Publicaciones Imprimir Lee I, Ganesan A, Kalesinskas L, Zheng H, Ahn HC, Christenson S, Erzurum SC, Zein J, Bleecker ER, Meyers DA, Castro M, Fahy JV, Israel E, Jarjour NN, Moore W, Wenzel SE, Mauger DT, Levy BD, Woodruff PG, Ortega VE, Khatri P. Multicohort Analysis of Bronchial Epithelial Cell Expression in Healthy Subjects and Patients with Asthma Reveals Four Clinically Distinct Clusters. Am J Respir Cell Mol Biol. 2024 Dec 19 [Epub ahead of print] View PubMed Zein J, Owora A, Kim HJ, Marozkina N, Gaston B. Asthma Among Children With Primary Ciliary Dyskinesia. JAMA Netw Open. 2024 Dec 2; 7 (12):e2449795 Epub 2024 Dec 02 View PubMed Zein JG, Zounemat-Kerman N, Adcock IM, Hu B, Attaway A, Castro M, Dahlen SE, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Hastie AT, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore W, Peters MC, Sumino K, Townsend E, Woodruff P, Ortega VE, Wenzel SE, Meyers DA, Chung KF, Bleecker ER, Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) Consortium and the the US National Heart, Lung, and Blood Institute Severe Asthma Research Program (SARP III). Development of an asthma health-care burden score as a measure of severity and predictor of remission in SARP III and U-BIOPRED: results from two major longitudinal asthma cohorts. Lancet Respir Med. 2024 Nov 22 [Epub ahead of print] View PubMed Fakhry B, Attaway A, Kim HJ, Yaqoob Z, Al-Kindi SG, Chedraoui C, Sleiman J, Zein JG. Polycystic ovary syndrome and the risk of asthma in reproductive-age women: Insights from 2 real-world large cohorts. J Allergy Clin Immunol Pract. 2024 Nov; 12 (11):3132-3134 Epub 2024 Aug 08 View PubMed Jarjour NN, Winders T, Hansen AM, Akuthota P, Chung KF, Durrington H, Fowler SJ, Gaston B, Mendonca EA, Siddiqui S, Walker S, Zein J, Djukanovic R. Asthma innovations from the second International Collaborative Asthma Network (ICAN) forum. J Asthma. 2024 Sep 23; 1-4 Epub 2024 Sept 23 View PubMed Melen E, Zar HJ, Siroux V, Shaw D, Saglani S, Koppelman GH, Hartert T, Gern JE, Gaston B, Bush A, Zein J. Asthma Inception: Epidemiologic Risk Factors and Natural History Across the Life Course. Am J Respir Crit Care Med. 2024 Sep 15; 210 (6):737-754 View PubMed Xu W, Hong YS, Hu B, Comhair SAA, Janocha AJ, Zein JG, Chen R, Meyers DA, Mauger DT, Ortega VE, Bleecker ER, Castro M, Denlinger LC, Fahy JV, Israel E, Levy BD, Jarjour NN, Moore WC, Wenzel SE, Gaston B, Liu C, Arking DE, Erzurum SC, National Heart, Lung, and Blood Institute (NHLBI) Severe Asthma Research Program and TOPMed mtDNA Working Group in NHLBI Trans-omics for Precision Medicine (TOPMed) Consortium. Mitochondrial DNA copy number variation in asthma risk, severity, and exacerbations. J Allergy Clin Immunol. 2024 Sep 3 Epub 2024 Sept 03 View PubMed Attaway AH, Mehra R, Zein JG, Hatipoglu U, Grund M, Orsini E, Scheraga RG, Dasarathy S, Olman MA. Nocturnal Hypoxemia Is Associated with Sarcopenia in Patients with Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2024 Sep; 21 (9):1316-1325 View PubMed Wu CP, Sleiman J, Fakhry B, Chedraoui C, Attaway A, Bhattacharyya A, Bleecker ER, Erdemir A, Hu B, Kethireddy S, Meyers DA, Rashidi HH, Zein JG. Novel Machine Learning Identifies 5 Asthma Phenotypes Using Cluster Analysis of Real-World Data. J Allergy Clin Immunol Pract. 