacy and Tolerability. Pediatr Neurol. 2018 May; 82:13-18 Epub 2018 Jan 31
    View PubMed
  96. Grinspan ZM, Shellhaas RA, Coryell J, Sullivan JE, Wirrell EC, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ Jr, Millichap J, Berg AT. Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy. JAMA Pediatr. 2018 Apr 1; 172 (4):352-360
    View PubMed
  97. Knupp KG, Wirrell EC. Treatment Strategies for Dravet Syndrome. CNS Drugs. 2018 Apr; 32 (4):335-350
    View PubMed
  98. Berg AT, Chakravorty S, Koh S, Grinspan ZM, Shellhaas RA, Saneto RP, Wirrell EC, Coryell J, Chu CJ, Mytinger JR, Gaillard WD, Valencia I, Knupp KG, Loddenkemper T, Sullivan JE, Poduri A, Millichap JJ, Keator C, Wusthoff C, Ryan N, Dobyns WB, Hegde M. Why West? Comparisons of clinical, genetic and molecular features of infants with and without spasms. PLoS One. 2018; 13 (3):e0193599 Epub 2018 Mar 08
    View PubMed
  99. Demarest ST, Shellhaas RA, Gaillard WD, Keator C, Nickels KC, Hussain SA, Loddenkemper T, Patel AD, Saneto RP, Wirrell E, Sanchez Fernandez I, Chu CJ, Grinspan Z, Wusthoff CJ, Joshi S, Mohamed IS, Stafstrom CE, Stack CV, Yozawitz E, Bluvstein JS, Singh RK, Knupp KG, Pediatric Epilepsy Research Consortium. The impact of hypsarrhythmia on infantile spasms treatment response: Observational cohort study from the National Infantile Spasms Consortium. Epilepsia. 2017 Dec; 58 (12):2098-2103 Epub 2017 Nov 03
    View PubMed
  100. Nickels KC, Wirrell EC. Cognitive and Social Outcomes of Epileptic Encephalopathies. Semin Pediatr Neurol. 2017 Nov; 24 (4):264-275 Epub 2017 Oct 07
    View PubMed
  101. Shellhaas RA, Berg AT, Grinspan ZM, Wusthoff CJ, Millichap JJ, Loddenkemper T, Coryell J, Saneto RP, Chu CJ, Joshi SM, Sullivan JE, Knupp KG, Kossoff EH, Keator C, Wirrell EC, Mytinger JR, Valencia I, Massey S, Gaillard WD. Initial Treatment for Nonsyndromic Early-Life Epilepsy: An Unexpected Consensus. Pediatr Neurol. 2017 Oct; 75:73-79 Epub 2017 June 27
    View PubMed
  102. Sadleir LG, Mountier EI, Gill D, Davis S, Joshi C, DeVile C, Kurian MA, Mandelstam S, Wirrell E, Nickels KC, Murali HR, Carvill G, Myers CT, Mefford HC, Scheffer IE, DDD Study. Not all SCN1A epileptic encephalopathies are Dravet syndrome: Early profound Thr226Met phenotype. Neurology. 2017 Sep 5; 89 (10):1035-1042 Epub 2017 Aug 09
    View PubMed
  103. Berg AT, Coryell J, Saneto RP, Grinspan ZM, Alexander JJ, Kekis M, Sullivan JE, Wirrell EC, Shellhaas RA, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Dobyns WB, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ Jr, Koh S. Early-Life Epilepsies and the Emerging Role of Genetic Testing. JAMA Pediatr. 2017 Sep 1; 171 (9):863-871
    View PubMed
  104. Dubey D, Singh J, Britton JW, Pittock SJ, Flanagan EP, Lennon VA, Tillema JM, Wirrell E, Shin C, So E, Cascino GD, Wingerchuk DM, Hoerth MT, Shih JJ, Nickels KC, McKeon A. Predictive models in the diagnosis and treatment of autoimmune epilepsy. Epilepsia. 2017 Jul; 58 (7):1181-1189 Epub 2017 May 26
    View PubMed
  105. Nickels KC, Wirrell EC. Stiripentol in the Management of Epilepsy. CNS Drugs. 2017 May; 31 (5):405-416
    View PubMed
  106. Donner EJ, Camfield P, Brooks L, Buchhalter J, Camfield C, Loddenkemper T, Wirrell E. Understanding Death in Children With Epilepsy. Pediatr Neurol. 2017 May; 70:7-15 Epub 2017 Jan 31
    View PubMed
  107. deVeber GA, Kirton A, Booth FA, Yager JY, Wirrell EC, Wood E, Shevell M, Surmava AM, McCusker P, Massicotte MP, MacGregor D, MacDonald EA, Meaney B, Levin S, Lemieux BG, Jardine L, Humphreys P, David M, Chan AK, Buckley DJ, Bjornson BH. Epidemiology and Outcomes of Arterial Ischemic Stroke in Children: The Canadian Pediatric Ischemic Stroke Registry. Pediatr Neurol. 2017 Apr; 69:58-70 Epub 2017 Jan 26
    View PubMed
  108. Wirrell EC, Laux L, Donner E, Jette N, Knupp K, Meskis MA, Miller I, Sullivan J, Welborn M, Berg AT. Optimizing the Diagnosis and Management of Dravet Syndrome: Recommendations From a North American Consensus Panel. Pediatr Neurol 2017 Mar; 68:18-34.e3 Epub 2017 Feb 04
    View PubMed
  109. Whealy M, Wirrell E, Wong-Kisiel L, Nickels K, Payne ET. Prevalence and Risk Factors of Peri-ictal Autonomic Changes in Children With Temporal Lobe Seizures. Pediatr Neurol. 2017 Feb; 67:36-39 Epub 2016 Oct 11
    View PubMed
  110. Wallace A, Shin C, Wirrell EC, Burkholder DB. False ictal-appearing EEG from a frontal sinus pseudomeningocele. Neurology. 2016 Dec 13; 87 (24):2600-2601
    View PubMed
  111. Kenney-Jung DL, Vezzani A, Kahoud RJ, LaFrance-Corey RG, Ho ML, Wampler Muskardin T, Muskardin TW, Wirrell EC, Howe CL, Payne ET. Febrile infection-related epilepsy syndrome treated with anakinra. Ann Neurol. 2016 Dec; 80 (6):939-945 Epub 2016 Nov 14
    View PubMed
  112. Cooper MS, Mcintosh A, Crompton DE, McMahon JM, Schneider A, Farrell K, Ganesan V, Gill D, Kivity S, Lerman-Sagie T, McLellan A, Pelekanos J, Ramesh V, Sadleir L, Wirrell E, Scheffer IE. Mortality in Dravet syndrome. Epilepsy Res. 2016 Dec; 128:43-47 Epub 2016 Oct 26
    View PubMed
  113. Knupp KG, Leister E, Coryell J, Nickels KC, Ryan N, Juarez-Colunga E, Gaillard WD, Mytinger JR, Berg AT, Millichap J, Nordli DR Jr, Joshi S, Shellhaas RA, Loddenkemper T, Dlugos D, Wirrell E, Sullivan J, Hartman AL, Kossoff EH, Grinspan ZM, Hamikawa L, Pediatric Epilepsy Research Consortium. Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort. Epilepsia. 2016 Nov; 57 (11):1834-1842 Epub 2016 Sept 12
    View PubMed
  114. Tovar Quiroga DF, Britton JW, Wirrell EC. Patient and caregiver view on seizure detection devices: A survey study. Seizure. 2016 Oct; 41:179-81.
