搜索医生

Keith A. Josephs, M.D.

  1. Neurologist
预约门诊

出版物

  1. Blazek AM, Meade G, Jackson LM, Gavrilova R, Stierwalt J, Martinez-Thompson JM, Duffy JR, Clark H, Machulda MM, Whitwell JL, Josephs KA, Utianski RL, Botha H. Progressive Apraxia of Speech as a Manifestation of Spinocerebellar Ataxia 2: Case Report. Neurol Genet. 2024 Dec; 10 (6):e200202 Epub 2024 Nov 01
    View PubMed
  2. Sekiya H, Satoh R, Ali F, Dickson DW, Whitwell JL, Josephs KA. Utilizing quantitative susceptibility mapping to differentiate primary lateral sclerosis from progressive supranuclear palsy: A case report. Neuropathology. 2024 Nov 18 [Epub ahead of print]
    View PubMed
  3. Meade G, Pham NTT, Clark HM, Duffy JR, Whitwell JL, Josephs KA, Utianski RL. Progression of Motor Speech Function in Speakers With Primary Progressive Apraxia of Speech. J Speech Lang Hear Res. 2024 Nov 15; 1-12 [Epub ahead of print]
    View PubMed
  4. Coburn RP, Graff-Radford J, Machulda MM, Schwarz CG, Lowe VJ, Jones DT, Jack CR Jr, Josephs KA, Whitwell JL, Botha H. Baseline multimodal imaging to predict longitudinal clinical decline in atypical Alzheimer's disease. Cortex. 2024 Nov; 180:18-34 Epub 2024 Sept 11
    View PubMed
  5. Gatto RG, Hossam Y, Reichard RR, Lowe VJ, Whitwell JL, Josephs KA. Microscopy assessment of a fluorescence [(18)F] flortaucipir analog (T726) shows neuropathological overlap with 3R and 4R tau lesions. Alzheimers Dement. 2024 Oct 22 [Epub ahead of print]
    View PubMed
  6. Lavrova A, Satoh R, Pham NTT, Nguyen A, Jack CR Jr, Petersen RC, Ross RR, Dickson DW, Lowe VJ, Whitwell JL, Josephs KA. Investigating the feasibility of (18)F-flortaucipir PET imaging in the antemortem diagnosis of primary age-related tauopathy (PART): An observational imaging-pathological study. Alzheimers Dement. 2024 Oct 17 [Epub ahead of print]
    View PubMed
  7. Badihian N, Tosakulwong N, Weigand SD, Ali F, Clark HM, Stierwalt J, Botha H, Savica R, Dickson DW, Whitwell JL, Josephs KA. Relationships between regional burden of tau pathology and age at death and disease duration in PSP. Parkinsonism Relat Disord. 2024 Oct; 127:107109 Epub 2024 Aug 17
    View PubMed
  8. Tetzloff KA, Wiepert D, Botha H, Duffy JR, Clark HM, Whitwell JL, Josephs KA, Utianski RL. Automatic Speech Recognition in Primary Progressive Apraxia of Speech. J Speech Lang Hear Res. 2024 Sep 12; 67 (9):2964-2976 Epub 2024 Aug 06
    View PubMed
  9. Spinelli EG, Ghirelli A, Bottale I, Basaia S, Canu E, Castelnovo V, Volonte MA, Galantucci S, Magnani G, Caso F, Cecchetti G, Caroppo P, Prioni S, Villa C, Josephs KA, Whitwell JL, Filippi M, Agosta F. Stepwise Functional Brain Architecture Correlates with Atrophy in Progressive Supranuclear Palsy. Mov Disord. 2024 Sep; 39 (9):1493-1503 Epub 2024 June 17
    View PubMed
  10. Garcia-Guaqueta DP, Ghayal NB, Lowe VJ, Dickson DW, Whitwell JL, Josephs KA. Patterns of glucose hypometabolism can help differentiate FTLD-FET from other types of FTLD. J Neurol. 2024 Sep; 271 (9):6264-6273 Epub 2024 Aug 01
    View PubMed
  11. Garcia-Guaqueta DP, Botha H, Utianski RL, Duffy JR, Clark H, Meade G, Machulda MM, Dickson DW, Pham NTT, Whitwell JL, Josephs KA. Clinicopathologic and Neuroimaging Correlations of Nonverbal Oral Apraxia in Patients With Neurodegenerative Disease. Neurology. 2024 Aug 27; 103 (4):e209717 Epub 2024 July 30
    View PubMed
  12. Turcano P, Whitwell JL, Duffy JR, Machulda MM, Mullan A, Josephs KA, Savica R. Incidence of Primary Progressive Apraxia of Speech and Primary Progressive Aphasia in Olmsted County, MN, 2011-2022. Neurology. 2024 Aug 27; 103 (4):e209693 Epub 2024 July 30
    View PubMed
  13. Shir D, Corriveau-Lecavalier N, Bermudez Noguera C, Barnard L, Pham NTT, Botha H, Duffy JR, Clark HM, Utianski RL, Knopman DS, Petersen RC, Boeve BF, Murray ME, Nguyen AT, Reichard RR, Dickson DW, Day GS, Kremers WK, Graff-Radford NR, Jones DT, Machulda MM, Fields JA, Whitwell JL, Josephs KA, Graff-Radford J. Clinicoradiological and neuropathological evaluation of primary progressive aphasia. J Neurol Neurosurg Psychiatry. 2024 Aug 16; 95 (9):812-821
    View PubMed
  14. Amrami A, Singh NA, Ali F, Pham NTT, Stephens YC, Josephs KA, Whitwell JL. Clinical Utility of Tectal Plate Measurements on Magnetic Resonance Imaging in Progressive Supranuclear Palsy. Mov Disord. 2024 Aug; 39 (8):1402-1407 Epub 2024 Apr 08
    View PubMed
  15. Badihian N, Gatto RG, Satoh R, Ali F, Clark HM, Pham NTT, Whitwell JL, Josephs KA. Clinical and neuroimaging characteristics of primary lateral sclerosis with overlapping features of progressive supranuclear palsy. Eur J Neurol. 2024 Aug; 31 (8):e16320 Epub 2024 Apr 30
    View PubMed
  16. Meade G, Thu Pham NT, Schwarz CG, Clark HM, Duffy JR, Senjem ML, Lowe V, Botha H, Whitwell JL, Josephs KA, Utianski RL. The yes-no reversal phenomenon in patients with primary progressive apraxia of speech. Cortex. 2024 Aug; 177:28-36 Epub 2024 May 04
    View PubMed
  17. Garcia-Guaqueta DP, Stephens YC, Ali F, Utianski RL, Duffy JR, Clark HM, Thu Pham NT, Machulda MM, Lowe VJ, Dickson DW, Whitwell JL, Josephs KA. Comparing classic-onset corticobasal syndrome to speech/language-onset corticobasal syndrome. Parkinsonism Relat Disord. 2024 Aug; 125:107025 Epub 2024 June 03
    View PubMed
  18. Li W, Petersen RC, Algeciras-Schimnich A, Cogswell PM, Bornhorst JA, Kremers WK, Boeve BF, Jones DT, Botha H, Ramanan VK, Knopman DS, Savica R, Josephs KA, Cliatt-Brown C, Andersen E, Day GS, Graff-Radford NR, Ertekin-Taner N, Lachner C, Wicklund M, van Harten A, Woodruff BK, Caselli RJ, Graff-Radford J. Alzheimer Disease Cerebrospinal Fluid Biomarkers in a Tertiary Neurology Practice. Mayo Clin Proc. 2024 Aug; 99 (8):1284-1296 Epub 2024 June 25
    View PubMed
  19. Ulugut H, Bertoux M, Younes K, Montembeault M, Fumagalli GG, Samanci B, Illan-Gala I, Kuchcinski G, Leroy M, Thompson JC, Kobylecki C, Santillo AF, Englund E, Waldo ML, Riedl L, Van den Stock J, Vandenbulcke M, Vandenberghe R, Laforce R Jr, Ducharme S, Pressman PS, Caramelli P, de Souza LC, Takada LT, Gurvit H, Hansson O, Diehl-Schmid J, Galimberti D, Pasquier F, Miller BL, Scheltens P, Ossenkoppele R, van der Flier WM, Barkhof F, Fox NC, Sturm VE, Miyagawa T, Whitwell JL, Boeve B, Rohrer JD, Gorno-Tempini ML, Josephs KA, Snowden J, Warren JD, Rankin KP, Pijnenburg YAL, International rtvFTD Working Group. Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study. Alzheimers Dement. 2024 Aug; 20 (8):5647-5661 Epub 2024 July 10
    View PubMed
  20. Josephs KA, Tosakulwong N, Weigand SD, Graff-Radford J, Schwarz CG, Senjem ML, Machulda MM, Kantarci K, Knopman DS, Nguyen A, Reichard RR, Dickson DW, Petersen RC, Lowe VJ, Jack CR Jr, Whitwell JL. Flortaucipir PET uncovers relationships between tau and amyloid-beta in primary age-related tauopathy and Alzheimer's disease. Sci Transl Med. 2024 Jul 24; 16 (757):eado8076 Epub 2024 July 24
    View PubMed
  21. Manzoni C, Kia DA, Ferrari R, Leonenko G, Costa B, Saba V, Jabbari E, Tan MM, Albani D, Alvarez V, Alvarez I, Andreassen OA, Angiolillo A, Arighi A, Baker M, Benussi L, Bessi V, Binetti G, Blackburn DJ, Boada M, Boeve BF, Borrego-Ecija S, Borroni B, Brathen G, Brooks WS, Bruni AC, Caroppo P, Bandres-Ciga S, Clarimon J, Colao R, Cruchaga C, Danek A, de Boer SC, de Rojas I, di Costanzo A, Dickson DW, Diehl-Schmid J, Dobson-Stone C, Dols-Icardo O, Donizetti A, Dopper E, Durante E, Ferrari C, Forloni G, Frangipane F, Fratiglioni L, Kramberger MG, Galimberti D, Gallucci M, Garcia-Gonzalez P, Ghidoni R, Giaccone G, Graff C, Graff-Radford NR, Grafman J, Halliday GM, Hernandez DG, Hjermind LE, Hodges JR, Holloway G, Huey ED, Illan-Gala I, Josephs KA, Knopman DS, Kristiansen M, Kwok JB, Leber I, Leonard HL, Libri I, Lleo A, Mackenzie IR, Madhan GK, Maletta R, Marquie M, Maver A, Menendez-Gonzalez M, Milan G, Miller BL, Morris CM, Morris HR, Nacmias B, Newton J, Nielsen JE, Nilsson C, Novelli V, Padovani A, Pal S, Pasquier F, Pastor P, Perneczky R, Peterlin B, Petersen RC, Piguet O, Pijnenburg YA, Puca AA, Rademakers R, Rainero I, Reus LM, Richardson AM, Riemenschneider M, Rogaeva E, Rogelj B, Rollinson S, Rosen H, Rossi G, Rowe JB, Rubino E, Ruiz A, Salvi E, Sanchez-Valle R, Sando SB, Santillo AF, Saxon JA, Schlachetzki JC, Scholz SW, Seelaar H, Seeley WW, Serpente M, Sorbi S, Sordon S, St George-Hyslop P, Thompson JC, Van Broeckhoven C, Van Deerlin VM, Van der Lee SJ, Van Swieten J, Tagliavini F, van der Zee J, Veronesi A, Vitale E, Waldo ML, Yokoyama JS, Nalls MA, Momeni P, Singleton AB, Hardy J, Escott-Price V. Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia. Am J Hum Genet. 2024 Jul 11; 111 (7):1316-1329 Epub 2024 June 17
    View PubMed
  22. Meade G, Machulda MM, Clark HM, Duffy JR, Botha H, Whitwell JL, Josephs KA, Utianski RL. Identifying and Addressing Functional Communication Challenges in Patients With Behavioral Variant Frontotemporal Dementia. Am J Speech Lang Pathol. 2024 Jul 3; 33 (4):1573-1589 Epub 2024 June 06
    View PubMed
  23. Lavrova A, Pham NTT, Vernon CJ, Carlos AF, Petersen RC, Dickson DW, Lowe VJ, Jack CR Jr, Whitwell JL, Josephs KA. A multimodal clinical diagnostic approach using MRI and (18)F-FDG-PET for antemortem diagnosis of TDP-43 in cases with low-intermediate Alzheimer's disease neuropathologic changes and primary age-related tauopathy. J Neurol. 2024 Jul; 271 (7):4105-4118 Epub 2024 Apr 05
    View PubMed
  24. Garcia-Guaqueta DP, Botha H, Utianski RL, Duffy JR, Clark HM, Goodrich AW, Pham NTT, Machulda MM, Baker M, Rademakers R, Whitwell JL, Josephs KA. Progression to corticobasal syndrome: a longitudinal study of patients with nonfluent primary progressive aphasia and primary progressive apraxia of speech. J Neurol. 2024 Jul; 271 (7):4168-4179 Epub 2024 Apr 07
    View PubMed
  25. Black JA, Pham NTT, Ali F, Machulda MM, Lowe VJ, Josephs KA, Whitwell JL. Frontal hypometabolism in the diagnosis of progressive supranuclear palsy clinical variants. J Neurol. 2024 Jul; 271 (7):4267-4280 Epub 2024 Apr 17
    View PubMed
  26. Robinson CG, Goodrich AW, Weigand SD, Pham NTT, Carlos AF, Buciuc M, Murray ME, Nguyen AT, Reichard RR, Knopman DS, Petersen RC, Dickson DW, Utianski RL, Whitwell JL, Josephs KA, Machulda MM. Determinants of confrontation naming deficits on the Boston Naming Test associated with transactive response DNA-binding protein 43 pathology. J Int Neuropsychol Soc. 2024 Jul; 30 (6):575-583 Epub 2024 Mar 25
    View PubMed
  27. Singh NA, Alnobani A, Graff-Radford J, Machulda MM, Mielke MM, Schwarz CG, Senjem ML, Jack CR Jr, Lowe VJ, Kanekiyo T, Josephs KA, Whitwell JL. Relationships between PET and blood plasma biomarkers in corticobasal syndrome. Alzheimers Dement. 2024 Jul; 20(7):4765-4774. Epub 2024 Jun 17.
    View PubMed
  28. Singh NA, Graff-Radford J, Machulda MM, Carlos AF, Schwarz CG, Senjem ML, Jack CR Jr, Lowe VJ, Josephs KA, Whitwell JL. Atypical Alzheimer's disease: new insights into an overlapping spectrum between the language and visual variants. J Neurol. 2024 Jun; 271 (6):3571-3585 Epub 2024 Mar 29
    View PubMed
  29. Gatto RG, Pham NTT, Duffy JR, Clark HM, Utianski RL, Botha H, Machulda MM, Lowe VJ, Schwarz CG, Jack CR Jr, Josephs KA, Whitwell JL. Multimodal cross-examination of progressive apraxia of speech by diffusion tensor imaging-based tractography and Tau-PET scans. Hum Brain Mapp. 2024 Jun 1; 45 (8):e26704
    View PubMed
  30. Tetzloff KA, Martin PR, Duffy JR, Utianski RL, Clark HM, Botha H, Machulda MM, Thu Pham NT, Schwarz CG, Senjem ML, Jack CR Jr, Lowe VJ, Josephs KA, Whitwell JL. Longitudinal flortaucipir, metabolism and volume differ between phonetic and prosodic speech apraxia. Brain. 2024 May 3; 147 (5):1696-1709
    View PubMed
  31. Sintini I, Singh NA, Li D, Mielke MM, Machulda MM, Schwarz CG, Senjem ML, Jack CR Jr, Lowe VJ, Graff-Radford J, Josephs KA, Whitwell JL. Plasma glial fibrillary acidic protein in the visual and language variants of Alzheimer's disease. Alzheimers Dement. 2024 May; 20 (5):3679-3686 Epub 2024 Mar 25
    View PubMed
  32. Udine E, DeJesus-Hernandez M, Tian S, das Neves SP, Crook R, Finch NA, Baker MC, Pottier C, Graff-Radford NR, Boeve BF, Petersen RC, Knopman DS, Josephs KA, Oskarsson B, Da Mesquita S, Petrucelli L, Gendron TF, Dickson DW, Rademakers R, van Blitterswijk M. Abundant transcriptomic alterations in the human cerebellum of patients with a C9orf72 repeat expansion. Acta Neuropathol. 2024 Apr 19; 147 (1):73
    View PubMed
  33. Singh NA, Goodrich AW, Graff-Radford J, Machulda MM, Sintini I, Carlos AF, Robinson CG, Reid RI, Lowe VJ, Jack CR Jr, Petersen RC, Boeve BF, Josephs KA, Kantarci K, Whitwell JL. Altered structural and functional connectivity in Posterior Cortical Atrophy and Dementia with Lewy bodies. Neuroimage. 2024 Apr 15; 290:120564 Epub 2024 Mar 03
    View PubMed
  34. Meade G, Whitwell JL, Dickson DW, Duffy JR, Clark HM, Ahlskog JE, Machulda MM, Josephs KA, Utianski RL. Primary Progressive Apraxia of Speech Caused by TDP-43: A Case Report. Neurol Genet. 2024 Apr; 10 (2):e200134 Epub 2024 Mar 19
    View PubMed
  35. Carlos AF, Koga S, Graff-Radford NR, Baker MC, Rademakers R, Ross OA, Dickson DW, Josephs KA. Senile plaque-associated transactive response DNA-binding protein 43 in Alzheimer's disease: A case report spanning 16 years of memory loss. Neuropathology. 2024 Apr; 44 (2):115-125 Epub 2023 July 31
    View PubMed
  36. Petroi-Bock D, Clark HM, Stierwalt JAG, Botha H, Ali F, Whitwell JL, Josephs KA. Influences of motor speech impairments on the presentation of dysphagia in progressive supranuclear palsy. Int J Speech Lang Pathol. 2024 Apr; 26 (2):278-288 Epub 2023 June 19
    View PubMed
  37. Tetzloff KA, Duffy JR, Clark HM, Josephs KA, Whitwell JL, Utianski RL. Characterizing Speech Errors Across Primary Progressive Apraxia of Speech Subtypes. J Speech Lang Hear Res. 2024 Mar 11; 67 (3):811-820 Epub 2024 Feb 20
    View PubMed
  38. Robinson CG, Lee J, Min PH, Przybelski SA, Josephs KA, Jones DT, Graff-Radford J, Boeve BF, Knopman DS, Jack CR Jr, Petersen RC, Machulda MM, Fields JA, Lowe VJ. Significance of a positive tau PET scan with a negative amyloid PET scan. Alzheimers Dement. 2024 Mar; 20 (3):1923-1932 Epub 2023 Dec 30
    View PubMed
  39. Badihian N, Ali F, Botha H, Savica R, Machulda MM, Clark HM, Stierwalt JAG, Pham NTT, Baker MC, Rademakers R, Lowe V, Whitwell JL, Josephs KA. The MAPT p.E342K and p.R406W mutations are associated with progressive supranuclear palsy with atypical features. Parkinsonism Relat Disord. 2024 Feb; 119:105962 Epub 2023 Dec 17
    View PubMed
  40. Satoh R, Ali F, Botha H, Lowe VJ, Josephs KA, Whitwell JL. Direct comparison between (18)F-Flortaucipir tau PET and quantitative susceptibility mapping in progressive supranuclear palsy. Neuroimage. 2024 Feb 1; 286:120509 Epub 2024 Jan 04
    View PubMed
  41. Gatto RG, Martin PR, Utianski RL, Duffy JR, Clark HM, Botha H, Machulda MM, Josephs KA, Whitwell JL. Diffusion tensor imaging-based multi-fiber tracking reconstructions can regionally differentiate phonetic versus prosodic subtypes of progressive apraxia of speech. Cortex. 2024 Feb; 171:272-286 Epub 2023 Nov 08
    View PubMed
  42. Dickson DW, Graff-Radford NR, Wu L, Chapleau M, La Joie R, Yong K, Agosta F, Allen IE, Apostolova L, Best J, Boon BDC, Crutch S, Filippi M, Fumagalli GG, Galimberti D, Graff-Radford J, Grinberg LT, Irwin DJ, Josephs KA, Mendez MF, Mendez PC, Migliaccio R, Miller ZA, Montembeault M, Murray ME, Nemes S, Pelak V, Perani D, Phillips J, Pijnenburg Y, Rogalski E, Schott JM, Seeley W, Sullivan AC, Spina S, Tanner J, Walker J, Whitwell JL, Wolk DA, Ossenkoppele R, Rabinovici GD, PCA International Work Group. Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis. Lancet Neurol. 2024 Feb; 23 (2):168-177
    View PubMed
  43. Marks JD, Ayuso VE, Carlomagno Y, Yue M, Todd TW, Hao Y, Li Z, McEachin ZT, Shantaraman A, Duong DM, Daughrity LM, Jansen-West K, Shao W, Calliari A, Bejarano JG, DeTure M, Rawlinson B, Casey MC, Lilley MT, Donahue MH, Jawahar VM, Boeve BF, Petersen RC, Knopman DS, Oskarsson B, Graff-Radford NR, Wszolek ZK, Dickson DW, Josephs KA, Qi YA, Seyfried NT, Ward ME, Zhang YJ, Prudencio M, Petrucelli L, Cook CN. TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia. Sci Transl Med. 2024 Jan 17; 16 (730):eadf9735
    View PubMed
  44. Robinson CG, Coleman T, Buciuc M, Singh NA, Pham NTT, Machulda MM, Graff-Radford J, Whitwell JL, Josephs KA. Behavioral and Neuropsychiatric Differences Across Two Atypical Alzheimer's Disease Variants: Logopenic Progressive Aphasia and Posterior Cortical Atrophy. J Alzheimers Dis. 2024; 97 (2):895-908
    View PubMed
  45. Orlandi F, Carlos AF, Ali F, Clark HM, Duffy JR, Utianski RL, Botha H, Machulda MM, Stephens YC, Schwarz CG, Senjem ML, Jack CR, Agosta F, Filippi M, Dickson DW, Josephs KA, Whitwell JL. Histologic tau lesions and magnetic resonance imaging biomarkers differ across two progressive supranuclear palsy variants. Brain Commun. 2024; 6 (2):fcae113 Epub 2024 Apr 05
    View PubMed
  46. Josephs KA, Josephs KA Jr. Prosopagnosia: face blindness and its association with neurological disorders. Brain Commun. 2024; 6 (1):fcae002 Epub 2024 Jan 05
    View PubMed
  47. Carlos AF, Weigand SD, Duffy JR, Clark HM, Utianski RL, Machulda MM, Botha H, Thu Pham NT, Lowe VJ, Schwarz CG, Whitwell JL, Josephs KA. Volumetric analysis of hippocampal subregions and subfields in left and right semantic dementia. Brain Commun. 2024; 6 (2):fcae097 Epub 2024 Mar 25
    View PubMed
  48. Gatto RG, Meade G, Duffy JR, Clark HM, Utianski RL, Botha H, Machulda MM, Josephs KA, Whitwell JL. Combined assessment of progressive apraxia of speech brain microstructure by diffusion tensor imaging tractography and multishell neurite orientation dispersion and density imaging. Brain Behav. 2024 Jan; 14 (1):e3346
    View PubMed
  49. Sintini I, Corriveau-Lecavalier N, Jones DT, Machulda MM, Gunter JL, Schwarz CG, Botha H, Carlos AF, Kamykowski MG, Singh NA, Petersen RC, Jack CR Jr, Lowe VJ, Graff-Radford J, Josephs KA, Whitwell JL. Longitudinal default mode sub-networks in the language and visual variants of Alzheimer's disease. Brain Commun. 2024; 6 (2):fcae005 Epub 2024 Jan 08
    View PubMed
  50. Singh-Reilly N, Botha H, Duffy JR, Clark HM, Utianski RL, Machulda MM, Graff-Radford J, Schwarz CG, Petersen RC, Lowe VJ, Jack CR Jr, Josephs KA, Whitwell JL. Speech-language within and between network disruptions in primary progressive aphasia variants. Neuroimage Clin. 2024; 43:103639. Epub 2024 Jul 04.