2024 Aug; 12 (8):2084-2091.e4 Epub 2024 Apr 27 View PubMed Fakhry B, Chedraoui C, Sleiman J, Attaway A, Carr T, Gaston B, Hu B, Meyers D, Ortega VE, Bleecker ER, Zein J. Paradoxical bronchodilator response is associated with increased risk of asthma exacerbations. J Allergy Clin Immunol Pract 2024 Jul; 12 (7):1910-1913.e1 Epub 2024 Mar 26 View PubMed Chedraoui C, Fakhry B, Sleiman J, Hu B, Attaway A, Bazeley P, Kim HJ, Zhang P, Cleveland Cleveland, Zein JG, Phoenix Phoenix. Sex Differences in Lung Function in Asthma Across the Ages. CHEST Pulm. 2024 Jun; 2 (2) Epub 2024 Mar 11 View PubMed Attaway AH, Lopez R, Welch N, Bellar A, Hatipoglu U, Zein J, Engelen MP, Dasarathy S. Muscle loss phenotype in COPD is associated with adverse outcomes in the UK Biobank. BMC Pulm Med. 2024 Apr 17; 24 (1):186 View PubMed Kocaturk E, Abrams EM, Maurer M, Mitri J, Oppenheimer J, Vestergaard C, Zein J. COVID-19 and Its Impact on Common Diseases in the Allergy Clinics. J Allergy Clin Immunol Pract. 2023 Nov; 11 (11):3289-3303 Epub 2023 Sept 01 View PubMed Li X, Li H, Christenson SA, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston BM, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Bleecker ER, Meyers DA, NHLBI Severe Asthma Research Program (SARP). Genetic analyses of chr11p15.5 region identify MUC5AC-MUC5B associated with asthma-related phenotypes. J Asthma. 2023 Oct; 60 (10):1824-1835 Epub 2023 Apr 21 View PubMed Li H, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Wenzel SE, Zein J, Bleecker ER, Meyers DA, Chen Y, Li X, NHLBI Severe Asthma Research Program (SARP). Investigations of a combination of atopic status and age of asthma onset identify asthma subphenotypes. J Asthma. 2023 Oct; 60(10):1843-1852. Epub 2023 Apr 21. View PubMed Izquierdo M, Marion CR, Genese F, Newell JD, O'Neal WK, Li X, Hawkins GA, Barjaktarevic I, Barr RG, Christenson S, Cooper CB, Couper D, Curtis J, Han MK, Hansel NN, Kanner RE, Martinez FJ, Paine R 3rd, Tejwani V, Woodruff PG, Zein JG, Hoffman EA, Peters SP, Meyers DA, Bleecker ER, Ortega VE, SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) investigators. Impact of Bronchiectasis on COPD Severity and Alpha-1 Antitrypsin Deficiency as a Risk Factor in Individuals with a Heavy Smoking History. Chronic Obstr Pulm Dis. 2023 Jul 26; 10 (3):199-210 View PubMed Wang X, Zein J, Ji X, Lin DY. Impact of Vaccination, Prior Infection, and Therapy on Omicron Infection and Mortality. J Infect Dis. 2023 Apr 18; 227 (8):970-976 View PubMed Zein JG, Bazeley P, Meyers D, Bleecker E, Gaston B, Hu B, Attaway A, Ortega V. A Between-Sex Comparison of the Genomic Architecture of Asthma. Am J Respir Cell Mol Biol 2023 Apr; 68 (4):456-458 View PubMed Attaway AH, Bellar A, Welch N, Sekar J, Kumar A, Mishra S, Hatipoglu U, McDonald ML, Regan EA, Smith JD, Washko G, Estepar RSJ, Bazeley P, Zein J, Dasarathy S. Gene polymorphisms associated with heterogeneity and senescence characteristics of sarcopenia in chronic obstructive pulmonary disease. J Cachexia Sarcopenia Muscle. 2023 Apr; 14 (2):1083-1095 Epub 2023 Mar 01 View PubMed Li X, Guerra S, Ledford JG, Kraft M, Li H, Hastie AT, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Meyers DA, Bleecker ER. Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity. Am J Respir Crit Care Med. 2023 Feb 15; 207 (4):438-451 View PubMed Merhej T, Zein JG. Epidemiology of Asthma: Prevalence and Burden of Disease. Adv Exp Med Biol. 2023; 1426:3-23 View PubMed Peters MC, Schiebler ML, Cardet JC, Johansson MW, Sorkness R, DeBoer MD, Bleecker ER, Meyers DA, Castro M, Sumino K, Erzurum SC, Tattersall MC, Zein JG, Hastie AT, Moore W, Levy BD, Israel E, Phillips BR, Mauger DT, Wenzel SE, Fajt ML, Koliwad SK, Denlinger LC, Woodruff PG, Jarjour NN, Fahy JV, National Heart, Lung, and Blood Institute Severe Asthma Research Program-3. The Impact of Insulin Resistance on Loss of Lung Function and Response to Treatment in Asthma. Am J Respir Crit Care Med. 2022 Nov 01; 206(9):1096-1106. View PubMed Wang Z, Xu W, Comhair SAA, Fu X, Shao Z, Bearden R, Zein JG, Bleecker ER, Castro M, Denlinger LC, Fahy JV, Israel E, Levy BD, Jarjour NN, Moore WC, Wenzel SE, Mauger DT, Gaston B, Hazen SL, Erzurum SC. Urinary total conjugated 3-bromotyrosine, asthma severity, and exacerbation risk. Am J Physiol Lung Cell Mol Physiol. 2022 Nov 1; 323 (5):L548-L557 Epub 2022 Sept 20 View PubMed Zhang P, Lopez R, Arrigain S, Rath M, Khatri SB, Zein JG. Dietary patterns in patients with asthma and their relationship with asthma-related emergency room visits: NHANES 2005-2016. J Asthma. 2022 Oct; 59 (10):2051-2059 Epub 2021 Oct 06 View PubMed Attaway A, Welch N, Dasarathy D, Amaya-Hughley J, Bellar A, Biehl M, Dugar S, Engelen MPKJ, Zein J, Dasarathy S. Acute skeletal muscle loss in SARS-CoV-2 infection contributes to poor clinical outcomes in COVID-19 patients. J Cachexia Sarcopenia Muscle. 2022 Oct; 13 (5):2436-2446 Epub 2022 July 19 View PubMed Belligund P, Attaway A, Lopez R, Damania D, Hatipoglu U, Zein JG. Diabetes associated with higher health care utilization and poor outcomes after COPD-related hospitalizations. Am J Manag Care. 2022 Sep 1; 28 (9):e325-e332 Epub 2022 Sept 01 View PubMed Trivedi AP, Hall C, Goss CW, Lew D, Krings JG, McGregor MC, Samant M, Sieren JP, Li H, Schechtman KB, Schirm J, McEleney S, Peterson S, Moore WC, Bleecker ER, Meyers DA, Israel E, Washko GR, Levy BD, Leader JK, Wenzel SE, Fahy JV, Schiebler ML, Fain SB, Jarjour NN, Mauger DT, Reinhardt JM, Newell JD Jr, Hoffman EA, Castro M, Sheshadri A, NHLBI Severe Asthma Research Program (SARP). Quantitative CT Characteristics of Cluster Phenotypes in the Severe Asthma Research Program Cohorts. Radiology. 2022 Aug; 304(2):450-459. Epub 2022 Apr 26. View PubMed Izquierdo ME, Marion CR, Moore WC, Raraigh KS, Taylor-Cousar JL, Cutting GR, Ampleford E, Hawkins GA, Zein J, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Jarjour NN, Mauger D, Levy BD, Wenzel SE, Woodruff P, Bleecker ER, Meyers DA, Ortega VE. DNA sequencing analysis of cystic fibrosis transmembrane conductance regulator gene identifies cystic fibrosis-associated variants in the Severe Asthma Research Program. Pediatr Pulmonol 2022 Jul; 57 (7):1782-1788 Epub 2022 May 05 View PubMed McManus JM, Gaston B, Zein J, Sharifi N. Association Between Asthma and Reduced Androgen Receptor Expression in Airways. J Endocr Soc. 2022 May 1; 6 (5):bvac047 Epub 2022 Mar 21 View PubMed Zein JG, Strauss R, Attaway AH, Hu B, Milinovich A, Jawhari N, Chamat SS, Ortega VE. Eosinophilia Is Associated with Improved COVID-19 Outcomes in Inhaled Corticosteroid-Treated Patients. J Allergy Clin Immunol Pract. 