Publicaciones Imprimir Dcunha R, Mutalik SP, Reji RA, Mutalik S, Kalthur SG, Hegde P, Murari MS, Raghu SV, Banerjee S, Kumar A, Adiga SK, Zhao Y, Kannan N, Kalthur G. Liposome-based Freezing Medium Improves the Outcome of Mouse Prepubertal Testicular Tissue Cryopreservation. Reprod Sci. 2024 Nov; 31 (11):3532-3548 Epub 2024 Sept 19 View PubMed Mun DG, Bhat FA, Joshi N, Sandoval L, Ding H, Jain A, Peterson JA, Kang T, Pujari GP, Tomlinson JL, Budhraja R, Zenka RM, Kannan N, Kipp BR, Dasari S, Gaspar-Maia A, Smoot RL, Kandasamy RK, Pandey A. Diversity of post-translational modifications and cell signaling revealed by single cell and single organelle mass spectrometry. Commun Biol. 2024 Jul 19; 7 (1):884 Epub 2024 July 19 View PubMed Kannan N, Deshpande AJ. Connie J. Eaves (1944-2024). Nat Rev Cancer 2024 Jul; 24 (7):443 View PubMed Aalam SMM, Nguyen LV, Ritting ML, Kannan N. Clonal tracking in cancer and metastasis. Cancer Metastasis Rev. 2024 Jun; 43 (2):639-656 Epub 2023 Nov 01 View PubMed Dcunha R, Kumari S, Najar MA, Aravind A, Suvarna KS, Hanumappa A, Mutalik SP, Mutalik S, Kalthur SG, Rajanikant GK, Siddiqui S, Alrumman S, Alamri SAM, Raghu SV, Adiga SK, Kannan N, Thottethodi Subrahmanya KP, Kalthur G. High doses of clethodim-based herbicide GrassOut Max poses reproductive hazard by affecting male reproductive function and early embryogenesis in Swiss albino mice. Chemosphere. 2023 Sep; 336:139215 Epub 2023 June 17 View PubMed Crasta DN, Nair R, Kumari S, Dutta R, Adiga SK, Zhao Y, Kannan N, Kalthur G. Haploid Parthenogenetic Embryos Exhibit Unique Stress Response to pH, Osmotic and Oxidative Stress. Reprod Sci. 2023 Jul; 30 (7):2137-2151 Epub 2023 Jan 23 View PubMed Ogony J, Hoskin TL, Stallings-Mann M, Winham S, Brahmbhatt R, Arshad MA, Kannan N, Pena A, Allers T, Brown A, Sherman ME, Visscher DW, Knutson KL, Radisky DC, Degnim AC. Immune cells are increased in normal breast tissues of BRCA1/2 mutation carriers. Breast Cancer Res Treat. 2023 Jan; 197 (2):277-285 Epub 2022 Nov 16 View PubMed Thirusangu P, Ray U, Sarkar Bhattacharya S, Oien DB, Jin L, Staub J, Kannan N, Molina JR, Shridhar V. Correction to: PFKFB3 regulates cancer stemness through the hippo pathway in small cell lung carcinoma. Oncogene. 2023 Jan; 42 (1):79-82 View PubMed Aalam SMM, Crasta DN, Roy P, Miller AL 2nd, Gamb SI, Johnson S, Till LM, Chen J, Kashyap P, Kannan N. Genesis of fecal floatation is causally linked to gut microbial colonization in mice. Sci Rep. 2022 Oct 27; 12 (1):18109 View PubMed Poojary PS, Nayak G, Panchanan G, Rao A, Kundapur SD, Kalthur SG, Mutalik S, Adiga SK, Zhao Y, Bakkum-Gamez J, Chang AY, DeStephano C, Sherman M, Kannan N, Kalthur G. Distinctions in PCOS Induced by Letrozole Vs Dehydroepiandrosterone With High-fat Diet in Mouse Model. Endocrinology. 