    View PubMed
  51. Ali F, Clark H, Machulda M, Senjem ML, Lowe VJ, Jack CR Jr, Josephs KA, Whitwell J, Botha H. Patterns of brain volume and metabolism predict clinical features in the progressive supranuclear palsy spectrum. Brain Commun. 2024; 6 (4):fcae233 Epub 2024 July 16
    View PubMed
  52. Youssef H, Gatto RG, Pham NTT, Petersen RC, Machulda MM, Reichard RR, Dickson DW, Jack CR, Whitwell JL, Josephs KA. TDP-43 Is Associated with Subiculum and Cornu Ammonis 1 Hippocampal Subfield Atrophy in Primary Age-Related Tauopathy. J Alzheimers Dis. 2024; 99 (3):1023-1032
    View PubMed
  53. Carlos AF, Sekiya H, Koga S, Gatto RG, Casey MC, Pham NTT, Sintini I, Machulda MM, Jack CR, Lowe VJ, Whitwell JL, Petrucelli L, Reichard RR, Petersen RC, Dickson DW, Josephs KA. Clinicopathologic features of a novel star-shaped transactive response DNA-binding protein 43 (TDP-43) pathology in the oldest old. J Neuropathol Exp Neurol. 2023 Dec 22; 83 (1):36-52
    View PubMed
  54. Satoh R, Weigand SD, Pham NTT, Ali F, Arani A, Senjem ML, Jack CR Jr, Whitwell JL, Josephs KA. Magnetic Susceptibility in Progressive Supranuclear Palsy Variants, Parkinson's Disease, and Corticobasal Syndrome. Mov Disord. 2023 Dec; 38 (12):2282-2290 Epub 2023 Sept 29
    View PubMed
  55. Sintini I, Graff-Radford J, Schwarz CG, Machulda MM, Singh NA, Carlos AF, Senjem ML, Jr CRJ, Lowe VJ, Josephs KA, Whitwell JL. Longitudinal rates of atrophy and tau accumulation differ between the visual and language variants of atypical Alzheimer's disease. Alzheimers Dement. 2023 Oct; 19 (10):4396-4406 Epub 2023 July 23
    View PubMed
  56. Utianski RL, Meade G, Duffy JR, Clark HM, Botha H, Machulda MM, Dickson DW, Whitwell JL, Josephs KA. Longitudinal characterization of patients with progressive apraxia of speech without clearly predominant phonetic or prosodic speech features. Brain Lang. 2023 Oct; 245:105314 Epub 2023 Aug 20
    View PubMed
  57. Singh NA, Martin PR, Graff-Radford J, Machulda MM, Carrasquillo MM, Ertekin-Taner N, Josephs KA, Whitwell JL. APOE epsilon4 influences within and between network functional connectivity in posterior cortical atrophy and logopenic progressive aphasia. Alzheimers Dement. 2023 Sep; 19 (9):3858-3866 Epub 2023 Mar 31
    View PubMed
  58. Estades Ayuso V, Pickles S, Todd T, Yue M, Jansen-West K, Song Y, Gonzalez Bejarano J, Rawlinson B, DeTure M, Graff-Radford NR, Boeve BF, Knopman DS, Petersen RC, Dickson DW, Josephs KA, Petrucelli L, Prudencio M. TDP-43-regulated cryptic RNAs accumulate in Alzheimer's disease brains. Mol Neurodegener. 2023 Aug 21; 18 (1):57
    View PubMed
  59. Utianski RL, Martin PR, Duffy JR, Clark HM, Stierwalt JAG, Botha H, Ali F, Whitwell JL, Josephs KA. Assessing Patients and Care Partner Ratings of Communication-Related Participation Restrictions: Insights From Degenerative Disease. Am J Speech Lang Pathol. 2023 Aug 17; 32 (4S):1793-1805 Epub 2023 Feb 09
    View PubMed
  60. Utianski RL, Duffy JR, Martin PR, Clark HM, Stierwalt JAG, Botha H, Ali F, Whitwell JL, Josephs KA. Rate Modulation Abilities in Acquired Motor Speech Disorders. J Speech Lang Hear Res. 2023 Aug 17; 66 (8S):3194-3205 Epub 2023 Feb 13
    View PubMed
  61. Cheshire WP, Koga S, Tipton PW, Sekiya H, Ross OA, Uitti RJ, Josephs KA, Dickson DW. Cancer in pathologically confirmed multiple system atrophy. Clin Auton Res. 2023 Aug; 33 (4):451-458 Epub 2023 May 13
    View PubMed
  62. Shir D, Pham NTT, Botha H, Koga S, Kouri N, Ali F, Knopman DS, Petersen RC, Boeve BF, Kremers WK, Nguyen AT, Murray ME, Reichard RR, Dickson DW, Graff-Radford N, Josephs KA, Whitwell J, Graff-Radford J. Clinicoradiologic and Neuropathologic Evaluation of Corticobasal Syndrome. Neurology. 2023 Jul 18; 101 (3):e289-e299 Epub 2023 June 02
    View PubMed
  63. Koga S, Murakami A, Soto-Beasley AI, Walton RL, Baker MC, Castanedes-Casey M, Josephs KA, Ross OA, Dickson DW. Publisher Correction to: Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies. Acta Neuropathol Commun. 2023 Jul 12; 11 (1):117 Epub 2023 July 12
    View PubMed
  64. Koga S, Murakami A, Soto-Beasley AI, Walton RL, Baker MC, Castanedes-Casey M, Josephs KA, Ross OA, Dickson DW. Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies. Acta Neuropathol Commun. 2023 Jul 6; 11 (1):109 Epub 2023 July 06
    View PubMed
  65. Carlos AF, Josephs KA. The Role of Clinical Assessment in the Era of Biomarkers. Neurotherapeutics. 2023 Jul; 20 (4):1001-1018 Epub 2023 Aug 18
    View PubMed
  66. Utianski RL, Josephs KA. An Update on Apraxia of Speech. Curr Neurol Neurosci Rep. 2023 Jul; 23 (7):353-359 Epub 2023 June 03
    View PubMed
  67. Carlos AF, Tosakulwong N, Weigand SD, Senjem ML, Schwarz CG, Knopman DS, Boeve BF, Petersen RC, Nguyen AT, Reichard RR, Dickson DW, Jack CR Jr, Lowe V, Whitwell JL, Josephs KA. TDP-43 pathology effect on volume and flortaucipir uptake in Alzheimer's disease. Alzheimers Dement. 2023 Jun; 19 (6):2343-2354 Epub 2022 Dec 04
    View PubMed
  68. Agosta F, Spinelli EG, Basaia S, Cividini C, Falbo F, Pavone C, Riva N, Canu E, Castelnovo V, Magnani G, Caso F, Caroppo P, Prioni S, Villa C, Tremolizzo L, Appollonio I, Silani V, Josephs KA, Whitwell J, Filippi M. Functional Connectivity From Disease Epicenters in Frontotemporal Dementia. Neurology. 2023 May 30; 100 (22):e2290-e2303 Epub 2023 Apr 17
    View PubMed
  69. Josephs KA, Duffy JR, Martin PR, Stephens YC, Singh NA, Clark HM, Botha H, Lowe VJ, Whitwell JL, Utianski RL. Acoustic Analysis and Neuroimaging Correlates of Diadochokinetic Rates in Mild-Moderate Primary Progressive Apraxia of Speech. Brain Lang. 2023 May; 240 Epub 2023 Apr 06
    View PubMed
  70. Robinson CG, Duffy JR, Clark HA, Utianski RL, Machulda MM, Botha H, Singh NA, Pham NTT, Ertekin-Taner N, Dickson DW, Lowe VJ, Whitwell JL, Josephs KA. Clinicopathological associations of hemispheric dominance in primary progressive apraxia of speech. Eur J Neurol. 2023 May; 30 (5):1209-1219 Epub 2023 Mar 15
    View PubMed
  71. Chandregowda A, Clark HM, Machulda MM, Pham NTT, Lowe VJ, Josephs KA, Whitwell JL. A Case of Atypical Alzheimer's Disease With Clinical Manifestation That Straddled the Boundary Between Primary Progressive Aphasia and Posterior Cortical Atrophy. Neurologist. 2023 May 1; 28 (3):195-197 Epub 2023 May 01
    View PubMed
  72. Duffy JR, Martin PR, Clark HM, Utianski RL, Strand EA, Whitwell JL, Josephs KA. The Apraxia of Speech Rating Scale: Reliability, Validity, and Utility. Am J Speech Lang Pathol. 2023 Mar 9; 32 (2):469-491 Epub 2023 Jan 11
    View PubMed
  73. Singh NA, Tosakulwong N, Graff-Radford J, Machulda MM, Pham NTT, Sintini I, Weigand SD, Schwarz CG, Senjem ML, Carrasquillo MM, Ertekin-Taner N, Jack CR Jr, Lowe VJ, Josephs KA, Whitwell JL. APOE epsilon4 influences medial temporal atrophy and tau deposition in atypical Alzheimer's disease. Alzheimers Dement. 2023 Mar; 19 (3):784-796 Epub 2022 June 12
    View PubMed
  74. Pavone C, Weigand SW, Ali F, Clark HM, Botha H, Machulda MM, Savica R, Pham NTT, Grijalva RM, Schwarz CG, Senjem ML, Agosta F, Filippi M, Jack CR, Lowe VJ, Josephs KA, Whitwell JL. Longitudinal clinical decline and baseline predictors in progressive supranuclear palsy. Parkinsonism Relat Disord. 2023 Feb; 107:105290 Epub 2023 Jan 16
    View PubMed
  75. Buciuc M, Koga S, Pham NTT, Duffy JR, Knopman DS, Ali F, Boeve BF, Graff-Radford J, Botha H, Lowe VJ, Nguyen A, Reichard RR, Dickson DW, Petersen RC, Whitwell JL, Josephs KA. The many faces of globular glial tauopathy: A clinical and imaging study. Eur J Neurol. 2023 Feb; 30(2):321-333. Epub 2022 Nov 01.
    View PubMed
  76. Satoh R, Arani A, Senjem ML, Duffy JR, Clark HM, Utianski RL, Botha H, Machulda MM, Jack CR Jr, Whitwell JL, Josephs KA. Spatial patterns of elevated magnetic susceptibility in progressive apraxia of speech. Neuroimage Clin. 2023; 38:103394 Epub 2023 Mar 28
    View PubMed
  77. Tetzloff KA, Duffy JR, Clark HM, Pham NTT, Machulda MM, Botha H, Jack CR, Dickson DW, Lowe VJ, Josephs KA, Whitwell JL, Utianski RL. Amyloid and Tau PET Positivity in Progressive Agrammatic Aphasia and Apraxia of Speech. J Alzheimers Dis. 2023; 96 (4):1759-1765
    View PubMed
  78. Josephs KA, Koga S, Tosakulwong N, Weigand SD, Nha Pham TT, Baker M, Whitwell JL, Rademakers R, Petrucelli L, Dickson DW. Molecular fragment characteristics and distribution of tangle associated TDP-43 (TATs) and other TDP-43 lesions in Alzheimer's disease. Free Neuropathol. 2023 Jan; 4 Epub 2023 Dec 08
    View PubMed
  79. Pickles S, Zanetti Alepuz D, Koike Y, Yue M, Tong J, Liu P, Zhou Y, Jansen-West K, Daughrity LM, Song Y, DeTure M, Oskarsson B, Graff-Radford NR, Boeve BF, Petersen RC, Josephs KA, Dickson DW, Ward ME, Dong L, Prudencio M, Cook CN, Petrucelli L. CRISPR interference to evaluate modifiers of C9ORF72-mediated toxicity in FTD. Front Cell Dev Biol. 2023; 11:1251551 Epub 2023 Aug 07
    View PubMed
  80. Singh NA, Martin PR, Graff-Radford J, Sintini I, Machulda MM, Duffy JR, Gunter JL, Botha H, Jones DT, Lowe VJ, Jack CR Jr, Josephs KA, Whitwell JL. Altered within- and between-network functional connectivity in atypical Alzheimer's disease. Brain Commun. 2023; 5 (4):fcad184 Epub 2023 June 14
    View PubMed
  81. Utianski RL, Trang Thu Pham N, Botha H, Ali F, Duffy JR, Clark HM, Lowe VJ, Whitwell JL, Josephs KA. Longitudinal changes in dopamine transporter uptake scans in progressive apraxia of speech. Clin Park Relat Disord. 2023; 9:100207 Epub 2023 June 16
    View PubMed
  82. Carlos AF, Machulda MM, Rutledge MH, Nguyen AT, Reichard RR, Baker MC, Rademakers R, Dickson DW, Petersen RC, Josephs KA. Comparison of Clinical, Genetic, and Pathologic Features of Limbic and Diffuse Transactive Response DNA-Binding Protein 43 Pathology in Alzheimer's Disease Neuropathologic Spectrum. J Alzheimers Dis. 2023; 93 (4):1521-1535
    View PubMed
  83. Singh NA, Graff-Radford J, Machulda MM, Pham NTT, Schwarz CG, Reid RI, Lowe VJ, Petersen RC, Jack CR, Josephs KA, Whitwell JL. Diffusivity Changes in Posterior Cortical Atrophy and Logopenic Progressive Aphasia: A Longitudinal Diffusion Tensor Imaging Study. J Alzheimers Dis. 2023; 94 (2):709-725
    View PubMed
  84. Gatto RG, Carlos AF, Reichard RR, Lowe VJ, Whitwell JL, Josephs KA. Comparative assessment of regional tau distribution by Tau-PET and Post-mortem neuropathology in a representative set of Alzheimer's & frontotemporal lobar degeneration patients. PLoS One. 2023; 18 (5):e0284182 Epub 2023 May 11
    View PubMed
  85. Utianski RL, Clark HM, Martin PR, Stierwalt JAG, Duffy JR, Botha H, Ali F, Josephs KA. Patient and Care Partner Ratings of Communication Participation in Frontotemporal Dementia. Alzheimers Dement. 2022 Dec; 18 Suppl 9:e060715
    View PubMed
  86. Singh NA, Graff-Radford J, Machulda MM, Schwarz CG, Baker MC, Rademakers R, Ertekin-Taner N, Lowe VJ, Josephs KA, Whitwell JL. Atypical Alzheimer's disease phenotypes with normal or borderline PET biomarker profiles. J Neurol. 2022 Dec; 269(12):6613-6626. Epub 2022 Aug 24.
