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David I. Smith, Ph.D.

预约门诊

出版物

  1. Gao G, Smith DI. Clinical Massively Parallel Sequencing. Clin Chem. 2020 Jan 1; 66 (1):77-88
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  2. Gao G, Wang J, Kasperbauer JL, Tombers NM, Teng F, Gou H, Zhao Y, Bao Z, Smith DI. Whole genome sequencing reveals complexity in both HPV sequences present and HPV integrations in HPV-positive oropharyngeal squamous cell carcinomas. BMC Cancer. 2019 Apr 11; 19 (1):352
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  3. Chung TKH, Cheung TH, Yim SF, Yu MY, Chiu RWK, Lo KWK, Lee IPC, Wong RRY, Lau KKM, Wang VW, Worley MJ Jr, Elias KM, Fiascone SJ, Smith DI, Berkowitz RS, Wong YF. Liquid biopsy of PIK3CA mutations in cervical cancer in Hong Kong Chinese women. Gynecol Oncol. 2017 Aug; 146 (2):334-339 Epub 2017 June 03
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  4. Gao G, Smith DI. How can mate-pair sequencing be utilized for cancer patients? Expert Rev Mol Diagn 2017 Jan; 17 (1):1-3 Epub 2016 Nov 24
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  5. Gao G, Johnson SH, Vasmatzis G, Pauley CE, Tombers NM, Kasperbauer JL, Smith DI. Common fragile sites (CFS) and extremely large CFS genes are targets for human papillomavirus integrations and chromosome rearrangements in oropharyngeal squamous cell carcinoma. Genes Chromosomes Cancer. 2017 Jan; 56 (1):59-74 Epub 2016 Nov 01
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  6. Brobst TD, Garcia JJ, Price KA, Gao G, Smith DI, Price DL. Concurrent Human Papillomavirus-Positive Squamous Cell Carcinoma of the Oropharynx in a Married Couple. Case Rep Otolaryngol. 2016; 2016:8481235 Epub 2016 June 22
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  7. Gao G, Smith DI. Role of the Common Fragile Sites in Cancers with a Human Papillomavirus Etiology. Cytogenet Genome Res. 2016; 150: (3-4)217-226.
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  8. Gao G, Smith DI. Human Papillomavirus and the Development of Different Cancers. Cytogenet Genome Res. 2016; 150: (3-4)185-193.
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  9. Chung TK, Van Hummelen P, Chan PK, Cheung TH, Yim SF, Yu MY, Ducar MD, Thorner AR, MacConaill LE, Doran G, Pedamallu CS, Ojesina AI, Wong RR, Wang VW, Freeman SS, Lau TS, Kwong J, Chan LK, Fromer M, May T, Worley MJ Jr, Esselen KM, Elias KM, Lawrence M, Getz G, Smith DI, Crum CP, Meyerson M, Berkowitz RS, Wong YF. Genomic aberrations in cervical adenocarcinomas in Hong Kong Chinese women. Int J Cancer. 2015 Aug 15; 137: (4)776-83.
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  10. Gao G, Smith DI. Mate-Pair Sequencing as a Powerful Clinical Tool for the Characterization of Cancers with a DNA Viral Etiology. Viruses. 2015 Aug 7; 7 (8):4507-28 Epub 2015 Aug 07
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  11. Stoddard DG Jr, Keeney MG, Gao G, Smith DI, Garcia JJ, O'Brien EK. Transcriptional activity of HPV in inverted papilloma demonstrated by in situ hybridization for E6/E7 mRNA. Otolaryngol Head Neck Surg. 2015 Apr; 152 (4):752-8 Epub 2015 Feb 27
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  12. Gao G, Smith DI. WWOX, large common fragile site genes, and cancer. Exp Biol Med (Maywood). 2015 Mar; 240 (3):285-95 Epub 2015 Jan 16
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  13. Gao G, Smith DI. Very large common fragile site genes and their potential role in cancer development. Cell Mol Life Sci. 2014 Dec; 71 (23):4601-15 Epub 2014 Oct 10
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  14. Gao G, Kasperbauer JL, Tombers NM, Cornell MD, Smith DI. Prognostic significance of decreased expression of six large common fragile site genes in oropharyngeal squamous cell carcinomas. Transl Oncol. 2014 Dec; 7 (6):726-31
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  15. Klein CJ, Middha S, Duan X, Wu Y, Litchy WJ, Gu W, Dyck PJ, Dyck PJ, Gavrilova RH, Smith DI, Kocher JP, Dyck PJ. Application of whole exome sequencing in undiagnosed inherited polyneuropathies. J Neurol Neurosurg Psychiatry. 2014 Nov; 85 (11):1265-72 Epub 2014 Mar 06
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  16. Gao G, Kasperbauer JL, Tombers NM, Wang V, Mayer K, Smith DI. A selected group of large common fragile site genes have decreased expression in oropharyngeal squamous cell carcinomas. Genes Chromosomes Cancer. 2014 May; 53: (5)392-401.
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  17. Gao G, Johnson SH, Kasperbauer JL, Eckloff BW, Tombers NM, Vasmatzis G, Smith DI. Mate pair sequencing of oropharyngeal squamous cell carcinomas reveals that HPV integration occurs much less frequently than in cervical cancer. J Clin Virol. 2014 Mar; 59(3):195-200. Epub 2013 Dec 28.
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  18. Lasho T, Johnson SH, Smith DI, Crispino JD, Pardanani A, Vasmatzis G, Tefferi A. Identification of submicroscopic genetic changes and precise breakpoint mapping in myelofibrosis using high resolution mate-pair sequencing. Am J Hematol. 2013 Sep; 88(9):741-6. Epub 2013 Aug 01.
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  19. Wang VW, Laborde RR, Asmann YW, Li Y, Ma J, Eckloff BW, Tombers NM, Olsen SM, Moore EJ, Olsen KD, Smith DI. Search for chromosome rearrangements: new approaches toward discovery of novel translocations in head and neck squamous cell carcinoma. Head Neck. 2013 Jun; 35(6):831-5. Epub 2012 Jul 17.
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  20. Haralambieva IH, Oberg AL, Ovsyannikova IG, Kennedy RB, Grill DE, Middha S, Bot BM, Wang VW, Smith DI, Jacobson RM, Poland GA. Genome-wide characterization of transcriptional patterns in high and low antibody responders to rubella vaccination. PLoS One. 2013; 8 (5):e62149 Epub 2013 May 01
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  21. Laborde RR, Janus JR, Olsen SM, Wang VW, Garcia JJ, Graham RP, Moore EJ, Olsen KD, Kasperbauer JL, Price DL, Berres M, Halling G, Smith DI. Human papillomavirus in oropharyngeal squamous cell carcinoma: assessing virus presence in normal tissue and activity in cervical metastasis. Laryngoscope. 2012 Dec; 122(12):2707-11. Epub 2012 Sep 7
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  22. Vasmatzis G, Johnson SH, Knudson RA, Ketterling RP, Braggio E, Fonseca R, Viswanatha DS, Law ME, Kip NS, Ozsan N, Grebe SK, Frederick LA, Eckloff BW, Thompson EA, Kadin ME, Milosevic D, Porcher JC, Asmann YW, Smith DI, Kovtun IV, Ansell SM, Dogan A, Feldman AL. Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas. Blood. 2012 Sep 13; 120 (11):2280-9 Epub 2012 Aug 01
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  23. Cheung TH, Man KN, Yu MY, Yim SF, Siu NS, Lo KW, Doran G, Wong RR, Wang VW, Smith DI, Worley MJ Jr, Berkowitz RS, Chung TK, Wong YF. Dysregulated microRNAs in the pathogenesis and progression of cervical neoplasm. Cell Cycle. 2012 Aug 01; 11(15):2876-84.
