Otolaryngology

Oct. 12, 2024

The James Russell Crawford and Martha Crawford Endowed Clinical Research Fellowship in Otolaryngology at Mayo Clinic in Florida advances clinical care and contributes to the larger body of scientific knowledge in the field of otolaryngology. Crawford fellow Estephania Candelo Gomez, M.D., (2022-2023) examined predictors of chronic rhinosinusitis (CRS) in transplant recipients. The manuscript for this project was recently featured in the American Journal of Rhinology and Allergy.

Previous studies suggest that transplant patients are at higher risk of developing CRS. However, there are few studies describing the factors that may be linked to this development. To identify risk factors, a retrospective cohort study was conducted using data from 3,347 Mayo Clinic transplant recipients seen between 2017 and 2022. Of these, 2,128 patients met the inclusion criteria and were grouped according to whether they were diagnosed with CRS during the post-transplant period.

The study results found that 30.4% of the 2,128 patients had CRS. Compared with the non-CRS group, the patients with CRS had an increased prevalence of previous endoscopic sinus surgery, allergic rhinitis and recurrent acute rhinosinusitis in the pretransplant period. Patients with primary immunodeficiencies and additional transplants were 1.9 and 3.1 times more likely to develop CRS during the post-transplant period, respectively. Sirolimus use also was associated with the development of CRS.

In conclusion, patients with pretransplant rhinologic conditions, hematologic deficiencies and who use specific immunosuppressants were found to have a higher likelihood of developing CRS following transplantation.

For more information

Candelo E, et al. Predictors for development of chronic rhinosinusitis in transplant recipients. American Journal of Rhinology and Allergy. 2024; doi:10.1177/19458924241272990.

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