Publicaciones Imprimir Joyner MJ, Carter RE, Wright RS, Senefeld JW. The Safety Profile of COVID-19 Convalescent Plasma. Curr Top Microbiol Immunol. 2024 Dec 19 [Epub ahead of print] View PubMed Manzato M, Wright RS, Jaffe AS, Vasile VC. Lipoprotein (a): Underrecognized Risk with a Promising Future. Rev Cardiovasc Med. 2024 Nov; 25 (11):393 Epub 2024 Nov 06 View PubMed Wright RS, Raal FJ, Koenig W, Landmesser U, Leiter LA, Vikarunnessa S, Lesogor A, Maheux P, Talloczy Z, Zang X, Schwartz GG, Ray KK. Inclisiran administration potently and durably lowers LDL-C over an extended-term follow-up: the ORION-8 trial. Cardiovasc Res. 2024 Oct 14; 120 (12):1400-1410 View PubMed Dragotakes Q, Johnson PW, Buras MR, Carter RE, Joyner MJ, Bloch E, Gebo KA, Hanley DF, Henderson JP, Pirofski LA, Shoham S, Senefeld JW, Tobian AAR, Wiggins CC, Wright RS, Paneth NS, Sullivan DJ, Casadevall A. Estimates of actual and potential lives saved in the United States from the use of COVID-19 convalescent plasma. Proc Natl Acad Sci U S A. 2024 Oct 8; 121 (41):e2414957121 Epub 2024 Oct 01 View PubMed Vaszar LT, Sharp RR, Carter RE, Wright RS. Pragmatic Clinical Trials: The Ethics of Conducting Research in the Real World. Mayo Clin Proc. 2024 Sep; 99 (9):1369-1373 Epub 2024 Aug 05 View PubMed Leiter LA, Raal FJ, Schwartz GG, Koenig W, Ray KK, Landmesser U, Han J, Conde LG, Wright RS. Inclisiran in individuals with diabetes or obesity: Post hoc pooled analyses of the ORION-9, ORION-10 and ORION-11 Phase 3 randomized trials. Diabetes Obes Metab. 2024 Aug; 26 (8):3223-3237 Epub 2024 May 17 View PubMed Wright RS, Ray KK, Landmesser U, Koenig W, Raal FJ, Leiter LA, Conde LG, Han J, Schwartz GG. Effects of Inclisiran in Patients With Atherosclerotic Cardiovascular Disease: A Pooled Analysis of the ORION-10 and ORION-11 Randomized Trials. Mayo Clin Proc. 2024 Jul 5 Epub 2024 July 05 View PubMed Koenig W, Conde LG, Landmesser U, Leiter LA, Ray KK, Schwartz GG, Wright RS, Han J, Raal FJ. Efficacy and Safety of Inclisiran in Patients with Polyvascular Disease: Pooled, Post Hoc Analysis of the ORION-9, ORION-10, and ORION-11 Phase 3 Randomized Controlled Trials. Cardiovasc Drugs Ther. 2024 Jun; 38 (3):493-503 Epub 2022 Dec 23 View PubMed Ray KK, Gunn LH, Conde LG, Raal FJ, Wright RS, Gosselin NH, Leiter LA, Koenig W, Schwartz GG, Landmesser U, ORION investigators. Estimating potential cardiovascular health benefits of improved population level control of LDL cholesterol through a twice-yearly siRNA-based approach: A simulation study of a health-system level intervention. Atherosclerosis. 2024 Apr; 391:117472 Epub 2024 Feb 15 View PubMed Wright RS, Koenig W, Landmesser U, Leiter LA, Raal FJ, Schwartz GG, Lesogor A, Maheux P, Stratz C, Zang X, Ray KK. Safety and Tolerability of Inclisiran for Treatment of Hypercholesterolemia in 7 Clinical Trials. J Am Coll Cardiol. 2023 Dec 12; 82 (24):2251-2261 View PubMed Landmesser U, Koenig W, Leiter LA, Raal FJ, Ray KK, Wright RS, Han J, Conde LG, Schwartz GG. Inclisiran in patients with prior myocardial infarction: A post hoc pooled analysis of the ORION-10 and ORION-11 Phase 3 randomised trials. Atherosclerosis. 2023 Dec; 386:117354 Epub 2023 Oct 18 View PubMed Senefeld JW, Gorman EK, Johnson PW, Moir ME, Klassen SA, Carter RE, Paneth NS, Sullivan DJ, Morkeberg OH, Wright RS, Fairweather D, Bruno KA, Shoham S, Bloch EM, Focosi D, Henderson JP, Juskewitch JE, Pirofski LA, Grossman BJ, Tobian AAR, Franchini M, Ganesh R, Hurt RT, Kay NE, Parikh SA, Baker SE, Buchholtz ZA, Buras MR, Clayburn AJ, Dennis JJ, Diaz Soto JC, Herasevich V, Klompas AM, Kunze KL, Larson KF, Mills JR, Regimbal RJ, Ripoll JG, Sexton MA, Shepherd JRA, Stubbs JR, Theel ES, van Buskirk CM, van Helmond N, Vogt MNP, Whelan ER, Wiggins CC, Winters JL, Casadevall A, Joyner MJ. Rates Among Hospitalized Patients With COVID-19 Treated With Convalescent Plasma: A Systematic Review and Meta-Analysis. Mayo Clin Proc Innov Qual Outcomes. 2023 Oct; 7 (5):499-513 Epub 2023 Oct 10 View PubMed Koenig W, Ray KK, Landmesser U, Leiter LA, Schwartz GG, Wright RS, Conde LG, Han J, Raal FJ. Efficacy and safety of inclisiran in patients with cerebrovascular disease: ORION-9, ORION-10, and ORION-11. Am J Prev Cardiol. 