Clinical Trials 下面列出了当前开展的临床试验。100 研究 Digestive Diseases (仅限开放研究). 根据地点、状态和其他条件对此研究列表进行过滤。 A Quality of Life Assessment of Patients with Biliary Obstruction Undergoing Endoscopic or Percutaneous Drainage Rochester, Minn., Scottsdale/Phoenix, Ariz., Jacksonville, Fla. The aim of this study is to compare the quality of life of patients with biliary obstruction who have undergone an endoscopic or percutaneous drainage. The quality of life of patients witll be assessed using the validated "European Quality of Life-5 Dimensions Questionnaire" and the "Intervention-Dependent Questionnaire" which was developed according to current literature as well as the expert opinion of gastroeneterologists. A Study to Evaluate Encorafenib Plus Cetuximab with/without Chemotherapy to Treat Metastatic Colorectal Cancer Scottsdale/Phoenix, Ariz., Rochester, Minn. The purpose of this study is to evaluate whether encorafenib plus cetuximab (EC), alone or in combination with chemotherapy, can improve clinical outcomes relative to current standard of care chemotherapy in participants with previously untreated BRAF V600E-mutant metastatic colorectal cancer (mCRC). SOFEED: Six Food vs. One Food Eosinophilic Esophagitis Diet Study Rochester, Minn. The purpose of this interventional study is to test and compare the effectiveness of two elimination diets—the 1-food elimination diet (1FED, milk only) and the 6-food elimination diet (6FED, milk, egg, wheat, soy, tree nut/peanuts, and fish/shellfish). The study will also test the effectiveness of swallowed glucocorticoid therapy in some of the study participants for whom diet therapy was not effective. A Study to Evaluate Ramucirumab Plus Trifluridine/Tipiracil to Treat Patients with Previously-treated Advanced Gastric or Gastro-esophageal Junction Adenocarcinoma Jacksonville, Fla., Scottsdale/Phoenix, Ariz. The purpose of this study is to compare, in a non-inferiority fashion, the progression-free survival (PFS) in patients with metastatic refractory gastric/Gastroesophageal Junction (GEJ) adenocarcinoma receiving the combination of ramucirumab with TAS-102 vs. paclitaxel and ramucirumab. A Study to Evaluate the Effect of POSE2 on Long-term Gastric Motor Function Rochester, Minn. The purpose of this study is to explore the effectiveness and safety of a modified gastroplication technique for weight loss in five patients with obesity, and includes physiologic appraisal of gastric emptying (via gastric emptying breath test) and post-prandial gastric accommodation (via SPECT). Novel Stomal Occlusion Device in Patients With a Brooke Ileostomy Rochester, Minn. This investigation constitutes an initial evaluation of the stoma occlusion device in humans with a mature permanent Brooke ileostomy. The overall objective of this study is to assess feasibility and initial operating characteristics of a novel stoma occlusion device. The study will recruit 20 patients for placement of the device into the mature Brooke ileostomy and subsequent 2 hour observation period. The device will remain in the ileostomy for up to 2 hours. Mucosal and Microbiota Changes During Acute Campylobacteriosis Rochester, Minn. Gastrointestinal (GI) infection with Campylobacter causes inflammation in the bowel and can change bacteria in the gut. Certain individuals with Campylobacter infection are also known to develop chronic bowel problems such as Irritable Bowel Syndrome (IBS). The researchers are doing this study to understand if changes in gut bacteria and gut mucosal lining during an acute infection can help identify individuals who might be at risk for developing problems in the future. Cohort of Patients With Fatty Liver Disease Jacksonville, Fla. The purpose of this research is to create a registry of patients having or at risk for metabolic liver disease for investigations into the molecular pathogenesis of cirrhosis, liver cancer, and end-stage liver disease. A Bio-bank for Patients with Inflammatory Bowel Disease Associated Neoplasia Rochester, Minn. The purpose of this study is to collect blood and stool samples to validate and improve the performance of stool and blood DNA markers for inflammatory bowel disease and colorectal neoplasia critical to the long-term goal of improving effectiveness of neoplasia detection in patients using non-invasive biomarkers to assist colonoscopy and radiographic screening. Post-sleeve Gastrectomy Gastroesophageal Reflux Disease Prediction Rochester, Minn. The purpose of this study is to identify a predictive model for worsening of preexisting gastroesophageal reflux disease (GERD) or development of de novo GERD after laparoscopic sleeve gastrectomy (LSG) by using EndoFLIP, upper endoscopy and esophageal manometry to assess patients preoperatively in a discovery cohort. This prospective predictive model will then identify sensitivity, specificity, positive and negative predictive values for prediction of worsening or de novo GERD. Pagination 临床研究 PrevPrevious Page Go to page 88 Go to page 99 Go to page 1010 医疗专业人员 Digestive Diseases clinical-trials