أورام الخلايا الجرثومية

نظرة عامة

أورام الخلايا الجرثومية هي نمو للخلايا يتكوّن من الخلايا التناسلية. وقد تكون هذه الأورام سرطانية أو غير سرطانية. تصيب معظم أورام الخلايا الجرثومية الخصيتين أو المبيضين.

وتظهر بعض أورام الخلايا الجرثومية في مناطق أخرى من الجسم كالبطن والدماغ والصدر، رغم عدم وضوح سبب ذلك. إلا أن أورام الخلايا الجرثومية التي تصيب مناطق أخرى غير الخصيتين والمبيضين (أورام الخلايا الجرثومية خارج الغدد التناسلية) نادرة جدًا.

يمكن أن تشمل الخيارات العلاجية لأورام الخلايا الجرثومية الجراحة لاستئصال الورم، والعلاج الكيميائي بالأدوية التي تقتل الخلايا السرطانية، والعلاج الإشعاعي بالحزم عالية الطاقة.

الأعراض

Symptoms of germ cell tumors depend on where they happen. Symptoms often happen because a growing tumor puts pressure on nearby tissue or organs. For example, a germ cell tumor in an ovary may lead to pelvic pain, back pain, bloating or swelling in the belly. A germ cell tumor in a testicle may cause swelling or pain in the testicle or scrotum. A lump in the testicle is a common symptom of a testicular germ cell tumor.

الأسباب

It's not clear what causes germ cell tumors. Germ cell tumors form in the cells that turn into eggs in the ovaries and into sperm in the testicles. Germ cell tumors happen when germ cells develop changes in their DNA. A cell's DNA holds the instructions that tell the cell what to do. In healthy cells, the DNA tells the cells to grow and multiply at a set rate. The DNA also tells the cells to die at a set time.

In tumor cells, the DNA changes give different instructions. The changes tell the tumor cells to grow and multiply quickly. Tumor cells can keep living when healthy cells would die. This causes too many cells. The tumor cells can form a mass that can grow and press on nearby tissue or organs.

Sometimes the DNA changes turn germ cells into cancer cells. Cancer cells can invade and destroy healthy body tissue. Cancer cells sometimes break away and spread to other parts of the body.

عوامل الخطورة

Factors that may raise the risk of germ cell tumors include:

• Young age. Germ cell tumors tend to happen at a young age. For example, germ cell tumors that form in the ovaries are more common before age 20. Germ cell tumors that form in the testicles are most common between the ages of 15 and 35.
• Undescended testicle. Having a testicle that doesn't move down into its proper place in the scrotum before birth may raise the risk of a germ cell tumor in that testicle. The medical term for this condition is cryptorchidism.

Healthcare professionals haven't found anything that can prevent germ cell tumors.