医疗专业人员

下面列出了当前开展的临床试验。

根据地点、状态和其他条件对此研究列表进行过滤。

1. Hearing Genomics

   Rochester, Minn.

   Aims, purpose, or objectives:

   1) Develop hypotheses related to how the human genome and genetic variants affect hearing loss in children and adults.

   2) Understand phenotypes of hearing loss on a deeper level by combining and analyzing information from audiometric, genetic, and radiologic data.

   3) Explore genetic variants with an unknown significance to develop an understanding of their potential significance and explore other genes may influence an individual's hearing ability.

2. A Study to Identify Biomarkers in the Blood, Saliva or Tissue for Oropharyngeal Squamous Cell Cancer

   Rochester, Minn.

   The purpose of this study is to identify a biomarker (or biomarkers) that is present when disease is present (i.e., at diagnosis or recurrence) and not present when disease is absent (i.e., after treatment, in HPV negative patients or in normal controls).

3. Quality of Life in Patients with Acoustic Neuromas

   Rochester, Minn.

   Acoustic neuromas (also known as vestibular schwannomas) are benign slow growing tumors that arise from the vestibular portion of the eighth cranial nerve. Current treatment options include microsurgery, stereotactic radiosurgery and observation, using a “wait-and-scan” approach. The primary objective of this study is to compare long-term quality of life outcomes between treatments for sporadic acoustic neuromas.

4. A Study to Evaluate Quality of Life Outcomes for Cholesteatoma

   Rochester, Minn.

   The purpose of this study is to determine the quality of life scores for patients that have undergone subtotal petrosectomy and ear canal closure for cholesteatoma and/or chronic otitis media utilizing two previously validated quality-of-life scales.

5. Vocal Disorders Co-existing in Patients with Spasmotic Dsyphonia (SD)

   Jacksonville, Fla.

   The purpose of this study is to investigate if SD patients have vocal disorders (nodules, polyps, muscle tension dysphonia etc) more than in normal population.

6. BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

   Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

   The purpose of this study is to evaluate the feasibility of molecular characterization based on tumor mutational burden (TMB) for participant stratification, as assessed by the proportion of participants with less than or equal to a 21-day turnaround time for biopsy results in Stage I of the study. Also, to evaluate the feasibility of molecular characterization based on TMB and gene expression profiling (GEP) (for TIS - tumor inflammation signature) for stratification in the overall study (Stage I and Stage II). Additinoally, to evaluate the effectiveness by overall response rate (ORR – defined as confirmed and unconfirmed partial responses plus complete responses) of cabozantinib plus nivolumab in each disease cohort, both across and within tumor biomarker subgroups.

7. A Study of the Biological System of Allergic Fungal Sinusitis Mucin

   Jacksonville, Fla.

   The purpose of this study is to describe the proteome of mucus in patients without chronic rhinosinusitis (nCRS) with an emphasis on cytokines and bone morphogenic proteins present (BMPs), to describe the proteome of mucus in patients with chronic rhinosinusitis without polyps (CRSsNP) with an emphasis on cytokines and BMPs present, to describe the proteome of mucus in patients with allergic fungal sinusitis (AFRS) with an emphasis on cytokines and BMPs present, and to identify BMPs differentially elevated in patients with AFRS compared to patients with nCRS or CRS.

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8. In-home Versus In-Clinic Subcutaneous Nivolumab Administration through Connected and Remote Cancer CARE Beyond Walls

   Jacksonville, Fla.

   The purpose of this study is to evaluate the impact of the location of SQ Nivo administration, at the infusion center or in the home, on patient preference and acceptability, safety, patient reported outcomes (PROs), and clinical outcomes.

9. A Study to Develop a Biorepository of Blood Samples from Cancer Patients Participating in the Gemini (IRB 19-006717) Protocol

   Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

   The purpose of this study is to develop a biorepository of blood samples  from cancer patients participating in the Gemini (IRB 19-006717) protocol. These samples will be used for future biomarker discovery and other translational studies. 

10. A Study to Evaluate Impedance Monitoring in Cochlear Implants

    Rochester, Minn.

    The purpose of this study is to determine changes in cochlear implant electrode impedances as a function over a period of time.