Surgery

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study to Evaluate Support Services for Managing Urological Conditions

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to assess if men and women seeking care for urological diseases have interest in support services in conjunction with standard of care.

2. A Study of Mood Symptoms in Epilepsy Patients

   Rochester, Minn.

   The purpose of this study is to track neuropsychiatric symptoms in patients with epilepsy.

3. A Study to Evaluate the Safety and Effectiveness of Adherus™ AutoSpray and Adherus™ AutoSpray ET Dural Sealant

   Rochester, Minn., Jacksonville, Fla.

   The purpose of this study is to evaluate the safety and effectiveness of Adherus Dural Sealant when used in conjunction with standard methods of dural repair in spinal procedures. This trial uses the commercially available DuraSeal Exact (P080013b) as an active control. The trial is designed to demonstrate non-inferiority of Adherus Dural Sealant to DuraSeal Exact.
   Subjects who have consented to participate in this study prior to undergoing spinal surgery and experience a durotomy, will be considered for study enrollment.
    

4. A Study to Evaluate Novel Nipple Reconstruction Technique Using Nipple Sharing of a Half-Split Nipple in Female-to-Male Transgender Chest-Wall Contouring

   Rochester, Minn.

   The purpose of this study is to describe a new surgical technique for nipple reconstruction in female-to-male transgender chest wall reconstruction and demonstrate its safety, patient satisfaction, aesthetic evaluation and complications. Subsequently, correlate these findings to assess overall surgical and clinical outcomes.

5. Posterior Fossa Decompression with or without Duraplasty for Chiari Type I Malformation with Syringomyelia

   Rochester, Minn.

   The purpose of this study is to determine whether a posterior fossa decompression or a posterior fossa decompression with duraplasty results in better patient outcomes with fewer complications and improved quality of life in those who have Chiari malformation type I and syringomyelia.

6. A Study to Evaluate Outcomes of Pectoralis Minor and Brachial Plexus Release

   Rochester, Minn.

   The purpose of this study is to to assess the clinical and radiographic outcomes of patients who have undergone shoulder arthroplasty.

7. A Study to Evaluate Whether or Not Pelvic Peritonectomy Improves Quality of Life for Patients Regardless of Endometriosis Pathology?

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to investigate if complete pelvic peritonectomy is associated with improved quality of life in patients with chronic pelvic pain without histologic diagnosis of endometriosis as compared to patients with histologic diagnosis of endometriosis. 

8. Randomized Phase II/III Trial of Adjuvant Radiation Therapy with Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck

   Rochester, Minn.

   This randomized phase II/III trial studies how well radiation therapy works when given together with cisplatin compared to docetaxel or cetuximab and docetaxel after surgery in treating patients with stage III-IV squamous cell head and neck cancer. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or transmit tumor killing molecules to them. It is not yet known whether radiation therapy is more effective when given with cisplatin, docetaxel, or cetuximab and docetaxel.

9. A Study to Analyze NMS-03305293 and Temozolomide in Adult Patients with Recurrent Glioblastoma

   Rochester, Minn., Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

   The objectives of this study are to determine the Maximum Tolerated Dose (MTD) and the Recommended Phase 2 Dose (RP2D) of NMS-03305293 in combination with temozolomide (TMZ) in patients with diffuse gliomas at first relapse (Phase I),  and to determine the antitumor effectiveness of the combination of NMS-03305293 and TMZ in patients with isocitrate dehydrogenase (IDH) wild type glioblastoma at first relapse as measured by the 6-month Progression Free Survival (PFS) rate (Phase II).

10. Early Outcomes of Volar Capsulodesis for the Treatment of Scapholunate Ligament Injury

    Rochester, Minn.

    The purpose of this study is to:

    1. To provide a comprehensive review of Mayo Clinic’s experience with volar SLIL capsulodesis
    2. Investigate the relationships between patient risk factors and clinical variables with functional outcomes and patient satisfaction
    3. Determine rates of complication, revision surgeries and salvage for failure