2022 Sep 1; 163 (9) View PubMed Musheer Aalam SM, Viringipurampeer IA, Walb MC, Tryggestad EJ, Emperumal CP, Song J, Xu X, Saini R, Lombaert IMA, Sarkaria JN, Garcia J, Janus JR, Kannan N. Characterization of Transgenic NSG-SGM3 Mouse Model of Precision Radiation-Induced Chronic Hyposalivation. Radiat Res. 2022 Sep 1; 198 (3):243-254 View PubMed Aalam SMM, Tang X, Song J, Ray U, Russell SJ, Weroha SJ, Bakkum-Gamez J, Shridhar V, Sherman ME, Eaves CJ, Knapp DJHF, Kalari KR, Kannan N. DNA barcoded competitive clone-initiating cell analysis reveals novel features of metastatic growth in a cancer xenograft model. NAR Cancer. 2022 Sep; 4 (3):zcac022 Epub 2022 July 22 View PubMed Thirusangu P, Ray U, Sarkar Bhattacharya S, Oien DB, Jin L, Staub J, Kannan N, Molina JR, Shridhar V. PFKFB3 regulates cancer stemness through the hippo pathway in small cell lung carcinoma. Oncogene. 2022 Aug; 41 (33):4003-4017 Epub 2022 July 08 View PubMed Ray U, Pathoulas CL, Thirusangu P, Purcell JW, Kannan N, Shridhar V. Exploiting LRRC15 as a Novel Therapeutic Target in Cancer. Cancer Res. 2022 May 3; 82 (9):1675-1681 View PubMed He Z, Ghorayeb R, Tan S, Chen K, Lorentzian AC, Bottyan J, Aalam SMM, Pujana MA, Lange PF, Kannan N, Eaves CJ, Maxwell CA. Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation. Nat Commun. 2022 Apr 22; 13 (1):2200 View PubMed Ray U, Jung DB, Jin L, Xiao Y, Dasari S, Sarkar Bhattacharya S, Thirusangu P, Staub JK, Roy D, Roy B, Weroha SJ, Hou X, Purcell JW, Bakkum-Gamez JN, Kaufmann SH, Kannan N, Mitra AK, Shridhar V. Targeting LRRC15 Inhibits Metastatic Dissemination of Ovarian Cancer. Cancer Res. 2022 Mar 15; 82 (6):1038-1054 View PubMed Dcunha R, Hussein RS, Ananda H, Kumari S, Adiga SK, Kannan N, Zhao Y, Kalthur G. Current Insights and Latest Updates in Sperm Motility and Associated Applications in Assisted Reproduction. Reprod Sci. 2022 Jan; 29 (1):7-25 Epub 2020 Dec 07 View PubMed Crasta DN, Adiga SK, Kannan N, Kalthur G. Artificial Activation of Murine Oocytes Using Strontium to Derive Haploid and Diploid Parthenotes. Methods Mol Biol. 2022; 2429:15-26 View PubMed Feng L, Yang W, Zhao H, Bakkum-Gamez J, Sherman ME, Kannan N. Protocol for the Detection of Organoid-Initiating Cell Activity in Patient-Derived Single Fallopian Tube Epithelial Cells. Methods Mol Biol. 2022; 2429:445-454 View PubMed Young K, Lawlor RT, Ragulan C, Patil Y, Mafficini A, Bersani S, Antonello D, Mansfield D, Cingarlini S, Landoni L, Pea A, Luchini C, Piredda L, Kannan N, Nyamundanda G, Morganstein D, Chau I, Wiedenmann B, Milella M, Melcher A, Cunningham D, Starling N, Scarpa A, Sadanandam A. Immune landscape, evolution, hypoxia-mediated viral mimicry pathways and therapeutic potential in molecular subtypes of pancreatic neuroendocrine tumours. Gut. 2021 Oct; 70 (10):1904-1913 Epub 2020 Sept 03 View PubMed Osborne J, Salta E, Hu H, Shook B, Li Y, Kannan N. Introductions to the Community: Early-Career Researchers in the Time of COVID-19. Cell Stem Cell. 2021 Mar 4; 28 (3):367-369 View PubMed Sadanandam A, Bopp T, Dixit S, Knapp DJHF, Emperumal CP, Vergidis P, Rajalingam K, Melcher A, Kannan N. A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patients. Cell Death Discov. 