2022 Mar; 10 (3):742-750.e14 Epub 2022 Jan 13 View PubMed Georas SN, Wright RJ, Ivanova A, Israel E, LaVange LM, Akuthota P, Carr TF, Denlinger LC, Fajt ML, Kumar R, O'Neal WK, Phipatanakul W, Szefler SJ, Aronica MA, Bacharier LB, Burbank AJ, Castro M, Crotty Alexander L, Bamdad J, Cardet JC, Comhair SAA, Covar RA, DiMango EA, Erwin K, Erzurum SC, Fahy JV, Gaffin JM, Gaston B, Gerald LB, Hoffman EA, Holguin F, Jackson DJ, James J, Jarjour NN, Kenyon NJ, Khatri S, Kirwan JP, Kraft M, Krishnan JA, Liu AH, Liu MC, Marquis MA, Martinez F, Mey J, Moore WC, Moy JN, Ortega VE, Peden DB, Pennington E, Peters MC, Ross K, Sanchez M, Smith LJ, Sorkness RL, Wechsler ME, Wenzel SE, White SR, Zein J, Zeki AA, Noel P, PrecISE Study Team. The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions. J Allergy Clin Immunol. 2022 Feb; 149(2):488-516.e9. Epub 2021 Nov 29. View PubMed Macmurdo M, Lopez R, Udeh BL, Zein J. Beyond tobacco - the secondary impact of substance misuse in chronic obstructive lung disease. J Asthma. 2022 Feb; 59 (2):223-229 Epub 2020 Nov 19 View PubMed Zein JG, Mitri J, Bell JM, Lopez D, Strauss R, Attaway AH. The relationship of asthma severity to COVID-19 outcomes. J Allergy Clin Immunol Pract. 2022 Jan; 10 (1):318-321.e2 Epub 2021 Oct 27 View PubMed Belligund P, Lee D, Balasubramaniam M, Khanijao S, Damania D, Vallumsetla N, Sajawal Q, Perez-Gandara B, Perez-Perez J, Shalom I, Dubey G, Sanghavi S, Lu C, Mitre C, Zein J, Al-Ajam M. Right Ventricle Dilation Detected on Point-of-Care Ultrasound Is a Predictor of Poor Outcomes in Critically Ill Patients With COVID-19. Fed Pract. 2021 Sep; 38 (9):396-401 Epub 2021 Sept 12 View PubMed Strauss R, Jawhari N, Attaway AH, Hu B, Jehi L, Milinovich A, Ortega VE, Zein JG. Intranasal Corticosteroids Are Associated with Better Outcomes in Coronavirus Disease 2019. J Allergy Clin Immunol Pract. 2021 Aug 23 [Epub ahead of print] View PubMed Zein JG, McManus JM, Sharifi N, Erzurum SC, Marozkina N, Lahm T, Giddings O, Davis MD, DeBoer MD, Comhair SA, Bazeley P, Kim HJ, Busse W, Calhoun W, Castro M, Chung KF, Fahy JV, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Ortega VE, Peters M, Bleecker ER, Meyers DA, Zhao Y, Wenzel SE, Gaston B. Benefits of Airway Androgen Receptor Expression in Human Asthma. Am J Respir Crit Care Med. 2021 Aug 01; 204(3):285-293. View PubMed Marozkina N, Smith L, Zhao Y, Zein J, Chmiel JF, Kim J, Kiselar J, Davis MD, Cunningham RS, Randell SH, Gaston B. Somatic cell hemoglobin modulates nitrogen oxide metabolism in the human airway epithelium. Sci Rep. 2021 Jul 29; 11 (1):15498 Epub 2021 July 29 View PubMed Gaston B, Marozkina N, Newcomb DC, Sharifi N, Zein J. Asthma Risk Among Individuals With Androgen Receptor Deficiency. JAMA Pediatr. 2021 Jul 1; 175 (7):743-745 View PubMed MacMurdo M, Lopez R, Udeh BL, Zein JG. Alcohol use disorder and healthcare utilization in patients with chronic asthma and obstructive lung disease. Alcohol. 2021 Jun; 93:11-16 Epub 2021 Mar 10 View PubMed Chen R, Aldred MA, Xu W, Zein J, Bazeley P, Comhair SAA, Meyers DA, Bleecker ER, Liu C, Erzurum SC, Hu B, NHLBI Severe Asthma Research Program (SARP). Comparison of whole genome sequencing and targeted sequencing for mitochondrial DNA. Mitochondrion. 2021 May; 58:303-310. Epub 2021 Jan 26. View PubMed Zein JG, Wu CP, Attaway AH, Zhang P, Nazha A. Novel Machine Learning Can Predict Acute Asthma Exacerbation. Chest. 