    View PubMed
  87. Josephs KA, Tosakulwong N, Gatto RG, Weigand SD, Ali F, Botha H, Graff-Radford J, Machulda MM, Savica R, Schwarz CG, Senjem ML, Boeve BF, Kantarci K, Jones DT, Ramanan VK, Fields JA, Reichard RR, Dickson DW, Petersen RC, Jack CR Jr, Lowe VJ, Whitwell JL. Optimum Differentiation of Frontotemporal Lobar Degeneration from Alzheimer Disease Achieved with Cross-Sectional Tau Positron Emission Tomography. Ann Neurol. 2022 Dec; 92 (6):1016-1029 Epub 2022 Aug 29
    View PubMed
  88. Sintini I, Duffy JR, Clark HM, Utianski RL, Botha H, Machulda MM, Senjem ML, Strand EA, Schwarz CG, Lowe VJ, Jack CR, Josephs KA, Whitwell JL. Functional connectivity to the premotor cortex maps onto longitudinal brain neurodegeneration in progressive apraxia of speech. Neurobiol Aging. 2022 Dec; 120:105-116 Epub 2022 Sept 02
    View PubMed
  89. Pham NTT, Graff-Radford J, Machulda MM, Spychalla AJ, Schwarz CG, Senjem ML, Lowe VJ, Vemuri P, Kantarci K, Knopman DS, Petersen RC, Jack CR, Josephs KA, Whitwell JL. Regional white matter hyperintensities in posterior cortical atrophy and logopenic progressive aphasia. Neurobiol Aging. 2022 Nov; 119:46-55 Epub 2022 July 28
    View PubMed
  90. Murakami A, Koga S, Sekiya H, Oskarsson B, Boylan K, Petrucelli L, Josephs KA, Dickson DW. Old age amyotrophic lateral sclerosis and limbic TDP-43 pathology. Brain Pathol. 2022 Nov; 32 (6):e13100 Epub 2022 June 17
    View PubMed
  91. Hassan A, Mittal SO, Hu WT, Josephs KA, Sorenson EJ, Ahlskog JE. Does limited EMG denervation in early primary lateral sclerosis predict amyotrophic lateral sclerosis? Amyotroph Lateral Scler Frontotemporal Degener. 2022 Nov; 23 (7-8):554-561 Epub 2022 Feb 16
    View PubMed
  92. Ali S, Tipton PW, Koga S, Middlebrooks EH, Josephs KA, Strongosky A, Dickson DW, Wszolek ZK. A novel CSF1R variant in a South Dakota family with CSF1R-related leukoencephalopathy. Parkinsonism Relat Disord 2022 Sep; 102:51-53 Epub 2022 July 31
    View PubMed
  93. Chandregowda A, Duffy JR, Machulda MM, Lowe VJ, Whitwell JL, Josephs KA. Dynamic aphasia with emerging agrammatism, anomia, and aberrant frontal behaviors in a case of atypical parkinsonism. Neurol Clin Neurosci. 2022 Sep; 10 (5):262-265 Epub 2022 July 20
    View PubMed
  94. Carlos AF, Sekiya H, Koga S, Pham NTT, Ali F, Botha H, Clark HM, Coon EA, Lowe V, Ahlskog JE, Trejo-Lopez JA, Dickson DW, Whitwell JL, Josephs KA. Tau-PET and multimodal imaging in clinically atypical multiple system atrophy masquerading as progressive supranuclear palsy. Parkinsonism Relat Disord. 2022 Aug; 101:9-14 Epub 2022 June 16
    View PubMed
  95. Carlos AF, Josephs KA. Frontotemporal lobar degeneration with TAR DNA-binding protein 43 (TDP-43): its journey of more than 100 years. J Neurol. 2022 Aug; 269 (8):4030-4054 Epub 2022 Mar 23
    View PubMed
  96. Pottier C, Mateiu L, Baker MC, DeJesus-Hernandez M, Teixeira Vicente C, Finch NA, Tian S, van Blitterswijk M, Murray ME, Ren Y, Petrucelli L, Oskarsson B, Biernacka JM, Graff-Radford NR, Boeve BF, Petersen RC, Josephs KA, Asmann YW, Dickson DW, Rademakers R. Shared brain transcriptomic signature in TDP-43 type A FTLD patients with or without GRN mutations. Brain. 2022 Jul 29; 145 (7):2472-2485
    View PubMed
  97. Pickles S, Gendron TF, Koike Y, Yue M, Song Y, Kachergus JM, Shi J, DeTure M, Thompson EA, Oskarsson B, Graff-Radford NR, Boeve BF, Petersen RC, Wszolek ZK, Josephs KA, Dickson DW, Petrucelli L, Cook CN, Prudencio M. Evidence of cerebellar TDP-43 loss of function in FTLD-TDP. Acta Neuropathol Commun. 2022 Jul 25; 10 (1):107 Epub 2022 July 25
    View PubMed
  98. Carlos AF, Tosakulwong N, Weigand SD, Boeve BF, Knopman DS, Petersen RC, Nguyen A, Reichard RR, Murray ME, Dickson DW, Josephs KA. Frequency and distribution of TAR DNA-binding protein 43 (TDP-43) pathology increase linearly with age in a large cohort of older adults with and without dementia. Acta Neuropathol. 2022 Jul; 144 (1):159-160 Epub 2022 May 10
    View PubMed
  99. Shir D, Graff-Radford J, Machulda MM, Pham NTT, Jack CR Jr, Lowe VJ, Whitwell JL, Josephs KA. Posterior cortical atrophy: Primary occipital variant. Eur J Neurol. 2022 Jul; 29 (7):2138-2143 Epub 2022 Mar 30
    View PubMed
  100. Koga S, Josephs KA, Aiba I, Yoshida M, Dickson DW. Neuropathology and emerging biomarkers in corticobasal syndrome. J Neurol Neurosurg Psychiatry. 2022 Jun 13; 93 (9):919-29 Epub 2022 June 13
    View PubMed
  101. Whitwell JL, Martin PR, Graff-Radford J, Machulda MM, Sintini I, Buciuc M, Senjem ML, Schwarz CG, Botha H, Carrasquillo MM, Ertekin-Taner N, Lowe VJ, Jack CR, Josephs KA. Investigating Heterogeneity and Neuroanatomic Correlates of Longitudinal Clinical Decline in Atypical Alzheimer Disease. Neurology. 2022 Jun 13; 98 (24):e2436-e2445 Epub 2022 June 13
    View PubMed
  102. Josephs KA, Tosakulwong N, Weigand SD, Buciuc M, Lowe VJ, Dickson DW, Whitwell JL. Relationship Between (18)F-Flortaucipir Uptake and Histologic Lesion Types in 4-Repeat Tauopathies. J Nucl Med. 2022 Jun; 63 (6):931-935 Epub 2021 Sept 23
    View PubMed
  103. Josephs KA, Weigand SD, Whitwell JL. Characterizing Amyloid-Positive Individuals With Normal Tau PET Levels After 5 Years: An ADNI Study. Neurology. 2022 May 31; 98 (22):e2282-e2292 Epub 2022 Mar 21
    View PubMed
  104. Polsinelli AJ, Machulda MM, Martin PR, Duffy JR, Clark HM, Butts AM, Botha H, Lowe VJ, Whitwell JL, Josephs KA, Utianski RL. Neuropsychological Profiles of Patients with Progressive Apraxia of Speech and Aphasia. J Int Neuropsychol Soc. 2022 May; 28 (5):441-451 Epub 2021 July 22
    View PubMed
  105. Grijalva RM, Pham NTT, Huang Q, Martin PR, Ali F, Clark HM, Duffy JR, Utianski RL, Botha H, Machulda MM, Weigand SD, Ahlskog JE, Dickson DW, Josephs KA, Whitwell JL. Brainstem Biomarkers of Clinical Variant and Pathology in Progressive Supranuclear Palsy. Mov Disord. 2022 Apr; 37 (4):702-712 Epub 2021 Dec 31
    View PubMed
  106. Utianski RL, Botha H, Caviness JN, Worrell GA, Duffy JR, Clark HM, Whitwell JL, Josephs KA. A Preliminary Report of Network Electroencephalographic Measures in Primary Progressive Apraxia of Speech and Aphasia. Brain Sci. 2022 Mar 12; 12 (3)
    View PubMed
  107. Raghavan S, Przybelski SA, Reid RI, Lesnick TG, Ramanan VK, Botha H, Matchett BJ, Murray ME, Reichard RR, Knopman DS, Graff-Radford J, Jones DT, Lowe VJ, Mielke MM, Machulda MM, Petersen RC, Kantarci K, Whitwell JL, Josephs KA, Jack CR Jr, Vemuri P. White matter damage due to vascular, tau, and TDP-43 pathologies and its relevance to cognition. Acta Neuropathol Commun. 2022 Feb 5; 10 (1):16 Epub 2022 Feb 05
    View PubMed
  108. Koga S, Murakami A, Josephs KA, Dickson DW. Diffuse Lewy body disease presenting as Parkinson's disease with progressive aphasia. Neuropathology. 2022 Feb; 42 (1):82-89 Epub 2022 Jan 13
    View PubMed
  109. Bower SM, Weigand SD, Ali F, Clark HM, Botha H, Stierwalt JA, Whitwell JL, Josephs KA. Depression and Apathy across Different Variants of Progressive Supranuclear Palsy. Mov Disord Clin Pract. 2022 Feb; 9 (2):212-217 Epub 2021 Dec 31
    View PubMed
  110. Josephs KA, Pham NTT, Graff-Radford J, Machulda MM, Lowe VJ, Whitwell JL. Medial Temporal Atrophy in Posterior Cortical Atrophy and Its Relationship to the Cingulate Island Sign. J Alzheimers Dis. 2022; 86 (1):491-498
    View PubMed
  111. Gatto RG, Martin PR, Ali F, Clark HM, Duffy JR, Utianski RL, Botha H, Machulda MM, Dickson DW, Josephs KA, Whitwell JL. Diffusion tractography of superior cerebellar peduncle and dentatorubrothalamic tracts in two autopsy confirmed progressive supranuclear palsy variants: Richardson syndrome and the speech-language variant. Neuroimage Clin. 2022; 35:103030 Epub 2022 May 11
    View PubMed
  112. Carlos AF, Tosakulwong N, Weigand SD, Buciuc M, Ali F, Clark HM, Botha H, Utianski RL, Machulda MM, Schwarz CG, Reid RI, Senjem ML, Jack CR Jr, Ahlskog JE, Dickson DW, Josephs KA, Whitwell JL. Histologic lesion type correlates of magnetic resonance imaging biomarkers in four-repeat tauopathies. Brain Commun. 2022; 4 (3):fcac108 Epub 2022 Apr 28
    View PubMed
  113. Hokelekli FO, Duffy JR, Clark HM, Utianski RL, Botha H, Stierwalt JA, Strand EA, Machulda MM, Whitwell JL, Josephs KA. Cross-Sectional and Longitudinal Assessment of Behavior in Primary Progressive Apraxia of Speech and Agrammatic Aphasia. Dement Geriatr Cogn Disord. 2022; 51 (2):193-202 Epub 2022 May 06
    View PubMed
  114. Hokelekli FO, Duffy JR, Clark HM, Utianski RL, Botha H, Ali F, Stierwalt JA, Machulda MM, Reichard RR, Dickson DW, Whitwell JL, Josephs KA. Autopsy Validation of Progressive Supranuclear Palsy-Predominant Speech/Language Disorder Criteria. Mov Disord. 2022 Jan; 37 (1):213-218 Epub 2021 Oct 10
    View PubMed
  115. Stang CD, Mullan AF, Camerucci E, Hajeb M, Turcano P, Martin P, Mielke MM, Josephs KA, Splett M, Abler V, Boeve BF, Bower JH, Savica R. Incidence, Prevalence, and Mortality of Psychosis Associated with Parkinson's Disease (1991-2010). J Parkinsons Dis. 2022; 12 (4):1319-1327
    View PubMed
  116. Buciuc M, Martin PR, Tosakulwong N, Murray ME, Petrucelli L, Senjem ML, Spychalla AJ, Knopman DS, Boeve BF, Petersen RC, Parisi JE, Reichard RR, Dickson DW, Jack CR Jr, Whitwell JL, Josephs KA. TDP-43-associated atrophy in brains with and without frontotemporal lobar degeneration. Neuroimage Clin. 2022; 34:102954 Epub 2022 Feb 04
    View PubMed
  117. Valls Carbo A, Reid RI, Tosakulwong N, Weigand SD, Duffy JR, Clark HM, Utianski RL, Botha H, Machulda MM, Strand EA, Schwarz CG, Jack CR, Josephs KA, Whitwell JL. Tractography of supplementary motor area projections in progressive speech apraxia and aphasia. Neuroimage Clin. 2022; 34:102999 Epub 2022 Mar 30
    View PubMed
  118. Lachner C, Day GS, Camsari GB, Kouri N, Ertekin-Taner N, Boeve BF, Labuzan SA, Lucas JA, Thompson EA, Siddiqui H, Crook JE, Cabrera-Rodriguez JN, Josephs KA, Petersen RC, Dickson DW, Reichard RR, Mielke MM, Knopman DS, Graff-Radford NR, Murray ME. Cancer and Vascular Comorbidity Effects on Dementia Risk and Neuropathology in the Oldest-Old. J Alzheimers Dis. 2022; 90 (1):405-417
    View PubMed
  119. Singh NA, Arani A, Graff-Radford J, Senjem ML, Martin PR, Machulda MM, Schwarz CG, Shu Y, Cogswell PM, Knopman DS, Petersen RC, Lowe VJ, Jack CR Jr, Josephs KA, Whitwell JL. Distinct brain iron profiles associated with logopenic progressive aphasia and posterior cortical atrophy. Neuroimage Clin. 2022; 36:103161. Epub 2022 Aug 22.
    View PubMed
  120. Butts AM, Machulda MM, Martin P, Przybelski SA, Duffy JR, Graff-Radford J, Knopman DS, Petersen RC, Jack CR Jr, Lowe VJ, Josephs KA, Whitwell JL. Temporal Cortical Thickness and Cognitive Associations among Typical and Atypical Phenotypes of Alzheimer's Disease. J Alzheimers Dis Rep. 2022; 6 (1):479-491 Epub 2022 Aug 05
    View PubMed
  121. Chandregowda A, Clark HM, Duffy JR, Machulda MM, Lowe VJ, Whitwell JL, Josephs KA. Dynamic Aphasia as a Variant of Frontotemporal Dementia. Cogn Behav Neurol. 2021 Dec 2; 34 (4):303-318 Epub 2021 Dec 02
    View PubMed
  122. Whitwell JL, Tosakulwong N, Weigand SD, Graff-Radford J, Ertekin-Taner N, Machulda MM, Duffy JR, Schwarz CG, Senjem ML, Jack CR, Lowe VJ, Josephs KA, Alzheimer's Disease Neuroimaging Initiative. Relationship of APOE, age at onset, amyloid and clinical phenotype in Alzheimer disease. Neurobiol Aging. 2021 Dec; 108:90-98 Epub 2021 Aug 25
    View PubMed
  123. Dang J, Graff-Radford J, Duffy JR, Utianski RL, Clark HM, Stierwalt JA, Whitwell JL, Josephs KA, Botha H. Progressive apraxia of speech: delays to diagnosis and rates of alternative diagnoses. J Neurol. 2021 Dec; 268 (12):4752-4758 Epub 2021 May 04
    View PubMed
  124. Buciuc M, Whitwell JL, Baker MC, Rademakers R, Dickson DW, Josephs KA. Old age genetically confirmed frontotemporal lobar degeneration with TDP-43 has limbic predominant TDP-43 deposition. Neuropathol Appl Neurobiol. 2021 Dec; 47 (7):1050-1059 Epub 2021 May 21
    View PubMed
  125. Buciuc M, Josephs KA, Jones DT, Whitwell JL, Graff-Radford J. Progressive Auditory Verbal Agnosia Secondary to Alzheimer Disease. Neurology. 2021 Nov 9; 97 (19):908-909 Epub 2021 Sept 09
    View PubMed
  126. Scheffel L, Duffy JR, Strand EA, Josephs KA. Word Fluency Test Performance in Primary Progressive Aphasia and Primary Progressive Apraxia of Speech. Am J Speech Lang Pathol. 2021 Nov 4; 30 (6):2635-2642 Epub 2021 Oct 21
    View PubMed
  127. Utianski RL, Martin PR, Duffy JR, Botha H, Clark HM, Josephs KA. Assessing Change in Communication Limitations in Primary Progressive Apraxia of Speech and Aphasia: A 1-Year Follow-Up Study. Am J Speech Lang Pathol. 2021 Nov 4; 30 (6):2368-2378 Epub 2021 Sept 07
    View PubMed
  128. Clark HM, Tosakulwong N, Weigand SD, Ali F, Botha H, Pham NTT, Schwarz CG, Reid RI, Senjem ML, Jack CR Jr, Lowe VJ, Ahlskog JE, Josephs KA, Whitwell JL. Gray and White Matter Correlates of Dysphagia in Progressive Supranuclear Palsy. Mov Disord. 2021 Nov; 36 (11):2669-2675 Epub 2021 Aug 23
    View PubMed
  129. Ali F, Loushin SR, Botha H, Josephs KA, Whitwell JL, Kaufman K. Laboratory based assessment of gait and balance impairment in patients with progressive supranuclear palsy. J Neurol Sci. 2021 Oct 15; 429:118054 Epub 2021 Aug 25
    View PubMed
  130. Hokelekli FO, Ali F, Carlos AF, Martin PR, Clark HM, Duffy JR, Utianski RL, Botha H, St Louis EK, Whitwell JL, Josephs KA. Sleep disturbances in the speech-language variant of progressive supranuclear palsy. Parkinsonism Relat Disord. 2021 Oct; 91:9-12 Epub 2021 Aug 18
    View PubMed
  131. Schwarz CG, Therneau TM, Weigand SD, Gunter JL, Lowe VJ, Przybelski SA, Senjem ML, Botha H, Vemuri P, Kantarci K, Boeve BF, Whitwell JL, Josephs KA, Petersen RC, Knopman DS, Jack CR Jr. Selecting software pipelines for change in flortaucipir SUVR: Balancing repeatability and group separation. Neuroimage. 2021 Sep; 238:118259 Epub 2021 June 09
    View PubMed
  132. Whitwell JL, Tosakulwong N, Clark HM, Ali F, Botha H, Weigand SD, Sintini I, Machulda MM, Schwarz CG, Reid RI, Jack CR Jr, Ahlskog JE, Josephs KA. Diffusion tensor imaging analysis in three progressive supranuclear palsy variants. J Neurol. 2021 Sep; 268 (9):3409-3420 Epub 2021 Mar 12
    View PubMed
  133. Buciuc M, Duffy JR, Machulda MM, Graff-Radford J, Pham NTT, Martin PR, Senjem ML, Jack CR Jr, Ertekin-Taner N, Dickson DW, Lowe VJ, Whitwell JL, Josephs KA. Clinical, Imaging, and Pathologic Characteristics of Patients With Right vs Left Hemisphere-Predominant Logopenic Progressive Aphasia. Neurology. 2021 Aug 3; 97 (5):e523-e534 Epub 2021 June 04
    View PubMed
  134. Chandregowda A, Duffy JR, Machulda MM, Lowe VJ, Whitwell JL, Josephs KA. Neurodegeneration of the visual word form area in a patient with word form alexia. Neurol Clin Neurosci. 2021 Jul; 9 (4):359-360 Epub 2021 May 24
    View PubMed
  135. Clark HM, Utianski RL, Ali F, Botha H, Whitwell JL, Josephs KA. Motor Speech Disorders and Communication Limitations in Progressive Supranuclear Palsy. Am J Speech Lang Pathol. 2021 Jun 18; 30 (3S):1361-1372 Epub 2021 Mar 09
    View PubMed
  136. Josephs KA, Duffy JR, Clark HM, Utianski RL, Strand EA, Machulda MM, Botha H, Martin PR, Pham NTT, Stierwalt J, Ali F, Buciuc M, Baker M, Fernandez De Castro CH, Spychalla AJ, Schwarz CG, Reid RI, Senjem ML, Jack CR Jr, Lowe VJ, Bigio EH, Reichard RR, Polley EJ, Ertekin-Taner N, Rademakers R, DeTure MA, Ross OA, Dickson DW, Whitwell JL. A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech. Nat Commun. 2021 Jun 8; 12 (1):3452 Epub 2021 June 08
    View PubMed
  137. Whitwell JL, Martin P, Duffy JR, Clark HM, Utianski RL, Botha H, Machulda MM, Strand EA, Josephs KA. Survival Analysis in Primary Progressive Apraxia of Speech and Agrammatic Aphasia. Neurol Clin Pract. 2021 Jun; 11 (3):249-255
    View PubMed
  138. Petroi D, Walker GM, Duffy JR, Hickok GS, Josephs KA. A Cognitive Psychometric Investigation of Word Production and Phonological Error Rates in Logopenic Progressive Aphasia. Am J Speech Lang Pathol. 2021 May 18; 30 (3):1194-1202 Epub 2021 Apr 19
    View PubMed
  139. DeJesus-Hernandez M, Aleff RA, Jackson JL, Finch NA, Baker MC, Gendron TF, Murray ME, McLaughlin IJ, Harting JR, Graff-Radford NR, Oskarsson B, Knopman DS, Josephs KA, Boeve BF, Petersen RC, Fryer JD, Petrucelli L, Dickson DW, Rademakers R, Ebbert MTW, Wieben ED, van Blitterswijk M. Long-read targeted sequencing uncovers clinicopathological associations for C9orf72-linked diseases. Brain. 2021 May 7; 144 (4):1082-1088
    View PubMed
  140. Hassan A, Mittal SO, Hu WT, Josephs KA, Sorenson EJ, Ahlskog JE. Natural History of "Pure" Primary Lateral Sclerosis. Neurology. 2021 Apr 27; 96 (17):e2231-e2238 Epub 2021 Feb 26
    View PubMed
  141. Hokelekli FO, Whitwell JL, Machulda MM, Jones DT, Uitti RJ, Pham NTT, Giannini C, Baker M, Lowe VJ, Dickson DW, Josephs KA. Underlying pathology identified after 20 years of disease course in two cases of slowly progressive frontotemporal dementia syndromes. Neurocase. 2021 Apr; 27 (2):212-222 Epub 2021 Apr 27
    View PubMed
  142. Buciuc M, Whitwell JL, Kasanuki K, Graff-Radford J, Machulda MM, Duffy JR, Strand EA, Lowe VJ, Graff-Radford NR, Rush BK, Franczak MB, Flanagan ME, Baker MC, Rademakers R, Ross OA, Ghetti BF, Parisi JE, Raghunathan A, Reichard RR, Bigio EH, Dickson DW, Josephs KA. Lewy Body Disease is a Contributor to Logopenic Progressive Aphasia Phenotype. Ann Neurol. 2021 Mar; 89 (3):520-533 Epub 2020 Dec 17
    View PubMed
  143. Utianski RL, Martin PR, Hanley H, Duffy JR, Botha H, Clark HM, Whitwell JL, Josephs KA. A Longitudinal Evaluation of Speech Rate in Primary Progressive Apraxia of Speech. J Speech Lang Hear Res. 2021 Feb 17; 64 (2):392-404 Epub 2021 Jan 21
    View PubMed
  144. Sintini I, Graff-Radford J, Jones DT, Botha H, Martin PR, Machulda MM, Schwarz CG, Senjem ML, Gunter JL, Jack CR, Lowe VJ, Josephs KA, Whitwell JL. Tau and Amyloid Relationships with Resting-state Functional Connectivity in Atypical Alzheimer's Disease. Cereb Cortex. 2021 Feb 5; 31 (3):1693-1706
    View PubMed
  145. Utianski RL, Schwarz CG, Murray ME, Tranovich JF, Scott NE, Lowe VJ, Whitwell JL, Josephs KA. In Vivo Imaging and Autoradiography in a Case of Autopsy-Confirmed Pick Disease. Neurol Clin Pract. 2021 Feb; 11 (1):e11-e14
    View PubMed
  146. Buciuc M, Duffy JR, Machulda MM, Spychalla AJ, Gunter JL, Jack CR Jr, Giannini C, Raghunathan A, Dickson DW, Josephs KA, Whitwell JL. Association of amyloid angiopathy with microbleeds in logopenic progressive aphasia: an imaging-pathology study. Eur J Neurol. 2021 Feb; 28 (2):670-675 Epub 2020 Nov 12
    View PubMed
  147. Stang CD, Mullan AF, Hajeb M, Camerucci E, Turcano P, Martin P, Mielke MM, Josephs KA, Bower JH, St Louis EK, Boeve BF, Savica R. Timeline of Rapid Eye Movement Sleep Behavior Disorder in Overt Alpha-Synucleinopathies. Ann Neurol. 2021 Feb; 89 (2):293-303 Epub 2020 Nov 20
    View PubMed
  148. Townley RA, Botha H, Graff-Radford J, Whitwell J, Boeve BF, Machulda MM, Fields JA, Drubach DA, Savica R, Petersen RC, Senjem ML, Knopman DS, Lowe VJ, Jack CR Jr, Josephs KA, Jones DT. Posterior cortical atrophy phenotypic heterogeneity revealed by decoding (18)F-FDG-PET. Brain Commun. 2021; 3 (4):fcab182 Epub 2021 Aug 19
    View PubMed
  149. Sintini I, Kaufman K, Botha H, Martin PR, Loushin SR, Senjem ML, Reid RI, Schwarz CG, Jack CR Jr, Lowe VJ, Josephs KA, Whitwell JL, Ali F. Neuroimaging correlates of gait abnormalities in progressive supranuclear palsy. Neuroimage Clin. 2021; 32:102850 Epub 2021 Oct 12
    View PubMed
  150. Tetzloff KA, Duffy JR, Strand EA, Machulda MM, Schwarz CG, Senjem ML, Jack CR, Josephs KA, Whitwell JL. Phonological Errors in Posterior Cortical Atrophy. Dement Geriatr Cogn Disord. 2021; 50 (2):195-203 Epub 2021 July 16
    View PubMed
  151. Coughlin DG, Dickson DW, Josephs KA, Litvan I. Progressive Supranuclear Palsy and Corticobasal Degeneration. Adv Exp Med Biol. 2021; 1281:151-176
    View PubMed
  152. Duffy JR, Utianski RL, Josephs KA. Primary Progressive Apraxia of Speech: From Recognition to Diagnosis and Care. Aphasiology. 2021; 35 (4):560-591 Epub 2020 July 07
    View PubMed
  153. Curet Burleson AX, Pham NTT, Buciuc M, Botha H, Duffy JR, Clark HM, Utianski RL, Machulda MM, Baker MC, Rademakers R, Lowe VJ, Whitwell JL, Josephs KA. Neurobehavioral Characteristics of FDG-PET Defined Right-Dominant Semantic Dementia: A Longitudinal Study. Dement Geriatr Cogn Disord. 2021; 50 (1):17-28 Epub 2021 Mar 23
    View PubMed
  154. Buciuc M, Tosakulwong N, Machulda MM, Whitwell JL, Weigand SD, Murray ME, Reichard RR, Parisi JE, Dickson DW, Boeve BF, Knopman DS, Petersen RC, Josephs KA. TAR DNA-Binding Protein 43 Is Associated with Rate of Memory, Functional and Global Cognitive Decline in the Decade Prior to Death. J Alzheimers Dis. 2021; 80 (2):683-693
    View PubMed
  155. Whitwell JL, Tosakulwong N, Schwarz CC, Senjem ML, Spychalla AJ, Duffy JR, Graff-Radford J, Machulda MM, Boeve BF, Knopman DS, Petersen RC, Lowe VJ, Jack CR Jr, Dickson DW, Parisi JE, Josephs KA. Longitudinal anatomic, functional, and molecular characterization of Pick disease phenotypes. Neurology. 2020 Dec 15; 95(24):e3190-e3202. Epub 2020 Sep 28.