2020 Dec 8; 6 (1):141 Epub 2020 Dec 08 View PubMed Mun DG, Renuse S, Saraswat M, Madugundu A, Udainiya S, Kim H, Park SR, Zhao H, Nirujogi RS, Na CH, Kannan N, Yates JR 3rd, Lee SW, Pandey A. PASS-DIA: A Data-Independent Acquisition Approach for Discovery Studies. Anal Chem. 2020 Nov 3; 92 (21):14466-14475 Epub 2020 Oct 20 View PubMed Kent DG, Knapp DJHF, Kannan N. Survey Says: "COVID-19 Lockdown Hits Young Faculty and Clinical Trials". Stem Cell Reports. 2020 Jul 14; 15 (1):1-5 Epub 2020 June 22 View PubMed Trabert B, Sherman ME, Kannan N, Stanczyk FZ. Progesterone and Breast Cancer. Endocr Rev. 2020 Apr 1; 41 (2) View PubMed Huda N, Xu Y, Bates AM, Rankin DA, Kannan N, Gilley D. Onset of Telomere Dysfunction and Fusions in Human Ovarian Carcinoma. Cells. 2019 May 4; 8 (5) Epub 2019 May 04 View PubMed Nguyen LV, Makarem M, Kannan N, Carles A, Balani S, Moksa M, Hirst M, Eaves CJ. Clonal Analysis of Mouse Mammary Luminal Epithelial Cell Transplants. Stem Cells Dev. 2019 Mar 1; 28 (5):353-355 Epub 2019 Jan 31 View PubMed Aalam SMM, Beer PA, Kannan N. Assays for functionally defined normal and malignant mammary stem cells. Adv Cancer Res. 2019; 141:129-174 Epub 2019 Jan 17 View PubMed Kannan N, Eaves CJ. Macrophages stimulate mammary stem cells. Science 2018 Jun 29; 360 (6396):1401-1402 View PubMed Knapp DJHF, Kannan N, Pellacani D, Eaves CJ. Mass Cytometric Analysis Reveals Viable Activated Caspase-3(+) Luminal Progenitors in the Normal Adult Human Mammary Gland. Cell Rep. 2017 Oct 24; 21 (4):1116-1126 View PubMed He Z, Kannan N, Nemirovsky O, Chen H, Connell M, Taylor B, Jiang J, Pilarski LM, Fleisch MC, Niederacher D, Pujana MA, Eaves CJ, Maxwell CA. BRCA1 controls the cell division axis and governs ploidy and phenotype in human mammary cells. Oncotarget. 2017 May 16; 8 (20):32461-32475 View PubMed Morris EJ, Kawamura E, Gillespie JA, Balgi A, Kannan N, Muller WJ, Roberge M, Dedhar S. Stat3 regulates centrosome clustering in cancer cells via StathminPLK1. Nat Commun. 2017 May 05; 8:15289. View PubMed Pellacani D, Bilenky M, Kannan N, Heravi-Moussavi A, Knapp DJ, Gakkhar S, Moksa M, Carles A, Moore R, Mungall AJ, Marra MA, Jones SJ, Aparicio S, Hirst M, Eaves CJ. Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks. Cell Rep. 2016 Nov 15; 17: (8)2060-2074. View PubMed Nguyen LV, Pellacani D, Lefort S, Kannan N, Osako T, Makarem M, Cox CL, Kennedy W, Beer P, Carles A, Moksa M, Bilenky M, Balani S, Babovic S, Sun I, Rosin M, Aparicio S, Hirst M, Eaves CJ. Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells. Nature. 2015 Dec 10; 528: (7581)267-71. View PubMed Kang SY, Kannan N, Zhang L, Martinez V, Rosin MP, Eaves CJ. Characterization of Epithelial Progenitors in Normal Human Palatine Tonsils and Their HPV16 E6/E7-Induced Perturbation. Stem Cell Reports. 