Surgery

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer

   Rochester, Minn., Scottsdale/Phoenix, Ariz., Jacksonville, Fla.

   The purpose of this study is to compare the effectiveness of RO7198457 versus watchful waiting in patients with circulating tumor DNA (ctDNA) positive, surgically resected Stage II/III rectal cancer, or Stage II (high risk)/Stage III colon cancer.

2. A Study to Evaluate a Virtual Assistant for Plastic Surgery Patients

   Jacksonville, Fla.

   The purpose of this study is to determine the impact of a recently developed artificial intelligence virtual assistant (AIVA) on plastic surgery patients and providers’ experience and leverage the use of new technologies to promote high-quality service and meaningful relationships between plastic surgeons and patients.

3. A Study to Evaluate the Use of Micropulse Trans-Scleral Cyclophotocoagulation Laser (MP-TSCPC) for Glaucoma Patients

   Jacksonville, Fla.

   The purpose of this study is to evaluate the clinical outcomes of the Micropulse Trans-Scleral Cyclophotocoagulation Laser (MPTSCPC) after 1 day, 1 week,1 month, 3 months, 6 months and one year of follow-up. Its primary objective is to conduct a prospective observational study on the efficacy of using MP-TSCPC to treat glaucoma patients.

4. Validating Watson Talent Software as a Useful Tool to Aid Program Directors in Selecting Applicants to Interview

   Jacksonville, Fla.

   The purpose of this study is to validate Watson Talent software as a useful tool to aid program directors in their task of selecting applicants to interview, reducing time and costs to review applications and improve reliability, accuracy, and precision of this process.

5. A Study to Compare Nivolumab Administered Subcutaneously vs Intravenous in Melanoma Participants Following Complete Resection

   Jacksonville, Fla.

   The purpose of this study is to compare the drug levels of nivolumab administered subcutaneously versus intravenous administration in participants with melanoma following complete resection.

6. Image-based Mapping of Brain Tumors

   Scottsdale/Phoenix, Ariz., Rochester, Minn.

   The purpose of this study is to combine MRI images with histologic and genetic analysis of cancer (from blood and tissue samples) to improve the overall accuracy of diagnosis and effectiveness of cancer treatment.

    

7. Brain Tumor Repository

   Scottsdale/Phoenix, Ariz.

   The main objective of the Brain Tumor Repository is to allow access to coded patient data by researchers both inside and outside of the Mayo Clinic system so that important research questions can be answered.  Biospecimens will be collected and curated including excess fresh tissue collected during routine surgery, peripheral blood and urine at routine clinical followup times.

8. A Study to Evaluate Comprehensive Arthroscopic Management (CAM) Procedure with Bone Marrow Aspirate Concentrate (BMAC) for Shoulder Osteoarthritis (OA)

   Jacksonville, Fla.

   The purpose of this study is to evaluate the safety and feasibility of concentrated bone marrow aspirate administration after Comprehensive Arthroscopic Management (CAM) surgical procedure, and to determine pain relief, disease progression and range of motion in patients with osteoarthritis of the shoulder.

9. Study to Evaluate the Utility, Safety, Effectiveness, and Cost of Physical Therapy on Elective Spine Surgery Patients

   Jacksonville, Fla.

   The purpose of this study is to evaluate the utility, safety, effectiveness, and cost of physical therapy on elective spine surgery patients.

10. A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients with Recurrent Glioblastoma with Elevated Mutational Burden

    Jacksonville, Fla., Rochester, Minn., La Crosse, Wis., Scottsdale/Phoenix, Ariz., Eau Claire, Wis.

    The purpose of this study is to evaluate the effect of immunotherapy drugs (ipilimumab and nivolumab) in treating patients with glioblastoma that has come back (recurrent) and carries a high number of mutations. Cancer is caused by changes (mutations) to genes that control the way cells function. Tumors with high number of mutations may respond well to immunotherapy. Immunotherapy with monoclonal antibodies such as ipilimumab and nivolumab may help the body's immune system attack the cancer and may interfere with the ability of tumor cells to grow and spread. Giving ipilimumab and nivolumab may lower the chance of recurrent glioblastoma with high number of mutations from growing or spreading compared to usual care (surgery or chemotherapy).