2021 May; 159 (5):1747-1757 Epub 2021 Jan 10 View PubMed Lowe KE, Zein J, Hatipoglu U, Attaway A. Association of Smoking and Cumulative Pack-Year Exposure With COVID-19 Outcomes in the Cleveland Clinic COVID-19 Registry. JAMA Intern Med. 2021 May 1; 181 (5):709-711 View PubMed Kasela S, Ortega VE, Martorella M, Garudadri S, Nguyen J, Ampleford E, Pasanen A, Nerella S, Buschur KL, Barjaktarevic IZ, Barr RG, Bleecker ER, Bowler RP, Comellas AP, Cooper CB, Couper DJ, Criner GJ, Curtis JL, Han MK, Hansel NN, Hoffman EA, Kaner RJ, Krishnan JA, Martinez FJ, McDonald MN, Meyers DA, Paine R 3rd, Peters SP, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Jarjour NN, Levy BD, Li X, Moore WC, Wenzel SE, Zein J, NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Langelier C, Woodruff PG, Lappalainen T, Christenson SA. Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium. Genome Med. 2021 Apr 21; 13(1):66. View PubMed Denlinger LC, Phillips BR, Sorkness RL, Bleecker ER, Castro M, DeBoer MD, Fitzpatrick AM, Hastie AT, Gaffin JM, Moore WC, Peters MC, Peters SP, Phipatanakul W, Cardet JC, Erzurum SC, Fahy JV, Fajt ML, Gaston B, Levy BD, Meyers DA, Ross K, Teague WG, Wenzel SE, Woodruff PG, Zein J, Jarjour NN, Mauger DT, Israel E. Responsiveness to Parenteral Corticosteroids and Lung Function Trajectory in Adults with Moderate-to-Severe Asthma. Am J Respir Crit Care Med. 2021 Apr 01; 203(7):841-852. View PubMed Zhang P, Lopez R, Attaway AH, Georas SN, Khatri SB, Abi-Saleh S, Zein JG. Diabetes Mellitus Is Associated with Worse Outcome in Patients Hospitalized for Asthma. J Allergy Clin Immunol Pract. 2021 Apr; 9 (4):1562-1569.e1 Epub 2020 Nov 09 View PubMed Attaway AH, Welch N, Yadav R, Bellar A, Hatipoglu U, Meli Y, Engelen MPKJ, Zein J, Dasarathy S. Quantitative Computed Tomography Assessment of Pectoralis and Erector Spinae Muscle Area and Disease Severity in Chronic Obstructive Pulmonary Disease Referred for Lung Volume Reduction. COPD. 2021 Apr; 18 (2):191-200 Epub 2021 Mar 19 View PubMed Sen P, Majumdar U, Zein J, Hatipoglu U, Attaway AH. Inhaled corticosteroids do not adversely impact outcomes in COVID-19 positive patients with COPD: An analysis of Cleveland Clinic's COVID-19 registry. PLoS One. 2021; 16 (6):e0252576 Epub 2021 June 03 View PubMed Attaway AH, Welch N, Hatipoglu U, Zein JG, Dasarathy S. Muscle loss contributes to higher morbidity and mortality in COPD: An analysis of national trends. Respirology. 2021 Jan; 26 (1):62-71 Epub 2020 June 16 View PubMed Vural A, Attaway A, Welch N, Zein J, Dasarathy S. Skeletal muscle loss phenotype in cirrhosis: A nationwide analysis of hospitalized patients. Clin Nutr. 2020 Dec; 39 (12):3711-3720 Epub 2020 Apr 03 View PubMed Zhou Y, Hou Y, Shen J, Mehra R, Kallianpur A, Culver DA, Gack MU, Farha S, Zein J, Comhair S, Fiocchi C, Stappenbeck T, Chan T, Eng C, Jung JU, Jehi L, Erzurum S, Cheng F. A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19. PLoS Biol. 2020 Nov; 18 (11):e3000970 Epub 2020 Nov 06 View PubMed Attaway AA, Zein J, Hatipoglu US. SARS-CoV-2 infection in the COPD population is associated with increased healthcare utilization: An analysis of Cleveland clinic's COVID-19 registry. EClinicalMedicine. 