2015 Dec 8; 5: (6)1210-25. View PubMed Bugide S, David D, Nair A, Kannan N, Samanthapudi VS, Prabhakar J, Manavathi B. Hematopoietic PBX-interacting protein (HPIP) is over expressed in breast infiltrative ductal carcinoma and regulates cell adhesion and migration through modulation of focal adhesion dynamics. Oncogene. 2015 Aug 27; 34: (35)4601-12. View PubMed Joshi PA, Waterhouse PD, Kannan N, Narala S, Fang H, Di Grappa MA, Jackson HW, Penninger JM, Eaves C, Khokha R. RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1. Stem Cell Reports. 2015 Jul 14; 5: (1)31-44. View PubMed von Palffy S, Bulaeva E, Babovic S, Kannan N, Knapp DJ, Wei L, Eaves CJ, Beer PA. Dominant-negative IKAROS enhances IL-3-stimulated signaling in wild-type but not BCR-ABL1(+) mouse BA/F3 cells. Exp Hematol. 2015 Jul; 43 (7):514-23.e1-2 Epub 2015 May 04 View PubMed Beer PA, Knapp DJ, Miller PH, Kannan N, Sloma I, Heel K, Babovic S, Bulaeva E, Rabu G, Terry J, Druker BJ, Loriaux MM, Loeb KR, Radich JP, Erber WN, Eaves CJ. Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression. Blood. 2015 Jan 15; 125: (3)504-15. View PubMed Beer PA, Knapp DJ, Kannan N, Miller PH, Babovic S, Bulaeva E, Aghaeepour N, Rabu G, Rostamirad S, Shih K, Wei L, Eaves CJ. A dominant-negative isoform of IKAROS expands primitive normal human hematopoietic cells. Stem Cell Reports. 2014 Nov 11; 3: (5)841-57. View PubMed Chakrabarti R, Wei Y, Hwang J, Hang X, Andres Blanco M, Choudhury A, Tiede B, Romano RA, DeCoste C, Mercatali L, Ibrahim T, Amadori D, Kannan N, Eaves CJ, Sinha S, Kang Y. DeltaNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling. Nat Cell Biol. 2014 Oct; 16: (10)1004-15, 1-13. View PubMed Kannan N, Eaves CJ. Tipping the balance: MTDH-SND1 curbs oncogene-induced apoptosis and promotes tumorigenesis. Cell Stem Cell. 2014 Aug 7; 15: (2)118-20. View PubMed Kannan N, Nguyen LV, Makarem M, Dong Y, Shih K, Eirew P, Raouf A, Emerman JT, Eaves CJ. Glutathione-dependent and -independent oxidative stress-control mechanisms distinguish normal human mammary epithelial cell subsets. Proc Natl Acad Sci U S A. 2014 May 27; 111: (21)7789-94. View PubMed Kannan N, Nguyen LV, Eaves CJ. Integrin beta3 links therapy resistance and cancer stem cell properties. Nat Cell Biol. 2014 May; 16: (5)397-9. View PubMed Nguyen LV, Makarem M, Carles A, Moksa M, Kannan N, Pandoh P, Eirew P, Osako T, Kardel M, Cheung AM, Kennedy W, Tse K, Zeng T, Zhao Y, Humphries RK, Aparicio S, Eaves CJ, Hirst M. Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells. Cell Stem Cell. 2014 Feb 6; 14: (2)253-63. View PubMed Nguyen LV, Cox CL, Eirew P, Knapp DJ, Pellacani D, Kannan N, Carles A, Moksa M, Balani S, Shah S, Hirst M, Aparicio S, Eaves CJ. DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts. Nat Commun. 2014; 5:5871. View PubMed Kawamura E, Fielding AB, Kannan N, Balgi A, Eaves CJ, Roberge M, Dedhar S. Identification of novel small molecule inhibitors of centrosome clustering in cancer cells. Oncotarget. 