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  24. Peterson LM, Kipp BR, Halling KC, Kerr SE, Smith DI, Distad TJ, Clayton AC, Medeiros F. Molecular characterization of endometrial cancer: a correlative study assessing microsatellite instability, MLH1 hypermethylation, DNA mismatch repair protein expression, and PTEN, PIK3CA, KRAS, and BRAF mutation analysis. Int J Gynecol Pathol. 2012 May; 31 (3):195-205
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  25. Laborde RR, Wang VW, Smith TM, Olson NE, Olsen SM, Garcia JJ, Olsen KD, Moore EJ, Kasperbauer JL, Tombers NM, Smith DI. Transcriptional profiling by sequencing of oropharyngeal cancer. Mayo Clin Proc. 2012 Mar; 87 (3):226-32
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  26. Chung TK, Lau TS, Cheung TH, Yim SF, Lo KW, Siu NS, Chan LK, Yu MY, Kwong J, Doran G, Barroilhet LM, Ng AS, Wong RR, Wang VW, Mok SC, Smith DI, Berkowitz RS, Wong YF. Dysregulation of microRNA-204 mediates migration and invasion of endometrial cancer by regulating FOXC1. Int J Cancer. 2012 Mar 1; 130(5):1036-45. Epub 2011 Jun 02.
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  27. Janus JR, Laborde RR, Greenberg AJ, Wang VW, Wei W, Trier A, Olsen SM, Moore EJ, Olsen KD, Smith DI. Linking expression of FOXM1, CEP55 and HELLS to tumorigenesis in oropharyngeal squamous cell carcinoma. Laryngoscope. 2011 Dec; 121 (12):2598-603
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  28. Li Y, Chien J, Smith DI, Ma J. FusionHunter: identifying fusion transcripts in cancer using paired-end RNA-seq. Bioinformatics. 2011 Jun 15; 27(12):1708-10. Epub 2011 May 05.
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  29. Klein CJ, Botuyan MV, Wu Y, Ward CJ, Nicholson GA, Hammans S, Hojo K, Yamanishi H, Karpf AR, Wallace DC, Simon M, Lander C, Boardman LA, Cunningham JM, Smith GE, Litchy WJ, Boes B, Atkinson EJ, Middha S, B Dyck PJ, Parisi JE, Mer G, Smith DI, Dyck PJ. Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss. Nat Genet. 2011 Jun; 43 (6):595-600 Epub 2011 May 01
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  30. Silva JM, Boczek NJ, Berres MW, Ma X, Smith DI. LSINCT5 is over expressed in breast and ovarian cancer and affects cellular proliferation. RNA Biol. 2011 May-Jun; 8 (3):496-505 Epub 2011 May 01
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  31. Feldman AL, Dogan A, Smith DI, Law ME, Ansell SM, Johnson SH, Porcher JC, Ozsan N, Wieben ED, Eckloff BW, Vasmatzis G. Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing. Blood. 2011 Jan 20; 117 (3):915-9 Epub 2010 Oct 28
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  32. Mitsui J, Takahashi Y, Goto J, Tomiyama H, Ishikawa S, Yoshino H, Minami N, Smith DI, Lesage S, Aburatani H, Nishino I, Brice A, Hattori N, Tsuji S. Mechanisms of genomic instabilities underlying two common fragile-site-associated loci, PARK2 and DMD, in germ cell and cancer cell lines. Am J Hum Genet. 2010 Jul 9; 87(1):75-89.
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  33. Silva JM, Perez DS, Pritchett JR, Halling ML, Tang H, Smith DI. Identification of long stress-induced non-coding transcripts that have altered expression in cancer. Genomics. 2010 Jun; 95: (6)355-62.
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  34. Laborde RR, Novakova V, Olsen KD, Kasperbauer JL, Moore EJ, Smith DI. Expression profiles of viral responsive genes in oral and oropharyngeal cancers. Eur J Cancer. 2010 Apr; 46(6):1153-8. Epub 2010 Feb 19.
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  35. Tuch BB, Laborde RR, Xu X, Gu J, Chung CB, Monighetti CK, Stanley SJ, Olsen KD, Kasperbauer JL, Moore EJ, Broomer AJ, Tan RY, Brzoska PM, Muller MW, Siddiqui AS, Asmann YW, Sun YM, Kuersten S, Barker MA, De La, Smith DI. Tumor transcriptome sequencing reveals allelic expression imbalances associated with copy number alterations. PLoS ONE. 2010 Feb 19; 5(2).
  36. Asmann YW, Klee EW, Thompson EA, Perez EA, Middha S, Oberg AL, Therneau TM, Smith DI, Poland GA, Wieben ED, Kocher JP. 3' tag digital gene expression profiling of human brain and universal reference RNA using Illumina Genome Analyzer. BMC Genomics. 2009 Nov 16; 10:531
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  37. Ukpo OC, Pritchett CV, Lewis JE, Weaver AL, Smith DI, Moore EJ. Human papillomavirus-associated oropharyngeal squamous cell carcinomas: primary tumor burden and survival in surgical patients. Ann Otol Rhinol Laryngol. 2009 May; 118: (5)368-73.
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  38. Zou H, Taylor WR, Harrington JJ, Hussain FT, Cao X, Loprinzi CL, Levine TR, Rex DK, Ahnen D, Knigge KL, Lance P, Jiang X, Smith DI, Ahlquist DA. High detection rates of colorectal neoplasia by stool DNA testing with a novel digital melt curve assay. Gastroenterology. 2009 Feb; 136 (2):459-70 Epub 2008 Oct 15
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  39. Liang XH, Lewis J, Foote R, Smith D, Kademani D. Prevalence and significance of human papillomavirus in oral tongue cancer: the Mayo Clinic experience. J Oral Maxillofac Surg. 2008 Sep; 66 (9):1875-80
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  40. Perez DS, Hoage TR, Pritchett JR, Ducharme-Smith AL, Halling ML, Ganapathiraju SC, Streng PS, Smith DI. Long, abundantly expressed non-coding transcripts are altered in cancer. Hum Mol Genet. 2008 Mar 1; 17 (5):642-55 Epub 2007 Nov 15
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  41. McAvoy S, Zhu Y, Perez DS, James CD, Smith DI. Disabled-1 is a large common fragile site gene, inactivated in multiple cancers. Genes Chromosomes Cancer. 2008 Feb; 47(2):165-74.
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  42. Soderberg C, Perez DS, Ukpo OC, Liang X, O'Reilly AG, Moore EJ, Kademani D, Smith DI. Differential loss of expression of common fragile site genes between oral tongue and oropharyngeal squamous cell carcinomas. Cytogenet Genome Res. 2008; 121(3-4):201-10. Epub 2008 Aug 28.
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  43. Poland GA, Ovsyannikova IG, Jacobson RM, Smith DI. Heterogeneity in vaccine immune response: the role of immunogenetics and the emerging field of vaccinomics. Clin Pharmacol Ther. 2007 Dec; 82(6):653-64. Epub 2007 Oct 31.
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  44. Wong YF, Cheung TH, Lo KWK, Yim SF, Siu NSS, Chan SCS, Ho TWF, Wong KW, Yu MY, Wang VW, Li C, Gardner GJ, Bonome T, Johnson WB, Smith DI, Chung TKH, Birrer MJ. Identification of molecular markers and signaling pathway in endometrial cancer in Hong Kong Chinese women by genome-wide gene expression profiling. Oncogene. 2007 Mar 22; 26(13):1971-82.
