Children's Center

Below are current clinical trials.

78 studies in Children's Center
(open studies only).

Filter this list of studies by location, status and more.

1. Monogenic Kidney Stone - Genetic Testing

   Rochester, Minn.

   90 genes related to Monogenic Stone Disease will be determined via DNA analysis by the Mayo Rare Kidney Stone Consortium (RKSC) research staff.

2. Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma

   Rochester, Minn.

   The purpose of this study is to estimate the event-free survival (EFS) distribution for newly-diagnosed patients with BRAFV600-mutant high-grade glioma (HGG) without H3 K27M mutations excluding anaplastic pleomorphic xanthoastrocytoma (aPXA) and anaplastic ganglioglioma (aGG) treated with radiation therapy followed by a maintenance combination of dabrafenib and trametinib and to compare this EFS to contemporary historical controls.

3. Accelerated vs Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours

   Rochester, Minn.

   The purpose of this study is to determine whether accelerated BEP chemotherapy is more effective than standard BEP chemotherapy in males with intermediate and poor-risk metastatic germ cell tumours.

4. A Study to Establish a Retinoblastoma Patient Clinical Database and Tissue Repository

   Rochester, Minn.

   The purpose of this study is to systematically and prospectively record accurate and complete data regarding the clinical presentation, treatment, and outcomes of patients diagnosed with RB; collect, bank, preserve, and analyze biomaterials from patients with RB, and to correlate phenotypic data with findings from human biomaterials.

    

5. Extension Study to Evaluate How Safe and Tolerable NBI-921352 is as an Adjunctive Therapy for Subjects With SCN8A-DEE

   Rochester, Minn.

   The purpose of this study is to evaluate the long-term safety and tolerability of NBI-921352 when administered for up to 106 weeks. Also, to investigate the effect of NBI-921352 on long-term seizure control.

6. A Study to Evaluate the Spectrum of Healthy Pediatric Inflammatory Responses to Vaccinations

   Rochester, Minn.

   The purpose of this study is to understand the role of systemic inflammation in the genesis of seizures in susceptible children by gaining a clearer understanding of the spectrum of inflammatory responses that occur in healthy children post-vaccinations.

7. Evaluating Patterns of and Changes in Hair Cortisol Levels in Pediatric Patients With Chronic Pain

   Rochester, Minn.

   The purpose of this study is to evaluate patterns of and changes in secretion levels of the stress hormone, cortisol and other steroid hormones (i.e. DHEA, testosterone, progesterone) from hair samples of 150 pediatric patients with chronic pain and a parent or caregiver upon admission and at 3 and 6 months after participation in Mayo Clinic’s intensive, interdisciplinary pediatric pain treatment program.

    

8. Pediatric Pain Rehabilitation Treatment Outcomes for Chronic Noncancer Pain

   Rochester, Minn.

   The purpose of the study is to learn more about adolescent and young adults' experience with chronic pain. In particular, we are studying factors which lead to pain-associated disability and factors which predict decreased disability during and after participation in a three-week intensive treatment program. In addition to gathering information from the young people with chronic pain, parents are also asked to give their perspective.