    View PubMed
  115. Kenney DL, Kelly-Williams KM, Krecke KN, Witte RJ, Watson RE Jr, Kotsenas AL, Wirrell EC, Nickels KC, Wong-Kisiel LC, So E. Usefulness of repeat review of head magnetic resonance images during presurgical epilepsy conferences. Epilepsy Res. 2016 Oct; 126:106-8 Epub 2016 July 01
    View PubMed
  116. Nickels KC, Zaccariello MJ, Hamiwka LD, Wirrell EC. Cognitive and neurodevelopmental comorbidities in paediatric epilepsy. Nat Rev Neurol. 2016 Aug; 12 (8):465-76 Epub 2016 July 22
    View PubMed
  117. Panjwani N, Wilson MD, Addis L, Crosbie J, Wirrell E, Auvin S, Caraballo RH, Kinali M, McCormick D, Oren C, Taylor J, Trounce J, Clarke T, Akman CI, Kugler SL, Mandelbaum DE, McGoldrick P, Wolf SM, Arnold P, Schachar R, Pal DK, Strug LJ. A microRNA-328 binding site in PAX6 is associated with centrotemporal spikes of rolandic epilepsy. Ann Clin Transl Neurol. 2016 Jul; 3 (7):512-22 Epub 2016 June 02
    View PubMed
  118. Wallace A, Wirrell E, Kenney-Jung DL. Pharmacotherapy for Dravet Syndrome. Paediatr Drugs. 2016 Jun; 18 (3):197-208
    View PubMed
  119. Wirrell EC. Treatment of Dravet Syndrome. Can J Neurol Sci. 2016 Jun; 43 Suppl 3:S13-8.
    View PubMed
  120. Feyissa AM, Wirrell EC, Jones DT, Young NP, Britton JW. Focal photoparoxysmal response in the Heidenhain variant of CJD: Hidden from view! Neurology. 2016 Apr 26; 86 (17):1647-8
    View PubMed
  121. Burkholder DB, Britton JW, Rajasekaran V, Fabris RR, Cherian PJ, Kelly-Williams KM, So EL, Nickels KC, Wong-Kisiel LC, Lagerlund TD, Cascino GD, Worrell GA, Wirrell EC. Routine vs extended outpatient EEG for the detection of interictal epileptiform discharges. Neurology. 2016 Apr 19; 86 (16):1524-30 Epub 2016 Mar 16
    View PubMed
  122. Knupp KG, Coryell J, Nickels KC, Ryan N, Leister E, Loddenkemper T, Grinspan Z, Hartman AL, Kossoff EH, Gaillard WD, Mytinger JR, Joshi S, Shellhaas RA, Sullivan J, Dlugos D, Hamikawa L, Berg AT, Millichap J, Nordli DR Jr, Wirrell E, Pediatric Epilepsy Research Consortium. Response to treatment in a prospective national infantile spasms cohort. Ann Neurol. 2016 Mar; 79 (3):475-84 Epub 2016 Feb 13
    View PubMed
  123. Wirrell E. Infantile, childhood, and adolescent epilepsies CONTINUUM: Lifelong Learning in Neurology. 2016 Feb; 22: (1)60-93.
  124. Joshi C, Berg AT, Wirrell E. Do Patients Require Inpatient Admission to Receive Adrenocorticotropic Hormone (ACTH)? A Survey of US-Based Prescribers. J Child Neurol. 2016 Feb; 31: (2)164-9.
    View PubMed
  125. Mrelashvili A, Witte RJ, Wirrell EC, Nickels KC, Wong-Kisiel LC. Seizure Freedom in Children With Pathology-Confirmed Focal Cortical Dysplasia. Pediatr Neurol. 2015 Dec; 53 (6):513-8 Epub 2015 Sept 12
    View PubMed
  126. Devinsky O, Asato M, Camfield P, Geller E, Kanner AM, Keller S, Kerr M, Kossoff EH, Lau H, Kothare S, Singh BK, Wirrell E. Delivery of epilepsy care to adults with intellectual and developmental disabilities. Neurology. 2015 Oct 27; 85 (17):1512-21 Epub 2015 Sept 30
    View PubMed
  127. Sun PY, Wyatt K, Nickels KC, Wong-Kisiel LC, Mandrekar J, Wirrell E. Predictors of Length of Stay in Children Admitted for Presurgical Evaluation for Epilepsy Surgery. Pediatr Neurol. 2015 Sep; 53: (3)207-10.
    View PubMed
  128. Fine AL, Wirrell EC, Wong-Kisiel LC, Nickels KC. Acetazolamide for electrical status epilepticus in slow-wave sleep. Epilepsia. 2015 Sep; 56: (9)e134-8.
    View PubMed
  129. Aypar U, Wirrell EC, Hoppman NL. CNKSR2 deletions: a novel cause of X-linked intellectual disability and seizures. Am J Med Genet A. 2015 Jul; 167 (7):1668-70 Epub 2015 Mar 05
    View PubMed
  130. Haque OJ, Mandrekar J, Wyatt K, Nickels KC, Wong-Kisiel L, Wetjen N, Wirrell EC. Yield and Predictors of Epilepsy Surgery Candidacy in Children Admitted for Surgical Evaluation. Pediatr Neurol. 2015 Jul; 53: (1)58-64.