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  45. Smith DI, McAvoy S, Zhu Y, Perez DS. Large common fragile site genes and cancer. Semin Cancer Biol. 2007 Feb; 17 (1):31-41 Epub 2006 Oct 26
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  46. Lewis JD, Payton LA, Whitford JG, Byrne JA, Smith DI, Yang L, Bright RK. Induction of tumorigenesis and metastasis by the murine orthologue of tumor protein D52. Mol Cancer Res. 2007 Feb; 5(2):133-44.
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  47. Reshmi SC, Huang X, Schoppy DW, Black RC, Saunders WS, Smith DI, Gollin SM. Relationship between FRA11F and 11q13 gene amplification in oral cancer. Genes Chromosomes Cancer. 2007 Feb; 46(2):143-54.
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  48. McAvoy S, Ganapathiraju SC, Ducharme-Smith AL, Pritchett JR, Kosari F, Perez DS, Zhu Y, James CD, Smith DI. Non-random inactivation of large common fragile site genes in different cancers. Cytogenet Genome Res. 2007; 118(2-4):260-9.
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  49. McAvoy S, Ganapathiraju S, Perez DS, James CD, Smith DI. DMD and IL1RAPL1: two large adjacent genes localized within a common fragile site (FRAXC) have reduced expression in cultured brain tumors. Cytogenet Genome Res. 2007; 119(3-4):196-203. Epub 2008 Feb 01.
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  50. Wong YF, Cheung TH, Tsao GS, Lo KW, Yim SF, Wang VW, Heung MM, Chan SC, Chan LK, Ho TW, Wong KW, Li C, Guo Y, Chung TK, Smith DI. Genome-wide gene expression profiling of cervical cancer in Hong Kong women by oligonucleotide microarray. Int J Cancer. 2006 May 15; 118(10):2461-9.
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  51. Zhu Y, McAvoy S, Kuhn R, Smith DI. RORA, a large common fragile site gene, is involved in cellular stress response. Oncogene. 2006 May 11; 25(20):2901-8.
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  52. Wong YF, Sahota DS, Cheung TH, Lo KW, Yim SF, Chung TK, Chang AM, Smith DI. Gene expression pattern associated with radiotherapy sensitivity in cervical cancer. Cancer J. 2006 May-Jun; 12(3):189-93.
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  53. Smith DI, Zhu Y, McAvoy S, Kuhn R. Common fragile sites, extremely large genes, neural development and cancer. Cancer Lett. 2006 Jan 28; 232 (1):48-57 Epub 2005 Oct 10
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  54. Kim JE, McAvoy SA, Smith DI, Chen J. Human TopBP1 ensures genome integrity during normal S phase. Mol Cell Biol. 2005 Dec; 25 (24):10907-15
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  55. Dowdy SC, Gostout BS, Shridhar V, Wu X, Smith DI, Podratz KC, Jiang SW. Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines. Gynecol Oncol. 2005 Oct; 99(1):126-34.
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  56. Marquez RT, Baggerly KA, Patterson AP, Liu J, Broaddus R, Frumovitz M, Atkinson EN, Smith DI, Hartmann L, Fishman D, Berchuck A, Whitaker R, Gershenson DM, Mills GB, Bast RC, Lu KH. Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon. Clin Cancer Res. 2005 Sep 1; 11(17):6116-26.
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  57. Chien J, Staub J, Avula R, Zhang H, Liu W, Hartmann LC, Kaufmann SH, Smith DI, Shridhar V. Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer. Oncogene. 2005 Jul 28; 24 (32):5089-100
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  58. Zhang JS, Gong A, Cheville JC, Smith DI, Young CY. AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer. Genes Chromosomes Cancer. 2005 Jul; 43 (3):249-59
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  59. Wang F, Zhu Y, Huang Y, McAvoy S, Johnson WB, Cheung TH, Chung TK, Lo KW, Yim SF, Yu MM, Ngan HY, Wong YF, Smith DI. Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis. Oncogene. 2005 Jun 2; 24(24):3875-85.
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  60. Yu TX, Ferber MJ, Cheung TH, Chung TKH, Wong YF, Smith DI. The role of viral integration in the development of cervical cancer. Cancer Genetics & Cytogenetics. 2005 Apr 1; 158(1):27-34.
  61. Hartmann LC, Lu KH, Linette GP, Cliby WA, Kalli KR, Gershenson D, Bast RC, Stec J, Iartchouk N, Smith DI, Ross JS, Hoersch S, Shridhar V, Lillie J, Kaufmann SH, Clark EA, Damokosh AI. Gene expression profiles predict early relapse in ovarian cancer after platinum-paclitaxel chemotherapy. Clin Cancer Res. 2005 Mar 15; 11(6):2149-55.
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  62. Huang H, Regan KM, Wang F, Wang D, Smith DI, van Deursen JM, Tindall DJ. Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc Natl Acad Sci U S A. 2005 Feb 1; 102 (5):1649-54 Epub 2005 Jan 24
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  63. Ferber MJ, Eilers P, Schuuring E, Fenton JA, Fleuren GJ, Kenter G, Szuhai K, Smith DI, Raap AK, Brink AA. Positioning of cervical carcinoma and Burkitt lymphoma translocation breakpoints with respect to the human papillomavirus integration cluster in FRA8C at 8q24.13. Cancer Genet Cytogenet. 2004 Oct 1; 154(1):1-9.
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  64. Eisenhofer G, Bornstein SR, Brouwers FM, Cheung NK, Dahia PL, de Krijger RR, Giordano TJ, Greene LA, Goldstein DS, Lehnert H, Manger WM, Maris JM, Neumann HPH, Pacak K, Shulkin BL, Smith DI, Tischler AS, Young WF. Malignant pheochromocytoma: current status and initiatives for future progress. Endocr Relat Cancer. 2004 Sep; 11(3):423-36.
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  65. Wang F, Denison S, Lai JP, Philips LA, Montoya D, Kock N, Schule B, Klein C, Shridhar V, Roberts LR, Smith DI. Parkin gene alterations in hepatocellular carcinoma. Genes Chromosomes Cancer. 2004 Jun; 40 (2):85-96
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  66. Lu KH, Patterson AP, Wang L, Marquez RT, Atkinson EN, Baggerly KA, Ramoth LR, Rosen DG, Liu JS, Hellstrom I, Smith D, Hartmann L, Fishman D, Berchuck A, Schmandt R, Whitaker R, Gershenson DM, Mills GB, Bast RC. Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis. Clin Cancer Res. 2004 May 15; 10(10):3291-300.
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  67. Chien J, Staub J, Hu SI, Erickson-Johnson MR, Couch FJ, Smith DI, Crowl RM, Kaufmann SH, Shridhar V. A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer. Oncogene. 2004 Feb 26; 23 (8):1636-44
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  68. Lai JP, Chien J, Strome SE, Staub J, Montoya DP, Greene EL, Smith DI, Roberts LR, Shridhar V. HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma. Oncogene. 2004 Feb 19; 23 (7):1439-47
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  69. Pett MR, Alazawi WO, Roberts I, Dowen S, Smith DI, Stanley MA, Coleman N. Acquisition of high-level chromosomal instability is associated with integration of human papillomavirus type 16 in cervical keratinocytes. Cancer Res. 2004 Feb 15; 64(4):1359-68.
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  70. Petrova PS, Raibekas A, Pevsner J, Vigo N, Anafi M, Moore MK, Peaire A, Shridhar V, Smith DI, Kelly J, Durocher Y, Commissiong JW. Discovering novel phenotype-selective neurotrophic factors to treat neurodegenerative diseases. Prog Brain Res. 2004; 146:168-83.