    View PubMed
  156. Josephs KA, Martin PR, Weigand SD, Tosakulwong N, Buciuc M, Murray ME, Petrucelli L, Senjem ML, Spychalla AJ, Knopman DS, Boeve BF, Petersen RC, Parisi JE, Dickson DW, Jack CR, Whitwell JL. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain. 2020 Dec 5; 143 (11):3463-3476
    View PubMed
  157. Seckin ZI, Duffy JR, Strand EA, Clark HM, Utianski RL, Machulda MM, Botha H, Ali F, Thu Pham NT, Lowe VJ, Whitwell JL, Josephs KA. The evolution of parkinsonism in primary progressive apraxia of speech: A 6-year longitudinal study. Parkinsonism Relat Disord. 2020 Dec; 81:34-40. Epub 2020 Oct 07.
    View PubMed
  158. Utianski RL, Clark HM, Duffy JR, Botha H, Whitwell JL, Josephs KA. Communication Limitations in Patients With Progressive Apraxia of Speech and Aphasia. Am J Speech Lang Pathol. 2020 Nov 12; 29 (4):1976-1986 Epub 2020 Aug 05
    View PubMed
  159. Prudencio M, Humphrey J, Pickles S, Brown AL, Hill SE, Kachergus JM, Shi J, Heckman MG, Spiegel MR, Cook C, Song Y, Yue M, Daughrity LM, Carlomagno Y, Jansen-West K, de Castro CF, DeTure M, Koga S, Wang YC, Sivakumar P, Bodo C, Candalija A, Talbot K, Selvaraj BT, Burr K, Chandran S, Newcombe J, Lashley T, Hubbard I, Catalano D, Kim D, Propp N, Fennessey S, Fagegaltier D, Phatnani H, Secrier M, Fisher EM, Oskarsson B, van Blitterswijk M, Rademakers R, Graff-Radford NR, Boeve BF, Knopman DS, Petersen RC, Josephs KA, Thompson EA, Raj T, Ward M, Dickson DW, Gendron TF, Fratta P, Petrucelli L, NYGC ALS Consortium. Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia. J Clin Invest. 2020 Nov 2; 130 (11):6080-6092
    View PubMed
  160. Ghirelli A, Tosakulwong N, Weigand SD, Clark HM, Ali F, Botha H, Duffy JR, Utianski RL, Buciuc M, Murray ME, Labuzan SA, Spychalla AJ, Pham NTT, Schwarz CG, Senjem ML, Machulda MM, Baker M, Rademakers R, Filippi M, Jack CR Jr, Lowe VJ, Parisi JE, Dickson DW, Josephs KA, Whitwell JL. Sensitivity-Specificity of Tau and Amyloid beta Positron Emission Tomography in Frontotemporal Lobar Degeneration. Ann Neurol. 2020 Nov; 88 (5):1009-1022 Epub 2020 Sept 12
    View PubMed
  161. Boes S, Botha H, Machulda M, Lowe V, Graff-Radford J, Whitwell JL, Utianski RL, Duffy JR, Josephs KA. Dementia with Lewy bodies presenting as Logopenic variant primary progressive Aphasia. Neurocase. 2020 Oct; 26 (5):259-263 Epub 2020 July 16
    View PubMed
  162. Jack CR, Wiste HJ, Weigand SD, Therneau TM, Lowe VJ, Knopman DS, Botha H, Graff-Radford J, Jones DT, Ferman TJ, Boeve BF, Kantarci K, Vemuri P, Mielke MM, Whitwell J, Josephs K, Schwarz CG, Senjem ML, Gunter JL, Petersen RC. Predicting future rates of tau accumulation on PET. Brain. 2020 Oct 1; 143 (10):3136-3150
    View PubMed
  163. Seckin ZI, Whitwell JL, Utianski RL, Botha H, Ali F, Duffy JR, Clark HM, Machulda MM, Jordan LG, Min HK, Lowe VJ, Josephs KA. Ioflupane 123I (DAT scan) SPECT identifies dopamine receptor dysfunction early in the disease course in progressive apraxia of speech. J Neurol. 2020 Sep; 267(9):2603-2611. Epub 2020 May 09.
    View PubMed
  164. Choudhury P, Scharf EL, Paolini MA 2nd, Graff-Radford J, Alden EC, Machulda MM, Jones DT, Fields JA, Murray ME, Graff-Radford NR, Constantopoulos E, Reichard RR, Knopman DS, Duffy JR, Dickson DW, Parisi JE, Josephs KA, Petersen RC, Boeve BF. Pick's disease: clinicopathologic characterization of 21 cases. J Neurol. 2020 Sep; 267 (9):2697-2704 Epub 2020 May 21
    View PubMed
  165. Iankova V, Respondek G, Saranza G, Painous C, Camara A, Compta Y, Aiba I, Balint B, Giagkou N, Josephs KA, Otsuki M, Golbe LI, Bhatia KP, Stamelou M, Lang AE, Hoglinger GU, Movement Disorder Society-endorsed PSP Study Group. Video-tutorial for the Movement Disorder Society criteria for progressive supranuclear palsy. Parkinsonism Relat Disord. 2020 Sep; 78:200-203 Epub 2020 Sept 22
    View PubMed
  166. Chen Z, Yan Yau W, Jaunmuktane Z, Tucci A, Sivakumar P, Gagliano Taliun SA, Turner C, Efthymiou S, Ibanez K, Sullivan R, Bibi F, Athanasiou-Fragkouli A, Bourinaris T, Zhang D, Revesz T, Lashley T, DeTure M, Dickson DW, Josephs KA, Gelpi E, Kovacs GG, Halliday G, Rowe DB, Blair I, Tienari PJ, Suomalainen A, Fox NC, Wood NW, Lees AJ, Haltia MJ, Hardy J, Ryten M, Vandrovcova J, Houlden H, Genomics England Research Consortium. Neuronal intranuclear inclusion disease is genetically heterogeneous. Ann Clin Transl Neurol. 2020 Sep; 7 (9):1716-1725 Epub 2020 Aug 10
    View PubMed
  167. Buciuc M, Whitwell JL, Tosakulwong N, Weigand SD, Murray ME, Boeve BF, Knopman DS, Parisi JE, Petersen RC, Dickson DW, Josephs KA. Association between transactive response DNA-binding protein of 43 kDa type and cognitive resilience to Alzheimer's disease: a case-control study. Neurobiol Aging. 2020 Aug; 92:92-97 Epub 2020 Apr 15
    View PubMed
  168. Utianski RL, Botha H, Whitwell JL, Martin PR, Schwarz CG, Duffy JR, Clark HM, Spychalla AJ, Senjem ML, Petersen RC, Knopman DS, Jack CR Jr, Lowe VJ, Josephs KA. Longitudinal flortaucipir ([(18)F]AV-1451) PET uptake in semantic dementia. Neurobiol Aging. 2020 Aug; 92:135-140 Epub 2020 Apr 18
    View PubMed
  169. Clark HM, Stierwalt JAG, Tosakulwong N, Botha H, Ali F, Whitwell JL, Josephs KA. Dysphagia in Progressive Supranuclear Palsy. Dysphagia. 2020 Aug; 35 (4):667-676 Epub 2019 Nov 01
    View PubMed
  170. Buciuc M, Botha H, Murray ME, Schwarz CG, Senjem ML, Jones DT, Knopman DS, Boeve BF, Petersen RC, Jack CR Jr, Petrucelli L, Parisi JE, Dickson DW, Lowe V, Whitwell JL, Josephs KA. Utility of FDG-PET in diagnosis of Alzheimer-related TDP-43 proteinopathy. Neurology. 2020 Jul 7; 95 (1):e23-e34 Epub 2020 June 09
    View PubMed
  171. Sakae N, Santos OA, Pedraza O, Litvan I, Murray ME, Duara R, Uitti RJ, Wszolek ZK, Graff-Radford NR, Josephs KA, Dickson DW. Clinical and pathologic features of cognitive-predominant corticobasal degeneration. Neurology. 2020 Jul 7; 95 (1):e35-e45 Epub 2020 June 09
    View PubMed
  172. Sintini I, Graff-Radford J, Senjem ML, Schwarz CG, Machulda MM, Martin PR, Jones DT, Boeve BF, Knopman DS, Kantarci K, Petersen RC, Jack CR, Lowe VJ, Josephs KA, Whitwell JL. Longitudinal neuroimaging biomarkers differ across Alzheimer's disease phenotypes. Brain. 2020 Jul 1; 143 (7):2281-2294
    View PubMed
  173. Utianski RL, Duffy JR, Clark HM, Strand EA, Botha H, Schwarz CG, Machulda MM, Senjem ML, Spychalla AJ, Jack CR Jr, Petersen RC, Lowe VJ, Whitwell JL, Josephs KA. Corrigendum to "Prosodic and phonetic subtypes of primary progressive apraxia of speech" [Brain Lang. 184 (2018) 54-65]. Brain Lang. 2020 Jun; 205:104792 Epub 2020 Apr 02
    View PubMed
  174. Tisel SM, Ahlskog JE, Duffy JR, Matsumoto JY, Josephs KA. PSP-like syndrome after aortic surgery in adults (Mokri syndrome). Neurol Clin Pract. 2020 Jun; 10 (3):245-254
    View PubMed
  175. Koga S, Roemer SF, Tipton PW, Low PA, Josephs KA, Dickson DW. Cerebrovascular pathology and misdiagnosis of multiple system atrophy: An autopsy study. Parkinsonism Relat Disord. 2020 Jun; 75:34-40 Epub 2020 May 16
    View PubMed
  176. Josephs KA, Tosakulwong N, Graff-Radford J, Weigand SD, Buciuc M, Machulda MM, Jones DT, Schwarz CG, Senjem ML, Ertekin-Taner N, Kantarci K, Boeve BF, Knopman DS, Jack CR Jr, Petersen RC, Lowe VJ, Whitwell JL. MRI and flortaucipir relationships in Alzheimer's phenotypes are heterogeneous. Ann Clin Transl Neurol. 2020 May; 7 (5):707-721 Epub 2020 Apr 15
    View PubMed
  177. Petroi D, Duffy JR, Borgert A, Strand EA, Machulda MM, Senjem ML, Jack CR Jr, Josephs KA, Whitwell JL. Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia. Brain Lang. 2020 May; 204:104773 Epub 2020 Feb 27
    View PubMed
  178. Buciuc M, Whitwell JL, Boeve BF, Ferman TJ, Graff-Radford J, Savica R, Kantarci K, Fields JA, Knopman DS, Petersen RC, Parisi JE, Murray ME, Dickson DW, Josephs KA. TDP-43 is associated with a reduced likelihood of rendering a clinical diagnosis of dementia with Lewy bodies in autopsy-confirmed cases of transitional/diffuse Lewy body disease. J Neurol. 2020 May; 267 (5):1444-1453 Epub 2020 Jan 31
    View PubMed
  179. Utianski RL, Martin PR, Botha H, Schwarz CG, Duffy JR, Petersen RC, Knopman DS, Clark HM, Butts AM, Machulda MM, Jack CR Jr, Lowe VJ, Whitwell JL, Josephs KA. Longitudinal flortaucipir ([(18)F]AV-1451) PET imaging in primary progressive apraxia of speech. Cortex. 2020 Mar; 124:33-43 Epub 2019 Nov 19
    View PubMed
  180. Turcano P, Stang CD, Mielke MM, Martin PR, Upadhyaya SG, Josephs KA, Boeve BF, Knopman DS, Petersen RC, Savica R. Incidence of frontotemporal disorders in Olmsted County: A population-based study. Alzheimers Dement. 2020 Mar; 16 (3):482-490 Epub 2020 Jan 04
    View PubMed
  181. Clark HM, Utianski RL, Duffy JR, Strand EA, Botha H, Josephs KA, Whitwell JL. Western Aphasia Battery-Revised Profiles in Primary Progressive Aphasia and Primary Progressive Apraxia of Speech. Am J Speech Lang Pathol. 2020 Feb 21; 29 (1S):498-510 Epub 2019 Oct 22
    View PubMed
  182. Townley RA, Graff-Radford J, Mantyh WG, Botha H, Polsinelli AJ, Przybelski SA, Machulda MM, Makhlouf AT, Senjem ML, Murray ME, Reichard RR, Savica R, Boeve BF, Drubach DA, Josephs KA, Knopman DS, Lowe VJ, Jack CR Jr, Petersen RC, Jones DT. Progressive dysexecutive syndrome due to Alzheimer's disease: a description of 55 cases and comparison to other phenotypes. Brain Commun. 2020; 2 (1):fcaa068 Epub 2020 May 27
    View PubMed
  183. Buciuc M, Wennberg AM, Weigand SD, Murray ME, Senjem ML, Spychalla AJ, Boeve BF, Knopman DS, Jack CR, Kantarci K, Parisi JE, Dickson DW, Petersen RC, Whitwell JL, Josephs KA. Effect Modifiers of TDP-43-Associated Hippocampal Atrophy Rates in Patients with Alzheimer's Disease Neuropathological Changes. J Alzheimers Dis. 2020; 73 (4):1511-1523
    View PubMed
  184. Whitwell JL, Tosakulwong N, Botha H, Ali F, Clark HM, Duffy JR, Utianski RL, Stevens CA, Weigand SD, Schwarz CG, Senjem ML, Jack CR, Lowe VJ, Ahlskog JE, Dickson DW, Josephs KA. Brain volume and flortaucipir analysis of progressive supranuclear palsy clinical variants. Neuroimage Clin. 2020; 25:102152 Epub 2019 Dec 28
    View PubMed
  185. Whitwell JL, Tosakulwong N, Weigand SD, Graff-Radford J, Duffy JR, Clark HM, Machulda MM, Botha H, Utianski RL, Schwarz CG, Senjem ML, Strand EA, Ertekin-Taner N, Jack CR, Lowe VJ, Josephs KA. Longitudinal Amyloid-beta PET in Atypical Alzheimer's Disease and Frontotemporal Lobar Degeneration. J Alzheimers Dis. 2020; 74 (1):377-389
    View PubMed
  186. Bieniek KF, Josephs KA, Lin WL, Dickson DW. Neuronal intermediate filament inclusion disease may be incorrectly classified as a subtype of FTLD-FUS. Free Neuropathol. 2020; 1 Epub 2020 Mar 11
    View PubMed
  187. Gabere M, Thu Pham NT, Graff-Radford J, Machulda MM, Duffy JR, Josephs KA, Whitwell JL, for Alzheimer's Disease Neuroimaging Initiative. Automated Hippocampal Subfield Volumetric Analyses in Atypical Alzheimer's Disease. J Alzheimers Dis. 2020; 78 (3):927-937
    View PubMed
  188. Stang CD, Turcano P, Mielke MM, Josephs KA, Bower JH, Ahlskog JE, Boeve BF, Martin PR, Upadhyaya SG, Savica R. Incidence and Trends of Progressive Supranuclear Palsy and Corticobasal Syndrome: A Population-Based Study. J Parkinsons Dis. 2020; 10 (1):179-184
    View PubMed
  189. McCarter SJ, Feemster JC, Tabatabai GM, Sandness DJ, Timm PC, McCarter AR, Talley HN, Junna MR, Savica R, Singer W, Coon EA, Benarroch EE, Josephs KA, Boeve BF, Silber MH, St Louis EK. Submentalis Rapid Eye Movement Sleep Muscle Activity: A Potential Biomarker for Synucleinopathy. Ann Neurol. 2019 Dec; 86 (6):969-974
    View PubMed
  190. Bejanin A, Murray ME, Martin P, Botha H, Tosakulwong N, Schwarz CG, Senjem ML, Chetelat G, Kantarci K, Jack CR, Boeve BF, Knopman DS, Petersen RC, Giannini C, Parisi JE, Dickson DW, Whitwell JL, Josephs KA. Antemortem volume loss mirrors TDP-43 staging in older adults with non-frontotemporal lobar degeneration. Brain. 2019 Nov 1; 142 (11):3621-3635
    View PubMed
  191. Sakae N, Josephs KA, Litvan I, Murray ME, Duara R, Uitti RJ, Wszolek ZK, Graff-Radford NR, Dickson DW. Neuropathologic basis of frontotemporal dementia in progressive supranuclear palsy. Mov Disord. 2019 Nov; 34 (11):1655-1662 Epub 2019 Aug 21
    View PubMed
  192. Dickson DW, Baker MC, Jackson JL, DeJesus-Hernandez M, Finch NA, Tian S, Heckman MG, Pottier C, Gendron TF, Murray ME, Ren Y, Reddy JS, Graff-Radford NR, Boeve BF, Petersen RC, Knopman DS, Josephs KA, Petrucelli L, Oskarsson B, Sheppard JW, Asmann YW, Rademakers R, van Blitterswijk M. Extensive transcriptomic study emphasizes importance of vesicular transport in C9orf72 expansion carriers. Acta Neuropathol Commun. 2019 Oct 8; 7 (1):150 Epub 2019 Oct 08
    View PubMed
  193. Utianski RL, Botha H, Martin PR, Schwarz CG, Duffy JR, Clark HM, Machulda MM, Butts AM, Lowe VJ, Jack CR Jr, Senjem ML, Spychalla AJ, Whitwell JL, Josephs KA. Clinical and neuroimaging characteristics of clinically unclassifiable primary progressive aphasia. Brain Lang. 2019 Oct; 197:104676 Epub 2019 Aug 13
    View PubMed
  194. van Gerpen JA, Al-Shaikh RH, Tipton PW, Wszolek ZK, Uitti RJ, Ferman TJ, Dickson DW, Benarroch EE, Singer W, Cutsforth-Gregory JK, Heckman MG, Brushaber DE, Josephs KA, Low PA, Ahlskog JE, Cheshire WP. Progressive supranuclear palsy is not associated with neurogenic orthostatic hypotension. Neurology. 2019 Oct 1; 93 (14):e1339-e1347 Epub 2019 Sept 04
    View PubMed
  195. Josephs KA, Mackenzie I, Frosch MP, Bigio EH, Neumann M, Arai T, Dugger BN, Ghetti B, Grossman M, Hasegawa M, Herrup K, Holton J, Jellinger K, Lashley T, McAleese KE, Parisi JE, Revesz T, Saito Y, Vonsattel JP, Whitwell JL, Wisniewski T, Hu W. LATE to the PART-y. Brain 2019 Sep 1; 142 (9):e47
    View PubMed
  196. Sintini I, Schwarz CG, Senjem ML, Reid RI, Botha H, Ali F, Ahlskog JE, Jack CR Jr, Lowe VJ, Josephs KA, Whitwell JL. Multimodal neuroimaging relationships in progressive supranuclear palsy. Parkinsonism Relat Disord. 2019 Sep; 66:56-61. Epub 2019 Jul 02.