    View PubMed
  131. Bower RS, Wirrell EC, Eckel LJ, Wong-Kisiel LC, Nickels KC, Wetjen NM. Repeat resective surgery in complex pediatric refractory epilepsy: lessons learned. J Neurosurg Pediatr. 2015 Jul; 16 (1):94-100 Epub 2015 Apr 24
    View PubMed
  132. Bitton JY, Demos M, Elkouby K, Connolly M, Weiss SK, Donner EJ, Whiting S, Ronen GM, Bello-Espinosa L, Wirrell EC, Mohamed IS, Dooley JM, Carmant L. Does treatment have an impact on incidence and risk factors for autism spectrum disorders in children with infantile spasms? Epilepsia. 2015 Jun; 56 (6):856-63 Epub 2015 May 05
    View PubMed
  133. Wirrell EC, Shellhaas RA, Joshi C, Keator C, Kumar S, Mitchell WG, Pediatric Epilepsy Research Consortium. How should children with West syndrome be efficiently and accurately investigated? Results from the National Infantile Spasms Consortium. Epilepsia. 2015 Apr; 56 (4):617-25 Epub 2015 Mar 16
    View PubMed
  134. Tobin WO, Lennon VA, Komorowski L, Probst C, Clardy SL, Aksamit AJ, Appendino JP, Lucchinetti CF, Matsumoto JY, Pittock SJ, Sandroni P, Tippmann-Peikert M, Wirrell EC, McKeon A. DPPX potassium channel antibody: frequency, clinical accompaniments, and outcomes in 20 patients. Neurology. 2014 Nov 11; 83 (20):1797-803 Epub 2014 Oct 15
    View PubMed
  135. Lee RW, Mandrekar J, Worrell GA, Cascino GD, Wetjen NM, Meyer FB, Wirrell EC, Marsh WR, So E. Factors contributing to the yield of asymmetric bilateral implantation of intracranial electrodes. Epilepsia. 2014 Oct; 55(10):1620-5. Epub 2014 Sep 05.
    View PubMed
  136. Camfield CS, Berg A, Stephani U, Wirrell EC. Transition issues for benign epilepsy with centrotemporal spikes, nonlesional focal epilepsy in otherwise normal children, childhood absence epilepsy, and juvenile myoclonic epilepsy. Epilepsia. 2014 Aug; 55:16-20.
    View PubMed
  137. Lee RW, Hoogs MM, Burkholder DB, Trenerry MR, Drazkowski JF, Shih JJ, Doll KE, Tatum WO 4th, Cascino GD, Marsh WR, Wirrell EC, Worrell GA, So EL. Outcome of intracranial electroencephalography monitoring and surgery in magnetic resonance imaging-negative temporal lobe epilepsy. Epilepsy Res. 2014 Jul; 108(5):937-44. Epub 2014 Mar 27.
    View PubMed
  138. Ahmadi L, Wirrell E. Intractable epilepsy, hemispheric malformation, and generalized electroencephalography abnormalities. Semin Pediatr Neurol. 2014 Jun; 21(2):73-5. Epub 2014 Apr 18.
    View PubMed
  139. Wirrell E. Early-onset focal seizures and spasms--is it surgical? Semin Pediatr Neurol. 2014 Jun; 21(2):101-3. Epub 2014 Apr 13.
    View PubMed
  140. Nozile-Firth K, Wirrell E, Giannini C. Bizarre semiology and medically intractable seizures. Semin Pediatr Neurol. 2014 Jun; 21: (2)154-9.
    View PubMed
  141. Lee RW, Worrell GA, Marsh WR, Cascino GD, Wetjen NM, Meyer FB, Wirrell EC, So EL. Diagnostic outcome of surgical revision of intracranial electrode placements for seizure localization. J Clin Neurophysiol. 2014 Jun; 31 (3):199-202
    View PubMed
  142. Toledano M, Britton JW, McKeon A, Shin C, Lennon VA, Quek AM, So E, Worrell GA, Cascino GD, Klein CJ, Lagerlund TD, Wirrell EC, Nickels KC, Pittock SJ. Utility of an immunotherapy trial in evaluating patients with presumed autoimmune epilepsy. Neurology. 2014 May 6; 82 (18):1578-86 Epub 2014 Apr 04
    View PubMed
  143. Dhamija R, Erickson MK, St Louis EK, Wirrell E, Kotagal S. Sleep abnormalities in children with Dravet syndrome. Pediatr Neurol. 2014 May; 50(5):474-8. Epub 2014 Jan 07.
    View PubMed
  144. Shull S, Diaz-Medina G, Wong-Kisiel L, Nickels K, Eckert S, Wirrell E. Early efficacy of the ketogenic diet is not affected by initial body mass index percentile. Pediatr Neurol. 2014 May; 50 (5):469-73 Epub 2014 Jan 07
    View PubMed
  145. Wirrell EC, Wong-Kisiel LC, Nickels KC. Seizure outcome after AED failure in pediatric focal epilepsy: impact of underlying etiology. Epilepsy Behav. 2014 May; 34:20-4. Epub 2014 Mar 25.
    View PubMed
  146. Wyatt KD, Mandrekar J, Wong-Kisiel L, Nickels K, Wirrell E. Predictors of recording an event during prolonged inpatient video electroencephalogram monitoring in children. Pediatr Neurol. 2014 May; 50(5):458-63. Epub 2014 Jan 24.
    View PubMed
  147. Child ND, Stead M, Wirrell EC, Nickels KC, Wetjen NM, Lee KH, Klassen BT. Chronic subthreshold subdural cortical stimulation for the treatment of focal epilepsy originating from eloquent cortex. Epilepsia. 2014 Mar; 55(3):e18-21. Epub 2014 Feb 26.
    View PubMed
  148. Kenney D, Wirrell E. Patient considerations in the management of focal seizures in children and adolescents. Adolesc Health Med Ther. 2014; 5:49-65 Epub 2014 Apr 09
    View PubMed
  149. Dhamija R, Wirrell E, Falcao G, Kirmani S, Wong-Kisiel LC. Novel de novo SCN2A mutation in a child with migrating focal seizures of infancy. Pediatr Neurol. 2013 Dec; 49(6):486-8. Epub 2013 Aug 26.
    View PubMed
  150. Bower RS, Wirrell E, Nwojo M, Wetjen NM, Marsh WR, Meyer FB. Seizure outcomes after corpus callosotomy for drop attacks. Neurosurgery. 2013 Dec; 73(6):993-1000.