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  71. Lai JP, Chien JR, Moser DR, Staub JK, Aderca I, Montoya DP, Matthews TA, Nagorney DM, Cunningham JM, Smith DI, Greene EL, Shridhar V, Roberts LR. hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling. Gastroenterology. 2004 Jan; 126 (1):231-48
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  72. Denison SR, Wang F, Becker NA, Schule B, Kock N, Phillips LA, Klein C, Smith DI. Alterations in the common fragile site gene Parkin in ovarian and other cancers. Oncogene. 2003 Nov 13; 22: (51)8370-8.
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  73. Ferber MJ, Thorland EC, Brink AA, Rapp AK, Phillips LA, McGovern R, Gostout BS, Cheung TH, Chung TK, Fu WY, Smith DI. Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma. Oncogene. 2003 Oct 16; 22 (46):7233-42
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  74. Denison SR, Callahan G, Becker NA, Phillips LA, Smith DI. Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer. Genes Chromosomes Cancer. 2003 Sep; 38: (1)40-52.
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  75. Tanyi JL, Hasegawa Y, Lapushin R, Morris AJ, Wolf JK, Berchuck A, Lu K, Smith DI, Kalli K, Hartmann LC, McCune K, Fishman D, Broaddus R, Cheng KW, Atkinson EN, Yamal JM, Bast RC, Felix EA, Newman RA, Mills GB. Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer. Clin Cancer Res. 2003 Sep 1; 9(10 Pt 1):3534-45.
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  76. Lai J, Chien J, Staub J, Avula R, Greene EL, Matthews TA, Smith DI, Kaufmann SH, Roberts LR, Shridhar V. Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer. J Biol Chem. 2003 Jun 20; 278 (25):23107-17 Epub 2003 Apr 09
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  77. Ferber MJ, Montoya DP, Yu C, Aderca I, McGee A, Thorland EC, Nagorney DM, Gostout BS, Burgart LJ, Boix L, Bruix J, McMahon BJ, Cheung TH, Chung TK, Wong YF, Smith DI, Roberts LR. Integrations of the hepatitis B virus (HBV) and human papillomavirus (HPV) into the human telomerase reverse transcriptase (hTERT) gene in liver and cervical cancers. Oncogene. 2003 Jun 12; 22(24):3813-20.
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  78. Petrova P, Raibekas A, Pevsner J, Vigo N, Anafi M, Moore MK, Peaire AE, Shridhar V, Smith DI, Kelly J, Durocher Y, Commissiong JW. MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons. J Mol Neurosci. 2003 Apr; 20(2):173-88.
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  79. Thorland EC, Myers SL, Gostout BS, Smith DI. Common fragile sites are preferential targets for HPV16 integrations in cervical tumors. Oncogene. 2003 Feb 27; 22(8):1225-37.
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  80. Dong X, Wang L, Taniguchi K, Wang X, Cunningham JM, McDonnell SK, Qian C, Marks AF, Slager SL, Peterson BJ, Smith DI, Cheville JC, Blute ML, Jacobsen SJ, Schaid DJ, Tindall DJ, Thibodeau SN, Liu W. Mutations in CHEK2 associated with prostate cancer risk. Am J Hum Genet. 2003 Feb; 72 (2):270-80 Epub 2003 Jan 17
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  81. Callahan G, Denison SR, Phillips LA, Shridhar V, Smith DI. Characterization of the common fragile site FRA9E and its potential role in ovarian cancer. Oncogene. 2003 Jan 30; 22(4):590-601.
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  82. Bodmer W, Liu E, Gray J, Rodland K, Smith D, Tsang B, Trench GC. Discussion: Somatic genetics and signaling/genomics/proteomics. Gynecol Oncol. 2003 Jan; 88(1 Part 2):S22-4.
  83. Becker NA, Thorland EC, Denison SR, Phillips LA, Smith DI. Evidence that instability within the FRA3B region extends four megabases. Oncogene. 2002 Dec 12; 21(57):8713-22.
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  84. Morelli C, Karayianni E, Magnanini C, Mungall AJ, Thorland E, Negrini M, Smith DI, Barbanti-Brodano G. Cloning and characterization of the common fragile site FRA6F harboring a replicative senescence gene and frequently deleted in human tumors. Oncogene. 2002 Oct 17; 21(47):7266-76.
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  85. Denison SR, Becker NA, Ferber MJ, Phillips LA, Kalli KR, Lee J, Lillie J, Smith DI, Shridhar V. Transcriptional profiling reveals that several common fragile-site genes are downregulated in ovarian cancer. Genes Chromosomes Cancer. 2002 Aug; 34(4):406-15.
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  86. Calhoun ES, McGovern RM, Janney CA, Cerhan JR, Iturria SJ, Smith DI, Gostout BS, Persing DH. Host genetic polymorphism analysis in cervical cancer. Clin Chem. 2002 Aug; 48 (8):1218-24
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  87. Taniguchi K, Roberts LR, Aderca IN, Dong X, Qian C, Murphy LM, Nagorney DM, Burgart LJ, Roche PC, Smith DI, Ross JA, Liu W. Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene. 2002 Jul 18; 21 (31):4863-71
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  88. Krummel KA, Denison SR, Calhoun E, Phillips LA, Smith DI. The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1. Genes Chromosomes Cancer. 2002 Jun; 34 (2):154-67
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  89. Hellman A, Zlotorynski E, Scherer SW, Cheung J, Vincent JB, Smith DI, Trakhtenbrot L, Kerem B. A role for common fragile site induction in amplification of human oncogenes. Cancer Cell. 2002 Feb; 1 (1):89-97
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  90. Smith DI. Transcriptional profiling develops molecular signatures for ovarian tumors. Cytometry. 2002 Jan 1; 47 (1):60-2
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  91. Shridhar V, Sen A, Chien J, Staub J, Avula R, Kovats S, Lee J, Lillie J, Smith DI. Identification of underexpressed genes in early- and late-stage primary ovarian tumors by suppression subtraction hybridization. Cancer Res. 2002 Jan 1; 62(1):262-70.
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  92. Bast RC Jr, Urban N, Shridhar V, Smith D, Zhang Z, Skates S, Lu K, Liu J, Fishman D, Mills G. Early detection of ovarian cancer: promise and reality. Cancer Treatment Res. 2002; 107:61-97.
  93. Murillo H, Huang H, Schmidt LJ, Smith DI, Tindall DJ. Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state. Endocrinology. 2001 Nov; 142 (11):4795-805
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  94. Shridhar V, Lee J, Pandita A, Iturria S, Avula R, Staub J, Morrissey M, Calhoun E, Sen A, Kalli K, Keeney G, Roche P, Cliby W, Lu K, Schmandt R, Mills GB, Bast RC Jr, James CD, Couch FJ, Hartmann LC, Lillie J, Smith DI. Genetic analysis of early- versus late-stage ovarian tumors. Cancer Res. 2001 Aug 1; 61(15):5895-904.
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  95. Shridhar V, Bible KC, Staub J, Avula R, Lee YK, Kalli K, Huang H, Hartmann LC, Kaufmann SH, Smith DI. Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer. Cancer Res. 2001 May 15; 61 (10):4258-65
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  96. Acquati F, Morelli C, Cinquetti R, Bianchi MG, Porrini D, Varesco L, Gismondi V, Rocchetti R, Talevi S, Possati L, Magnanini C, Tibiletti MG, Bernasconi B, Daidone MG, Shridhar V, Smith DI, Negrini M, Barbanti-Brodano G, Taramelli R. Cloning and characterization of a senescence inducing and class II tumor suppressor gene in ovarian carcinoma at chromosome region 6q27. Oncogene. 2001 Feb 22; 20(8):980-8.