2023 Jun; 14:100503 Epub 2023 May 14 View PubMed Ray KK, Wright RS. Plain language summary of results from ORION-10 and ORION-11: two studies to learn how well inclisiran works in people with high cholesterol. Future Cardiol. 2023 Mar; 19 (4):175-184 Epub 2023 June 06 View PubMed Ray KK, Raal FJ, Kallend DG, Jaros MJ, Koenig W, Leiter LA, Landmesser U, Schwartz GG, Lawrence D, Friedman A, Garcia Conde L, Wright RS, ORION Phase III investigators. Inclisiran and cardiovascular events: a patient-level analysis of phase III trials. Eur Heart J. 2023 Jan 7; 44 (2):129-138 View PubMed Ray KK, Troquay RPT, Visseren FLJ, Leiter LA, Wright RS, Vikarunnessa S, Talloczy Z, Zang X, Maheux P, Lesogor A, Landmesser U. Long-term efficacy and safety of inclisiran in patients with high cardiovascular risk and elevated LDL cholesterol (ORION-3): results from the 4-year open-label extension of the ORION-1 trial. The Lancet Diabetes and Endocrinology. 2023; 11 (2):109-19 Ray KK, Kallend D, Leiter LA, Raal FJ, Koenig W, Jaros MJ, Schwartz GG, Landmesser U, Garcia Conde L, Wright RS, ORION-11 Investigators. Effect of inclisiran on lipids in primary prevention: the ORION-11 trial. Eur Heart J. 2022 Dec 21; 43 (48):5047-5057 View PubMed Greason KL, Spittell PC, Wright RS. Chordal Preservation Mitral Valve Replacement for Delayed MitraClip Failure. Tex Heart Inst J. 2022 Nov 1; 49 (6) View PubMed Ray KK, Wright RS. Clinical Update on Novel Lipid-Lowering Therapies to Reduce Cardiovascular Risk. JAMA 2021 Dec 7; 326 (21):2205 View PubMed Senefeld JW, Johnson PW, Kunze KL, Bloch EM, van Helmond N, Golafshar MA, Klassen SA, Klompas AM, Sexton MA, Diaz Soto JC, Grossman BJ, Tobian AAR, Goel R, Wiggins CC, Bruno KA, van Buskirk CM, Stubbs JR, Winters JL, Casadevall A, Paneth NS, Shaz BH, Petersen MM, Sachais BS, Buras MR, Wieczorek MA, Russoniello B, Dumont LJ, Baker SE, Vassallo RR, Shepherd JRA, Young PP, Verdun NC, Marks P, Haley NR, Rea RF, Katz L, Herasevich V, Waxman DA, Whelan ER, Bergman A, Clayburn AJ, Grabowski MK, Larson KF, Ripoll JG, Andersen KJ, Vogt MNP, Dennis JJ, Regimbal RJ, Bauer PR, Blair JE, Buchholtz ZA, Pletsch MC, Wright K, Greenshields JT, Joyner MJ, Wright RS, Carter RE, Fairweather D. Access to and safety of COVID-19 convalescent plasma in the United States Expanded Access Program: A national registry study. PLoS Med. 2021 Dec; 18 (12):e1003872 Epub 2021 Dec 20 View PubMed Lapid MI, Clarke BL, Ho JB, Ouellette Y, Armbrust TL, Wright RS. Research Involving Participants With Impaired Consent Capacity: An Examination of Methods to Determine Capacity to Consent. Mayo Clin Proc. 2021 Nov; 96 (11):2806-2822 View PubMed Kunze KL, Johnson PW, van Helmond N, Senefeld JW, Petersen MM, Klassen SA, Wiggins CC, Klompas AM, Bruno KA, Mills JR, Theel ES, Buras MR, Golafshar MA, Sexton MA, Diaz Soto JC, Baker SE, Shepherd JRA, Verdun NC, Marks P, Paneth NS, Fairweather D, Wright RS, van Buskirk CM, Winters JL, Stubbs JR, Senese KA, Pletsch MC, Buchholtz ZA, Rea RF, Herasevich V, Whelan ER, Clayburn AJ, Larson KF, Ripoll JG, Andersen KJ, Lesser ER, Vogt MNP, Dennis JJ, Regimbal RJ, Bauer PR, Blair JE, Casadevall A, Carter RE, Joyner MJ. Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors. Nat Commun. 2021 Aug 11; 12 (1):4864 View PubMed Senefeld JW, Klassen SA, Ford SK, Senese KA, Wiggins CC, Bostrom BC, Thompson MA, Baker SE, Nicholson WT, Johnson PW, Carter RE, Henderson JP, Hartman WR, Pirofski LA, Wright RS, Fairweather L, Bruno KA, Paneth NS, Casadevall A, Joyner MJ. Use of convalescent plasma in COVID-19 patients with immunosuppression. Transfusion. 2021 Aug; 61 (8):2503-2511 Epub 2021 June 01 View PubMed Casadevall A, Dragotakes Q, Johnson PW, Senefeld JW, Klassen SA, Wright RS, Joyner MJ, Paneth N, Carter RE. Convalescent plasma use in the USA was inversely correlated with COVID-19 mortality. Elife. 