    View PubMed
  151. Moseley BD, So E, Wirrell EC, Nelson C, Lee RW, Mandrekar J, Britton JW. Characteristics of postictal generalized EEG suppression in children. Epilepsy Res. 2013 Sep; 106(1-2):123-7. Epub 2013 Jun 17.
    View PubMed
  152. Wirrell EC, Laux L, Franz DN, Sullivan J, Saneto RP, Morse RP, Devinsky O, Chugani H, Hernandez A, Hamiwka L, Mikati MA, Valencia I, Le Guern ME, Chancharme L, de Menezes MS. Stiripentol in Dravet syndrome: results of a retrospective U.S. study. Epilepsia. 2013 Sep; 54 (9):1595-604 Epub 2013 July 12
    View PubMed
  153. Mulley JC, Hodgson B, McMahon JM, Iona X, Bellows S, Mullen SA, Farrell K, Mackay M, Sadleir L, Bleasel A, Gill D, Webster R, Wirrell EC, Harbord M, Sisodiya S, Andermann E, Kivity S, Berkovic SF, Scheffer IE, Dibbens LM. Role of the sodium channel SCN9A in genetic epilepsy with febrile seizures plus and Dravet syndrome. Epilepsia. 2013 Sep; 54(9):e122-6. Epub 2013 Jul 29.
    View PubMed
  154. Moseley BD, Wirrell EC, Wong-Kisiel LC, Nickels K. Early onset epilepsy is associated with increased mortality: a population-based study. Epilepsy Res. 2013 Aug; 105(3):410-4. Epub 2013 Apr 11.
    View PubMed
  155. Noe K, Sulc V, Wong-Kisiel L, Wirrell E, Van Gompel JJ, Wetjen N, Britton J, So E, Cascino GD, Marsh WR, Meyer F, Horinek D, Giannini C, Watson R, Brinkmann BH, Stead M, Worrell GA. Long-term outcomes after nonlesional extratemporal lobe epilepsy surgery. JAMA Neurol. 2013 Aug; 70 (8):1003-8
    View PubMed
  156. Berg AT, Nickels K, Wirrell EC, Geerts AT, Callenbach PM, Arts WF, Rios C, Camfield PR, Camfield CS. Mortality risks in new-onset childhood epilepsy. Pediatrics. 2013 Jul; 132(1):124-31. Epub 2013 Jun 10.
    View PubMed
  157. Wirrell EC, Wong-Kisiel LC, Mandrekar J, Nickels KC. What predicts enduring intractability in children who appear medically intractable in the first 2 years after diagnosis? Epilepsia. 2013 Jun; 54 (6):1056-64 Epub 2013 Apr 03
    View PubMed
  158. Wirrell E. Review of Dietary treatment of epilepsy. Practical implementation of ketogenic therapy. The Canadian Journal of Neurological Sciences / Le Journal Canadien Des Sciences Neurologiques. 2013 May; 40(3):440.
  159. Wirrell EC. Predicting pharmacoresistance in pediatric epilepsy. Epilepsia. 2013 May; 54 Suppl 2:19-22
    View PubMed
  160. Mirzaa GM, Paciorkowski AR, Marsh ED, Berry-Kravis EM, Medne L, Alkhateeb A, Grix A, Wirrell EC, Powell BR, Nickels KC, Burton B, Paras A, Kim K, Chung W, Dobyns WB, Das S. CDKL5 and ARX mutations in males with early-onset epilepsy. Pediatr Neurol. 2013 May; 48(5):367-77.
    View PubMed
  161. Moseley B, Bateman L, Millichap JJ, Wirrell E, Panayiotopoulos CP. Autonomic epileptic seizures, autonomic effects of seizures, and SUDEP. Epilepsy Behav. 2013 Mar; 26(3):375-85. Epub 2012 Oct 23.
    View PubMed
  162. Dhamija R, Eckert S, Wirrell E. Ketogenic diet. Can J Neurol Sci. 2013 Mar; 40 (2):158-67
    View PubMed
  163. Nickels KC, Grossardt BR, Wirrell EC. Epilepsy-related mortality is low in children: a 30-year population-based study in Olmsted County, MN. Epilepsia. 2012 Dec; 53 (12):2164-71 Epub 2012 Sept 18
    View PubMed
  164. Wirrell EC. What's new in the medical management of pediatric epilepsy? Can J Neurol Sci. 2012 Nov; 39(6):S30-4.
  165. Jette N, Quan H, Tellez-Zenteno JF, MacRodimitris S, Hader WJ, Sherman EM, Hamiwka LD, Wirrell EC, Burneo JG, Metcalfe A, Faris PD, Hernandez-Ronquillo L, Kwon CS, Kirk A, Wiebe S, CASES Expert Panelists. Development of an online tool to determine appropriateness for an epilepsy surgery evaluation. Neurology. 2012 Sep 11; 79(11):1084-93. Epub 2012 Aug 15.
    View PubMed
  166. Bitton JY, Sauerwein HC, Weiss SK, Donner EJ, Whiting S, Dooley JM, Snead C, Farrell K, Wirrell EC, Mohamed IS, Ronen GM, Salas-Prato M, Amre D, Lassonde M, Carmant L. A randomized controlled trial of flunarizine as add-on therapy and effect on cognitive outcome in children with infantile spasms. Epilepsia. 2012 Sep; 53(9):1570-6. Epub 2012 Aug 13.
    View PubMed
  167. Wirrell E, Wong-Kisiel L, Mandrekar J, Nickels K. Predictors and course of medically intractable epilepsy in young children presenting before 36 months of age: a retrospective, population-based study. Epilepsia. 2012 Sep; 53 (9):1563-9 Epub 2012 June 27
    View PubMed
  168. Moseley BD, Nickels K, Wirrell EC. Surgical outcomes for intractable epilepsy in children with epileptic spasms. J Child Neurol. 2012 Jun; 27(6):713-20. Epub 2011 Nov 28.
    View PubMed
  169. Quek AM, Britton JW, McKeon A, So E, Lennon VA, Shin C, Klein C, Watson RE Jr, Kotsenas AL, Lagerlund TD, Cascino GD, Worrell GA, Wirrell EC, Nickels KC, Aksamit AJ, Noe KH, Pittock SJ. Autoimmune epilepsy: clinical characteristics and response to immunotherapy. Arch Neurol. 2012 May; 69 (5):582-93
    View PubMed
  170. Dhamija R, Patterson MC, Wirrell EC. Epilepsy in children--when should we think neurometabolic disease? J Child Neurol. 2012 May; 27(5):663-71. Epub 2012 Feb 28.