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  97. Zhang JS, Wang L, Huang H, Nelson M, Smith DI. Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells. Genes Chromosomes Cancer. 2001 Feb; 30(2):123-35.
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  98. Thorland EC, Myers SL, Persing DH, Sarkar G, McGovern RM, Gostout BS, Smith DI. Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites. Cancer Res. 2000 Nov 1; 60(21):5916-21.
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  99. Irwin M, Marin MC, Phillips AC, Seelan RS, Smith DI, Liu W, Flores ER, Tsai KY, Jacks T, Vousden KH, Kaelin WG Jr. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature. 2000 Oct 5; 407(6804):645-8.
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  100. Krummel KA, Roberts LR, Kawakami M, Glover TW, Smith DI. The characterization of the common fragile site FRA16D and its involvement in multiple myeloma translocations. Genomics. 2000 Oct 1; 69(1):37-46.
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  101. Seelan RS, Qian C, Yokomizo A, Bostwick DG, Smith DI, Liu W, Liu W. Human acid ceramidase is overexpressed but not mutated in prostate cancer. Genes Chromosomes Cancer. 2000 Oct; 29 (2):137-46
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  102. Liu W, Dong X, Mai M, Seelan RS, Taniguchi K, Krishnadath KK, Halling KC, Cunningham JM, Boardman LA, Qian C, Christensen E, Schmidt SS, Roche PC, Smith DI, Thibodeau SN. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. Nat Genet. 2000 Oct; 26(2):146-7.
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  103. McIver B, Grebe SK, Wang L, Hay ID, Yokomizo A, Liu W, Goellner JR, Grant CS, Smith DI, Eberhardt NL. FHIT and TSG101 in thyroid tumours: aberrant transcripts reflect rare abnormal RNA processing events of uncertain pathogenetic or clinical significance. Clin Endocrinol (Oxf). 2000 Jun; 52(6):749-57.
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  104. McIver B, Grebe SKG, Wang L, Hay ID, Yokomizo Yokomizo, Liu W, Goellner JR, Grant CS, Smith DI, Eberhardt NL. FHIT and TSG101 in thyroid tumours: aberrant transcripts reflect rare abnormal RNA processing events of uncertain pathogenetic or clinical significance. Clin Endocrinol (Oxf). 2000 Jun; 52 (6):749-757
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  105. Ren SR, Smith MJ, Louro ID, McKie-Bell P, Bani MR, Wagner M, Zochodne B, Redden DT, Grizzle WE, Wang ND, Smith DI, Herbst RA, Bardenheuer W, Opalka B, Schutte J, Trent JM, Ben-David Y, Ruppert JM. The p44(S10) locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma. Oncogene. 2000 Mar 9; 19(11):1419-1427.
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  106. Vockley J, Rogan PK, Vockley J, Anderson BD, Willard J, Seelan RS, Smith DI, Liu W, Liu W. Exon skipping in IVD RNA processing in isovaleric acidemia caused by point mutations in the coding region of the IVD gene. Am J Hum Genet. 2000 Feb; 66 (2):356-67
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  107. Liu W, Mai M, Yokomizo A, Qian C, Tindall DJ, Smith DI, Thibodeau SN. Differential expression and allelotyping of the p73 gene in neuroblastoma. Int J Oncol. 2000 Jan; 16 (1):181-5
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  108. Wang L, Darling J, Wang L, Zhang JS, Liu W, Zhang JS, Liu W, Qian J, Bostwick D, Hartmann L, Bostwick D, Hartmann L, Jenkins R, Bardenhauer W, Jenkins R, Schutte J, Opalka B, Smith DI. Loss of expression of the DRR 1 gene at chromosomal segment 3p21.1 in renal cell carcinoma. Genes Chromosomes Cancer. 2000 Jan; 27 (1):1-10
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  109. Wang L, Darling J, Zhang J, Liu W, Qian J, Bostwick D, Hartmann L, Jenkins R, Bardenhauer W, Schutte J, Opalka B, Smith D. Loss of expression of the DRR I gene at chromosomal segment 3p21.1 in renal cell carcinoma. Genes Chromosom Cancer. 2000; 27(1):1-10.
  110. Schwartz DI, Lindor NM, Walsh-Vockley C, Roche PC, Mai M, Smith DI, Liu W, Liu W, Couch FJ. p73 mutations are not detected in sporadic and hereditary breast cancer. Breast Cancer Res Treat. 1999 Nov; 58 (1):25-9
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  111. Kawakami M, Staub J, Cliby W, Hartmann L, Cliby W, Hartmann L, Smith DI, Shridhar V. Involvement of H-cadherin (CDH13) on 16q in the region of frequent deletion in ovarian cancer. Int J Oncol. 1999 Oct; 15 (4):715-20
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  112. Shridhar V, Staub J, Huntley B, Cliby W, Jenkins R, Pass HI, Hartmann L, Smith DI. A novel region of deletion on chromosome 6q23.3 spanning less than 500 Kb in high grade invasive epithelial ovarian cancer. Oncogene. 1999 Jul 1; 18(26):3913-8.
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  113. Huang H, Reed CP, Zhang JS, Shridhar V, Wang L, Smith DI. Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells. Cancer Res. 1999 Jun 15; 59(12):2981-8.
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  114. Yokomizo A, Mai M, Bostwick DG, Tindall DJ, Qian J, Cheng L, Jenkins RB, Smith DI, Liu W. Mutation and expression analysis of the p73 gene in prostate cancer. Prostate. 1999 May; 39 (2):94-100
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  115. Wang L, Darling J, Wang L, Zhang JS, Zhang JS, Huang H, Liu W, Liu W, Smith DI. Allele-specific late replication and fragility of the most active common fragile site, FRA3B. Hum Mol Genet. 1999 Mar; 8 (3):431-7
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  116. Yokomizo A, Mai M, Tindall DJ, Cheng L, Bostwick DG, Naito S, Smith DI, Liu W. Overexpression of the wild type p73 gene in human bladder cancer. Oncogene. 1999 Feb 25; 18 (8):1629-33
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  117. Mai M, Qian C, Yokomizo A, Smith DI, Liu W. Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24. Genomics. 1999 Feb 1; 55 (3):341-4
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  118. Huang H, Reed CP, Mordi A, Lomberk G, Wang L, Shridhar V, Hartmann L, Jenkins R, Smith DI. Frequent deletions within FRA7G at 7q31.2 in invasive epithelial ovarian cancer. Genes Chromosomes Cancer. 1999 Jan; 24(1):48-55.
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  119. Shridhar V, Jett JR, Smith DI. Molecular advances in the biology of premalignant lesions of lung cancer. Respiratory Care Matters. 1999; 3:14-5.
  120. Zhang JS, Nelson M, Wang L, Liu W, Qian CP, Shridhar V, Urrutia R, Smith DI. Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin. Genomics. 1998 Nov 15; 54(1):149-54.
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  121. Eley G, Frederick L, Eley G, Wang XY, Smith DI, James CD. 3' end structure and rearrangements of EGFR in glioblastomas. Genes Chromosomes Cancer. 1998 Nov; 23 (3):248-54
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  122. Mai M, Qian C, Yokomizo A, Tindall DJ, Bostwick D, Polychronakos C, Smith DI, Liu W. Loss of imprinting and allele switching of p73 in renal cell carcinoma. Oncogene. 1998 Oct 1; 17 (13):1739-41
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  123. Zhang JS, Nelson M, McIver B, Hay ID, Goellner JR, Grant CS, Eberhardt NL, Smith DI. Differential loss of heterozygosity at 7q31.2 in follicular and papillary thyroid tumors. Oncogene. 1998 Aug 13; 17(6):789-93.
