外科

以下为当前的临床试验。

按院区、状态和其他条件筛选该研究列表。

1. Genomic and Environmental Basis of Imperforate Anus

   Rochester, Minn.

   The study aims are to develop a consent-based IRB proposal that will enroll newborns who have imperforate anus.  The proposal will include permission for chart review and database information storage, to develop a database that will include MRN, imperforate anus phenotype, information on other congenital malformations, syndromic diagnosis if available, demographic information, and to develop a biobank of DNA and white blood cell samples from infants with imperforate anus. If patients are undergoing a skin biopsy for a medically indicated reason, cells will be requested.

   Imperforate Anus, also known as anal atresia, is a rare birth defect.  Unable to pass stool through the gastrointestinal tract, this condition can result in death of the newborn and emergency surgery is required once discovered.  More than two thirds of affected infants have other birth defects that include other parts of the gastrointestinal tract, airway, heart, skeleton, kidneys, eyes, or ears. The exact prevalence of imperforate anus in the newborn population is unknown. 

2. A Study to Evaluate the Use of Micropulse Trans-Scleral Cyclophotocoagulation Laser (MP-TSCPC) for Glaucoma Patients

   Jacksonville, Fla.

   The purpose of this study is to evaluate the clinical outcomes of the Micropulse Trans-Scleral Cyclophotocoagulation Laser (MPTSCPC) after 1 day, 1 week,1 month, 3 months, 6 months and one year of follow-up. Its primary objective is to conduct a prospective observational study on the efficacy of using MP-TSCPC to treat glaucoma patients.

3. Validating Watson Talent Software as a Useful Tool to Aid Program Directors in Selecting Applicants to Interview

   Jacksonville, Fla.

   The purpose of this study is to validate Watson Talent software as a useful tool to aid program directors in their task of selecting applicants to interview, reducing time and costs to review applications and improve reliability, accuracy, and precision of this process.

4. A Study to Compare Nivolumab Administered Subcutaneously vs Intravenous in Melanoma Participants Following Complete Resection

   Jacksonville, Fla.

   The purpose of this study is to compare the drug levels of nivolumab administered subcutaneously versus intravenous administration in participants with melanoma following complete resection.

5. Image-based Mapping of Brain Tumors

   Scottsdale/Phoenix, Ariz., Rochester, Minn.

   The purpose of this study is to combine MRI images with histologic and genetic analysis of cancer (from blood and tissue samples) to improve the overall accuracy of diagnosis and effectiveness of cancer treatment.

    

6. Study to Evaluate the Utility, Safety, Effectiveness, and Cost of Physical Therapy on Elective Spine Surgery Patients

   Jacksonville, Fla.

   The purpose of this study is to evaluate the utility, safety, effectiveness, and cost of physical therapy on elective spine surgery patients.

7. A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients with Recurrent Glioblastoma with Elevated Mutational Burden

   Jacksonville, Fla., Rochester, Minn., La Crosse, Wis., Scottsdale/Phoenix, Ariz., Eau Claire, Wis.

   The purpose of this study is to evaluate the effect of immunotherapy drugs (ipilimumab and nivolumab) in treating patients with glioblastoma that has come back (recurrent) and carries a high number of mutations. Cancer is caused by changes (mutations) to genes that control the way cells function. Tumors with high number of mutations may respond well to immunotherapy. Immunotherapy with monoclonal antibodies such as ipilimumab and nivolumab may help the body's immune system attack the cancer and may interfere with the ability of tumor cells to grow and spread. Giving ipilimumab and nivolumab may lower the chance of recurrent glioblastoma with high number of mutations from growing or spreading compared to usual care (surgery or chemotherapy).

8. Trainee Remediation Trends and Outcome

   Rochester, Minn.

   The aim of this study is to better identify trends in trainee remediation and outcome in a large quaternary care academic institution, in an effort to improve the success of these efforts.
    

9. A Study of the Making and Storage of a Bank of Special Stem Cells for Use in Future Research and the Growth of New Cells

   Jacksonville, Fla., Rochester, Minn., Scottsdale/Phoenix, Ariz.

   The purpose of this study is the growing and storage of stem cells, made using the tissue samples of patients and others. As new technologies develop, these cells may be able to be grown into new cells to replace those damaged by disease or injury.

10. A Study to Evaluate Thymoma Recurrence

    Rochester, Minn.

    The purpose of this study is to evaluate thymoma recurrence rates in patients who underwent thymectomy.

以下为当前的临床试验。

按院区、状态和其他条件筛选该研究列表。

1. Genomic and Environmental Basis of Imperforate Anus

   Rochester, Minn.