    View PubMed
  171. Wong-Kisiel LC, McKeon A, Wirrell EC. Autoimmune encephalopathies and epilepsies in children and teenagers. Can J Neurol Sci. 2012 Mar; 39 (2):134-44
    View PubMed
  172. Moseley BD, Dhamija R, Wirrell EC, Nickels KC. Historic, clinical, and prognostic features of epileptic encephalopathies caused by CDKL5 mutations. Pediatr Neurol. 2012 Feb; 46 (2):101-5
    View PubMed
  173. Nickels KC, Wong-Kisiel LC, Moseley BD, Wirrell EC. Temporal lobe epilepsy in children. Epilepsy Res Treat. 2012; 2012:849540 Epub 2011 Oct 20
    View PubMed
  174. Moseley BD, Dhamija R, Wirrell EC. The cessation of continuous spike wave in slow-wave sleep following a temporal lobectomy. J Child Neurol. 2012 Jan; 27(1):113-6. Epub 2011 Aug 23.
    View PubMed
  175. Crepeau AZ, Moseley BD, Wirrell EC. Specific safety and tolerability considerations in the use of anticonvulsant medications in children. Drug Healthc Patient Saf. 2012; 4:39-54 Epub 2012 June 06
    View PubMed
  176. Dhamija R, Gavrilova RH, Wirrell EC. Valproate-induced worsening of seizures: clue to underlying diagnosis. J Child Neurol. 2011 Oct; 26(10):1319-21. Epub 2011 Mar 31.
    View PubMed
  177. Aboian MS, Wong-Kisiel LC, Rank M, Wetjen NM, Wirrell EC, Witte RJ. SISCOM in children with tuberous sclerosis complex-related epilepsy. Pediatr Neurol. 2011 Aug; 45(2):83-8.
    View PubMed
  178. Dhamija R, Moseley BD, Cascino GD, Wirrell EC. A population-based study of long-term outcome of epilepsy in childhood with a focal or hemispheric lesion on neuroimaging. Epilepsia. 2011 Aug; 52 (8):1522-6 Epub 2011 July 18
    View PubMed
  179. Moseley BD, Wirrell EC, Nickels K, Johnson JN, Ackerman MJ, Britton J. Electrocardiographic and oximetric changes during partial complex and generalized seizures. Epilepsy Res. 2011 Aug; 95(3):237-45. Epub 2011 May 10
    View PubMed
  180. Carranza Rojo D, Hamiwka L, McMahon JM, Dibbens LM, Arsov T, Suls A, Stodberg T, Kelley K, Wirrell E, Appleton B, Mackay M, Freeman JL, Yendle SC, Berkovic SF, Bienvenu T, De Jonghe P, Thorburn DR, Mulley JC, Mefford HC, Scheffer IE. De novo SCN1A mutations in migrating partial seizures of infancy. Neurology. 2011 Jul 26; 77(4):380-3. Epub 2011 Jul 13.
    View PubMed
  181. Moseley BD, Wirrell EC, Nickels K. Generalized periodic epileptiform discharges in a child with Dravet syndrome. J Child Neurol. 2011 Jul; 26(7):907-10. Epub 2011 Feb 18.
    View PubMed
  182. Dhamija R, Breningstall G, Wong-Kisiel L, Dolan M, Hirsch B, Wirrell E. Microdeletion of chromosome 15q26.1 in a child with intractable generalized epilepsy. Pediatr Neurol. 2011 Jul; 45(1):60-2.
    View PubMed
  183. Hamiwka LD, Hamiwka LA, Sherman EM, Wirrell E. Social skills in children with epilepsy: how do they compare to healthy and chronic disease controls? Epilepsy Behav. 2011 Jul; 21(3):238-41. Epub 2011 May 13.
    View PubMed
  184. Wirrell EC, Grossardt BR, Wong-Kisiel LC, Nickels KC. Incidence and classification of new-onset epilepsy and epilepsy syndromes in children in Olmsted County, Minnesota from 1980 to 2004: a population-based study. Epilepsy Res. 2011 Jun; 95 (1-2):110-8 Epub 2011 Apr 08
    View PubMed
  185. Wirrell EC, Grossardt BR, So EL, Nickels KC. A population-based study of long-term outcomes of cryptogenic focal epilepsy in childhood: cryptogenic epilepsy is probably not symptomatic epilepsy. Epilepsia. 2011 Apr; 52 (4):738-45 Epub 2011 Feb 14
    View PubMed
  186. Dhamija R, Renaud DL, Pittock SJ, McKeon A, Lachance DH, Nickels KC, Wirrell EC, Kuntz NL, King MD, Lennon VA. Neuronal voltage-gated potassium channel complex autoimmunity in children. Pediatr Neurol. 2011 Apr; 44 (4):275-81
    View PubMed
  187. Dhamija R, Moseley BD, Wirrell EC. Clinical reasoning: a 10-month-old boy with myoclonic status epilepticus. Neurology. 2011 Feb 1; 76 (5):e22-5
    View PubMed
  188. Kwon CS, Liu M, Quan H, Wiebe S, McChesney J, Wirrell E, Hamiwka L, Jette N. The incidence of injuries in persons with and without epilepsy--a population-based study. Epilepsia. 2010 Nov; 51(11):2247-53. Epub 2010 Aug 17.
    View PubMed
  189. Hnojcikova M, Nickels KC, Wetjen NM, Buchhalter JR, Raffel C, Wirrell EC. EEG and neuroimaging studies in young children having epilepsy surgery. Pediatr Neurol. 2010 Nov; 43(5):335-40.
    View PubMed
  190. Wirrell EC. Prognostic significance of interictal epileptiform discharges in newly diagnosed seizure disorders. J Clin Neurophysiol. 2010 Aug; 27(4):239-48.
    View PubMed
  191. Moseley BD, Nickels K, Britton J, Wirrell E. How common is ictal hypoxemia and bradycardia in children with partial complex and generalized convulsive seizures? Epilepsia. 2010 Jul; 51: (7)1219-24.
    View PubMed
  192. Diaz GE, Wirrell EC, Matsumoto JY, Krecke KN. Bilateral striopallidodentate calcinosis with paroxysmal kinesigenic dyskinesia. Pediatr Neurol. 2010 Jul; 43(1):46-8.