2021 Jun 4; 10 Epub 2021 June 04 View PubMed Klassen SA, Senefeld JW, Johnson PW, Carter RE, Wiggins CC, Shoham S, Grossman BJ, Henderson JP, Musser J, Salazar E, Hartman WR, Bouvier NM, Liu STH, Pirofski LA, Baker SE, van Helmond N, Wright RS, Fairweather D, Bruno KA, Wang Z, Paneth NS, Casadevall A, Joyner MJ. The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis. Mayo Clin Proc. 2021 May; 96 (5):1262-1275 Epub 2021 Feb 17 View PubMed Rhainds D, Packard CJ, Brodeur MR, Niesor EJ, Sacks FM, Jukema JW, Wright RS, Waters DD, Heinonen T, Black DM, Laghrissi-Thode F, Dube MP, Pfeffer MA, Tardif JC. Role of Adenylate Cyclase 9 in the Pharmacogenomic Response to Dalcetrapib: Clinical Paradigm and Molecular Mechanisms in Precision Cardiovascular Medicine. Circ Genom Precis Med. 2021 Apr; 14 (2):e003219 Epub 2021 Apr 02 View PubMed Joyner MJ, Carter RE, Senefeld JW, Klassen SA, Mills JR, Johnson PW, Theel ES, Wiggins CC, Bruno KA, Klompas AM, Lesser ER, Kunze KL, Sexton MA, Diaz Soto JC, Baker SE, Shepherd JRA, van Helmond N, Verdun NC, Marks P, van Buskirk CM, Winters JL, Stubbs JR, Rea RF, Hodge DO, Herasevich V, Whelan ER, Clayburn AJ, Larson KF, Ripoll JG, Andersen KJ, Buras MR, Vogt MNP, Dennis JJ, Regimbal RJ, Bauer PR, Blair JE, Paneth NS, Fairweather D, Wright RS, Casadevall A. Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19. N Engl J Med. 2021 Mar 18; 384 (11):1015-1027 Epub 2021 Jan 13 View PubMed Wright RS, Ray KK, Raal FJ, Kallend DG, Jaros M, Koenig W, Leiter LA, Landmesser U, Schwartz GG, Friedman A, Wijngaard PLJ, Garcia Conde L, Kastelein JJP, ORION Phase III Investigators. Pooled Patient-Level Analysis of Inclisiran Trials in Patients With Familial Hypercholesterolemia or Atherosclerosis. J Am Coll Cardiol. 2021 Mar 9; 77 (9):1182-1193 View PubMed Landmesser U, Haghikia A, Leiter LA, Wright RS, Kallend D, Wijngaard P, Stoekenbroek R, Kastelein JJ, Ray KK. Effect of inclisiran, the small-interfering RNA against proprotein convertase subtilisin/kexin type 9, on platelets, immune cells, and immunological biomarkers: a pre-specified analysis from ORION-1. Cardiovasc Res. 2021 Jan 1; 117 (1):284-291 View PubMed Ma T, Wiggins CC, Kornatowski BM, Hailat RS, Clayburn AJ, Guo WL, Johnson PW, Senefeld JW, Klassen SA, Baker SE, Bruno KA, Fairweather D, Wright RS, Carter RE, Li C, Joyner MJ, Paneth NS. The Role of Disease Severity and Demographics in the Clinical Course of COVID-19 Patients Treated With Convalescent Plasma. Front Med (Lausanne). 2021; 8:707895 Epub 2022 Jan 26 View PubMed Klassen SA, Senefeld JW, Senese KA, Johnson PW, Wiggins CC, Baker SE, van Helmond N, Bruno KA, Pirofski LA, Shoham S, Grossman BJ, Henderson JP, Wright RS, Fairweather D, Paneth NS, Carter RE, Casadevall A, Joyner MJ. Convalescent Plasma Therapy for COVID-19: A Graphical Mosaic of the Worldwide Evidence. Front Med (Lausanne). 2021; 8:684151 Epub 2021 June 07 View PubMed Lapid MI, Meagher KM, Giunta HC, Clarke BL, Ouellette Y, Armbrust TL, Sharp RR, Wright RS. Ethical Challenges in COVID-19 Biospecimen Research: Perspectives From Institutional Review Board Members and Bioethicists. Mayo Clin Proc. 2021 Jan; 96 (1):165-173 Epub 2020 Oct 23 View PubMed Gharacholou SM, Del-Carpio Munoz F, Motiei A, Sandhu GS, Barsness GW, Gulati R, Wright RS, Pellikka PA, Lewis B, Johnson MP, Lane GE, Pollak PM, Pillai DP, Sabbagh AE, Paul TK, Pham SM, Singh M. Characteristics and Long-Term Outcomes of Patients With Prior Coronary Artery Bypass Grafting Undergoing Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction. Am J Cardiol. 2020 Nov 15; 135:1-8. Epub 2020 Aug 28. View PubMed Andersen KJ, Klassen SA, Larson KF, Ripoll JG, Senefeld JW, Clayburn AJ, Shepherd JRA, Tseng AS, Wiggins CC, Murphy BM, Ford SK, Johnson CP, Miller AD, Baker SE, Wright RS, Winters JL, Stubbs JR, Joyner MJ, van Buskirk CM. Recruitment Strategy for Potential COVID-19 Convalescent Plasma Donors. Mayo Clin Proc. 2020 Nov; 95 (11):2343-2349 Epub 2020 Sept 21 View PubMed Joyner MJ, Wright RS, Fairweather D, Senefeld JW, Bruno KA, Klassen SA, Carter RE, Klompas AM, Wiggins CC, Shepherd JR, Rea RF, Whelan ER, Clayburn AJ, Spiegel MR, Johnson PW, Lesser ER, Baker SE, Larson KF, Ripoll JG, Andersen KJ, Hodge DO, Kunze KL, Buras MR, Vogt MN, Herasevich V, Dennis JJ, Regimbal RJ, Bauer PR, Blair JE, Van Buskirk CM, Winters JL, Stubbs JR, Paneth NS, Verdun NC, Marks P, Casadevall A. Early safety indicators of COVID-19 convalescent plasma in 5000 patients. J Clin Invest. 