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  124. Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA. The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. Proc Natl Acad Sci U S A. 1998 Aug 4; 95(16):9572-7.
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  125. Mai M, Huang H, Reed C, Qian C, Smith JS, Alderete B, Jenkins R, Smith DI, Liu W. Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions. Genomics. 1998 Aug 1; 51 (3):359-63
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  126. Yokomizo A, Tindall DJ, Drabkin H, Gemmill R, Franklin W, Yang P, Sugio K, Smith DI, Liu W. PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers. Oncogene. 1998 Jul 30; 17: (4)475-9.
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  127. Yokomizo A, Tindall DJ, Hartmann L, Jenkins RB, Smith DI, Liu W. Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer. Int J Oncol. 1998 Jul; 13 (1):101-5
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  128. Mai M, Yokomizo A, Qian C, Yang P, Tindall DJ, Smith DI, Liu W. Activation of p73 silent allele in lung cancer. Cancer Res. 1998 Jun 1; 58 (11):2347-9
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  129. Huang H, Qian J, Proffit J, Wilber K, Jenkins R, Smith DI. FRA7G extends over a broad region: coincidence of human endogenous retroviral sequences (HERV-H) and small polydispersed circular DNAs (spcDNA) and fragile sites. Oncogene. 1998 May 7; 16(18):2311-9.
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  130. Wang XY, Smith DI, Liu W, Liu W, James CD. GBAS, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR. Genomics. 1998 May 1; 49 (3):448-51
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  131. Le Beau MM, Drabkin H, Glover TW, Gemmill R, Rassool FV, McKeithan TW, Smith DI. An FHIT tumor suppressor gene? Genes Chromosomes Cancer. 1998 Apr; 21(4):281-9.
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  132. Le Beau MM, Rassool FV, Neilly ME, Espinosa R 3rd, Glover TW, Smith DI, McKeithan TW. Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction. Hum Mol Genet. 1998 Apr; 7(4):755-61.
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  133. Willett CG, Wang MH, Emanuel RL, Graham SA, Smith DI, Shridhar V, Sugarbaker DJ, Sunday ME. Macrophage-stimulating protein and its receptor in non-small-cell lung tumors: induction of receptor tyrosine phosphorylation and cell migration. American Journal of Respiratory Cell & Molecular Biology. 1998 Apr; 18(4):489-96.
  134. Liu W, Liu W, Smith DI, Rechtzigel KJ, Thibodeau SN, James CD. Denaturing high performance liquid chromatography (DHPLC) used in the detection of germline and somatic mutations. Nucleic Acids Res. 1998 Mar 15; 26 (6):1396-400
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  135. Jenkins RB, Qian J, Lee HK, Huang H, Hirasawa K, Bostwick DG, Proffitt J, Wilber K, Lieber MM, Liu W, Smith DI. A molecular cytogenetic analysis of 7q31 in prostate cancer. Cancer Res. 1998 Feb 15; 58(4):759-66.
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  136. Wang L, Darling J, Zhang JS, Qian CP, Hartmann L, Conover C, Jenkins R, Smith DI. Frequent homozygous deletions in the FRA3B region in tumor cell lines still leave the FHIT exons intact. Oncogene. 1998 Feb 5; 16(5):635-42.
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  137. Huang H, Qian C, Jenkins RB, Smith DI. Fish mapping of YAC clones at human chromosomal band 7q31.2: identification of YACS spanning FRA7G within the common region of LOH in breast and prostate cancer. Genes Chromosomes Cancer. 1998 Feb; 21 (2):152-9
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  138. Wang XY, Smith DI, Frederick L, James CD. Analysis of EGF receptor amplicons reveals amplification of multiple expressed sequences. Oncogene. 1998 Jan 15; 16 (2):191-5
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  139. Smith DI, Huang H, Wang L. Common fragile sites and cancer (review). Int J Oncol. 1998 Jan; 12(1):187-96.
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  140. Shridhar V, Sun QC, Miller OJ, Kalemkerian GP, Petros J, Smith DI. Loss of heterozygosity on the long arm of human chromosome 7 in sporadic renal cell carcinomas. Oncogene. 1997 Nov 27; 15(22):2727-33.
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  141. Swanson DA, Rothenberg HJ, Boynton AL, Consigliere D, Halling KC, Oda H, Smith D. Future prognostic factors for renal cell carcinoma - workgroup #5. Cancer. 1997 Sep 1; 80(5):997-998.
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  142. Erdmann J, Shimron-Abarbanell D, Shridhar V, Smith DI, Propping P, Nothen MM. Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1). Mol Membr Biol. 1997 Jul-Sep; 14(3):133-5.
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  143. Willett CG, Smith DI, Shridhar V, Wang MH, Emanuel RL, Patidar K, Graham SA, Zhang F, Hatch V, Sugarbaker DJ, Sunday ME. Differential screening of a human chromosome 3 library identifies hepatocyte growth factor-like/macrophage-stimulating protein and its receptor in injured lung. Possible implications for neuroendocrine cell survival. J Clin Invest. 1997 Jun 15; 99(12):2979-91.
  144. Shridhar V, Rivard S, Wang X, Shridhar R, Paisley C, Mullins C, Beirnat L, Dugan M, Sarkar F, Miller OJ, Vaitkevicius VK, Smith DI. Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer. Oncogene. 1997 May 8; 14(18):2213-6.
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  145. Wang L, Paradee W, Mullins C, Shridhar R, Rosati R, Wilke CM, Glover TW, Smith DI. Aphidicolin-induced FRA3B breakpoints cluster in two distinct regions. Genomics. 1997 May 1; 41(3):485-8.
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  146. Shridhar V, Wang L, Rosati R, Paradee W, Shridhar R, Mullins C, Sakr W, Grignon D, Miller OJ, Sun QC, Petros J, Smith DI. Frequent breakpoints in the region surrounding FRA3B in sporadic renal cell carcinomas. Oncogene. 1997 Mar 20; 14(11):1269-77.
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  147. van den Berg A, Kok K, Timmer T, Draaijers TG, van der Veen AY, Veldhuis P, Naylor SL, Paradee W, Wang L, Smith DI, Buys CHCM. A homozygous deletion in a lung adenocarcinoma cell line located at the FRA3B fragile site in 3p14.2. Genes Chromosom Cancer. 1997; 19:1-8.
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  148. Luan X, Shi G, Zohouri M, Paradee W, Smith DI, Decker HJ, Cannizzaro LA. The FHIT gene is alternatively spliced in normal kidney and renal cell carcinoma. Oncogene. 1997; 15:79-86.
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  149. Zhang J-S, Nelson M, McIver B, Hay I, Eberhardt N, Smith DI. Differential loss of heterozygosity and deletion mapping in follicular and papillary thyroid cancers. Amer J Hum Genet. 1997; 61:A89.
  150. Shridhar R, Shridhar V, Rivard S, Siegfried JM, Pietraszkiewicz H, Ensley J, Pauley R, Grignon D, Sakr W, Miller OJ, Smith DI. Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck. Cancer Res. 1996 Dec 15; 56(24):5576-8.
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  151. Paradee W, Wilke CM, Wang L, Shridhar R, Mullins CM, Hoge A, Glover TW, Smith DI. A 350-kb cosmid contig in 3p14.2 that crosses the t(3;8) hereditary renal cell carcinoma translocation breakpoint and 17 aphidicolin-induced FRA3B breakpoints. Genomics. 1996 Jul 1; 35(1):87-93.
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  152. Shridhar V, Rivard S, Shridhar R, Mullins C, Bostick L, Sakr W, Grignon D, Miller OJ, Smith DI. A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas. Oncogene. 1996 May 2; 12(9):1931-9.