    View PubMed
  197. Sakae N, Josephs KA, Litvan I, Murray ME, Duara R, Uitti RJ, Wszolek ZK, van Gerpen J, Graff-Radford NR, Dickson DW. Clinicopathologic subtype of Alzheimer's disease presenting as corticobasal syndrome. Alzheimers Dement. 2019 Sep; 15 (9):1218-1228 Epub 2019 Aug 06
    View PubMed
  198. Utianski RL, Duffy JR, Clark HM, Machulda MM, Dickson DW, Whitwell JL, Josephs KA. Prominent auditory deficits in primary progressive aphasia: A case study. Cortex. 2019 Aug; 117:396-406 Epub 2019 Feb 21
    View PubMed
  199. Grimm MJ, Respondek G, Stamelou M, Arzberger T, Ferguson L, Gelpi E, Giese A, Grossman M, Irwin DJ, Pantelyat A, Rajput A, Roeber S, van Swieten JC, Troakes C, Antonini A, Bhatia KP, Colosimo C, van Eimeren T, Kassubek J, Levin J, Meissner WG, Nilsson C, Oertel WH, Piot I, Poewe W, Wenning GK, Boxer A, Golbe LI, Josephs KA, Litvan I, Morris HR, Whitwell JL, Compta Y, Corvol JC, Lang AE, Rowe JB, Hoglinger GU, Movement Disorder Society-endorsed PSP Study Group. How to apply the movement disorder society criteria for diagnosis of progressive supranuclear palsy. Mov Disord. 2019 Aug; 34 (8):1228-1232 Epub 2019 Mar 18
    View PubMed
  200. Ali F, Martin PR, Botha H, Ahlskog JE, Bower JH, Masumoto JY, Maraganore D, Hassan A, Eggers S, Boeve BF, Knopman DS, Drubach D, Petersen RC, Dunkley ED, van Gerpen J, Uitti R, Whitwell JL, Dickson DW, Josephs KA. Sensitivity and Specificity of Diagnostic Criteria for Progressive Supranuclear Palsy. Mov Disord. 2019 Aug; 34 (8):1144-1153 Epub 2019 Feb 06
    View PubMed
  201. Tetzloff KA, Duffy JR, Clark HM, Utianski RL, Strand EA, Machulda MM, Botha H, Martin PR, Schwarz CG, Senjem ML, Reid RI, Gunter JL, Spychalla AJ, Knopman DS, Petersen RC, Jack CR, Lowe VJ, Josephs KA, Whitwell JL. Progressive agrammatic aphasia without apraxia of speech as a distinct syndrome. Brain. 2019 Aug 01; 142(8):2466-2482.
    View PubMed
  202. Lowe VJ, Bruinsma TJ, Wiste HJ, Min HK, Weigand SD, Fang P, Senjem ML, Therneau TM, Boeve BF, Josephs KA, Pandey MK, Murray ME, Kantarci K, Jones DT, Vemuri P, Graff-Radford J, Schwarz CG, Machulda MM, Mielke MM, Roberts RO, Knopman DS, Petersen RC, Jack CR Jr. Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults. Neurology. 2019 Jul 2; 93 (1):e29-e39 Epub 2019 May 30
    View PubMed
  203. Josephs KA, Zhang YJ, Baker M, Rademakers R, Petrucelli L, Dickson DW. C-terminal and full length TDP-43 specie differ according to FTLD-TDP lesion type but not genetic mutation. Acta Neuropathol Commun. 2019 Jul 2; 7 (1):100 Epub 2019 July 02
    View PubMed
  204. Ali F, Botha H, Whitwell JL, Josephs KA. Utility of the Movement Disorders Society Criteria for Progressive Supranuclear Palsy in Clinical Practice. Mov Disord Clin Pract. 2019 Jul; 6 (6):436-439 Epub 2019 July 24
    View PubMed
  205. Whitwell JL, Stevens CA, Duffy JR, Clark HM, Machulda MM, Strand EA, Martin PR, Utianski RL, Botha H, Spychalla AJ, Senjem ML, Schwarz CG, Jack CR Jr, Ali F, Hassan A, Josephs KA. An Evaluation of the Progressive Supranuclear Palsy Speech/Language Variant. Mov Disord Clin Pract. 2019 Jul; 6 (6):452-461 Epub 2019 May 29
    View PubMed
  206. Pottier C, Ren Y, Perkerson RB 3rd, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, Matchett B, Karydas AM, Hsiung GR, Seelaar H, Mol MO, Finger EC, Graff C, Oijerstedt L, Neumann M, Heutink P, Synofzik M, Wilke C, Prudlo J, Rizzu P, Simon-Sanchez J, Edbauer D, Roeber S, Diehl-Schmid J, Evers BM, King A, Mesulam MM, Weintraub S, Geula C, Bieniek KF, Petrucelli L, Ahern GL, Reiman EM, Woodruff BK, Caselli RJ, Huey ED, Farlow MR, Grafman J, Mead S, Grinberg LT, Spina S, Grossman M, Irwin DJ, Lee EB, Suh E, Snowden J, Mann D, Ertekin-Taner N, Uitti RJ, Wszolek ZK, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Hodges JR, Piguet O, Geier EG, Yokoyama JS, Rissman RA, Rogaeva E, Keith J, Zinman L, Tartaglia MC, Cairns NJ, Cruchaga C, Ghetti B, Kofler J, Lopez OL, Beach TG, Arzberger T, Herms J, Honig LS, Vonsattel JP, Halliday GM, Kwok JB, White CL 3rd, Gearing M, Glass J, Rollinson S, Pickering-Brown S, Rohrer JD, Trojanowski JQ, Van Deerlin V, Bigio EH, Troakes C, Al-Sarraj S, Asmann Y, Miller BL, Graff-Radford NR, Boeve BF, Seeley WW, Mackenzie IRA, van Swieten JC, Dickson DW, Biernacka JM, Rademakers R. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathol. 2019 Jun; 137 (6):879-899 Epub 2019 Feb 09
    View PubMed
  207. Josephs KA, Murray ME, Tosakulwong N, Weigand SD, Knopman DS, Petersen RC, Jack CR Jr, Whitwell JL, Dickson DW. Brain atrophy in primary age-related tauopathy is linked to transactive response DNA-binding protein of 43 kDa. Alzheimers Dement. 2019 Jun; 15 (6):799-806 Epub 2019 May 02
    View PubMed
  208. Wennberg AM, Whitwell JL, Tosakulwong N, Weigand SD, Murray ME, Machulda MM, Petrucelli L, Mielke MM, Jack CR Jr, Knopman DS, Parisi JE, Petersen RC, Dickson DW, Josephs KA. The influence of tau, amyloid, alpha-synuclein, TDP-43, and vascular pathology in clinically normal elderly individuals. Neurobiol Aging. 2019 May; 77:26-36 Epub 2019 Jan 21
    View PubMed
  209. Whitwell JL, Martin P, Graff-Radford J, Machulda MM, Senjem ML, Schwarz CG, Weigand SD, Spychalla AJ, Drubach DA, Jack CR Jr, Lowe VJ, Josephs KA. The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease. Alzheimers Dement. 2019 May; 15 (5):675-685 Epub 2019 Mar 08
    View PubMed
  210. Ali F, Josephs K. Rare Tauopathies. Semin Neurol. 2019 Apr; 39 (2):264-273 Epub 2019 Mar 29
    View PubMed
  211. Sintini I, Schwarz CG, Martin PR, Graff-Radford J, Machulda MM, Senjem ML, Reid RI, Spychalla AJ, Drubach DA, Lowe VJ, Jack CR Jr, Josephs KA, Whitwell JL. Regional multimodal relationships between tau, hypometabolism, atrophy, and fractional anisotropy in atypical Alzheimer's disease. Hum Brain Mapp. 2019 Apr 1; 40 (5):1618-1631 Epub 2018 Dec 13
    View PubMed
  212. Nedelska Z, Josephs KA, Graff-Radford J, Przybelski SA, Lesnick TG, Boeve BF, Drubach DA, Knopman DS, Petersen RC, Jack CR Jr, Lowe VJ, Whitwell JL, Kantarci K. (18) F-AV-1451 uptake differs between dementia with lewy bodies and posterior cortical atrophy. Mov Disord. 2019 Mar; 34 (3):344-352 Epub 2019 Jan 07
    View PubMed
  213. Whitwell JL, Martin PR, Duffy JR, Clark HM, Machulda MM, Schwarz CG, Weigand SD, Sintini I, Senjem ML, Ertekin-Taner N, Botha H, Utianski RL, Graff-Radford J, Jones DT, Boeve BF, Knopman DS, Petersen RC, Jack CR Jr, Lowe VJ, Josephs KA. The influence of beta-amyloid on [(18)F]AV-1451 in semantic variant of primary progressive aphasia. Neurology. 2019 Feb 12; 92 (7):e710-e722 Epub 2019 Jan 11
    View PubMed
  214. Espay AJ, Vizcarra JA, Marsili L, Lang AE, Simon DK, Merola A, Josephs KA, Fasano A, Morgante F, Savica R, Greenamyre JT, Cambi F, Yamasaki TR, Tanner CM, Gan-Or Z, Litvan I, Mata IF, Zabetian CP, Brundin P, Fernandez HH, Standaert DG, Kauffman MA, Schwarzschild MA, Sardi SP, Sherer T, Perry G, Leverenz JB. Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases. Neurology. 2019 Feb 12; 92 (7):329-337
    View PubMed
  215. Josephs KA, Murray ME, Tosakulwong N, Weigand SD, Serie AM, Perkerson RB, Matchett BJ, Jack CR Jr, Knopman DS, Petersen RC, Parisi JE, Petrucelli L, Baker M, Rademakers R, Whitwell JL, Dickson DW. Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains. Acta Neuropathol. 2019 Feb; 137 (2):227-238 Epub 2019 Jan 02
    View PubMed
  216. Botha H, Josephs KA. Primary progressive aphasias and apraxia of speech CONTINUUM: Lifelong Learning in Neurology. 2019 Feb; 25 (1):101-27
  217. Sintini I, Martin PR, Graff-Radford J, Senjem ML, Schwarz CG, Machulda MM, Spychalla AJ, Drubach DA, Knopman DS, Petersen RC, Lowe VJ, Jack CR Jr, Josephs KA, Whitwell JL. Longitudinal tau-PET uptake and atrophy in atypical Alzheimer's disease. Neuroimage Clin. 2019; 23:101823 Epub 2019 Apr 10
    View PubMed
  218. Whitwell JL, Tosakulwong N, Schwarz CG, Botha H, Senjem ML, Spychalla AJ, Ahlskog JE, Knopman DS, Petersen RC, Jack CR Jr, Lowe VJ, Josephs KA. MRI Outperforms [18F]AV-1451 PET as a Longitudinal Biomarker in Progressive Supranuclear Palsy. Mov Disord. 2019 Jan; 34 (1):105-113 Epub 2018 Nov 23
    View PubMed
  219. Utianski RL, Caviness JN, Worrell GA, Duffy JR, Clark HM, Machulda MM, Whitwell JL, Josephs KA. Electroencephalography in Primary Progressive Aphasia and Apraxia of Speech. Aphasiology. 2019; 33 (11):1410-1417 Epub 2018 Nov 16
    View PubMed
  220. Ramanan VK, Morris KA, Graff-Radford J, Jones DT, Burkholder DB, Britton JW, Josephs KA, Boeve BF, Savica R. Transient Epileptic Amnesia: A Treatable Cause of Spells Associated With Persistent Cognitive Symptoms. Front Neurol. 2019; 10:939 Epub 2019 Aug 28
    View PubMed
  221. Utianski RL, Botha H, Duffy JR, Clark HM, Martin PR, Butts AM, Machulda MM, Whitwell JL, Josephs KA. Rapid rate on quasi-speech tasks in the semantic variant of primary progressive aphasia: A non-motor phenomenon? J Acoust Soc Am. 2018 Dec; 144 (6):3364
    View PubMed
  222. Sahoo A, Josephs KA. A Neuropsychiatric Analysis of the Cotard Delusion. J Neuropsychiatry Clin Neurosci. 2018 Winter; 30 (1):58-65 Epub 2017 June 23
    View PubMed
  223. Utianski RL, Duffy JR, Clark HM, Strand EA, Boland SM, Machulda MM, Whitwell JL, Josephs KA. Clinical Progression in Four Cases of Primary Progressive Apraxia of Speech. Am J Speech Lang Pathol. 2018 Nov 21; 27 (4):1303-1318
    View PubMed
  224. Wennberg AM, Tosakulwong N, Lesnick TG, Murray ME, Whitwell JL, Liesinger AM, Petrucelli L, Boeve BF, Parisi JE, Knopman DS, Petersen RC, Dickson DW, Josephs KA. Association of Apolipoprotein E epsilon4 With Transactive Response DNA-Binding Protein 43. JAMA Neurol. 2018 Nov 1; 75 (11):1347-1354
    View PubMed
  225. Utianski RL, Whitwell JL, Schwarz CG, Duffy JR, Botha H, Clark HM, Machulda MM, Senjem ML, Knopman DS, Petersen RC, Jack CR Jr, Lowe VJ, Josephs KA. Tau uptake in agrammatic primary progressive aphasia with and without apraxia of speech. Eur J Neurol. 2018 Nov; 25 (11):1352-1357 Epub 2018 July 26
    View PubMed
  226. Tetzloff KA, Whitwell JL, Utianski RL, Duffy JR, Clark HM, Machulda MM, Strand EA, Josephs KA. Quantitative assessment of grammar in amyloid-negative logopenic aphasia. Brain Lang. 2018 Nov; 186:26-31. Epub 2018 Sep 08.
    View PubMed
  227. Tetzloff KA, Utianski RL, Duffy JR, Clark HM, Strand EA, Josephs KA, Whitwell JL. Quantitative Analysis of Agrammatism in Agrammatic Primary Progressive Aphasia and Dominant Apraxia of Speech. J Speech Lang Hear Res. 2018 Sep 19; 61(9):2337-2346.
    View PubMed
  228. Utianski RL, Duffy JR, Clark HM, Strand EA, Botha H, Schwarz CG, Machulda MM, Senjem ML, Spychalla AJ, Jack CR Jr, Petersen RC, Lowe VJ, Whitwell JL, Josephs KA. Prosodic and phonetic subtypes of primary progressive apraxia of speech. Brain Lang. 2018 Sep; 184:54-65 Epub 2018 July 04
    View PubMed
  229. Koga S, Kouri N, Walton RL, Ebbert MTW, Josephs KA, Litvan I, Graff-Radford N, Ahlskog JE, Uitti RJ, van Gerpen JA, Boeve BF, Parks A, Ross OA, Dickson DW. Corticobasal degeneration with TDP-43 pathology presenting with progressive supranuclear palsy syndrome: a distinct clinicopathologic subtype. Acta Neuropathol. 2018 Sep; 136 (3):389-404 Epub 2018 June 20
    View PubMed
  230. Whitwell JL, Graff-Radford J, Tosakulwong N, Weigand SD, Machulda MM, Senjem ML, Spychalla AJ, Vemuri P, Jones DT, Drubach DA, Knopman DS, Boeve BF, Ertekin-Taner N, Petersen RC, Lowe VJ, Jack CR Jr, Josephs KA. Imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical Alzheimer's disease. Alzheimers Dement. 2018 Aug; 14 (8):1005-1014 Epub 2018 Mar 30
    View PubMed
  231. Kasanuki K, Josephs KA, Ferman TJ, Murray ME, Koga S, Konno T, Sakae N, Parks A, Uitti RJ, Van Gerpen JA, Graff-Radford NR, Wszolek ZK, Dickson DW. Diffuse Lewy body disease manifesting as corticobasal syndrome: A rare form of Lewy body disease. Neurology. 2018 Jul 17; 91 (3):e268-e279 Epub 2018 June 13
    View PubMed
  232. Botha H, Duffy JR, Whitwell JL, Strand EA, Machulda MM, Spychalla AJ, Tosakulwong N, Senjem ML, Knopman DS, Petersen RC, Jack CR Jr, Lowe VJ, Josephs KA. Non-right handed primary progressive apraxia of speech. J Neurol Sci. 2018 Jul 15; 390:246-254 Epub 2018 May 07
    View PubMed
  233. Ali F, Josephs K. The diagnosis of progressive supranuclear palsy: current opinions and challenges. Expert Rev Neurother. 2018 Jul; 18 (7):603-616 Epub 2018 June 28
    View PubMed
  234. Pottier C, Zhou X, Perkerson RB 3rd, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, Lopez de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, Sanchez-Valle R, Antonell A, Llado A, Parsons TM, Finch NA, Finger EC, Lippa CF, Huey ED, Neumann M, Heutink P, Synofzik M, Wilke C, Rissman RA, Slawek J, Sitek E, Johannsen P, Nielsen JE, Ren Y, van Blitterswijk M, DeJesus-Hernandez M, Christopher E, Murray ME, Bieniek KF, Evers BM, Ferrari C, Rollinson S, Richardson A, Scarpini E, Fumagalli GG, Padovani A, Hardy J, Momeni P, Ferrari R, Frangipane F, Maletta R, Anfossi M, Gallo M, Petrucelli L, Suh E, Lopez OL, Wong TH, van Rooij JGJ, Seelaar H, Mead S, Caselli RJ, Reiman EM, Noel Sabbagh M, Kjolby M, Nykjaer A, Karydas AM, Boxer AL, Grinberg LT, Grafman J, Spina S, Oblak A, Mesulam MM, Weintraub S, Geula C, Hodges JR, Piguet O, Brooks WS, Irwin DJ, Trojanowski JQ, Lee EB, Josephs KA, Parisi JE, Ertekin-Taner N, Knopman DS, Nacmias B, Piaceri I, Bagnoli S, Sorbi S, Gearing M, Glass J, Beach TG, Black SE, Masellis M, Rogaeva E, Vonsattel JP, Honig LS, Kofler J, Bruni AC, Snowden J, Mann D, Pickering-Brown S, Diehl-Schmid J, Winkelmann J, Galimberti D, Graff C, Oijerstedt L, Troakes C, Al-Sarraj S, Cruchaga C, Cairns NJ, Rohrer JD, Halliday GM, Kwok JB, van Swieten JC, White CL 3rd, Ghetti B, Murell JR, Mackenzie IRA, Hsiung GR, Borroni B, Rossi G, Tagliavini F, Wszolek ZK, Petersen RC, Bigio EH, Grossman M, Van Deerlin VM, Seeley WW, Miller BL, Graff-Radford NR, Boeve BF, Dickson DW, Biernacka JM, Rademakers R. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. Lancet Neurol. 2018 Jun; 17 (6):548-558 Epub 2018 Apr 30
    View PubMed
  235. Ali F, Whitwell JL, Martin PR, Senjem ML, Knopman DS, Jack CR, Lowe VJ, Petersen RC, Boeve BF, Josephs KA. [(18)F] AV-1451 uptake in corticobasal syndrome: the influence of beta-amyloid and clinical presentation. J Neurol. 2018 May; 265 (5):1079-1088 Epub 2018 Mar 01
    View PubMed
  236. Utianski RL, Duffy JR, Savica R, Whitwell JL, Machulda MM, Josephs KA. Molecular neuroimaging in primary progressive aphasia with predominant agraphia. Neurocase. 2018 Apr; 24 (2):121-123 Epub 2018 Mar 23
    View PubMed
  237. Botha H, Mantyh WG, Murray ME, Knopman DS, Przybelski SA, Wiste HJ, Graff-Radford J, Josephs KA, Schwarz CG, Kremers WK, Boeve BF, Petersen RC, Machulda MM, Parisi JE, Dickson DW, Lowe V, Jack CR Jr, Jones DT. FDG-PET in tau-negative amnestic dementia resembles that of autopsy-proven hippocampal sclerosis. Brain. 2018 Apr 1; 141 (4):1201-1217
    View PubMed
  238. Tetzloff KA, Duffy JR, Strand EA, Machulda MM, Boland SM, Utianski RL, Botha H, Senjem ML, Schwarz CG, Josephs KA, Whitwell JL. Clinical and imaging progression over 10 years in a patient with primary progressive apraxia of speech and autopsy-confirmed corticobasal degeneration. Neurocase. 2018 Apr; 24(2):111-120. Epub 2018 May 25.