2020 Sep 1; 130 (9):4791-4797 View PubMed Joyner MJ, Bruno KA, Klassen SA, Kunze KL, Johnson PW, Lesser ER, Wiggins CC, Senefeld JW, Klompas AM, Hodge DO, Shepherd JRA, Rea RF, Whelan ER, Clayburn AJ, Spiegel MR, Baker SE, Larson KF, Ripoll JG, Andersen KJ, Buras MR, Vogt MNP, Herasevich V, Dennis JJ, Regimbal RJ, Bauer PR, Blair JE, van Buskirk CM, Winters JL, Stubbs JR, van Helmond N, Butterfield BP, Sexton MA, Diaz Soto JC, Paneth NS, Verdun NC, Marks P, Casadevall A, Fairweather D, Carter RE, Wright RS. Safety Update: COVID-19 Convalescent Plasma in 20,000 Hospitalized Patients. Mayo Clin Proc. 2020 Sep; 95 (9):1888-1897 Epub 2020 July 19 View PubMed Sher T, Wright RS. Public Health Crises and the Human Subjects of Biomedical Research: A Focus on COVID-19. Mayo Clin Proc. 2020 Jun; 95 (6):1130-1131 Epub 2020 Apr 20 View PubMed Meagher KM, Cummins NW, Bharucha AE, Badley AD, Chlan LL, Wright RS. COVID-19 Ethics and Research. Mayo Clin Proc. 2020 Jun; 95 (6):1119-1123 Epub 2020 Apr 24 View PubMed Joyner M, Wright RS, Fairweather D, Senefeld J, Bruno K, Klassen S, Carter R, Klompas A, Wiggins C, Shepherd JR, Rea R, Whelan E, Clayburn A, Spiegel M, Johnson P, Lesser E, Baker S, Larson K, Ripoll Sanz J, Andersen K, Hodge D, Kunze K, Buras M, Vogt M, Herasevich V, Dennis J, Regimbal R, Bauer P, Blair J, van Buskirk C, Winters J, Stubbs J, Paneth N, Casadevall A. Early Safety Indicators of COVID-19 Convalescent Plasma in 5,000 Patients. medRxiv 2020 May 14 View PubMed Ray KK, Wright RS, Kallend D, Koenig W, Leiter LA, Raal FJ, Bisch JA, Richardson T, Jaros M, Wijngaard PLJ, Kastelein JJP, ORION-10 and ORION-11 Investigators. Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol. N Engl J Med. 2020 Apr 16; 382 (16):1507-1519 Epub 2020 Mar 18 View PubMed Raal FJ, Kallend D, Ray KK, Turner T, Koenig W, Wright RS, Wijngaard PLJ, Curcio D, Jaros MJ, Leiter LA, Kastelein JJP, ORION-9 Investigators. Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia. N Engl J Med. 2020 Apr 16; 382 (16):1520-1530 Epub 2020 Mar 18 View PubMed Wright RS, Collins MG, Stoekenbroek RM, Robson R, Wijngaard PLJ, Landmesser U, Leiter LA, Kastelein JJP, Ray KK, Kallend D. Effects of Renal Impairment on the Pharmacokinetics, Efficacy, and Safety of Inclisiran: An Analysis of the ORION-7 and ORION-1 Studies. Mayo Clin Proc. 2020 Jan; 95 (1):77-89 Epub 2019 Oct 17 View PubMed Ray KK, Stoekenbroek RM, Kallend D, Nishikido T, Leiter LA, Landmesser U, Wright RS, Wijngaard PLJ, Kastelein JJP. Effect of 1 or 2 Doses of Inclisiran on Low-Density Lipoprotein Cholesterol Levels: One-Year Follow-up of the ORION-1 Randomized Clinical Trial. JAMA Cardiol. 2019 Nov 1; 4 (11):1067-1075 View PubMed Raal FJ, Tuomilehto J, Sposito AC, Fonseca FA, Averna M, Farnier M, Santos RD, Ferdinand KC, Wright RS, Navarese EP, Lerch DM, Louie MJ, Lee LV, Letierce A, Robinson JG. Treatment effect of alirocumab according to age group, smoking status, and hypertension: Pooled analysis from 10 randomized ODYSSEY studies. J Clin Lipidol. 2019 Sep - Oct; 13 (5):735-743 Epub 2019 June 29 View PubMed Jentzer JC, van Diepen S, Barsness GW, Katz JN, Wiley BM, Bennett CE, Mankad SV, Sinak LJ, Best PJ, Herrmann J, Jaffe AS, Murphy JG, Morrow DA, Wright RS, Bell MR, Anavekar NS. Changes in comorbidities, diagnoses, therapies and outcomes in a contemporary cardiac intensive care unit population. Am Heart J. 2019 Sep; 215:12-19 Epub 2019 June 04 View PubMed Bennett CE, Wright RS, Jentzer J, Gajic O, Murphree DH, Murphy JG, Mankad SV, Wiley BM, Bell MR, Barsness GW. Severity of illness assessment with application of the APACHE IV predicted mortality and outcome trends analysis in an academic cardiac intensive care unit. J Crit Care. 2019 Apr; 50:242-246 Epub 2018 Dec 24 View PubMed Lapid MI, Clarke BL, Wright RS. Institutional Review Boards: What Clinician Researchers Need to Know. Mayo Clin Proc. 2019 Mar; 94 (3):515-525 View PubMed Leiter LA, Teoh H, Kallend D, Wright RS, Landmesser U, Wijngaard PLJ, Kastelein JJP, Ray KK. Inclisiran Lowers LDL-C and PCSK9 Irrespective of Diabetes Status: The ORION-1 Randomized Clinical Trial. Diabetes Care. 2019 Jan; 42 (1):173-176 Epub 2018 Nov 28 View PubMed Jentzer JC, Murphree DH, Wiley B, Bennett C, Goldfarb M, Keegan MT, Murphy JG, Wright RS, Barsness GW. Comparison of Mortality Risk Prediction Among Patients >/=70 Versus <70 Years of Age in a Cardiac Intensive Care Unit. Am J Cardiol. 