Orthopedic Surgery

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study to Evaluate Manipulation Under Anesthesia After Bilateral Primary Total Knee Arthroplasty

   Rochester, Minn.

   The purpose of this study is to determine unique genetic profile of patients requiring MUA following bilateral pTKA via genetic sequencing, to determine outcomes of patients receiving MUA in terms of KSS, implant durability, survival free of reoperation, and to define characteristics and comorbidities of patients undergoing unilateral and bilateral MUA.

2. A Study to Validate the Patient-Specific Functional Survey in Patients with Carpal Tunnel Syndrome

   Rochester, Minn.

   The purpose of this study is to determine if the Patient-Specific Functional Survey (PSFS) is a valid and reliable measure to evaluate functional difficulties with carpal tunnel syndrome.

3. Spasticity After Spinal Cord Injury

   Rochester, Minn.

   A growing body of research demonstrates a correlation between residual corticospinal connectivity and severity of spasticity following SCI (Sangari et al., 2019b). The purpose of this study is to analyze this correlation to better understand the relationship between spasticity as a biomarker of residual corticospinal connectivity and neurologic and functional recovery.  

4. 3D US Imaging of Acute Nerve Root Avulsions in Injuries of the Brachial Plexus

   Jacksonville, Fla.

   The purpose of this study is to address a knowledge gap. Early diagnosis of nerve root avulsion injuries following brachial plexus trauma remain a barrier to the early treatment of these complex injuries.  Traditionally, an observation period of 6 months following brachial plexus injuries has been utilized to allow for reinnervation.  Reinnervation is not possible in the setting of nerve root avulsion from the spinal cord and waiting for reinnervation in this setting unnecessarily delays treatment and potentially compromises outcome.  Having the ability to provide a real time evaluation of nerve root integrity would obviate the need of other more expensive and complex advanced imaging such as CT/myelography, currently considered the good standard.

5. Detection of Infection in Arthroplasty

   Rochester, Minn.

   The purpose of this study is to determine the sensitivity, specificity, positive and negative predictive values of molecular detection of microorganisms, detection of microbial proteins and antibodies against microorganisms, and inflammatory markers (e.g., leukocyte esterase, CRP) in synovial fluid for the diagnosis of prosthetic joint infection (PJI).

6. A Study to Survey Epidural User Experience for Individuals with Spinal Cord Injury Paralysis

   Rochester, Minn.

   This is a survey study to identify user-reported motor, sensory, and autonomic functions that are enabled by epidural stimulation, establish correlations between epidural stimulation usage, rehabilitation, functional gains, and user experience in the laboratory and community settings, and to understand and identify subjective goals, benefits, and barriers that still exist with implanted epidural stimulator community.

7. A Study to Evaluate Awake vs. Asleep Spine Surgery

   Jacksonville, Fla.

   Patients undergoing spine lumbar surgery will be asked to perform short exams/questionnaires aimed at determining cognitive function, quality of life, health outcomes twice post surgery with a baseline performance prior to surgery.

8. Primary Tumor Research And Outcome Network (PTRON) Registry

   Rochester, Minn.

   The purpose of this registry is to collect clinical, diagnostic, and therapeutic data specific for primary spinal column tumor patients, and evaluate it to understand the predictive factors which influence survival, local recurrence, adverse events, perioperative morbidity, and health related quality of life.

9. Outcome of Capsular Release for Elbow Contracture

   Rochester, Minn.

   The purpose of this study is to assess the outcome and complications of capsular release for elbow contractures.

    

10. Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes Disease

    Rochester, Minn.

    Legg-Calvé-Perthes disease is a childhood hip disorder which is common enough to be a significant public health problem (affects 1 in 740 boys between ages 0-14), but uncommon enough to have a sufficient number of patients from a single institution to perform a definitive prospective study comparing the results of current treatments. The present study will establish a database of prospectively identified patients with Legg-Calvé-Perthes (LCP) Disease and collect information regarding their presentation, treatment, and outcomes in the course of receiving currently available treatments. This study seeks to compare the outcomes of current treatments in the management of different age groups (ages 1-6, 6-8, 8-11, >11) of patients with Perthes disease at two- and five-year followup and at skeletal maturity. For each age group, two to three common treatment regimens currently used by practicing pediatric orthopaedic surgeons will be compared. The intervention a patient receives is determined through physician treatment expertise, and is not pre-determined by the study.