طب القلب والأوعية الدموية

بالأسفل التجارب السريرية الحالية.

غربل قائمة الدراسات هذه بالموقع والحالة وغيرها.

1. A Study to Evaluate Decision-support Interventions for Atrial Fibrillation (RED-AF)

   Rochester, Minn.

   1. The primary purpose of this study is to assess the comparative effectiveness of the following 4 approaches to promote high-quality SDM for at-risk patients with AF:  a PDA alone, (2) an EDA alone, (3) a combination of a PDA and an EDA, and (4) control with neither a PDA nor an EDA.

    

2. International Bicuspid Aortic Valve Consortium (BAVCon)

   Rochester, Minn.

   Bicuspid aortic valve (BAV) disease is the most frequent congenital cardiac malformation, occurring in 0.5-1.2% of the US population. In young adults, it is generally a benign abnormality; but in older adults it is associated with thoracic aortic aneurysm or dissection in 20-30% of those with BAV. BAV is strongly associated with early development of aortic valve calcification or incompetence in >50% of BAV patients, and accounts for ~40% of the >30,000 aortic valve replacements (AVR) performed in the US each year. Yet, we know little of the etiology, cellular events and modifiers of progression of BAV to calcific aortic valve disease and we still do not understand the genetic cause(s) of BAV despite evidence for its high heritability.

   The Specific Aims of this study are:

   1. To identify the genetic causes of bicuspid aortic valve disease and its associated thoracic aortic disease.

   2. To identify potential pathways to predict the clinical course of BAV disease and for treating human BAV disease.

   To achieve these aims, we have created the International Bicuspid Aortic Valve Consortium (BAVCon), a consortium of institutions with cohorts of BAV patients and the expertise to fulfill the performance of these aims.

3. A Study to Evaluate the Influence of Pulse Electromagnetic Field Therapy on Myocardial Ischemia

   Rochester, Minn., Scottsdale/Phoenix, Ariz.

   The purpose of this study is to determine the impact of pulse electromagnetic field (PEMF) therapy using the Bioboosti device (Biomobie Regenerative Medicine Company) and therapeutic protocol on cardiac ischemia in patients with coronary artery disease as quantified using an assessment of myocardial blood flow using 13N-ammonia myocardial perfusion positron emission tomography (PET) scanning to quantify blood flow during chemical induced stress.

4. Autologous Induced Pluripotent Stem Cells of Cardiac Lineage Delivered Into Heart Muscle for Congenital Heart Disease

   Rochester, Minn.

   The purpose of this study to test the feasibility and safety for autologous (from your own body) skin cells that are manufactured into stem cells of cardiac lineage to be delivered into the heart muscle to determine if those stem cells will strengthen the heart muscle and can be used as an additional treatment for the management of  congenital heart disease. 

5. A Study to Assess the Role of Biomarkers in Risk Stratification in Adults with Congenital Heart Disease

   Rochester, Minn.

   The purporse of this study is to determine if biomarker assay obtained at baseline can predict future risk of cardiovascular adverse events, and to  determine if temporal changes in biomarker levels can provide a better risk prediction compared to biomarker assay obtained at baseline.

6. Exercise during Heart Cath in CHD Patients

   Rochester, Minn.

   The purpose of this study is to compare the difference in the ability to detect blood flow abnormalities between invasive assessments performed at rest versus exercise.

7. Genotype-Phenotype Correlation in Cardiovascular Disease

   Rochester, Minn.

   This research study is being done to help characterize cardiovascular disease and improve diagnostic tests.

   OBJECTIVES

   1. To understand the pathogenesis, molecular mechanisms, and disease progression of heritable cardiovascular disease

   2. To evaluate the incidence of occult heritable cardiovascular disease in various populations.

   3. To correlate imaging and pathological phenotype with genotype to the ends described above.

8. A Study to Evaluate Potential Myocardial Injury Following Magnetic Resonance Imaging (MRI)

   Rochester, Minn.

   The purpose of this study is to prospectively determine if magnetic resonance imaging (MRI) in patients with cardiac implantable electronic devices (CIED) results in myocardial injury as assessed by changes in high sensitivity cardiac troponin T (hs-cTnT) assay. This will be done by comparing pre-and-post MRI hs-cTnT levels in these patients.

9. Echocardiographic Measures of Pulmonary Vascular Distensibility and Effects on Lung Diffusing Capacity

   Rochester, Minn.

   The purpose of this study is to determine if the change in pulmonary vascular compliance with positional changes (upright, supine, and Trendelenburg position) is different in younger versus older individuals.

10. Peripheral Nerve Stimulation Therapy for Atrial Fibrillation

    Rochester, Minn.

    The purpose of this study is to determine and compare the safety and efficacy of transcutaneous afferent patterned stimulation (TAPS) and respiratory-gated auricular vagal afferent nerve stimulation (RAVANS) therapies for the reduction of paroxysmal atrial fibrillation (AF) burden.