2013 Oct; 4: (10)1763-76. View PubMed Makarem M, Spike BT, Dravis C, Kannan N, Wahl GM, Eaves CJ. Stem cells and the developing mammary gland. J Mammary Gland Biol Neoplasia. 2013 Jun; 18: (2)209-19. View PubMed Kannan N, Huda N, Tu L, Droumeva R, Aubert G, Chavez E, Brinkman RR, Lansdorp P, Emerman J, Abe S, Eaves C, Gilley D. The luminal progenitor compartment of the normal human mammary gland constitutes a unique site of telomere dysfunction. Stem Cell Reports. 2013; 1: (1)28-37. View PubMed Makarem M, Kannan N, Nguyen LV, Knapp DJ, Balani S, Prater MD, Stingl J, Raouf A, Nemirovsky O, Eirew P, Eaves CJ. Developmental changes in the in vitro activated regenerative activity of primitive mammary epithelial cells. PLoS Biol. 2013; 11: (8)e1001630. View PubMed Eirew P, Kannan N, Knapp DJ, Vaillant F, Emerman JT, Lindeman GJ, Visvader JE, Eaves CJ. Aldehyde dehydrogenase activity is a biomarker of primitive normal human mammary luminal cells. Stem Cells. 2012 Feb; 30: (2)344-8. View PubMed Kannan N, Kang J, Kong X, Tang J, Perry JK, Mohankumar KM, Miller LD, Liu ET, Mertani HC, Zhu T, Grandison PM, Liu DX, Lobie PE. Trefoil factor 3 is oncogenic and mediates anti-estrogen resistance in human mammary carcinoma. Neoplasia. 2010 Dec; 12: (12)1041-53. View PubMed Leung E, Kannan N, Krissansen GW, Findlay MP, Baguley BC. MCF-7 breast cancer cells selected for tamoxifen resistance acquire new phenotypes differing in DNA content, phospho-HER2 and PAX2 expression, and rapamycin sensitivity. Cancer Biol Ther. 2010 May 1; 9: (9)717-24. View PubMed Amiry N, Kong X, Muniraj N, Kannan N, Grandison PM, Lin J, Yang Y, Vouyovitch CM, Borges S, Perry JK, Mertani HC, Zhu T, Liu D, Lobie PE. Trefoil factor-1 (TFF1) enhances oncogenicity of mammary carcinoma cells. Endocrinology. 2009 Oct; 150: (10)4473-83. View PubMed Mohankumar KM, Perry JK, Kannan N, Kohno K, Gluckman PD, Emerald BS, Lobie PE. Transcriptional activation of signal transducer and activator of transcription (STAT) 3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell. Endocrinology. 2008 May; 149: (5)2219-29. View PubMed Perry JK, Kannan N, Grandison PM, Mitchell MD, Lobie PE. Are trefoil factors oncogenic? Trends Endocrinol Metab. 2008 Mar; 19: (2)74-81. View PubMed Mohankumar KM, Xu XQ, Zhu T, Kannan N, Miller LD, Liu ET, Gluckman PD, Sukumar S, Emerald BS, Lobie PE. HOXA1-stimulated oncogenicity is mediated by selective upregulation of components of the p44/42 MAP kinase pathway in human mammary carcinoma cells. Oncogene. 2007 Jun 7; 26: (27)3998-4008. View PubMed Xu XQ, Emerald BS, Goh EL, Kannan N, Miller LD, Gluckman PD, Liu ET, Lobie PE. Gene expression profiling to identify oncogenic determinants of autocrine human growth hormone in human mammary carcinoma. J Biol Chem. 2005 Jun 24; 280: (25)23987-4003. View PubMed PST-20306754 Inicio Publicaciones