    View PubMed
  239. Whitwell JL, Ahlskog JE, Tosakulwong N, Senjem ML, Spychalla AJ, Petersen RC, Jack CR Jr, Lowe VJ, Josephs KA. Pittsburgh Compound B and AV-1451 positron emission tomography assessment of molecular pathologies of Alzheimer's disease in progressive supranuclear palsy. Parkinsonism Relat Disord. 2018 Mar; 48:3-9 Epub 2017 Dec 13
    View PubMed
  240. Josephs KA, Martin PR, Botha H, Schwarz CG, Duffy JR, Clark HM, Machulda MM, Graff-Radford J, Weigand SD, Senjem ML, Utianski RL, Drubach DA, Boeve BF, Jones DT, Knopman DS, Petersen RC, Jack CR Jr, Lowe VJ, Whitwell JL. [(18) F]AV-1451 tau-PET and primary progressive aphasia. Ann Neurol. 2018 Mar; 83 (3):599-611 Epub 2018 Mar 13
    View PubMed
  241. Ali F, Josephs KA. Corticobasal degeneration: key emerging issues. J Neurol. 2018 Feb; 265 (2):439-445 Epub 2017 Oct 23
    View PubMed
  242. Josephs KA. Rest in peace FTDP-17. Brain 2018 Feb 1; 141 (2):324-331
    View PubMed
  243. Whitwell JL, Graff-Radford J, Tosakulwong N, Weigand SD, Machulda M, Senjem ML, Schwarz CG, Spychalla AJ, Jones DT, Drubach DA, Knopman DS, Boeve BF, Ertekin-Taner N, Petersen RC, Lowe VJ, Jack CR Jr, Josephs KA. [(18) F]AV-1451 clustering of entorhinal and cortical uptake in Alzheimer's disease. Ann Neurol. 2018 Feb; 83 (2):248-257 Epub 2018 Feb 06
    View PubMed
  244. Utianski RL, Whitwell JL, Schwarz CG, Senjem ML, Tosakulwong N, Duffy JR, Clark HM, Machulda MM, Petersen RC, Jack CR Jr, Lowe VJ, Josephs KA. Tau-PET imaging with [18F]AV-1451 in primary progressive apraxia of speech. Cortex. 2018 Feb; 99:358-374 Epub 2018 Jan 02
    View PubMed
  245. Owens TE, Machulda MM, Duffy JR, Strand EA, Clark HM, Boland S, Martin PR, Lowe VJ, Jack CR, Whitwell JL, Josephs KA. Patterns of neuropsychological dysfunction and cortical volume changes in logopenic aphasia Journal Of Alzheimers Disease. 2018; 66 (3):1015-25
  246. Tetzloff KA, Graff-Radford J, Martin PR, Tosakulwong N, Machulda MM, Duffy JR, Clark HM, Senjem ML, Schwarz CG, Spychalla AJ, Drubach DA, Jack CR, Lowe VJ, Josephs KA, Whitwell JL. Regional Distribution, Asymmetry, and Clinical Correlates of Tau Uptake on [18F]AV-1451 PET in Atypical Alzheimer's Disease. J Alzheimers Dis. 2018; 62(4):1713-1724.
    View PubMed
  247. Tetzloff KA, Duffy JR, Clark HM, Strand EA, Machulda MM, Schwarz CG, Senjem ML, Reid RI, Spychalla AJ, Tosakulwong N, Lowe VJ, Jack CR Jr, Josephs KA, Whitwell JL. Longitudinal structural and molecular neuroimaging in agrammatic primary progressive aphasia. Brain. 2018 Jan 1; 141 (1):302-317
    View PubMed
  248. Lowe VJ, Wiste HJ, Senjem ML, Weigand SD, Therneau TM, Boeve BF, Josephs KA, Fang P, Pandey MK, Murray ME, Kantarci K, Jones DT, Vemuri P, Graff-Radford J, Schwarz CG, Machulda MM, Mielke MM, Roberts RO, Knopman DS, Petersen RC, Jack CR Jr. Widespread brain tau and its association with ageing, Braak stage and Alzheimer's dementia. Brain. 2018 Jan 1; 141 (1):271-287
    View PubMed
  249. Botha H, Utianski RL, Whitwell JL, Duffy JR, Clark HM, Strand EA, Machulda MM, Tosakulwong N, Knopman DS, Petersen RC, Jack CR Jr, Josephs KA, Jones DT. Disrupted functional connectivity in primary progressive apraxia of speech. Neuroimage Clin. 2018; 18:617-629 Epub 2018 Mar 03
    View PubMed
  250. Lowe VJ, Bruinsma TJ, Min HK, Lundt ES, Fang P, Senjem ML, Boeve BF, Josephs KA, Pandey MK, Murray ME, Kantarci K, Jones DT, Schwarz CG, Knopman DS, Petersen RC, Jack CR Jr. Elevated medial temporal lobe and pervasive brain tau-PET signal in normal participants. Alzheimers Dement (Amst). 2018; 10:210-216 Epub 2018 Feb 07
    View PubMed
  251. Sahoo A, Bejanin A, Murray ME, Tosakulwong N, Weigand SD, Serie AM, Senjem ML, Machulda MM, Parisi JE, Boeve BF, Knopman DS, Petersen RC, Dickson DW, Whitwell JL, Josephs KA. TDP-43 and Alzheimer's Disease Pathologic Subtype in Non-Amnestic Alzheimer's Disease Dementia. J Alzheimers Dis. 2018; 64 (4):1227-1233
    View PubMed
  252. Bruinsma TJ, Johnson DR, Fang P, Senjem M, Josephs KA, Whitwell JL, Boeve BF, Pandey MK, Kantarci K, Jones DT, Vemuri P, Murray M, Graff-Radford J, Schwarz CG, Knopman DS, Petersen RC, Jack CR Jr, Lowe VJ. Uptake of AV-1451 in meningiomas. Ann Nucl Med. 2017 Dec; 31 (10):736-743 Epub 2017 Sept 08
    View PubMed
  253. Koga S, Parks A, Kasanuki K, Sanchez-Contreras M, Baker MC, Josephs KA, Ahlskog JE, Uitti RJ, Graff-Radford N, van Gerpen JA, Wszolek ZK, Rademakers R, Dickson DW. Cognitive impairment in progressive supranuclear palsy is associated with tau burden. Mov Disord. 2017 Dec; 32 (12):1772-1779 Epub 2017 Oct 30
    View PubMed
  254. Whitwell JL, Weigand SD, Duffy JR, Clark HM, Strand EA, Machulda MM, Spychalla AJ, Senjem ML, Jack CR Jr, Josephs KA. Predicting clinical decline in progressive agrammatic aphasia and apraxia of speech. Neurology. 2017 Nov 28; 89 (22):2271-2279 Epub 2017 Nov 01
    View PubMed
  255. Singh TD, Josephs KA. Symptom Prevalence of Neurodegenerative Diseases among Minorities Journal of Alzheimers Disease and Parkinsonism. 2017; 7(6):397.
  256. Josephs KA, Dickson DW, Tosakulwong N, Weigand SD, Murray ME, Petrucelli L, Liesinger AM, Senjem ML, Spychalla AJ, Knopman DS, Parisi JE, Petersen RC, Jack CR Jr, Whitwell JL. Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study. Lancet Neurol. 2017 Nov; 16 (11):917-924 Epub 2017 Sept 11
    View PubMed
  257. Turcano P, Mielke MM, Josephs KA, Bower JH, Parisi JE, Boeve BF, Savica R. Clinicopathologic discrepancies in a population-based incidence study of parkinsonism in olmsted county: 1991-2010. Mov Disord. 2017 Oct; 32 (10):1439-1446 Epub 2017 Aug 26
    View PubMed
  258. Tacik P, DeTure MA, Carlomagno Y, Lin WL, Murray ME, Baker MC, Josephs KA, Boeve BF, Wszolek ZK, Graff-Radford NR, Parisi JE, Petrucelli L, Rademakers R, Isaacson RS, Heilman KM, Petersen RC, Dickson DW, Kouri N. FTDP-17 with Pick body-like inclusions associated with a novel tau mutation, p.E372G. Brain Pathol. 2017 Sep; 27 (5):612-626 Epub 2016 Oct 05
    View PubMed
  259. Honorat JA, Komorowski L, Josephs KA, Fechner K, St Louis EK, Hinson SR, Lederer S, Kumar N, Gadoth A, Lennon VA, Pittock SJ, McKeon A. IgLON5 antibody: Neurological accompaniments and outcomes in 20 patients. Neurol Neuroimmunol Neuroinflamm. 2017 Sep; 4 (5):e385 Epub 2017 July 18
    View PubMed
  260. DeJesus-Hernandez M, Finch NA, Wang X, Gendron TF, Bieniek KF, Heckman MG, Vasilevich A, Murray ME, Rousseau L, Weesner R, Lucido A, Parsons M, Chew J, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Boeve BF, Graff-Radford NR, de Boer J, Asmann YW, Petrucelli L, Boylan KB, Dickson DW, van Blitterswijk M, Rademakers R. In-depth clinico-pathological examination of RNA foci in a large cohort of C9ORF72 expansion carriers. Acta Neuropathol. 2017 Aug; 134 (2):255-269 Epub 2017 May 15
    View PubMed
  261. Josephs KA. Current Understanding of Neurodegenerative Diseases Associated With the Protein Tau. Mayo Clin Proc. 2017 Aug; 92 (8):1291-1303
    View PubMed
  262. Finch NA, Wang X, Baker MC, Heckman MG, Gendron TF, Bieniek KF, Wuu J, DeJesus-Hernandez M, Brown PH, Chew J, Jansen-West KR, Daughrity LM, Nicholson AM, Murray ME, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Petrucelli L, Boeve BF, Graff-Radford NR, Asmann YW, Dickson DW, Benatar M, Bowser R, Boylan KB, Rademakers R, van Blitterswijk M. Abnormal expression of homeobox genes and transthyretin in C9ORF72 expansion carriers. Neurol Genet. 2017 Aug; 3 (4):e161 Epub 2017 June 07
    View PubMed
  263. Respondek G, Kurz C, Arzberger T, Compta Y, Englund E, Ferguson LW, Gelpi E, Giese A, Irwin DJ, Meissner WG, Nilsson C, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Josephs KA, Lang AE, Mollenhauer B, Muller U, Whitwell JL, Antonini A, Bhatia KP, Bordelon Y, Corvol JC, Colosimo C, Dodel R, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris H, Nestor P, Oertel WH, Rabinovici GD, Rowe JB, van Eimeren T, Wenning GK, Boxer A, Golbe LI, Litvan I, Stamelou M, Hoglinger GU, Movement Disorder Society-Endorsed PSP Study Group. Which ante mortem clinical features predict progressive supranuclear palsy pathology? Mov Disord. 2017 Jul; 32 (7):995-1005 Epub 2017 May 13
    View PubMed
  264. Whitwell JL, Hoglinger GU, Antonini A, Bordelon Y, Boxer AL, Colosimo C, van Eimeren T, Golbe LI, Kassubek J, Kurz C, Litvan I, Pantelyat A, Rabinovici G, Respondek G, Rominger A, Rowe JB, Stamelou M, Josephs KA, Movement Disorder Society-endorsed PSP Study Group. Radiological biomarkers for diagnosis in PSP: Where are we and where do we need to be? Mov Disord. 2017 Jul; 32 (7):955-971 Epub 2017 May 13
    View PubMed
  265. Hoglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, Mollenhauer B, Muller U, Nilsson C, Whitwell JL, Arzberger T, Englund E, Gelpi E, Giese A, Irwin DJ, Meissner WG, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Antonini A, Bhatia KP, Bordelon Y, Compta Y, Corvol JC, Colosimo C, Dickson DW, Dodel R, Ferguson L, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris HR, Nestor P, Oertel WH, Poewe W, Rabinovici G, Rowe JB, Schellenberg GD, Seppi K, van Eimeren T, Wenning GK, Boxer AL, Golbe LI, Litvan I, Movement Disorder Society-endorsed PSP Study Group. Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria. Mov Disord. 2017 Jun; 32 (6):853-864 Epub 2017 May 03
    View PubMed
  266. Whitwell JL, Duffy JR, Machulda MM, Clark HM, Strand EA, Senjem ML, Gunter JL, Spychalla AJ, Petersen RC, Jack CR Jr, Josephs KA. Tracking the development of agrammatic aphasia: A tensor-based morphometry study. Cortex. 2017 May; 90:138-148 Epub 2016 Sept 30
    View PubMed
  267. Josephs KA, Murray ME, Tosakulwong N, Whitwell JL, Knopman DS, Machulda MM, Weigand SD, Boeve BF, Kantarci K, Petrucelli L, Lowe VJ, Jack CR Jr, Petersen RC, Parisi JE, Dickson DW. Tau aggregation influences cognition and hippocampal atrophy in the absence of beta-amyloid: a clinico-imaging-pathological study of primary age-related tauopathy (PART). Acta Neuropathol. 2017 May; 133 (5):705-715 Epub 2017 Feb 03
    View PubMed
  268. Duffy JR, Hanley H, Utianski R, Clark H, Strand E, Josephs KA, Whitwell JL. Temporal acoustic measures distinguish primary progressive apraxia of speech from primary progressive aphasia. Brain Lang. 2017 May; 168:84-94 Epub 2017 Feb 07
    View PubMed
  269. Whitwell JL, Graff-Radford J, Singh TD, Drubach DA, Senjem ML, Spychalla AJ, Tosakulwong N, Lowe VJ, Josephs KA. (18)F-FDG PET in Posterior Cortical Atrophy and Dementia with Lewy Bodies. J Nucl Med. 2017 Apr; 58 (4):632-638 Epub 2016 Sept 29
    View PubMed
  270. Josephs KA, Tosakulwong N, Weigand SD, Murray ME, Whitwell JL, Parisi JE, Dickson DW, Petersen RC. Brain tau deposition linked to systemic causes of death in normal elderly. Neurobiol Aging. 2017 Feb; 50:163-166 Epub 2016 Nov 24
    View PubMed
  271. Koga S, Sanchez-Contreras M, Josephs KA, Uitti RJ, Graff-Radford N, van Gerpen JA, Cheshire WP, Wszolek ZK, Rademakers R, Dickson DW. Distribution and characteristics of transactive response DNA binding protein 43 kDa pathology in progressive supranuclear palsy. Mov Disord. 2017 Feb; 32 (2):246-255 Epub 2016 Dec 23
    View PubMed
  272. Whitwell JL, Lowe VJ, Tosakulwong N, Weigand SD, Senjem ML, Schwarz CG, Spychalla AJ, Petersen RC, Jack CR Jr, Josephs KA. [(18) F]AV-1451 tau positron emission tomography in progressive supranuclear palsy. Mov Disord. 2017 Jan; 32 (1):124-133 Epub 2016 Oct 27
    View PubMed
  273. Krishnan K, Machulda MM, Whitwell JL, Butts AM, Duffy JR, Strand EA, Senjem ML, Spychalla AJ, Jack CR, Lowe VJ, Josephs KA. Varying Degrees of Temporoparietal Hypometabolism on FDG-PET Reveal Amyloid-Positive Logopenic Primary Progressive Aphasia is not a Homogeneous Clinical Entity. J Alzheimers Dis. 2017; 55 (3):1019-1029
    View PubMed
  274. Janssen PH, Mandrekar J, Mielke MM, Ahlskog JE, Boeve BF, Josephs K, Savica R. High School Football and Late-Life Risk of Neurodegenerative Syndromes, 1956-1970. Mayo Clin Proc. 2017 Jan; 92 (1):66-71 Epub 2016 Dec 12
    View PubMed
  275. Honorat JA, Komorowski L, Josephs KA, Fechner K, St Louis EK, Hinson SR, Lederer S, Kumar N, Gadoth A, Lennon VA, Pittock SJ, McKeon A. IgLON5 antibody Neurology: Neuroimmunology and NeuroInflammation. 2017; 4 (5):385
  276. Owens E, Josephs KA, Savica R, Hassan A, Klassen B, Bower J, Maraganore D, Matsumoto J, Ahlskog JE. The clinical spectrum and natural history of pure akinesia with gait freezing. J Neurol. 2016 Dec; 263 (12):2419-2423 Epub 2016 Sept 13
    View PubMed
  277. Pottier C, Ravenscroft TA, Brown PH, Finch NA, Baker M, Parsons M, Asmann YW, Ren Y, Christopher E, Levitch D, van Blitterswijk M, Cruchaga C, Campion D, Nicolas G, Richard AC, Guerreiro R, Bras JT, Zuchner S, Gonzalez MA, Bu G, Younkin S, Knopman DS, Josephs KA, Parisi JE, Petersen RC, Ertekin-Taner N, Graff-Radford NR, Boeve BF, Dickson DW, Rademakers R. TYROBP genetic variants in early-onset Alzheimer's disease. Neurobiol Aging. 2016 Dec; 48:222.e9-222.e15 Epub 2016 Aug 08
    View PubMed
  278. Kramer NJ, Carlomagno Y, Zhang YJ, Almeida S, Cook CN, Gendron TF, Prudencio M, Van Blitterswijk M, Belzil V, Couthouis J, Paul JW 3rd, Goodman LD, Daughrity L, Chew J, Garrett A, Pregent L, Jansen-West K, Tabassian LJ, Rademakers R, Boylan K, Graff-Radford NR, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Boeve BF, Deng N, Feng Y, Cheng TH, Dickson DW, Cohen SN, Bonini NM, Link CD, Gao FB, Petrucelli L, Gitler AD. Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts. Science. 2016 Aug 12; 353 (6300):708-12
    View PubMed
  279. Hassan A, Josephs KA. Alien Hand Syndrome. Curr Neurol Neurosci Rep. 2016 Aug; 16 (8):73
    View PubMed
  280. Owens E, Krecke K, Ahlskog JE, Fealey R, Hassan A, Josephs KA, Klassen B, Matsumoto J, Bower J. Highly specific radiographic marker predates clinical diagnosis in progressive supranuclear palsy. Parkinsonism Relat Disord. 2016 Jul; 28:107-11 Epub 2016 May 03
    View PubMed
  281. Lowe VJ, Curran G, Fang P, Liesinger AM, Josephs KA, Parisi JE, Kantarci K, Boeve BF, Pandey MK, Bruinsma T, Knopman DS, Jones DT, Petrucelli L, Cook CN, Graff-Radford NR, Dickson DW, Petersen RC, Jack CR Jr, Murray ME. An autoradiographic evaluation of AV-1451 Tau PET in dementia. Acta Neuropathol Commun. 2016 Jun 13; 4 (1):58 Epub 2016 June 13
    View PubMed
  282. Josephs KA, Dickson DW. TDP-43 in the olfactory bulb in Alzheimer's disease. Neuropathol Appl Neurobiol 2016 Jun; 42 (4):390-3
    View PubMed
  283. Josephs KA, Whitwell JL, Parisi JE, Lapid MI. Coprophagia in neurologic disorders. J Neurol. 2016 May; 263 (5):1008-1014 Epub 2016 Mar 26
    View PubMed
  284. Koga S, Josephs KA, Ogaki K, Labbe C, Uitti RJ, Graff-Radford N, van Gerpen JA, Cheshire WP, Aoki N, Rademakers R, Wszolek ZK, Ross OA, Dickson DW. Cerebellar ataxia in progressive supranuclear palsy: An autopsy study of PSP-C. Mov Disord. 2016 May; 31 (5):653-62 Epub 2016 Feb 03
    View PubMed
  285. Josephs KA, Murray ME, Whitwell JL, Tosakulwong N, Weigand SD, Petrucelli L, Liesinger AM, Petersen RC, Parisi JE, Dickson DW. Updated TDP-43 in Alzheimer's disease staging scheme. Acta Neuropathol. 2016 Apr; 131 (4):571-85 Epub 2016 Jan 25
    View PubMed
  286. Arena JE, Weigand SD, Whitwell JL, Hassan A, Eggers SD, Hoglinger GU, Litvan I, Josephs KA. Progressive supranuclear palsy: progression and survival. J Neurol. 2016 Feb; 263 (2):380-389 Epub 2015 Dec 24
    View PubMed
  287. Jung Y, Whitwell JL, Duffy JR, Strand EA, Machulda MM, Senjem ML, Jack CR, Lowe VJ, Josephs KA. Regional beta-amyloid burden does not correlate with cognitive or language deficits in Alzheimer's disease presenting as aphasia. Eur J Neurol. 2016 Feb; 23 (2):313-9 Epub 2015 June 23
    View PubMed
  288. Whitwell JL, Weigand SD, Duffy JR, Strand EA, Machulda MM, Senjem ML, Gunter JL, Lowe VJ, Jack CR Jr, Josephs KA. Clinical and MRI models predicting amyloid deposition in progressive aphasia and apraxia of speech. Neuroimage Clin. 2016; 11:90-98 Epub 2016 Jan 20
    View PubMed
  289. Madhavan A, Schwarz CG, Duffy JR, Strand EA, Machulda MM, Drubach DA, Kantarci K, Przybelski SA, Reid RI, Senjem ML, Gunter JL, Apostolova LG, Lowe VJ, Petersen RC, Jack CR, Josephs KA, Whitwell JL. Characterizing White Matter Tract Degeneration in Syndromic Variants of Alzheimer's Disease: A Diffusion Tensor Imaging Study. J Alzheimers Dis. 2016; 49 (3):633-43
    View PubMed
  290. Graff-Radford J, Josephs KA, Parisi JE, Dickson DW, Giannini C, Boeve BF. Globular Glial Tauopathy Presenting as Semantic Variant Primary Progressive Aphasia. JAMA Neurol. 2016 Jan; 73 (1):123-5
    View PubMed
  291. Flanagan EP, Duffy JR, Whitwell JL, Vemuri P, Dickson DW, Josephs KA. Mixed tau and TDP-43 pathology in a patient with unclassifiable primary progressive aphasia. Neurocase. 2016; 22 (1):55-9 Epub 2015 May 01
    View PubMed
  292. van Blitterswijk M, Gendron TF, Baker MC, DeJesus-Hernandez M, Finch NA, Brown PH, Daughrity LM, Murray ME, Heckman MG, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Petrucelli L, Boeve BF, Graff-Radford NR, Boylan KB, Dickson DW, Rademakers R. Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72. Acta Neuropathol. 2015 Dec; 130 (6):863-76 Epub 2015 Oct 05
    View PubMed
  293. Golden EC, Josephs KA. Minds on replay: musical hallucinations and their relationship to neurological disease. Brain. 2015 Dec; 138: (Pt 12)3793-802.