2018 Nov 15; 122 (10):1773-1778 Epub 2018 Aug 22 View PubMed Ray KK, Stoekenbroek RM, Kallend D, Leiter LA, Landmesser U, Wright RS, Wijngaard P, Kastelein JJP. Effect of an siRNA Therapeutic Targeting PCSK9 on Atherogenic Lipoproteins: Prespecified Secondary End Points in ORION 1. Circulation. 2018 Sep 25; 138 (13):1304-1316 View PubMed Nicholls SJ, Puri R, Ballantyne CM, Jukema JW, Kastelein JJP, Koenig W, Wright RS, Kallend D, Wijngaard P, Borgman M, Wolski K, Nissen SE. Effect of Infusion of High-Density Lipoprotein Mimetic Containing Recombinant Apolipoprotein A-I Milano on Coronary Disease in Patients With an Acute Coronary Syndrome in the MILANO-PILOT Trial: A Randomized Clinical Trial. JAMA Cardiol. 2018 Sep 1; 3 (9):806-814 View PubMed Jentzer JC, Bennett C, Wiley BM, Murphree DH, Keegan MT, Gajic O, Wright RS, Barsness GW. Predictive Value of the Sequential Organ Failure Assessment Score for Mortality in a Contemporary Cardiac Intensive Care Unit Population. J Am Heart Assoc. 2018 Mar 10; 7 (6) View PubMed Jentzer JC, Clements CM, Murphy JG, Wright RS, Scott Wright R. Recent developments in the management of patients resuscitated from cardiac arrest. J Crit Care. 2017 Jun; 39:97-107 Epub 2017 Feb 16 View PubMed Le RJ, Cullen MW, Lahr BD, Wright RS, Kopecky SL. Side Effects of CV Medications Following Hospitalization for ACS Are Associated With More Frequent Health-Care Contacts. J Cardiovasc Pharmacol Ther. 2017 May; 22 (3):250-255 Epub 2016 Oct 02 View PubMed Ridker PM, Revkin J, Amarenco P, Brunell R, Curto M, Civeira F, Flather M, Glynn RJ, Gregoire J, Jukema JW, Karpov Y, Kastelein JJP, Koenig W, Lorenzatti A, Manga P, Masiukiewicz U, Miller M, Mosterd A, Murin J, Nicolau JC, Nissen S, Ponikowski P, Santos RD, Schwartz PF, Soran H, White H, Wright RS, Vrablik M, Yunis C, Shear CL, Tardif JC, SPIRE Cardiovascular Outcome Investigators. Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients. N Engl J Med. 2017 Apr 20; 376 (16):1527-1539 Epub 2017 Mar 17 View PubMed Ray KK, Landmesser U, Leiter LA, Kallend D, Dufour R, Karakas M, Hall T, Troquay RP, Turner T, Visseren FL, Wijngaard P, Wright RS, Kastelein JJ. Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol. N Engl J Med. 2017 Apr 13; 376 (15):1430-1440 Epub 2017 Mar 17 View PubMed Jentzer JC, Clements CM, Wright RS, White RD, Jaffe AS. Improving Survival From Cardiac Arrest: A Review of Contemporary Practice and Challenges. Ann Emerg Med. 2016 Dec; 68 (6):678-689 Epub 2016 June 16 View PubMed Wang F, Gulati R, Lennon RJ, Lewis BR, Park J, Sandhu GS, Wright RS, Lerman A, Herrmann J. Cancer History Portends Worse Acute and Long-term Noncardiac (but Not Cardiac) Mortality After Primary Percutaneous Coronary Intervention for Acute ST-Segment Elevation Myocardial Infarction. Mayo Clin Proc. 2016 Dec; 91 (12):1680-1692 View PubMed Stahli BE, Gebhard C, Duchatelle V, Cournoyer D, Petroni T, Tanguay JF, Robb S, Mann J, Guertin MC, Wright RS, L L'Allier P, Tardif JC. Effects of the P-Selectin Antagonist Inclacumab on Myocardial Damage After Percutaneous Coronary Intervention According to Timing of Infusion: Insights From the SELECT-ACS Trial. J Am Heart Assoc. 2016 Nov 16; 5 (11) View PubMed Siontis KC, Barsness GW, Lennon RJ, Holmen JL, Wright RS, Bell MR, Gersh BJ. Pharmacoinvasive and Primary Percutaneous Coronary Intervention Strategies in ST-Elevation Myocardial Infarction (from the Mayo Clinic STEMI Network). Am J Cardiol. 2016 Jun 15; 117: (12)1904-10. View PubMed Sakhuja A, Wright RS, Schold JD, McCarthy JT, Williams AW, Amer H, Albright RC. National Impact of Maintenance Dialysis or Renal Transplantation on Outcomes Following ST Elevation Myocardial Infarction. Am J Nephrol. 