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  153. Wilke CM, Hall BK, Miller D, Hoge A, Paradee W, Smith DI, Glover TW. Identification of a spontaneous HPV16 integration site within the FRA3B region: Direct evidence for the coincidence of viral integration sites and fragile sites. Hum Molec Genet. 1996; 5:187-92.
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  154. Bardenheuer W, Michaelis S, Lux A, Vieten L, Brocker F, Julcher K, Siebert R, Willers C, van der Hout A, Buys CHCM, Smith DI, LePaslier D, Cohen D, Schutte J, Opalka B. Construction of a consistent YAC contig for human chromosome region 3p14.1. Genome Res. 1996; 6:176-86.
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  155. Cai Y, Langley JG, Smith DI, Boros DL. A cloned major Schistosoma mansoni egg antigen with homologies to small heat shock proteins elicits Th1 responsiveness. Infect Imm. 1996; 64:1750-5.
  156. Drumheller T, McGillivray B, Behrner D, Weiss L, MacLeod P, McFadden DE, Roberson J, Venditti C, Chorney K, Chorney M, Van Dyke D, Smith DI. Precise localization of 3p25 breakpoints in four patients with the 3p- syndrome. J Med Genet. 1996; 33:842-7.
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  157. McAlinden TP, Smith DI, Smith SE, Krawetz SA. Isolation and characterization of a 1 Mb region of 5q23.3-q31.2 surrounding the human lysyl oxidase gene. J Mol Cell Cardiol. 1995 Oct; 27(10):2409-13.
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  158. Paradee W, Mullins C, He Z, Glover T, Wilke C, Opalka B, Schutte J, Smith DI. Precise localization of aphidicolin-induced breakpoints on the short arm of human chromosome 3. Genomics. 1995 May 20; 27(2):358-61.
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  159. Michaelis SC, Bardenheuer W, Lux A, Schramm A, Gockel A, Siebert R, Willers C, Schmidtke K, Todt B, van der Hout AH, Smith DI, et al. Characterization and chromosomal assignment of yeast artificial chromosomes containing human 3p13-p21-specific sequence tagged sites. Cancer Genet Cytogenet. 1995 May; 81(1):1-12.
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  160. Cid LP, Montrose-Rafizadeh C, Smith DI, Guggino WB, Cutting GR. Cloning of a putative human voltage-gated chloride channel (CIC-2) cDNA widely expressed in human tissues. Hum Mol Genet. 1995 Mar; 4(3):407-13.
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  161. Cotter PD, Drabkin HA, Varkony T, Smith DI, Bishop DF. Assignment of the human housekeeping delta-aminolevulinate synthase gene (ALAS1) to chromosome band 3p21.1 by PCR analysis of somatic cell hybrids. Cytogenet Cell Genet. 1995; 69(3-4):207-8.
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  162. Smith DI, Glover TW, Gemmill R, Drabkin H, O'Connell P, Naylor SL. Report and abstracts of the fifth international workshop on human chromosome 3 mapping 1994. Ann Arbor, Michigan, May 8-9, 1994. Cytogenet Cell Genet. 1995; 68(3-4):125-46.
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  163. Decker HJ, Klauck SM, Lawrence JB, McNeil J, Smith D, Gemmill RM, Sandberg AA, Neumann HH, Simon B, Green J. Cytogenetic and fluorescence in situ hybridization studies on sporadic and hereditary tumors associated with von Hippel-Lindau syndrome (VHL). Cancer Genetics & Cytogenetics. 1994 Oct; 77(1):1-13.
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  164. Swaroop A, Yang-Feng TL, Liu W, Gieser L, Barrow LL, Chen KC, Agarwal N, Meisler MH, Smith DI. Molecular characterization of a novel human gene, SEC13R, related to the yeast secretory pathway gene SEC13, and mapping to a conserved linkage group on human chromosome 3p24-p25 and mouse chromosome 6. Hum Mol Genet. 1994 Aug; 3(8):1281-6.
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  165. Shridhar V, Golembieski W, Kamat A, Smith SE, Phillips N, Miller OJ, Miller Y, Smith DI. Isolation of two contigs of overlapping cosmids derived from human chromosomal band 3p21.1 and identification of 5 new 3p21.1 genes. Somat Cell Mol Genet. 1994 Jul; 20(4):255-65.
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  166. Shridhar V, Siegfried J, Hunt J, del Mar Alonso M, Smith DI. Genetic instability of microsatellite sequences in many non-small cell lung carcinomas. Cancer Res. 1994 Apr 15; 54(8):2084-7.
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  167. Siden TS, Kumlien J, Drumheller T, Smith SE, Rohme D, Lehrach H, Smith DI. Identification of human chromosome region 3p14.2-21.3-specific YAC clones using Alu-PCR products from a radiation hybrid. Somat Cell Mol Genet. 1994 Mar; 20(2):137-42.
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  168. Siden TS, Golembieski W, Kumlien J, Rohme D, Smith DI. Physical map of small cell lung cancer deletion region on short arm of human chromosome 3 (3p13-22) based on radiation fusion hybrid analysis. Somat Cell Mol Genet. 1994 Mar; 20(2):121-32.
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  169. Bardenheuer W, Szymanski S, Lux A, Ludecke HJ, Horsthemke B, Claussen U, Senger G, Smith DI, Wang ND, LePaslier D, et al. Characterization of a microdissection library from human chromosome region 3p14. Genomics. 1994 Jan 15; 19(2):291-7.
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  170. Smith SE, Joseph A, Nadeau S, Shridhar V, Gemmill R, Drabkin H, Knuutila S, Smith DI. Cloning and characterization of the human t(3;6)(p14;p11) translocation breakpoint associated with hematologic malignancies. Cancer Genet Cytogenet. 1993 Nov; 71(1):15-21.
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  171. Smith DI, del Mar Alonso M. Cloning of tumor suppressor genes involved in solid tumor development. Arch Otolaryngol Head Neck Surg. 1993 Nov; 119(11):1210-6.
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  172. Loeb D, Lui W, Smith DI, Vance JM. Dinucleotide repeat polymorphisms in the VHL region of human chromosome 3p25. Hum Mol Genet. 1993 Oct; 2(10):1746.
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  173. Wang ND, Testa JR, Smith DI. Determination of the specificity of aphidicolin-induced breakage of the human 3p14.2 fragile site. Genomics. 1993 Aug; 17(2):341-7.
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  174. Liu W, Piechocki M, Shridhar V, Lyles G, Song Z, Nakamura Y, Drabkin H, Vance J, Smith DI. The isolation of a yeast artificial chromosome (YAC) contig extending for 2 megabases in the vicinity of the von Hippel Lindau disease gene. Hum Mol Genet. 1993 Aug; 2(8):1177-82.
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  175. Kaplan MH, Smith DI, Sundick RS. Identification of a G protein coupled receptor induced in activated T cells. J Immunol. 1993 Jul 15; 151(2):628-36.
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  176. Pericak-Vance MA, Nunes KJ, Whisenant E, Loeb DB, Small KW, Stajich JM, Rimmler JB, Yamaoka LH, Smith DI, Drabkin HA, et al. Genetic mapping of dinucleotide repeat polymorphisms and von Hippel-Lindau disease on chromosome 3p25-26. J Med Genet. 1993 Jun; 30(6):487-91.
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  177. Kamat AK, Rocchi M, Smith DI, Miller OJ. Lamin A/C gene and a related sequence map to human chromosomes 1q12.1-q23 and 10. Somat Cell Mol Genet. 1993 Mar; 19(2):203-8.