    View PubMed
  294. Josephs KA, Whitwell JL, Tosakulwong N, Weigand SD, Murray ME, Liesinger AM, Petrucelli L, Senjem ML, Ivnik RJ, Parisi JE, Petersen RC, Dickson DW. TAR DNA-binding protein 43 and pathological subtype of Alzheimer's disease impact clinical features. Ann Neurol. 2015 Nov; 78 (5):697-709 Epub 2015 Sept 16
    View PubMed
  295. Gendron TF, van Blitterswijk M, Bieniek KF, Daughrity LM, Jiang J, Rush BK, Pedraza O, Lucas JA, Murray ME, Desaro P, Robertson A, Overstreet K, Thomas CS, Crook JE, Castanedes-Casey M, Rousseau L, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Boeve BF, Graff-Radford NR, Rademakers R, Lagier-Tourenne C, Edbauer D, Cleveland DW, Dickson DW, Petrucelli L, Boylan KB. Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers. Acta Neuropathol. 2015 Oct; 130 (4):559-73 Epub 2015 Sept 08
    View PubMed
  296. Whitwell JL, Duffy JR, Strand EA, Machulda MM, Tosakulwong N, Weigand SD, Senjem ML, Spychalla AJ, Gunter JL, Petersen RC, Jack CR Jr, Josephs KA. Sample size calculations for clinical trials targeting tauopathies: a new potential disease target. J Neurol. 2015 Sep; 262 (9):2064-72 Epub 2015 June 17
    View PubMed
  297. Koga S, Aoki N, Uitti RJ, van Gerpen JA, Cheshire WP, Josephs KA, Wszolek ZK, Langston JW, Dickson DW. When DLB, PD, and PSP masquerade as MSA: an autopsy study of 134 patients. Neurology. 2015 Aug 4; 85 (5):404-12 Epub 2015 July 02
    View PubMed
  298. Tacik P, DeTure M, Lin WL, Sanchez Contreras M, Wojtas A, Hinkle KM, Fujioka S, Baker MC, Walton RL, Carlomagno Y, Brown PH, Strongosky AJ, Kouri N, Murray ME, Petrucelli L, Josephs KA, Rademakers R, Ross OA, Wszolek ZK, Dickson DW. A novel tau mutation, p.K317N, causes globular glial tauopathy. Acta Neuropathol. 2015 Aug; 130 (2):199-214 Epub 2015 Apr 22
    View PubMed
  299. Botha H, Duffy JR, Whitwell JL, Strand EA, Machulda MM, Schwarz CG, Reid RI, Spychalla AJ, Senjem ML, Jones DT, Lowe V, Jack CR, Josephs KA. Classification and clinicoradiologic features of primary progressive aphasia (PPA) and apraxia of speech. Cortex. 2015 Aug; 69:220-36 Epub 2015 May 27
    View PubMed
  300. Pottier C, Bieniek KF, Finch N, van de Vorst M, Baker M, Perkersen R, Brown P, Ravenscroft T, van Blitterswijk M, Nicholson AM, DeTure M, Knopman DS, Josephs KA, Parisi JE, Petersen RC, Boylan KB, Boeve BF, Graff-Radford NR, Veltman JA, Gilissen C, Murray ME, Dickson DW, Rademakers R. Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease. Acta Neuropathol. 2015 Jul; 130 (1):77-92 Epub 2015 May 06
    View PubMed
  301. Butts AM, Machulda MM, Duffy JR, Strand EA, Whitwell JL, Josephs KA. Neuropsychological Profiles Differ among the Three Variants of Primary Progressive Aphasia. J Int Neuropsychol Soc. 2015 Jul; 21 (6):429-35 Epub 2015 June 11
    View PubMed
  302. Kouri N, Ross OA, Dombroski B, Younkin CS, Serie DJ, Soto-Ortolaza A, Baker M, Finch NCA, Yoon H, Kim J, Fujioka S, McLean CA, Ghetti B, Spina S, Cantwell LB, Farlow MR, Grafman J, Huey ED, Ryung Han M, Beecher S, Geller ET, Kretzschmar HA, Roeber S, Gearing M, Juncos JL, Vonsattel JPG, Van Deerlin VM, Grossman M, Hurtig HI, Gross RG, Arnold SE, Trojanowski JQ, Lee VM, Wenning GK, White CL, Hoglinger GU, Muller U, Devlin B, Golbe LI, Crook J, Parisi JE, Boeve BF, Josephs KA, Wszolek ZK, Uitti RJ, Graff-Radford NR, Litvan I, Younkin SG, Wang LS, Ertekin-Taner N, Rademakers R, Hakonarsen H, Schellenberg GD, Dickson DW. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. Nat Commun. 2015 Jun 16; 6:7247 Epub 2015 June 16
    View PubMed
  303. Singh TD, Josephs KA, Machulda MM, Drubach DA, Apostolova LG, Lowe VJ, Whitwell JL. Clinical, FDG and amyloid PET imaging in posterior cortical atrophy. J Neurol. 2015 Jun; 262 (6):1483-92 Epub 2015 Apr 11
    View PubMed
  304. Whitwell JL, Boeve BF, Weigand SD, Senjem ML, Gunter JL, Baker MC, DeJesus-Hernandez M, Knopman DS, Wszolek ZK, Petersen RC, Rademakers R, Jack CR Jr, Josephs KA. Brain atrophy over time in genetic and sporadic frontotemporal dementia: a study of 198 serial magnetic resonance images. Eur J Neurol. 2015 May; 22 (5):745-52 Epub 2015 Feb 12
    View PubMed
  305. Whitwell JL, Duffy JR, Strand EA, Machulda MM, Senjem ML, Schwarz CG, Reid R, Baker MC, Perkerson RB, Lowe VJ, Rademakers R, Jack CR Jr, Josephs KA. Clinical and neuroimaging biomarkers of amyloid-negative logopenic primary progressive aphasia. Brain Lang. 2015 Mar; 142:45-53 Epub 2015 Feb 03
    View PubMed
  306. Josephs KA. Key emerging issues in progressive supranuclear palsy and corticobasal degeneration. J Neurol. 2015 Mar; 262 (3):783-8 Epub 2015 Feb 21
    View PubMed
  307. Whitwell JL, Jones DT, Duffy JR, Strand EA, Machulda MM, Przybelski SA, Vemuri P, Gregg BE, Gunter JL, Senjem ML, Petersen RC, Jack CR Jr, Josephs KA. Working memory and language network dysfunctions in logopenic aphasia: a task-free fMRI comparison with Alzheimer's dementia. Neurobiol Aging. 2015 Mar; 36 (3):1245-52 Epub 2014 Dec 16
    View PubMed
  308. Duffy JR, Strand EA, Clark H, Machulda M, Whitwell JL, Josephs KA. Primary progressive apraxia of speech: Clinical features and acoustic and neurologic correlates. Am J Speech Lang Pathol. 2015; 24(2):88-100.
    View PubMed
  309. Flanagan EP, Baker MC, Perkerson RB, Duffy JR, Strand EA, Whitwell JL, Machulda MM, Rademakers R, Josephs KA. Dominant frontotemporal dementia mutations in 140 cases of primary progressive aphasia and speech apraxia. Dement Geriatr Cogn Disord. 2015; 39 (5-6):281-6 Epub 2015 Feb 28
    View PubMed
  310. Whitwell JL, Kantarci K, Weigand SD, Lundt ES, Gunter JL, Duffy JR, Strand EA, Machulda MM, Spychalla AJ, Drubach DA, Petersen RC, Lowe VJ, Jack CR Jr, Josephs KA. Microbleeds in atypical presentations of Alzheimer's disease: a comparison to dementia of the Alzheimer's type. J Alzheimers Dis. 2015; 45(4):1109-17.
    View PubMed
  311. Singh TD, Duffy JR, Strand EA, Machulda MM, Whitwell JL, Josephs KA. Neuropsychiatric symptoms in primary progressive aphasia and apraxia of speech. Dement Geriatr Cogn Disord. 2015; 39 (3-4):228-38 Epub 2015 Jan 21
    View PubMed
  312. Josephs KA, Duffy JR, Strand EA, Machulda MM, Senjem ML, Lowe VJ, Jack CR Jr, Whitwell JL. APOE epsilon4 influences beta-amyloid deposition in primary progressive aphasia and speech apraxia. Alzheimers Dement. 2014 Nov; 10 (6):630-6 Epub 2014 June 28
    View PubMed
  313. van Blitterswijk M, Mullen B, Heckman MG, Baker MC, DeJesus-Hernandez M, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, Weintraub S, Mesulam M, Hatanpaa KJ, White CL 3rd, Neumann M, Strong MJ, Beach TG, Wszolek ZK, Lippa C, Caselli R, Petrucelli L, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Mackenzie IR, Seeley WW, Grinberg LT, Miller BL, Boylan KB, Graff-Radford NR, Boeve BF, Dickson DW, Rademakers R. Ataxin-2 as potential disease modifier in C9ORF72 expansion carriers. Neurobiol Aging. 2014 Oct; 35 (10):2421.e13-7 Epub 2014 May 02
    View PubMed
  314. Josephs KA, Duffy JR, Strand EA, Machulda MM, Senjem ML, Gunter JL, Schwarz CG, Reid RI, Spychalla AJ, Lowe VJ, Jack CR Jr, Whitwell JL. The evolution of primary progressive apraxia of speech. Brain. 2014 Oct; 137 (Pt 10):2783-95 Epub 2014 Aug 11
    View PubMed
  315. van Blitterswijk M, Mullen B, Wojtas A, Heckman MG, Diehl NN, Baker MC, DeJesus-Hernandez M, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, Weintraub S, Mesulam M, Hatanpaa KJ, White CL 3rd, Neumann M, Strong MJ, Beach TG, Wszolek ZK, Lippa C, Caselli R, Petrucelli L, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Mackenzie IR, Seeley WW, Grinberg LT, Miller BL, Boylan KB, Graff-Radford NR, Boeve BF, Dickson DW, Rademakers R. Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene. Mol Neurodegener. 2014 Sep 20; 9:38 Epub 2014 Sept 20
    View PubMed
  316. Strand EA, Duffy JR, Clark HM, Josephs K. The Apraxia of Speech Rating Scale: a tool for diagnosis and description of apraxia of speech. J Commun Disord. 2014 Sep-Oct; 51:43-50 Epub 2014 July 14
    View PubMed
  317. Duffy JR, Strand EA, Josephs KA. Motor Speech Disorders Associated with Primary Progressive Aphasia. Aphasiology. 2014 Aug; 28 (8-9):1004-1017
    View PubMed
  318. Jung Y, Dickson DW, Murray ME, Whitwell JL, Knopman DS, Boeve BF, Jack CR Jr, Parisi JE, Petersen RC, Josephs KA. TDP-43 in Alzheimer's disease is not associated with clinical FTLD or Parkinsonism. J Neurol. 2014 Jul; 261 (7):1344-8 Epub 2014 Apr 24
    View PubMed
  319. Ferrari R, Hernandez DG, Nalls MA, Rohrer JD, Ramasamy A, Kwok JB, Dobson-Stone C, Brooks WS, Schofield PR, Halliday GM, Hodges JR, Piguet O, Bartley L, Thompson E, Haan E, Hernandez I, Ruiz A, Boada M, Borroni B, Padovani A, Cruchaga C, Cairns NJ, Benussi L, Binetti G, Ghidoni R, Forloni G, Galimberti D, Fenoglio C, Serpente M, Scarpini E, Clarimon J, Lleo A, Blesa R, Waldo ML, Nilsson K, Nilsson C, Mackenzie IR, Hsiung GY, Mann DM, Grafman J, Morris CM, Attems J, Griffiths TD, McKeith IG, Thomas AJ, Pietrini P, Huey ED, Wassermann EM, Baborie A, Jaros E, Tierney MC, Pastor P, Razquin C, Ortega-Cubero S, Alonso E, Perneczky R, Diehl-Schmid J, Alexopoulos P, Kurz A, Rainero I, Rubino E, Pinessi L, Rogaeva E, St George-Hyslop P, Rossi G, Tagliavini F, Giaccone G, Rowe JB, Schlachetzki JC, Uphill J, Collinge J, Mead S, Danek A, Van Deerlin VM, Grossman M, Trojanowski JQ, van der Zee J, Deschamps W, Van Langenhove T, Cruts M, Van Broeckhoven C, Cappa SF, Le Ber I, Hannequin D, Golfier V, Vercelletto M, Brice A, Nacmias B, Sorbi S, Bagnoli S, Piaceri I, Nielsen JE, Hjermind LE, Riemenschneider M, Mayhaus M, Ibach B, Gasparoni G, Pichler S, Gu W, Rossor MN, Fox NC, Warren JD, Spillantini MG, Morris HR, Rizzu P, Heutink P, Snowden JS, Rollinson S, Richardson A, Gerhard A, Bruni AC, Maletta R, Frangipane F, Cupidi C, Bernardi L, Anfossi M, Gallo M, Conidi ME, Smirne N, Rademakers R, Baker M, Dickson DW, Graff-Radford NR, Petersen RC, Knopman D, Josephs KA, Boeve BF, Parisi JE, Seeley WW, Miller BL, Karydas AM, Rosen H, van Swieten JC, Dopper EG, Seelaar H, Pijnenburg YA, Scheltens P, Logroscino G, Capozzo R, Novelli V, Puca AA, Franceschi M, Postiglione A, Milan G, Sorrentino P, Kristiansen M, Chiang HH, Graff C, Pasquier F, Rollin A, Deramecourt V, Lebert F, Kapogiannis D, Ferrucci L, Pickering-Brown S, Singleton AB, Hardy J, Momeni P. Frontotemporal dementia and its subtypes: a genome-wide association study. Lancet Neurol. 2014 Jul; 13 (7):686-99
    View PubMed
  320. Schwarz CG, Reid RI, Gunter JL, Senjem ML, Przybelski SA, Zuk SM, Whitwell JL, Vemuri P, Josephs KA, Kantarci K, Thompson PM, Petersen RC, Jack CR Jr, Alzheimer's Disease Neuroimaging Initiative. Improved DTI registration allows voxel-based analysis that outperforms tract-based spatial statistics. Neuroimage. 2014 Jul 1; 94:65-78 Epub 2014 Mar 18
    View PubMed
  321. Jung Y, Whitwell JL, Duffy JR, Strand EA, Machulda MM, Senjem ML, Lowe V, Jack CR Jr, Josephs KA. Amyloid burden correlates with cognitive decline in Alzheimer's disease presenting with aphasia. Eur J Neurol. 2014 Jul; 21 (7):1040-3 Epub 2013 Dec 16
    View PubMed
  322. Botha H, Duffy JR, Strand EA, Machulda MM, Whitwell JL, Josephs KA. Nonverbal oral apraxia in primary progressive aphasia and apraxia of speech. Neurology. 2014 May 13; 82 (19):1729-35 Epub 2014 Apr 11
    View PubMed
  323. Whitwell JL, Schwarz CG, Reid RI, Kantarci K, Jack CR Jr, Josephs KA. Diffusion tensor imaging comparison of progressive supranuclear palsy and corticobasal syndromes. Parkinsonism Relat Disord. 2014 May; 20(5):493-8. Epub 2014 Feb 08.
    View PubMed
  324. Zalewski N, Botha H, Whitwell J, Lowe V, Dickson D, Josephs KA. FDG-PET in Pathologically Confirmed 4R-Tauopathy Variants Neurology. 2014; 82(10):P5.251.
  325. Zalewski N, Botha H, Whitwell JL, Lowe V, Dickson DW, Josephs KA. FDG-PET in pathologically confirmed spontaneous 4R-tauopathy variants. J Neurol. 2014 Apr; 261(4):710-6. Epub 2014 Feb 04.
