Adenosine (intravenous route)

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies have not been performed on the relationship of age to the effects of adenosine injection in the pediatric population. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of adenosine injection in the elderly.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aminophylline
• Carbamazepine
• Cobicistat
• Darunavir
• Dimenhydrinate
• Dyphylline
• Epinephrine
• Inotersen
• Pentoxifylline
• Theophylline
• Verapamil

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Dipyridamole

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Caffeine

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Angina, unstable or
• Unstable heart or blood vessel problem (eg, cardiovascular instability)—Avoid use, as this medicine may increase the risk for heart attack.

• Atrial fibrillation (heart rhythm problem), or history of or
• Breathing problems or lung disease (eg, bronchitis, emphysema) or
• Hypertension (high blood pressure) or
• Hypotension (low blood pressure) or
• Seizures or
• Stroke, history of—Use with caution. May make these conditions worse.

• Heart block, second or third degree (type of abnormal heart rhythm), without a pacemaker or
• Sinus node disease (such as sick sinus syndrome), without a pacemaker—Should not be used in patients with these conditions, unless patients have a pacemaker that works.

• Breathing problems or lung disease (eg, asthma)—Should not be used in patients with these conditions.

• Heart or blood vessel disease (eg, coronary artery stenosis, ischemia, pericardial effusion, pericarditis) or
• Heart valve disease or
• Hypovolemia (low blood volume), uncorrected—May increase risk for more serious side effects.

More common

• Chest discomfort
• difficult or labored breathing
• lightheadedness or dizziness
• throat, neck, or jaw discomfort
• tightness in the chest

Less common

• Chest pain
• confusion
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fainting
• fast, slow, or irregular heartbeat
• sweating
• troubled breathing
• unusual tiredness or weakness

Rare

• Fast, irregular, pounding, or racing heartbeat or pulse
• headache
• nervousness
• pounding in the ears

More common

• Diarrhea
• feeling of warmth
• indigestion
• loss of appetite
• nausea or vomiting
• passing of gas
• redness of the face, neck, arms, and occasionally, upper chest
• stomach pain, fullness, or discomfort

Rare

• Area of decreased vision
• cough
• discomfort in the back, ears, or tongue
• drowsiness
• dry mouth
• metallic taste
• mood changes
• shakiness in the legs, arms, hands, or feet
• stuffy nose
• trembling or shaking of the hands or feet