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  178. Wang ND, Testa JR, Smith DI. Localization of three novel hybrid breakpoints and refinement of 18 marker assignments in the human 3cen-p21.1 region. Genomics. 1992 Dec; 14(4):891-6.
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  179. Liu W, Vance J, Smith DI. cA479 (D3S719): a cosmid mapped telomeric of the Von Hippel Lindau disease gene contains the D3S18 locus. Hum Mol Genet. 1992 Jun; 1(3):201.
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  180. Ginzinger DG, Shridhar V, Baldini A, Taggart RT, Miller OJ, Smith DI. The human loci DNF15S2 and D3S94 have a high degree of sequence similarity to acyl-peptide hydrolase and are located at 3p21.3. Am J Hum Genet. 1992 Apr; 50(4):826-33.
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  181. Wernette C, Saldanha R, Smith D, Ming D, Perlman PS, Butow RA. Complex recognition site for the group I intron-encoded endonuclease I-SceII. Mol Cell Biol. 1992 Feb; 12(2):716-23.
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  182. Secore SL, Walker AP, Herbstreith MH, Siddique T, Jeffers AJ, DeShields TR, Speer MC, Pericak-Vance MA, Golembieski WA, Smith DI, et al. A StuI polymorphism on chromosome 3p14.1-14.2 (D3S622) defined by two polymorphic StuI sites 2.4 kb apart. Nucleic Acids Res. 1991 Nov 25; 19(22):6349.
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  183. Gemmill RM, Varella-Garcia M, Smith DI, Erickson P, Golembieski W, Miller Y, Coyle-Morris J, Tommerup N, Drabkin HA. A 2.5-Mb physical map within 3p21.1 spans the breakpoint associated with Greig cephalopolysyndactyly syndrome. Genomics. 1991 Sep; 11(1):93-102.
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  184. Golembieski WA, Smith SE, Recchia F, Judge A, Shridhar V, Miller OJ, Drabkin H, Smith DI. Isolation of large numbers of chromosome 3-specific cosmids containing clusters of rare restriction-endonuclease sites. Am J Hum Genet. 1991 Sep; 49(3):581-9.
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  185. Smith DI, Liu W, Ginzinger D, Green P, Smith S, Wang ND, Recchia F, Carolyn K, Drabkin H, Golembieski W. Localization of 616 human chromosome 3-specific cosmids using a somatic cell hybrid deletion mapping panel. Genomics. 1991 Sep; 11(1):179-87.
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  186. Fong D, Smith DI, Hsieh WT. The human kininogen gene (KNG) mapped to chromosome 3q26-qter by analysis of somatic cell hybrids using the polymerase chain reaction. Hum Genet. 1991 Jun; 87(2):189-92.
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  187. Seizinger BR, Smith DI, Filling-Katz MR, Neumann H, Green JS, Choyke PL, Anderson KM, Freiman RN, Klauck SM, Whaley J, et al. Genetic flanking markers refine diagnostic criteria and provide insights into the genetics of Von Hippel Lindau disease. Proc Natl Acad Sci U S A. 1991 Apr 1; 88(7):2864-8.
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  188. Hsieh WT, Fong D, Sloane BF, Golembieski W, Smith DI. Mapping of the gene for human cysteine proteinase inhibitor stefin A, STF1, to chromosome 3cen-q21. Genomics. 1991 Jan; 9(1):207-9.
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  189. Baldini A, Smith DI, Rocchi M, Miller OJ, Miller DA. A human alphoid DNA clone from the EcoRI dimeric family: genomic and internal organization and chromosomal assignment. Genomics. 1989 Nov; 5(4):822-8.
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  190. Smith DI, Golembieski W, Drabkin H, Kiousis S. Identification of two cosmids derived from within chromosomal band 3p21.1 that contain clusters of rare restriction sites and evolutionarily conserved sequences. Am J Hum Genet. 1989 Sep; 45(3):443-7.
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  191. Smith DI, Kiousis S, Miller D, Aleixandre C, Wasmuth J. Isolation and mapping of a polymorphic DNA sequence (lambda 64) on chromosome 3 [D3S95]. Nucleic Acids Res. 1989 Jul 25; 17(14):5878.
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  192. Smith DI, Kiousis S, Drabkin H, Wasmuth J. Isolation and mapping of a polymorphic sequence (3UCI 10) on chromosome 3 [D3S8]. Nucleic Acids Res. 1989 Jul 25; 17(14):5877.
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  193. Kiousis S, Drabkin H, Smith DI. Isolation and mapping of a polymorphic DNA sequence (cA476) on chromosome 3 [D3S94]. Nucleic Acids Res. 1989 Jul 25; 17(14):5876.
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  194. Drabkin H, Sage M, Helms C, Green P, Gemmill R, Smith D, Erickson P, Hart I, Ferguson-Smith A, Ruddle F. Regional and physical mapping studies characterizing the Greig polysyndactyly 3;7 chromosome translocation, t(3;7)(p21.1;p13). Genomics. 1989 May; 4(4):518-29.
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  195. Smith DI, Mangrulker R, Geist R, Gilbert J, Kinsman K, Drabkin H, Golembieski W. Saturation of human chromosome 3 with unique sequence hybridization probes. Genomics. 1989 May; 4(4):453-9.
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  196. Capriglione T, Olmo E, Odierna G, Smith DI, Miller OJ. Genome composition and tandemly repetitive sequence at some centromeres in the lizard Podarcis S. sicula. Genetica. 1989; 79:85-91.
  197. Drabkin HA, Smith DI, Jones C, Jonsen M, Sage M, Gold S, Glover T, Bradley WEC, Gemmill R. Regional and physical mapping studies involving rearrangements of human chromosome 3. of Human Cancer Cold Spring Harbor Laboratory, 1989; 7:Molecular Diagnosis.
  198. Gerber MJ, Drabkin HA, Firnhaber C, Miller YE, Scoggin CH, Smith DI. Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel. Am J Hum Genet. 1988 Oct; 43(4):442-51.
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  199. Seizinger BR, Rouleau GA, Ozelius LJ, Lane AH, Farmer GE, Lamiell JM, Haines J, Yuen JW, Collins D, Majoor-Krakauer D, Smith DI, et al. Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. Nature. 1988 Mar 17; 332(6161):268-9.
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  200. Smith DI, Golembieski W, Gilbert JD, Kizyma L, Miller OJ. Overabundance of rare-cutting restriction endonuclease sites in the human genome. Nucleic Acids Res. 1987 Feb 11; 15(3):1173-84.
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  201. Smith DI. The isolation of a large number of unique sequence DNA probes that map to 3p14-p23. Chest. 1987; (91):19S-20S.
  202. Carlock LR, Smith D, Wasmuth JJ. Genetic counterselective procedure to isolate interspecific cell hybrids containing single human chromosomes: construction of cell hybrids and recombinant DNA libraries specific for human chromosomes 3 and 4. Somat Cell Mol Genet. 1986 Mar; 12(2):163-74.
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  203. Davies J, Smith DI. Plasmid-determined resistance to antimicrobial agents. Annu Rev Microbiol. 1978; 32:469-518.
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  204. Hedges RW, Matthew M, Smith DI, Cresswell JM, Jacob AE. Properties of a transposon conferring resistance to penicillins and streptomycin. Gene. 1977 May; 1(3-4):241-53.
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  205. Smith DI, Blattner FR, Davies J. The isolation and partial characterization of a new restriction endonuclease from Providencia stuartii. Nucleic Acids Res. 1976 Feb; 3(2):343-53.
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  206. Smith DI, Lus RG, Rubio Calvo MC, Datta N, Jacob AE, Hedges RW. Third type of plasmid conferring gentamicin resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1975 Sep; 8(3):227-30.
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