2016; 44: (5)329-338. View PubMed Gupta BP, Steckelberg RC, Gullerud RE, Huddleston PM, Kirkland LL, Wright RS, Huddleston JM. Incidence and 1-Year Outcomes of Perioperative Atrial Arrhythmia in Elderly Adults After Hip Fracture Surgery. J Am Geriatr Soc. 2015 Nov; 63 (11):2269-74 Epub 2015 Oct 27 View PubMed Henkin S, Negrotto S, Pollak PM, Cullen MW, O'Cochlain DF, Wright RS. Platypnea-Orthodeoxia Syndrome: Diagnostic Challenge and the Importance of Heightened Clinical Suspicion. Tex Heart Inst J. 2015 Oct; 42(5):498-501. View PubMed Villablanca PA, Alegria JR, Mookadam F, Holmes DR Jr, Wright RS, Levine JA. Nonexercise activity thermogenesis in obesity management. Mayo Clin Proc. 2015 Apr; 90(4):509-19. View PubMed Lopez-Jimenez F, Simha V, Thomas RJ, Allison TG, Basu A, Fernandes R, Hurst RT, Kopecky SL, Kullo IJ, Mulvagh SL, Thompson WG, Trejo-Gutierrez JF, Wright RS. A summary and critical assessment of the 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults: filling the gaps. Mayo Clin Proc. 2014 Sep; 89 (9):1257-78 Epub 2014 Aug 12 View PubMed Nicholls SJ, Kastelein JJ, Schwartz GG, Bash D, Rosenson RS, Cavender MA, Brennan DM, Koenig W, Jukema JW, Nambi V, Wright RS, Menon V, Lincoff AM, Nissen SE, VISTA-16 Investigators. Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial. JAMA. 2014 Jan 15; 311(3):252-62. View PubMed Killu AM, Wright RS, Kopecky SL. Questions and answers on proper peri-operative management of antiplatelet therapy after coronary stent implantation to prevent stent thrombosis. Am J Cardiol. 2013 Oct 1; 112(7):1046-50. Epub 2013 Jul 25. View PubMed Gami AS, Olson EJ, Shen WK, Wright RS, Ballman KV, Hodge DO, Herges RM, Howard DE, Somers VK. Obstructive sleep apnea and the risk of sudden cardiac death: a longitudinal study of 10,701 adults. J Am Coll Cardiol. 2013 Aug 13; 62(7):610-6. Epub 2013 Jun 13. View PubMed Wright RS. Recent clinical trials evaluating benefit of drug therapy for modification of HDL cholesterol. Curr Opin Cardiol. 2013 Jul; 28(4):389-98. View PubMed Tardif JC, Tanguay JF, Wright SS, Duchatelle V, Petroni T, Gregoire JC, Ibrahim R, Heinonen TM, Robb S, Bertrand OF, Cournoyer D, Johnson D, Mann J, Guertin MC, L'Allier PL. Effects of the P-selectin antagonist inclacumab on myocardial damage after percutaneous coronary intervention for non-ST-segment elevation myocardial infarction: results of the SELECT-ACS trial. J Am Coll Cardiol. 2013 May 21; 61(20):2048-55. Epub 2013 Mar 10. View PubMed Nicholls SJ, Kastelein JP, Schwartz GG, Bash D, Rosenson RS, Cavender MA, Brennan DM, Koenig W, Jukema JW, Nambi V, Wright RS, Menon V, Lincoff AM, Nissen SE, VISTA-16 Investigators. Varespladib and Cardiovascular Events in Patients With an Acute Coronary Syndrome The VISTA-16 Randomized Clinical Trial. JAMA 1001/jama282836. 2013. Schwartz GG, Olsson AG, Abt M, Ballantyne CM, Barter PJ, Brumm J, Chaitman BR, Holme IM, Kallend D, Leiter LA, Leitersdorf E, McMurray JJ, Mundl H, Nicholls SJ, Shah PK, Tardif JC, Wright RS, dal-OUTCOMES Investigators. Effects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med. 2012 Nov 29; 367 (22):2089-99 Epub 2012 Nov 05 View PubMed Jouni H, Driver SL, Wright RS, Timimi F. Danger above: a classic case of an unruptured right sinus of Valsalva aneurysm. BMJ Case Rep. 2012 Nov 27; 2012 View PubMed Rosenson RS, Wright RS, Farkouh M, Plutzky J. Modulating peroxisome proliferator-activated receptors for therapeutic benefit? Biology, clinical experience, and future prospects. Am Heart J. 2012 Nov; 164(5):672-80. Epub 2012 Oct 16. 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ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine Journal of the American College of Cardiology.2007 Aug 14;50:(7):e1-e157. Elesber AA, Prasad A, Lennon RJ, Wright RS, Lerman A, Rihal CS. Four-year recurrence rate and prognosis of the apical ballooning syndrome. 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Effects of early treatment with statins on short-term clinical outcomes in acute coronary syndromes: a meta-analysis of randomized controlled trials. JAMA. 2006 May 3; 295(17):2046-56. View PubMed Wright RS, Bybee K, Miller WL, Laudon DA, Murphy JG, Jaffe AS. Reduced risks of death and CHF are associated with statin therapy administered acutely within the first 24 h of AMI. Int J Cardiol. 