Surgery

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Randomized Phase II/III Trial of Adjuvant Radiation Therapy with Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck

   Rochester, Minn.

   This randomized phase II/III trial studies how well radiation therapy works when given together with cisplatin compared to docetaxel or cetuximab and docetaxel after surgery in treating patients with stage III-IV squamous cell head and neck cancer. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or transmit tumor killing molecules to them. It is not yet known whether radiation therapy is more effective when given with cisplatin, docetaxel, or cetuximab and docetaxel.

2. A Study to Evaluate Manipulation Under Anesthesia After Bilateral Primary Total Knee Arthroplasty

   Rochester, Minn.

   The purpose of this study is to determine unique genetic profile of patients requiring MUA following bilateral pTKA via genetic sequencing, to determine outcomes of patients receiving MUA in terms of KSS, implant durability, survival free of reoperation, and to define characteristics and comorbidities of patients undergoing unilateral and bilateral MUA.

3. MElanoma Research Lymph node prediction Implementation National_001 (MERLIN_001)

   Rochester, Minn.

   This study aims to create a registry for primary melanoma gene-signature to predict sentinel node (SN) status and determine its prognostic value for more accurate staging of SN-negative melanoma patients.

4. Trial of Multi-epitope HER2 Peptide Vaccine in Patients with HER2-expressing DCIS

   Jacksonville, Fla., Rochester, Minn.

   The purpose of this study is to determine the safety, effcicacy and tolerability of H2NVAC in patients with HER2-expressing DCIS in order to  prevent future invasive breast cancer among patients who are diagnosed with DCIS.

5. A Study to Assess the Effect of Radial Deviation on the Pronated Grip

   Rochester, Minn.

   The purpose of this study is to describe a practical and reproducible radiographic view that can be used in the work-up of ulnocarpal impaction.

6. Outcome of Capsular Release for Elbow Contracture

   Rochester, Minn.

   The purpose of this study is to assess the outcome and complications of capsular release for elbow contractures.

    

7. A Study to Assess Long-term Symptom Improvement and Recurrence after Operative Management of Popliteal Artery Entrapment Syndrome (PAES)

   Rochester, Minn.

   The purpose of this study is to evaluate long-term symptom resolution and quality of life improvements after operative management of popliyteal artery entrapment syndrome (PAES).

8. A Study to Compare Somatostatin Analogues with Perioperative Antibiotics versus Prolonged Antibiotics

   Rochester, Minn.

   The purpose of this study is to to determine the individual treatment effect of somatostatin and whether duration of antibiotic therapy coupled with octreotide provides improved outcomes after pancreaticoduodenectomy. 

9. Mayo Clinic Upper Digestive Disease Survey

   Rochester, Minn.

   The Mayo Clinic Upper Digestive Disease Survey has been created in order to have a consistent evaluation tools for patients undergoing esophageal reconstruction or treatment  or patients that are experiencing an upper digestive disease in order to standardize and validate outcome measures.  Data will be used to establish the validation of the questionnaires/survey.  Data will also lead to the establishment of “normal” or expected scores for patients undergoing each type of esophagectomy procedure and for upper digestive diseases.  Data will contribute to creating treatment algorithms for symptom management for upper digestive diseases and for post-operative complications and symptoms as well as contribute to pre-operative education.  

10. Aggressive Malignancy PDX (Avatar) and Cryopreservation Program

    Rochester, Minn.

    The purpose of this study is to assess the ability to successfully create numerous validated patient-derived xenograft (PDX) models from patient tumor specimens obtained at surgery/biopsy via the new Pathology/TRAG cryopreservation protocol, and to generate a large catalog and repertoire of previously unavailable histologically validated PDX.