2020 Sep; 26:100515 Epub 2020 Aug 26 View PubMed Zein J, Gaston B, Bazeley P, DeBoer MD, Igo RP Jr, Bleecker ER, Meyers D, Comhair S, Marozkina NV, Cotton C, Patel M, Alyamani M, Xu W, Busse WW, Calhoun WJ, Ortega V, Hawkins GA, Castro M, Chung KF, Fahy JV, Fitzpatrick AM, Israel E, Jarjour NN, Levy B, Mauger DT, Moore WC, Noel P, Peters SP, Teague WG, Wenzel SE, Erzurum SC, Sharifi N. HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma. Proc Natl Acad Sci U S A. 2020 Jan 28; 117(4):2187-2193. Epub 2020 Jan 13. View PubMed Fitzpatrick AM, Szefler SJ, Mauger DT, Phillips BR, Denlinger LC, Moore WC, Sorkness RL, Wenzel SE, Gergen PJ, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Israel E, Levy BD, Meyers DA, Teague WG, Bacharier LB, Ly NP, Phipatanakul W, Ross KR, Zein J, Jarjour NN. Development and initial validation of the Asthma Severity Scoring System (ASSESS). J Allergy Clin Immunol. 2020 Jan; 145(1):127-139. Epub 2019 Oct 08. View PubMed Ross KR, Gupta R, DeBoer MD, Zein J, Phillips BR, Mauger DT, Li C, Myers RE, Phipatanakul W, Fitzpatrick AM, Ly NP, Bacharier LB, Jackson DJ, Celedón JC, Larkin A, Israel E, Levy B, Fahy JV, Castro M, Bleecker ER, Meyers D, Moore WC, Wenzel SE, Jarjour NN, Erzurum SC, Teague WG, Gaston B. Severe asthma during childhood and adolescence: A longitudinal study. J Allergy Clin Immunol. 2020 Jan; 145(1):140-146.e9. Epub 2019 Oct 14. View PubMed Marozkina N, Zein J, DeBoer MD, Logan L, Veri L, Ross K, Gaston B. Dehydroepiandrosterone Supplementation May Benefit Women with Asthma Who Have Low Androgen Levels: A Pilot Study. Pulm Ther. 2019 Dec; 5 (2):213-220 Epub 2019 Oct 21 View PubMed Zhang P, Zein J. Novel Insights on Sex-Related Differences in Asthma. Curr Allergy Asthma Rep. 2019 Sep 5; 19 (10):44 Epub 2019 Sept 05 View PubMed Siuba M, Attaway A, Zein J, Wang X, Han X, Strausbaugh S, Jacono F, Dasenbrook EC. Mortality in Adults with Cystic Fibrosis Requiring Mechanical Ventilation. Cross-Sectional Analysis of Nationwide Events. Ann Am Thorac Soc. 2019 Aug; 16 (8):1017-1023 View PubMed Pennington E, Yaqoob ZJ, Al-Kindi SG, Zein J. Trends in Asthma Mortality in the United States: 1999 to 2015. Am J Respir Crit Care Med. 2019 Jun 15; 199 (12):1575-1577 View PubMed Zein JG, Denson JL, Wechsler ME. Asthma over the Adult Life Course: Gender and Hormonal Influences. Clin Chest Med. 2019 Mar; 40 (1):149-161 Epub 2018 Dec 20 View PubMed DeBoer MD, Phillips BR, Mauger DT, Zein J, Erzurum SC, Fitzpatrick AM, Gaston BM, Myers R, Ross KR, Chmiel J, Lee MJ, Fahy JV, Peters M, Ly NP, Wenzel SE, Fajt ML, Holguin F, Moore WC, Peters SP, Meyers D, Bleecker ER, Castro M, Coverstone AM, Bacharier LB, Jarjour NN, Sorkness RL, Ramratnam S, Irani AM, Israel E, Levy B, Phipatanakul W, Gaffin JM, Gerald Teague W. Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma. BMC Pulm Med. 2018 Apr 10; 18(1):58. View PubMed Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston BM, Erzurum SC, Comhair SAA, Myers RE, Zein J, DeBoer MD, Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM, Holguin F, Fajt ML, Aujla SJ, Mauger DT, Jarjour NN. Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age. J Allergy Clin Immunol Pract. 