    View PubMed
  193. Wirrell E, Nickels KC. Pediatric epilepsy syndromes. Continuum. 2010 Jun; 16(3):57-85.
    View PubMed
  194. Davis SM, Katusic SK, Barbaresi WJ, Killian J, Weaver AL, Ottman R, Wirrell EC. Epilepsy in children with attention-deficit/hyperactivity disorder. Pediatr Neurol. 2010 May; 42 (5):325-30
    View PubMed
  195. Chioza BA, Aicardi J, Aschauer H, Brouwer O, Callenbach P, Covanis A, Dooley JM, Dulac O, Durner M, Eeg-Olofsson O, Feucht M, Friis ML, Guerrini R, Kjeldsen MJ, Nabbout R, Nashef L, Sander T, Siren A, Wirrell E, McKeigue P, Robinson R, Gardiner RM, Everett KV. Genome wide high density SNP-based linkage analysis of childhood absence epilepsy identifies a susceptibility locus on chromosome 3p23-p14. Epilepsy Res. 2009 Dec; 87(2-3):247-55. Epub 2009 Oct 17.
    View PubMed
  196. Aboian MS, Junna MR, Krecke KN, Wirrell EC. Mesial temporal sclerosis after posterior reversible encephalopathy syndrome. Pediatr Neurol. 2009 Sep; 41(3):226-8.
    View PubMed
  197. Hamiwka LD, Yu CG, Hamiwka LA, Sherman EM, Anderson B, Wirrell E. Are children with epilepsy at greater risk for bullying than their peers? Epilepsy Behav. 2009 Aug; 15(4):500-5. Epub 2009 Jul 23.
    View PubMed
  198. Hamiwka LD, Wirrell EC. Comorbidities in pediatric epilepsy: beyond "just'' treating the seizures. J Child Neurol. 2009 Jun; 24(6):734-42. Epub 2009 Apr 08.
    View PubMed
  199. Glass HC, Wirrell E. Controversies in neonatal seizure management. J Child Neurol. 2009 May; 24(5):591-9. Epub 2009 Feb 13.
    View PubMed
  200. Strug LJ, Clarke T, Chiang T, Chien M, Baskurt Z, Li W, Dorfman R, Bali B, Wirrell E, Kugler SL, Mandelbaum DE, Wolf SM, McGoldrick P, Hardison HM, Novotny ER, Greenberg DA, Hodge SE, Russo JJ, Pal DK. Centrotemporal sharp wave EEG trait in Rolandic epileposy maps to Elongator Protein Comples 4. Eur J Human Genetics (Jan 28. 2009; Epub):
  201. Hamiwka LD, Wirrell EC. Co-morbidities in Pediatric Epilepsy: Beyond "Just" Treating the Seizures. J Child NEurol Apresoline 8 (. 2009; Epub):
  202. Wirrell EC. Epileptic encephalopathies: cognitive and behavioural aspects. Paediatr. Child Health (CAN). 2009; 19: (Suppl 2)S226-30.
  203. Wirrell EC. Ketogenic ratio, calories, and fluids: do they matter? Epilepsia. 2008 Nov; 49 Suppl 8:17-9
    View PubMed
  204. Loney JC, Wirrell EC, Sherman EM, Hamiwka LD. Anxiety and depressive symptoms in children presenting with a first seizure. Pediatr Neurol. 2008 Oct; 39(4):236-40.
    View PubMed
  205. Kirton A, Winter A, Wirrell E, Snead OC. Seizure response dogs: evaluation of a formal training program. Epilepsy Behav. 2008 Oct; 13(3):499-504. Epub 2008 Jul 01.
    View PubMed
  206. Hamiwka L, Singh N, Niosi J, Wirrell E. Perceived health in children presenting with a "first seizure". Epilepsy Behav. 2008 Oct; 13(3):485-8. Epub 2008 Jul 09.
    View PubMed
  207. Kossoff EH, Zupec-Kania BA, Amark PE, Ballaban-Gil KR, Bergqvist ACG, Blackford R, Buchhalter JR, Caraballo RH, Cross JH, Dahlin MG, Donner EJ, Jehle RS, Klepper J, Kim HD, Liu YMC, Nation J, Nordli, DR Jr, Pfeifer HH, Rho JM, Stafstrom CE, Thiele EA, Turner Z, Veggiotti P, Vining EPG, Wheless JW, Wirrell EC, The Charlie Foundation, the Practice Committee of the Child Neurology Society. Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group. Epilepsia.2008;
  208. Ho J, Lee A, Kaminsky L, Wirrell E. Self-concept, attitude toward illness and family functioning in adolescents with type 1 diabetes. Paediatr Child Health. 2008 Sep; 13(7):600-4.
    View PubMed
  209. Cai S, Hamiwka LD, Wirrell EC. Peri-ictal headache in children: prevalence and character. Pediatr Neurol. 2008 Aug; 39(2):91-6.
    View PubMed
  210. Yu CG, Lee A, Wirrell E, Sherman EM, Hamiwka L. Health behavior in teens with epilepsy: how do they compare with controls? Epilepsy Behav. 2008 Jul; 13(1):90-5.
    View PubMed
  211. Wood LJ, Sherman E, Hamiwka LD, Blackman M, Wirrell E. Depression, anxiety, and quality of life in siblings of children with intractable epilepsy. Epilepsy Behav. 2008 Jul; 13(1):144-8. Epub 2008 May 05.
    View PubMed
  212. Hamiwka L, Singh N, Kozlik S, Wirrell E. Feasibility and clinical utility of early electroencephalogram (EEG) in children with first seizure. J Child Neurol. 2008 Jul; 23(7):762-5.
    View PubMed
  213. Wirrell EC, Wood L, Hamiwka LD, Sherman EM. Parenting stress in mothers of children with intractable epilepsy. Epilepsy Behav. 2008 Jul; 13(1):169-73. Epub 2008 Mar 11.
    View PubMed
  214. Wirrell E, Kozlik S, Tellez J, Wiebe S, Hamiwka L. Ambulatory electroencephalography (EEG) in children: diagnostic yield and tolerability. J Child Neurol. 2008 Jun; 23(6):655-62.
    View PubMed
  215. Nickels K, Wirrell E. Electrical status epilepticus in sleep. Semin Pediatr Neurol. 2008 Jun; 15(2):50-60.
    View PubMed
  216. Lee A, Hamiwka LD, Sherman EM, Wirrell EC. Self-concept in adolescents with epilepsy: biological and social correlates. Pediatr Neurol. 2008 May; 38(5):335-9.
