Ensifentrine (Inhalation Route)

Proper Use

Drug information provided by: Merative, Micromedex®

Use this medicine only as directed by your doctor. Do not use more of it and do not use it more often than your doctor ordered. Also, do not stop using this medicine without telling your doctor. To do so may increase the chance of side effects.

This medicine comes with patient information leaflet and patient instructions. Read the directions carefully before using this medicine. If you do not understand the directions or you are not sure how to use the nebulizer, ask your doctor for help. Also, ask your doctor to regularly check how you use the nebulizer to make sure you are using it properly.

To use this medicine:

• Ensifentrine should be used with a standard jet nebulizer with a mouthpiece that is connected to an air compressor. An air compressor is used with a nebulizer to turn the medicine into a fine spray. You will breathe in the spray through your mouth.
• This medicine comes in an ampule that is sealed in a foil pouch. Each ampule contains one full dose of ensifentrine. Do not mix it with other medicines.
• Remove the ampule from the foil pouch. Shake the ampule until the contents are mixed thoroughly. It will appear cloudy and yellow to pale yellow.
• Twist open the top of the ampule and use it right away. Squeeze all the medicine from the ampule into the nebulizer cup or reservoir.
• Connect the mouthpiece to the nebulizer, then connect the nebulizer to the compressor.
• Sit in an upright position. Place the mouthpiece in your mouth and close your lips around the mouthpiece.
• Use the nebulizer for about 5 to 7 minutes, or until no more mist is seen in the nebulizer reservoir.
• Follow the manufacturer's directions for care and cleaning of the nebulizer and compressor.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For inhalation dosage form (suspension):
  • For maintenance treatment of COPD:
    • Adults—3 milligrams (mg) (one ampule) 2 times a day, once in the morning and once in the evening.
    • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.