   The study aims are to develop a consent-based IRB proposal that will enroll newborns who have imperforate anus.  The proposal will include permission for chart review and database information storage, to develop a database that will include MRN, imperforate anus phenotype, information on other congenital malformations, syndromic diagnosis if available, demographic information, and to develop a biobank of DNA and white blood cell samples from infants with imperforate anus. If patients are undergoing a skin biopsy for a medically indicated reason, cells will be requested.

   Imperforate Anus, also known as anal atresia, is a rare birth defect.  Unable to pass stool through the gastrointestinal tract, this condition can result in death of the newborn and emergency surgery is required once discovered.  More than two thirds of affected infants have other birth defects that include other parts of the gastrointestinal tract, airway, heart, skeleton, kidneys, eyes, or ears. The exact prevalence of imperforate anus in the newborn population is unknown. 

2. A Study to Evaluate the Use of Micropulse Trans-Scleral Cyclophotocoagulation Laser (MP-TSCPC) for Glaucoma Patients

   Jacksonville, Fla.

   The purpose of this study is to evaluate the clinical outcomes of the Micropulse Trans-Scleral Cyclophotocoagulation Laser (MPTSCPC) after 1 day, 1 week,1 month, 3 months, 6 months and one year of follow-up. Its primary objective is to conduct a prospective observational study on the efficacy of using MP-TSCPC to treat glaucoma patients.

3. Validating Watson Talent Software as a Useful Tool to Aid Program Directors in Selecting Applicants to Interview

   Jacksonville, Fla.

   The purpose of this study is to validate Watson Talent software as a useful tool to aid program directors in their task of selecting applicants to interview, reducing time and costs to review applications and improve reliability, accuracy, and precision of this process.

4. A Study to Compare Nivolumab Administered Subcutaneously vs Intravenous in Melanoma Participants Following Complete Resection

   Jacksonville, Fla.

   The purpose of this study is to compare the drug levels of nivolumab administered subcutaneously versus intravenous administration in participants with melanoma following complete resection.

5. Image-based Mapping of Brain Tumors

   Scottsdale/Phoenix, Ariz., Rochester, Minn.

   The purpose of this study is to combine MRI images with histologic and genetic analysis of cancer (from blood and tissue samples) to improve the overall accuracy of diagnosis and effectiveness of cancer treatment.

    

6. Study to Evaluate the Utility, Safety, Effectiveness, and Cost of Physical Therapy on Elective Spine Surgery Patients

   Jacksonville, Fla.

   The purpose of this study is to evaluate the utility, safety, effectiveness, and cost of physical therapy on elective spine surgery patients.

7. A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients with Recurrent Glioblastoma with Elevated Mutational Burden

   Jacksonville, Fla., Rochester, Minn., La Crosse, Wis., Scottsdale/Phoenix, Ariz., Eau Claire, Wis.

   The purpose of this study is to evaluate the effect of immunotherapy drugs (ipilimumab and nivolumab) in treating patients with glioblastoma that has come back (recurrent) and carries a high number of mutations. Cancer is caused by changes (mutations) to genes that control the way cells function. Tumors with high number of mutations may respond well to immunotherapy. Immunotherapy with monoclonal antibodies such as ipilimumab and nivolumab may help the body's immune system attack the cancer and may interfere with the ability of tumor cells to grow and spread. Giving ipilimumab and nivolumab may lower the chance of recurrent glioblastoma with high number of mutations from growing or spreading compared to usual care (surgery or chemotherapy).

8. Trainee Remediation Trends and Outcome

   Rochester, Minn.

   The aim of this study is to better identify trends in trainee remediation and outcome in a large quaternary care academic institution, in an effort to improve the success of these efforts.
    

9. A Study to Evaluate Thymoma Recurrence

   Rochester, Minn.

   The purpose of this study is to evaluate thymoma recurrence rates in patients who underwent thymectomy.

10. A Safety to Evaluate the Safety and Effectiveness of Pressurized Intraperitoneal Aerosolized Chemotherapy in Ovarian, Uterine, Colorectal, and Gastric Cancer Patients

    Jacksonville, Fla.

    The purpose of this study is to evaluate the safety of pressurized intraperitoneal aerosol chemotherapy (PIPAC) in 2 groups of patients with peritoneal carcinomatosis (PC), either due to primary ovarian, uterine, or gastric carcinoma (Arm 1) or to primary colorectal carcinoma (Arm 2), based on treatment-related adverse events reported by National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.