Dalfampridine (oral route)

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies have not been performed on the relationship of age to the effects of dalfampridine in the pediatric population. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dalfampridine in the elderly. However, elderly patients are more likely to have seizures and age-related kidney problems, which may require caution in patients receiving dalfampridine.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Bictegravir
• Bupropion
• Dolutegravir
• Fedratinib
• Fexinidazole
• Trilaciclib

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

• Kidney disease, moderate to severe or
• Seizures, history of—Should not be used in patients with these conditions.

More common

• Bladder pain
• bloody or cloudy urine
• difficult, burning, or painful urination
• frequent urge to urinate
• lower back or side pain

Less common

• Blurred vision
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• difficulty controlling your bladder or bowels
• feeling sad or depressed
• forgetful
• muscle cramps
• problems with swallowing
• slurred speech
• unusual tiredness or weakness

Incidence not known

• Chest tightness
• cough
• dizziness or lightheadedness
• fast heartbeat
• feeling of constant movement of self or surroundings
• hives, itching, skin rash
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• sensation of spinning
• vomiting

Symptoms of overdose

• Confusion
• increased sweating
• memory loss
• reduced awareness
• seizures
• weakness

More common

• Headache
• lack or loss of strength
• nausea
• problems with balance
• trouble sleeping

Less common

• Back pain
• constipation
• fever
• muscle aches
• sore throat
• stomach discomfort, upset, or pain
• stuffy or runny nose