2006 Apr 14; 108(3):314-9. Epub 2005 Jun 22. View PubMed Bybee KA, Murphy J, Prasad A, Wright RS, Lerman A, Rihal CS, Chareonthaitawee P. Acute impairment of regional myocardial glucose uptake in the apical ballooning (takotsubo) syndrome. J Nucl Cardiol. 2006 Mar-Apr; 13 (2):244-50 View PubMed Williams BA, Wright RS, Murphy JG, Brilakis ES, Reeder GS, Jaffe AS. A new simplified immediate prognostic risk score for patients with acute myocardial infarction. Emerg Med J. 2006 Mar; 23 (3):186-92 View PubMed Haro LH, Decker WW, Boie ET, Wright RS. Initial approach to the patient who has chest pain. 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Am J Cardiol. 2004 Mar 15; 93(6):776-9. View PubMed Hillis GS, Moller JE, Pellikka PA, Gersh BJ, Wright RS, Ommen SR, Reeder GS, Oh JK. Noninvasive estimation of left ventricular filling pressure by E/e' is a powerful predictor of survival after acute myocardial infarction. J Am Coll Cardiol. 2004 Feb 4; 43 (3):360-7 View PubMed Xue J, Aufderheide T, Wright RS, Klein J, Farrell R, Rowlandson I, Young B. Added value of new acute coronary syndrome computer algorithm for interpretation of prehospital electrocardiograms. J Electrocardiol. 2004; 37(Suppl S):233-9. View PubMed Brilakis ES, Wright RS, Kopecky SL, Mavrogiorgos NC, Reeder GS, Rihal CS, Gersh BJ, Williams BA, Clements IP. Association of the PURSUIT risk score with predischarge ejection fraction, angiographic severity of coronary artery disease, and mortality in a nonselected, community-based population with non-ST-elevation acute myocardial infarction. Am Heart J. 2003 Nov; 146 (5):811-8 View PubMed Murphy JG, Wright RS, Bruce GK, Baddour LM, Farrell MA, Edwards WD, Kita H, Cooper LT. Eosinophilic-lymphocytic myocarditis after smallpox vaccination. Lancet. 2003 Oct 25; 362(9393):1378-80. View PubMed Hillis GS, Mulvagh SL, Pellikka PA, Hagen ME, Gunda M, Wright RS, Oh JK. Comparison of intravenous myocardial contrast echocardiography and low-dose dobutamine echocardiography for predicting left ventricular functional recovery following acute myocardial infarction. Am J Cardiol. 2003 Sep 1; 92 (5):504-8 View PubMed Tedesco JV, Williams BA, Wright RS, Reeder GS, Dvorak D, Kopecky SL, Miller WL, Coronary Care Unit Group. Baseline comorbidities and treatment strategy in elderly patients are associated with outcome of cardiogenic shock in a community-based population. Am Heart J. 2003 Sep; 146(3):472-8. View PubMed Gami AS, Wright RS, Ballman KV, Kopecky SL, Hayes SN. Hormone replacement therapy and risk of acute myocardial infarction in postmenopausal women with diabetes mellitus. Am J Cardiol. 2003 May 15; 91(10):1275-7. View PubMed Moller JE, Hillis GS, Oh JK, Seward JB, Reeder GS, Wright RS, Park SW, Bailey KR, Pellikka PA. Left atrial volume: a powerful predictor of survival after acute myocardial infarction. Circulation. 2003 May 6; 107 (17):2207-12 Epub 2003 Apr 14 View PubMed Tedesco JV, Wright RS, Williams BA, Kopecky SL, Dvorak DL, Reeder GS, Miller WL, Mayo Coronary Care Unit Group. Effect of diabetes on the mortality risk of cardiogenic shock in a community-based population. Mayo Clin Proc. 2003 May; 78 (5):561-6 View PubMed Murphy J, Wright RS, Gussak I, Williams B, Daly RN, Cain VA, Pieniaszek HJ, Sy SK, Ebling W, Simonson K, Wilcox RA, Kopecky SL. The use of roxifiban (DMP754), a novel oral platelet glycoprotein IIb/IIIa receptor inhibitor, in patients with stable coronary artery disease. Am J Cardiovasc Drugs. 2003; 3 (2):101-12 View PubMed Grines C, Nair R, Wright RS. Contemporary management of acute MI. Patient Care. 2003; 37(8):14-28. Gumina RJ, Wright RS, Kopecky SL, Miller WL, Williams BA, Reeder GS, Murphy JG. Strong predictive value of TIMI risk score analysis for in-hospital and long-term survival of patients with right ventricular infarction. Eur Heart J. 2002 Nov; 23 (21):1678-83 View PubMed Aviles RJ, Wright RS, Aviles JM, McDonald F, Ballman K, Harker-Murray A, Scott C, Lauer MS, Kopecky SL, Jaffe AS. Long-term prognosis of patients with clinical unstable angina pectoris without elevation of creatine kinase but with elevation of cardiac troponin i levels. Am J Cardiol. 