    View PubMed
  217. Thornton N, Hamiwka L, Sherman E, Tse E, Blackman M, Wirrell E. Family function in cognitively normal children with epilepsy: impact on competence and problem behaviors. Epilepsy Behav. 2008 Jan; 12(1):90-5. Epub 2007 Oct 24.
    View PubMed
  218. Wirrell E, Sherman EM, Vanmastrigt R, Hamiwka L. Deterioration in cognitive function in children with benign epilepsy of childhood with central temporal spikes treated with sulthiame. J Child Neurol. 2008 Jan; 23(1):14-21.
    View PubMed
  219. Tse E, Hamiwka L, Sherman EM, Wirrell E. Social skills problems in children with epilepsy: prevalence, nature and predictors. Epilepsy & Behavior. 2007 Dec; 11(4):499-505.
    View PubMed
  220. Wirrell EC, Hamiwka LD, Hamiwka LA, Grisaru S, Wei X. Acute glomerulonephritis presenting with PRES: a report of 4 cases. Can J Neurol Sci. 2007 Aug; 34(3):316-21.
    View PubMed
  221. Everett K, Chioza B, Aicardi J, Aschauer H, Brouwer O, Callenbach P, Covanis A, Dooley J, Dulac O, Durner M, Eeg-Olofsson O, Feucht M, Friis M, Guerrini R, Heils A, Kjeldsen M, Nabbout R, Sander T, Wirrell E, McKeigue P, Robinson R, Taske N, Gardiner M. Linkage and mutational analysis of CLCN2 in childhood absence epilepsy. Epilepsy Res. 2007 Jul; 75(2-3):145-53. Epub 2007 Jun 18.
    View PubMed
  222. Hamiwka LD, Singh N, Niosi J, Wirrell EC. Diagnostic inaccuracy in children referred with "first seizure": role for a first seizure clinic. Epilepsia. 2007 Jun; 48(6):1062-6.
    View PubMed
  223. Glass HC, Wirrell E, Sarnat HB, Dunham C, Lewis V, Morrish W. MRI findings in an immunocompromised boy with CNS fungal infection. Can J Neurol Sci. 2007 Feb; 34(1):88-91.
    View PubMed
  224. Glass HC, Prieur B, Molnar C, Hamiwka L, Wirrell E. Micturition and emotion-induced reflex epilepsy: case report and review of the literature. Epilepsia. 2006 Dec; 47(12):2180-2.
    View PubMed
  225. Wirrell EC, Hamiwka LD. Do children with benign rolandic epilepsy have a higher prevalence of migraine than those with other partial epilepsies or nonepilepsy controls? Epilepsia. 2006 Oct; 47(10):1674-81.
    View PubMed
  226. Heng K, Wirrell E. Sleep disturbance in children with migraine. J Child Neurol. 2006 Sep; 21(9):761-6.
    View PubMed
  227. Wirrell E, Ho AW, Hamiwka L. Sulthiame therapy for continuous spike and wave in slow-wave sleep. Pediatr Neurol. 2006 Sep; 35(3):204-8.
    View PubMed
  228. Berkovic SF, Harkin L, McMahon JM, Pelekanos JT, Zuberi SM, Wirrell EC, Gill DS, Iona X, Mulley JC, Scheffer IE. De-novo mutations of the sodium channel gene SCN1A in alleged vaccine encephalopathy: a retrospective study. Lancet Neurol. 2006 Jun; 5(6):488-92.
    View PubMed
  229. Kirton A, Diggle J, Hu W, Wirrell E. A pediatric case of reversible segmental cerebral vasoconstriction. Can J Neurol Sci. 2006 May; 33(2):250-3.
    View PubMed
  230. Cheung C, Wirrell E. Adolescents' perception of epilepsy compared with other chronic diseases: "through a teenager's eyes". J Child Neurol. 2006 Mar; 21(3):214-22.
    View PubMed
  231. Wong J, Wirrell E. Physical activity in children/teens with epilepsy compared with that in their siblings without epilepsy. Epilepsia. 2006 Mar; 47(3):631-9.
    View PubMed
  232. Wirrell E, Cheung C, Spier S. How do teens view the physical and social impact of asthma compared to other chronic diseases? J Asthma. 2006 Mar; 43(2):155-60.
    View PubMed
  233. Wirrell EC. Epilepsy-related injuries. Epilepsia. 2006; 47 Suppl 1:79-86.
    View PubMed
  234. Wirrell E, Whiting S, Farrell K. Management of intractable epilepsy in infancy and childhood. Adv Neurol. 2006; 97:463-91.
    View PubMed
  235. Whiting S, Farrell K, Wirrell E. Diseases and syndromes associated with intractable epilepsy. Adv Neurol. 2006; 97:443-62.
    View PubMed
  236. Farrell K, Wirrell E, Whiting S. The definition and prediction of intractable epilepsy in children. Adv Neurol. 2006; 97:435-42.
    View PubMed
  237. Lu C, Wirrell E, Blackman M. Where do families of children with epilepsy obtain their information? J Child Neurol. 2005 Nov; 20(11):905-10.
    View PubMed
  238. Soo I, Mah JK, Barlow K, Hamiwka L, Wirrell E. Use of complementary and alternative medical therapies in a pediatric neurology clinic. Can J Neurol Sci. 2005 Nov; 32(4):524-8.
    View PubMed
  239. Wirrell E, Farrell K, Whiting S. The epileptic encephalopathies of infancy and childhood. Can J Neurol Sci. 2005 Nov; 32(4):409-18.
    View PubMed
  240. Wirrell E, Blackman M, Barlow K, Mah J, Hamiwka L. Sleep disturbances in children with epilepsy compared with their nearest-aged siblings. Dev Med Child Neurol. 2005 Nov; 47(11):754-9.
    View PubMed
  241. Glass HC, Boycott KM, Adams C, Barlow K, Scott JN, Chudley AE, Fujiwara TM, Morgan K, Wirrell E, McLeod DR. Autosomal recessive cerebellar hypoplasia in the Hutterite population. Dev Med Child Neurol. 2005 Oct; 47(10):691-5.
    View PubMed
  242. Boycott KM, Flavelle S, Bureau A, Glass HC, Fujiwara TM, Wirrell E, Davey K, Chudley AE, Scott JN, McLeod DR, Parboosingh JS. Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification. Am J Hum Genet. 2005 Sep; 77(3):477-83. Epub 2005 Jul 22.