2018 Mar-Apr; 6(2):545-554.e4. Epub 2017 Aug 31. View PubMed Zein JG, Udeh BL, Teague WG, Koroukian SM, Schlitz NK, Bleecker ER, Busse WB, Calhoun WJ, Castro M, Comhair SA, Fitzpatrick AM, Israel E, Wenzel SE, Holguin F, Gaston BM, Erzurum SC, Severe Asthma Research Program. Impact of Age and Sex on Outcomes and Hospital Cost of Acute Asthma in the United States, 2011-2012. PLoS One. 2016; 11(6):e0157301. Epub 2016 Jun 13. View PubMed Zein JG, Menegay MC, Singer ME, Erzurum SC, Gildea TR, Cicenia JC, Khatri S, Castro M, Udeh BL. Cost effectiveness of bronchial thermoplasty in patients with severe uncontrolled asthma. J Asthma. 2016; 53 (2):194-200 Epub 2015 Sept 17 View PubMed Farha S, Hu B, Comhair S, Zein J, Dweik R, Erzurum SC, Aldred MA. Mitochondrial Haplogroups and Risk of Pulmonary Arterial Hypertension. PLoS One. 2016; 11 (5):e0156042 Epub 2016 May 25 View PubMed Bandyopadhyay D, Bajaj NS, Zein J, Minai OA, Dweik RA. Outcomes of beta-blocker use in pulmonary arterial hypertension: a propensity-matched analysis. Eur Respir J. 2015 Sep; 46 (3):750-60 Epub 2015 May 28 View PubMed Bandyopadhyay D, Sahoo D, Zein J, Brunken RC, Tchou PJ, Culver DA. Outcome of cardiac sarcoidosis after radiofrequency ablation and placement of AICD- A propensity matched analysis. Sarcoidosis Vasc Diffuse Lung Dis. 2015 Jun 22; 32 (1):70-9 Epub 2015 June 22 View PubMed Zein JG, Dweik RA, Comhair SA, Bleecker ER, Moore WC, Peters SP, Busse WW, Jarjour NN, Calhoun WJ, Castro M, Chung KF, Fitzpatrick A, Israel E, Teague WG, Wenzel SE, Love TE, Gaston BM, Erzurum SC, Severe Asthma Research Program. Asthma Is More Severe in Older Adults. PLoS One. 2015; 10(7):e0133490. Epub 2015 Jul 22. View PubMed Tonelli AR, Zein J, Adams J, Ioannidis JP. Effects of interventions on survival in acute respiratory distress syndrome: an umbrella review of 159 published randomized trials and 29 meta-analyses. Intensive Care Med. 2014 Jun; 40 (6):769-87 Epub 2014 Mar 26 View PubMed Tonelli AR, Zein J, Ioannidis JP. Geometry of the randomized evidence for treatments of pulmonary hypertension. Cardiovasc Ther. 2013 Dec; 31 (6):e138-46 View PubMed Anjum F, Lazar J, Zein J, Jamaleddine G, Demetis S, Wadgaonkar R. Characterization of altered patterns of endothelial progenitor cells in sickle cell disease related pulmonary arterial hypertension. Pulm Circ. 2012 Jan-Mar; 2 (1):54-60 View PubMed Joshi K, Anjum F, Gowda S, Damania D, Graham-Hill S, Gillette P, Zein J, Jamaleddine G, Demetis S, Wadgaonkar R. Uric Acid as a potential biomarker of pulmonary arterial hypertension in patients with sickle cell disease. Indian J Hematol Blood Transfus. 2011 Jun; 27 (2):96-100 Epub 2011 June 08 View PubMed Zein JG, Wallace DJ, Kinasewitz G, Toubia N, Kakoulas C. Early anion gap metabolic acidosis in acetaminophen overdose. Am J Emerg Med. 2010 Sep; 28 (7):798-802 Epub 2010 Feb 25 View PubMed Kinasewitz GT, Zein JG, Lee GL, Nazir SA, Taylor FB Jr. Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis. Crit Care Med. 2005 Oct; 33 (10):2214-21 View PubMed Manjuck J, Zein J, Carpati C, Astiz M. Clinical significance of increased lipase levels on admission to the ICU. Chest. 2005 Jan; 127 (1):246-50 View PubMed Sibai AN, Muallem M, Zein J. Double T-piece, an injector, and Bird ventilator use in MRI suite. Middle East J Anaesthesiol. 1999 Oct; 15 (3):327-34 View PubMed Sibai AN, Muallem M, Zein J. Modification of an anesthesia machine for MRI suite. Middle East J Anaesthesiol. 1999 Jun; 15 (2):153-7 View PubMed PST-20554014 Inicio Publicaciones