Depression Center

Mayo Clinic Depression Center offers comprehensive, evidence-based evaluation and treatment for people of all ages with depression or bipolar disorder. Programs in the center range from intensive inpatient treatment to outpatient consultations with care provided by an integrated team of Mayo Clinic psychiatrists, psychologists, nurse practitioners, social workers and other specialists with expertise in mood disorders.

Treatment in Mayo Clinic’s Depression Center, which is tailored to the needs of each patient, is based on a comprehensive initial evaluation that may include:

• Pharmacogenomic typing
• Clinical laboratory assessments
• Neuroimaging
• Neurocognitive testing
• Consultation with other medical disciplines

A range of treatment options is potentially available:

• Pharmacotherapy
• Interventional Psychiatry Services:
  • Electroconvulsive Therapy (ECT)
  • Transcranial Magnetic Stimulation (TMS)
  • Ketamine & Esketamine Treatments
• Occupational therapy
• Recreational therapy
• Participation in a clinical trial

The center also works closely with other areas in the Department of Psychiatry and Psychology and across Mayo Clinic to treat patients who have mood disorders associated with chronic pain, substance use and addiction, pregnancy or the postpartum period, obesity (pursuing bariatric surgery), Parkinson’s disease (pursuing deep brain stimulation) and other diseases.

Mood Clinic

Outpatient evaluation and treatment for adults with treatment-resistant depression or bipolar disorder is available in the Mood Clinic. After an initial assessment, your team will develop a roadmap of treatment recommendations for referring physicians and mental health providers. Depending on your needs, you may be referred to the Mood Disorders Unit, the 2-week Mood Program or John E. Herman Home and Treatment Facility.

Pediatric Mood Clinic
The Pediatric Mood Clinic is staffed by experts in childhood mood disorders, such as depression, bipolar disease, cyclothymic disorder and persistent depressive disorder (dysthymia). The clinic provides team-based diagnosis and treatment.

Adult Mood Program (temporarily closed)

ln this program, adults with a primary depressive or bipolar disorder undergo 2 weeks of full-day, group-based outpatient therapy. The Mood Program helps patients manage interpersonal issues and factors linked to their mood symptoms through lnterpersonal Social Rhythm Therapy and adjunctive therapies, such as:

• Behavioral activation
• Mindfulness techniques
• Physical movement experiences
• Psychoeducation
• Pharmacotherapy Optimization

Adult Mood Disorders Unit

This 16-bed hospital-based inpatient unit provides treatment for adults whose depression or bipolar illness is significantly affecting their quality of life, function or safety. Individualized intensive treatment includes:

• Evidence-based psychotherapy
• Occupational therapy
• Recreational therapy
• Interventional Psychiatry Services:
  • Electroconvulsive Therapy (ECT)
• Medications
• Relaxation skills training

John E. Herman Home and Treatment Facility

Mayo Clinic's John E. Herman Home and Treatment Facility is a residential treatment program for adults with mental illness. Its goal is to help residents return to the community to engage in value-driven, productive and meaningful lives.

The program is organized around functional and vocational recovery. Treatment includes:

• Group psychotherapy.
• Individual psychotherapy.
• Psychoeducation.
• Medicine management.
• Vocational program.
• Family program.
• Daily living activities.
• Referral to other specialty clinics based on need.

Learn more about John E. Herman Home.