    View PubMed
  243. Wirrell E. Epileptic encephalopathies. Lumina. 2005 Fall; 23(2):8-11.
  244. Wirrell EC. Neonatal seizures: to treat or not to treat? Semin Pediatr Neurol. 2005 Jun; 12(2):97-105.
    View PubMed
  245. Kirton A, Busche K, Ross C, Wirrell E. Acute necrotizing encephalopathy in caucasian children: two cases and review of the literature. J Child Neurol. 2005 Jun; 20(6):527-32.
    View PubMed
  246. Wirrell E, Hill MD, Jadavji T, Kirton A, Barlow K. Stroke after varicella vaccination. J Pediatr. 2004 Dec; 145(6):845-7.
    View PubMed
  247. Kirton A, Wirrell E, Zhang J, Hamiwka L. Seizure-alerting and -response behaviors in dogs living with epileptic children. Neurology. 2004 Jun 22; 62(12):2303-5.
    View PubMed
  248. Yager JY, Armstrong EA, Jaharus C, Saucier DM, Wirrell EC. Preventing hyperthermia decreases brain damage following neonatal hypoxic-ischemic seizures. Brain Res. 2004 Jun 11; 1011(1):48-57.
    View PubMed
  249. Kirton A, Darwish H, Wirrell E. Unique clinical phenomenology can help distinguish primary from secondary generalized seizures in children. J Child Neurol. 2004 Apr; 19(4):265-70.
    View PubMed
  250. Wirrell EC. Natural history of absence epilepsy in children. Can J Neurol Sci. 2003 Aug; 30(3):184-8.
    View PubMed
  251. Wirrell EC. Valproic acid-associated weight gain in older children and teens with epilepsy. Pediatr Neurol. 2003 Feb; 28(2):126-9.
    View PubMed
  252. Wirrell EC, Darwish HZ, Williams-Dyjur C, Blackman M, Lange V. Is a fast necessary when initiating the ketogenic diet? J Child Neurol. 2002 Mar; 17(3):179-82.
    View PubMed
  253. Yager JY, Armstrong EA, Miyashita H, Wirrell EC. Prolonged neonatal seizures exacerbate hypoxic-ischemic brain damage: correlation with cerebral energy metabolism and excitatory amino acid release. Dev Neurosci. 2002; 24(5):367-81.
    View PubMed
  254. Wirrell EC, Armstrong EA, Osman LD, Yager JY. Prolonged seizures exacerbate perinatal hypoxic-ischemic brain damage. Pediatr Res. 2001 Oct; 50(4):445-54.
    View PubMed
  255. Wirrell E, Camfield C, Camfield P, Dooley J. Prognostic significance of failure of the initial antiepileptic drug in children with absence epilepsy. Epilepsia. 2001 Jun; 42(6):760-3.
    View PubMed
  256. Kirsch R, Wirrell E. Do cognitively normal children with epilepsy have a higher rate of injury than their nonepileptic peers? J Child Neurol. 2001 Feb; 16(2):100-4.
    View PubMed
  257. Wirrell E, Turner T. Parental anxiety and family disruption following a first febrile seizure in children. Paediatr Child Health. 2001; 6:139-43.
  258. Datta AN, Wirrell EC. Prognosis of seizures occurring in the first year. Pediatr Neurol. 2000 May; 22(5):386-91.
    View PubMed
  259. Barnard C, Wirrell E. Does status epilepticus in children cause developmental deterioration and exacerbation of epilepsy? J Child Neurol. 1999 Dec; 14(12):787-94.
    View PubMed
  260. Holt-Seitz A, Wirrell EC, Sundaram MB. Seizures in the elderly: etiology and prognosis. Can J Neurol Sci. 1999 May; 26(2):110-4.
    View PubMed
  261. Wirrell E, Tong K. Pachygyria associated with childhood-onset epileptic spasms. J Child Neurol. 1998 Sep; 13(9):461-4.
    View PubMed
  262. Wirrell EC. Benign epilepsy of childhood with centrotemporal spikes. Epilepsia. 1998; 39 Suppl 4:S32-41.
    View PubMed
  263. Wirrell EC, Camfield CS, Camfield PR, Dooley JM, Gordon KE, Smith B. Long-term psychosocial outcome in typical absence epilepsy. Sometimes a wolf in sheeps' clothing. Arch Pediatr Adolesc Med. 1997 Feb; 151(2):152-8.
    View PubMed
  264. Wirrell EC, Camfield CS, Camfield PR, Gordon KE, Dooley JM. Long-term prognosis of typical childhood absence epilepsy: remission or progression to juvenile myoclonic epilepsy.[see comment]. Neurology. 1996 Oct; 47(4):912-8.
    View PubMed
  265. Wirrell EC, Camfield PR, Camfield CS, Dooley JM, Gordon KE. Accidental injury is a serious risk in children with typical absence epilepsy. Arch Neurol. 1996 Sep; 53(9):929-32.
    View PubMed
  266. Wirrell EC, Camfield PR, Gordon KE, Camfield CS, Dooley JM, Hanna BD. Will a critical level of hyperventilation-induced hypocapnia always induce an absence seizure? Epilepsia. 1996 May; 37(5):459-62.
    View PubMed
  267. Dooley J, Camfield P, Camfield C, Gordon K, Wirrell E, Smith E. Lamotrigine induced skin rash in children. Neurology. 1996; 46:240-2.
  268. Camfield CS, Camfield PR, Gordon K, Wirrell E, Dooley JM. Incidence of epilepsy in childhood and adolescence: a population-based study in Nova Scotia from 1977 to 1985. Epilepsia. 1996 Jan; 37(1):19-23.
    View PubMed
  269. Dooley J, Camfield P, Gordon K, Camfield C, Wirrell E, Smith E. Lamotrigine-induced rash in children. Neurology. 1996 Jan; 46(1):240-2.
    View PubMed
  270. Wirrell EC, Camfield PR, Gordon KE, Dooley JM, Camfield CS. Benign rolandic epilepsy: atypical features are very common. J Child Neurol. 1995 Nov; 10(6):455-8.
    View PubMed
  271. Wirrell EC, Pelausa EO, Allen AC, Stinson DA, Hanna BD. Massive pericardial effusion as a cause for sudden deterioration of a very low birthweight infant. Am J Perinatol. 1993 Nov; 10(6):419-23.
    View PubMed
  272. Wirrell EC, Pelausa EO, Allen AC, Stinson DA, Hanna BD. An unusual, massive pericardial effusion in a very low birthweight infant. Am J Perinatology. 1993; 10:419-23.
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