2002 Oct 15; 90 (8):875-8 View PubMed Wright RS, Reeder GS, Herzog CA, Albright RC, Williams BA, Dvorak DL, Miller WL, Murphy JG, Kopecky SL, Jaffe AS. Acute myocardial infarction and renal dysfunction: a high-risk combination. Ann Intern Med. 2002 Oct 1; 137 (7):563-70 View PubMed Wright RS, Murphy JG, Bybee KA, Kopecky SL, LaBlanche JM. Statin lipid-lowering therapy for acute myocardial infarction and unstable angina: efficacy and mechanism of benefit. Mayo Clin Proc. 2002 Oct; 77(10):1085-92. View PubMed Wright RS, Williams BA, Cramner H, Gallahue F, Willmore T, Lewis L, Ladenson JH, Jaffe AS. Elevations of cardiac troponin I are associated with increased short-term mortality in noncardiac critically ill emergency department patients. Am J Cardiol. 2002 Sep 15; 90 (6):634-6 View PubMed Bybee KA, Wright RS, Kopecky SL. Effect of early statin therapy after acute coronary syndromes: a concise review of the recent data. Cardiol Rev. 2002 Sep-Oct; 10 (5):301-5 View PubMed Cantwell RV, Aviles RJ, Bjornsson J, Wright RS, Freeman WK, Oh JK, Hoyer JD, Markovic S, Jaffe AS. Cardiac amyloidosis presenting with elevations of cardiac troponin I and angina pectoris. 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Bundle branch block as a predictor of long-term survival after acute myocardial infarction. Am J Cardiol. 2001 Aug 1; 88 (3):205-9 View PubMed Suwaidi JA, Wright RS, Grill JP, Hensrud DD, Murphy JG, Squires RW, Kopecky SL. Obesity is associated with premature occurrence of acute myocardial infarction. Clin Cardiol. 2001 Aug; 24 (8):542-7 View PubMed Sgura FA, Wright RS, Kopecky SL, Grill JP, Reeder GS. Length of stay in myocardial infarction. Cost Qual. 2001 Jun; 12-20, 25 View PubMed Miller WL, Sgura FA, Kopecky SL, Asirvatham SJ, Williams BA, Wright RS, Reeder GS. Characteristics of presenting electrocardiograms of acute myocardial infarction from a community-based population predict short- and long-term mortality. Am J Cardiol. 2001 May 1; 87 (9):1045-50 View PubMed Bybee KA, Wright RS, Williams BA, Murphy JG, Holmes DR Jr, Holmes DR Jr, Kopecky SL. Effect of concomitant or very early statin administration on in-hospital mortality and reinfarction in patients with acute myocardial infarction. Am J Cardiol. 2001 Mar 15; 87 (6):771-4, A7 View PubMed Xue J, Taha B, Reddy S, Wright RS, Aufderheide T. A new method to incorporate age and gender into the criteria for the detection of acute inferior myocardial infarction. J Electrocardiol. 2001; 34 Suppl:229-34. View PubMed Wright RS, Kopecky SL, Reeder GS. Update on intravenous fibrinolytic therapy for acute myocardial infarction. Mayo Clin Proc. 2000 Nov; 75 (11):1185-91; quiz 1192 View PubMed Miller WL, Wright RS, Grill JP, Kopecky SL. Improved survival after acute myocardial infarction in patients with advanced Killip class. Clin Cardiol. 2000 Oct; 23 (10):751-8 View PubMed Wright RS, Monnahan RL, Kopecky SL, Jones CT, Holmes DR Jr, Holmes DR Jr. Cardiac catheterization reduces resource utilization in patients with chronic chest pain. 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Improved Short and Long-Term Survival of Acute Myocardial Infarction in Patients with Advanced Killip Class: Impact of Reperfusion Therapy and Adjunct Medical Therapy on Survival. Clin Card. 2000; 23:751-8. Verneuil A, Boeve BF, Fulgham JR, Johnson CM, Wright RS. Persistent cauda equina syndrome following bilateral aortoiliac dissection as a complication of cardiac angiography. Cathet Cardiovasc Diagn. 1997 Apr; 40(4):377-9. View PubMed Wright RS, Wei CM, Kim CH, Kinoshita M, Matsuda Y, Aarhus LL, Burnett JC Jr, Miller WL. C-type natriuretic peptide-mediated coronary vasodilation: role of the coronary nitric oxide and particulate guanylate cyclase systems. J Am Coll Cardiol. 1996 Oct; 28 (4):1031-8 View PubMed Clavell AL, Mattingly MT, Stevens TL, Nir A, Wright S, Aarhus LL, Heublein DM, Burnett JC Jr. Angiotensin converting enzyme inhibition modulates endogenous endothelin in chronic canine thoracic inferior vena caval constriction. 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