    View PubMed
  326. Wicklund MR, Duffy JR, Strand EA, Machulda MM, Whitwell JL, Josephs KA. Quantitative application of the primary progressive aphasia consensus criteria. Neurology. 2014 Apr 1; 82 (13):1119-26 Epub 2014 Mar 05
    View PubMed
  327. Josephs KA, Duffy JR, Strand EA, Machulda MM, Vemuri P, Senjem ML, Perkerson RB, Baker MC, Lowe V, Jack CR Jr, Rademakers R, Whitwell JL. Progranulin-associated PiB-negative logopenic primary progressive aphasia. J Neurol. 2014 Mar; 261 (3):604-14 Epub 2014 Jan 22
    View PubMed
  328. van Blitterswijk M, Mullen B, Nicholson AM, Bieniek KF, Heckman MG, Baker MC, DeJesus-Hernandez M, Finch NA, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, Weintraub S, Mesulam M, Hatanpaa KJ, White CL 3rd, Strong MJ, Beach TG, Wszolek ZK, Lippa C, Caselli R, Petrucelli L, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Mackenzie IR, Seeley WW, Grinberg LT, Miller BL, Boylan KB, Graff-Radford NR, Boeve BF, Dickson DW, Rademakers R. TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia. Acta Neuropathol. 2014 Mar; 127 (3):397-406 Epub 2014 Jan 03
    View PubMed
  329. Clark HM, Duffy JR, Whitwell JL, Ahlskog JE, Sorenson EJ, Josephs KA. Clinical and imaging characterization of progressive spastic dysarthria. Eur J Neurol. 2014 Mar; 21 (3):368-76 Epub 2013 Sept 19
    View PubMed
  330. Josephs KA, Murray ME, Whitwell JL, Parisi JE, Petrucelli L, Jack CR, Petersen RC, Dickson DW. Staging TDP-43 pathology in Alzheimer's disease. Acta Neuropathol. 2014 Mar; 127 (3):441-50 Epub 2013 Nov 16
    View PubMed
  331. Botha H, Whitwell JL, Madhaven A, Senjem ML, Lowe V, Josephs KA. The pimple sign of progressive supranuclear palsy syndrome. Parkinsonism Relat Disord. 2014 Feb; 20 (2):180-5 Epub 2013 Nov 04
    View PubMed
  332. Kouri N, Carlomagno Y, Baker M, Liesinger AM, Caselli RJ, Wszolek ZK, Petrucelli L, Boeve BF, Parisi JE, Josephs KA, Uitti RJ, Ross OA, Graff-Radford NR, DeTure MA, Dickson DW, Rademakers R. Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration. Acta Neuropathol. 2014 Feb; 127 (2):271-82
    View PubMed
  333. Graff-Radford J, Jones DT, Strand EA, Rabinstein AA, Duffy JR, Josephs KA. The neuroanatomy of pure apraxia of speech in stroke. Brain Lang. 2014 Feb; 129:43-6 Epub 2014 Feb 18
    View PubMed
  334. Petroi D, Duffy JR, Strand EA, Josephs KA. Phonologic errors in the logopenic variant of primary progressive aphasia. Aphasiology. 2014; 28(10):1223-43.
  335. Josephs KA, Murray ME, Whitwell JL, Parisi JE, Petrucelli L, Jack CR, Petersen RC, Dickson DW. Staging TDP-43 pathology in Alzheimer's disease. Acta Neuropathol (Berl). 2014; 127(3):441-50.
  336. Whitwell JL, Jack CR Jr, Duffy JR, Strand EA, Gunter JL, Senjem ML, Murphy MC, Kantarci K, Machulda MM, Lowe VJ, Josephs KA. Microbleeds in the logopenic variant of primary progressive aphasia. Alzheimers Dement. 2014 Jan; 10 (1):62-6 Epub 2013 Apr 03
    View PubMed
  337. Josephs KA, Whitwell JL, Weigand SD, Murray ME, Tosakulwong N, Liesinger AM, Petrucelli L, Senjem ML, Knopman DS, Boeve BF, Ivnik RJ, Smith GE, Jack CR Jr, Parisi JE, Petersen RC, Dickson DW. TDP-43 is a key player in the clinical features associated with Alzheimer's disease. Acta Neuropathol. 2014; 127 (6):811-24 Epub 2014 Mar 23
    View PubMed
  338. Whitwell JL, Lowe VJ, Duffy JR, Strand EA, Machulda MM, Kantarci K, Wille SM, Senjem ML, Murphy MC, Gunter JL, Jack CR Jr, Josephs KA. Elevated occipital beta-amyloid deposition is associated with widespread cognitive impairment in logopenic progressive aphasia. J Neurol Neurosurg Psychiatry. 2013 Dec; 84 (12):1357-64 Epub 2013 Aug 14
    View PubMed
  339. Dean PM, Smith GE, Parisi JE, Dickson DW, Petersen RC, Josephs KA. Neurocognitive speed associates with frontotemporal lobar degeneration TDP-43 subtypes. J Clin Neurosci. 2013 Dec; 20 (12):1737-41 Epub 2013 Sept 04
    View PubMed
  340. Josephs KA, Dickson DW, Murray ME, Senjem ML, Parisi JE, Petersen RC, Jack CR Jr, Whitwell JL. Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia. Brain Lang. 2013 Nov; 127 (2):127-34 Epub 2013 Mar 28
    View PubMed
  341. Machulda MM, Whitwell JL, Duffy JR, Strand EA, Dean PM, Senjem ML, Jack CR Jr, Josephs KA. Identification of an atypical variant of logopenic progressive aphasia. Brain Lang. 2013 Nov; 127 (2):139-44 Epub 2013 Apr 06
    View PubMed
  342. Whitwell JL, Jack CR Jr, Parisi JE, Gunter JL, Weigand SD, Boeve BF, Ahlskog JE, Petersen RC, Dickson DW, Josephs KA. Midbrain atrophy is not a biomarker of progressive supranuclear palsy pathology. Eur J Neurol. 2013 Oct; 20 (10):1417-22 Epub 2013 June 07
    View PubMed
  343. Sundal C, Fujioka S, Van Gerpen JA, Wider C, Nicholson AM, Baker M, Shuster EA, Aasly J, Spina S, Ghetti B, Roeber S, Garbern J, Tselis A, Swerdlow RH, Miller BB, Borjesson-Hanson A, Uitti RJ, Ross OA, Stoessl AJ, Rademakers R, Josephs KA, Dickson DW, Broderick D, Wszolek ZK. Parkinsonian features in hereditary diffuse leukoencephalopathy with spheroids (HDLS) and CSF1R mutations. Parkinsonism Relat Disord. 2013 Oct; 19 (10):869-77 Epub 2013 June 17
    View PubMed
  344. van Blitterswijk M, DeJesus-Hernandez M, Niemantsverdriet E, Murray ME, Heckman MG, Diehl NN, Brown PH, Baker MC, Finch NA, Bauer PO, Serrano G, Beach TG, Josephs KA, Knopman DS, Petersen RC, Boeve BF, Graff-Radford NR, Boylan KB, Petrucelli L, Dickson DW, Rademakers R. Association between repeat sizes and clinical and pathological characteristics in carriers of C9ORF72 repeat expansions (Xpansize-72): a cross-sectional cohort study. Lancet Neurol. 2013 Oct; 12 (10):978-88 Epub 2013 Sept 05
    View PubMed
  345. Ahmed Z, Bigio EH, Budka H, Dickson DW, Ferrer I, Ghetti B, Giaccone G, Hatanpaa KJ, Holton JL, Josephs KA, Powers J, Spina S, Takahashi H, White CL 3rd, Revesz T, Kovacs GG. Globular glial tauopathies (GGT): consensus recommendations. Acta Neuropathol. 2013 Oct; 126 (4):537-544 Epub 2013 Aug 31
    View PubMed
  346. van Blitterswijk M, Baker MC, Bieniek KF, Knopman DS, Josephs KA, Boeve B, Caselli R, Wszolek ZK, Petersen R, Graff-Radford NR, Boylan KB, Dickson DW, Rademakers R. Profilin-1 mutations are rare in patients with amyotrophic lateral sclerosis and frontotemporal dementia. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Sep; 14 (5-6):463-9 Epub 2013 May 02
    View PubMed
  347. Ravenscroft TA, Baker MC, Rutherford NJ, Neumann M, Mackenzie IR, Josephs KA, Boeve BF, Petersen R, Halliday GM, Kril J, van Swieten JC, Seeley WW, Dickson DW, Rademakers R. Mutations in protein N-arginine methyltransferases are not the cause of FTLD-FUS. Neurobiol Aging. 2013 Sep; 34 (9):2235.e11-3 Epub 2013 Apr 28
    View PubMed
  348. Josephs KA, Papenfuss SM, Duffy JR, Strand EA, Machulda MM, Whitwell JL, Petersen RC. Occupational differences between Alzheimer's and aphasic dementias: implication for teachers. Am J Alzheimers Dis Other Demen. 2013 Sep; 28 (6):612-6 Epub 2013 July 09
    View PubMed
  349. Wicklund MR, Duffy JR, Strand EA, Whitwell JL, Machulda MM, Josephs KA. Aphasia with left occipitotemporal hypometabolism: a novel presentation of posterior cortical atrophy? J Clin Neurosci. 2013 Sep; 20 (9):1237-40 Epub 2013 July 11
    View PubMed
  350. Jung Y, Duffy JR, Josephs KA. Primary progressive aphasia and apraxia of speech. Semin Neurol. 2013 Sep; 33 (4):342-7 Epub 2013 Nov 14
    View PubMed
  351. Josephs KA, Duffy JR, Strand EA, Machulda MM, Senjem ML, Lowe VJ, Jack CR Jr, Whitwell JL. Syndromes dominated by apraxia of speech show distinct characteristics from agrammatic PPA. Neurology. 2013 Jul 23; 81 (4):337-45 Epub 2013 June 26
    View PubMed
  352. Josephs KA, Xia R, Mandrekar J, Gunter JL, Senjem ML, Jack CR Jr, Whitwell JL. Modeling trajectories of regional volume loss in progressive supranuclear palsy. Mov Disord. 2013 Jul; 28(8):1117-24. Epub 2013 Apr 08.
    View PubMed
  353. Graff-Radford J, Rubin MN, Jones DT, Aksamit AJ, Ahlskog JE, Knopman DS, Petersen RC, Boeve BF, Josephs KA. The alien limb phenomenon. J Neurol. 2013 Jul; 260 (7):1880-8 Epub 2013 Apr 10
    View PubMed
  354. Rayaprolu S, Mullen B, Baker M, Lynch T, Finger E, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, Lippa C, Josephs KA, Knopman DS, White CL 3rd, Caselli R, Mackenzie IR, Miller BL, Boczarska-Jedynak M, Opala G, Krygowska-Wajs A, Barcikowska M, Younkin SG, Petersen RC, Ertekin-Taner N, Uitti RJ, Meschia JF, Boylan KB, Boeve BF, Graff-Radford NR, Wszolek ZK, Dickson DW, Rademakers R, Ross OA. TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease. Mol Neurodegener. 2013 Jun 21; 8:19 Epub 2013 June 21
    View PubMed
  355. Whitwell JL, Duffy JR, Strand EA, Xia R, Mandrekar J, Machulda MM, Senjem ML, Lowe VJ, Jack CR Jr, Josephs KA. Distinct regional anatomic and functional correlates of neurodegenerative apraxia of speech and aphasia: an MRI and FDG-PET study. Brain Lang. 2013 Jun; 125 (3):245-52 Epub 2013 Mar 28
    View PubMed
  356. Adeli A, Whitwell JL, Duffy JR, Strand EA, Josephs KA. Ideomotor apraxia in agrammatic and logopenic variants of primary progressive aphasia. J Neurol. 2013 Jun; 260 (6):1594-600 Epub 2013 Jan 29
    View PubMed
  357. Whitwell JL, Duffy JR, Strand EA, Machulda MM, Senjem ML, Gunter JL, Kantarci K, Eggers SD, Jack CR Jr, Josephs KA. Neuroimaging comparison of primary progressive apraxia of speech and progressive supranuclear palsy. Eur J Neurol. 2013 Apr; 20 (4):629-37 Epub 2012 Oct 18
    View PubMed
  358. Bruns MB, Josephs KA. Neuropsychiatry of corticobasal degeneration and progressive supranuclear palsy. Int Rev Psychiatry. 2013 Apr; 25(2):197-209.
    View PubMed
  359. Coon EA, Daube JR, Dejesus-Hernandez M, Adeli A, Savica R, Parisi JE, Dickson DW, Josephs KA, Baker MC, Johnson KA, Ivnik RJ, Petersen RC, Knopman DS, Boylan KB, Rademakers R, Boeve BF. Clinical and electrophysiologic variability in amyotrophic lateral sclerosis within a kindred harboring the C9ORF72 repeat expansion. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Mar; 14 (2):132-7 Epub 2012 Oct 04
    View PubMed
  360. Josephs KA, Whitwell JL, Murray ME, Parisi JE, Graff-Radford NR, Knopman DS, Boeve BF, Senjem ML, Rademakers R, Jack CR Jr, Petersen RC, Dickson DW. Corticospinal tract degeneration associated with TDP-43 type C pathology and semantic dementia. Brain. 2013 Feb; 136 (Pt 2):455-70 Epub 2013 Jan 28
    View PubMed
  361. Whitwell JL, Xu J, Mandrekar J, Boeve BF, Knopman DS, Parisi JE, Senjem ML, Dickson DW, Petersen RC, Rademakers R, Jack CR Jr, Josephs KA. Frontal asymmetry in behavioral variant frontotemporal dementia: clinicoimaging and pathogenetic correlates. Neurobiol Aging. 2013 Feb; 34 (2):636-9 Epub 2012 Apr 11
    View PubMed
  362. Armstrong MJ, Litvan I, Lang AE, Bak TH, Bhatia KP, Borroni B, Boxer AL, Dickson DW, Grossman M, Hallett M, Josephs KA, Kertesz A, Lee SE, Miller BL, Reich SG, Riley DE, Tolosa E, Troster AI, Vidailhet M, Weiner WJ. Criteria for the diagnosis of corticobasal degeneration. Neurology. 2013 Jan 29; 80(5):496-503.
    View PubMed
  363. Chang FCF, Josephs KA. Levodopa responsiveness in adult-onset lower limb dystonia is associated with the development of Parkinson's disease. Proceedings of the Royal Society B: Biological Sciences. 2013; 280(1760).
  364. Chang FC, Josephs KA. Levodopa Responsiveness in Adult-onset Lower Limb Dystonia is Associated with the Development of Parkinson's Disease. Tremor Other Hyperkinet Mov (N Y). 2013; 3 Epub 2013 Apr 18
    View PubMed
  365. Madhavan A, Whitwell JL, Weigand SD, Duffy JR, Strand EA, Machulda MM, Tosakulwong N, Senjem ML, Gunter JL, Lowe VJ, Petersen RC, Jack CR Jr, Josephs KA. FDG PET and MRI in logopenic primary progressive aphasia versus dementia of the Alzheimer's type. PLoS One. 2013; 8 (4):e62471 Epub 2013 Apr 23
    View PubMed
  366. Whitwell JL, Josephs KA. Recent advances in the imaging of frontotemporal dementia. Curr Neurol Neurosci Rep. 2012 Dec; 12 (6):715-23
    View PubMed
  367. Whitwell JL, Josephs KA. Imaging brain atrophy in progressive supranuclear palsy and corticobasal syndromes: potential for diagnosis and monitoring of disease progression. Neurodegenerative Disease Management. 2012 Dec; 2(6):589-598.
  368. Whitwell JL, Xu J, Mandrekar J, Gunter JL, Jack CR Jr, Josephs KA. Imaging measures predict progression in progressive supranuclear palsy. Mov Disord. 2012 Dec; 27(14):1801-4. Epub 2012 Mar 13.
    View PubMed
  369. Graff-Radford J, Boeve BF, Drubach DA, Knopman DS, Ahlskog JE, Golden EC, Drubach DI, Petersen RC, Josephs KA. Limb immobilization and corticobasal syndrome. Parkinsonism Relat Disord. 2012 Dec; 18 (10):1097-9 Epub 2012 June 20
    View PubMed
  370. Josephs KA, Eggers SD, Jack CR Jr, Whitwell JL. Neuroanatomical correlates of the progressive supranuclear palsy corticobasal syndrome hybrid. Eur J Neurol. 2012 Nov; 19(11):1440-6. Epub 2012 Apr 23.
    View PubMed
  371. Duffy JR, Josephs KA. The diagnosis and understanding of apraxia of speech: why including neurodegenerative etiologies may be important. J Speech Lang Hear Res. 2012 Oct; 55 (5):S1518-22
    View PubMed
  372. Whitwell JL, Dickson DW, Murray ME, Weigand SD, Tosakulwong N, Senjem ML, Knopman DS, Boeve BF, Parisi JE, Petersen RC, Jack CR Jr, Josephs KA. Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study. Lancet Neurol. 2012 Oct; 11 (10):868-77 Epub 2012 Sept 03
    View PubMed
  373. Rutherford NJ, Carrasquillo MM, Li M, Bisceglio G, Menke J, Josephs KA, Parisi JE, Petersen RC, Graff-Radford NR, Younkin SG, Dickson DW, Rademakers R. TMEM106B risk variant is implicated in the pathologic presentation of Alzheimer disease. Neurology. 2012 Aug 14; 79 (7):717-8 Epub 2012 Aug 01
    View PubMed
  374. Sundal C, Van Gerpen JA, Nicholson AM, Wider C, Shuster EA, Aasly J, Spina S, Ghetti B, Roeber S, Garbern J, Borjesson-Hanson A, Tselis A, Swerdlow RH, Miller BB, Fujioka S, Heckman MG, Uitti RJ, Josephs KA, Baker M, Andersen O, Rademakers R, Dickson DW, Broderick D, Wszolek ZK. MRI characteristics and scoring in HDLS due to CSF1R gene mutations. Neurology. 2012 Aug 7; 79 (6):566-74 Epub 2012 July 25
    View PubMed
  375. Graff-Radford J, Duffy JR, Strand EA, Josephs KA. Parkinsonian motor features distinguish the agrammatic from logopenic variant of primary progressive aphasia. Parkinsonism Relat Disord. 2012 Aug; 18 (7):890-2 Epub 2012 May 08
    View PubMed
  376. Rubin M, Graff-Radford J, Boeve B, Josephs KA, Aksamit AJ. The alien limb phenomenon and Creutzfeldt-Jakob disease. Parkinsonism Relat Disord. 2012 Aug; 18: (7)842-6.
    View PubMed
  377. Graff-Radford J, Drubach DA, Strand EA, Josephs KA. Fluorodeoxyglucose F18 PET in progressive emotional dysprosody. Neurology. 2012 Jul 31; 79 (5):480-1 Epub 2012 July 18
    View PubMed
  378. Coon EA, Whitwell JL, Jack CR Jr, Josephs KA. Primary lateral sclerosis as progressive supranuclear palsy: diagnosis by diffusion tensor imaging. Mov Disord. 2012 Jun; 27 (7):903-6 Epub 2012 Apr 19
    View PubMed
  379. Perry DC, Whitwell JL, Boeve BF, Pankratz VS, Knopman DS, Petersen RC, Jack CR Jr, Josephs KA. Voxel-based morphometry in patients with obsessive-compulsive behaviors in behavioral variant frontotemporal dementia. Eur J Neurol. 2012 Jun; 19 (6):911-7 Epub 2012 Jan 28
    View PubMed
  380. Josephs KA, Duffy JR, Strand EA, Machulda MM, Senjem ML, Master AV, Lowe VJ, Jack CR Jr, Whitwell JL. Characterizing a neurodegenerative syndrome: primary progressive apraxia of speech. Brain. 2012 May; 135 (Pt 5):1522-36 Epub 2012 Mar 01
    View PubMed
  381. Tomiyasu A, Nakamura M, Ichiba M, Ueno S, Saiki S, Morimoto M, Kobal J, Kageyama Y, Inui T, Wakabayashi K, Yamada T, Kanemori Y, Jung HH, Tanaka H, Orimo S, Afawi Z, Blatt I, Aasly J, Ujike H, Babovic-Vuksanovic D, Josephs KA, Tohge R, Rodrigues GR, Dupre N, Yamada H, Yokochi F, Kotschet K, Takei T, Rudzinska M, Szczudlik A, Penco S, Fujiwara M, Tojo K, Sano A. "Novel pathogenic mutations and copy number variations in the VPS13A gene in patients with chorea-acanthocytosis" Addendum American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2012 Apr; 159B: (3)360.
  382. Savica R, Parisi JE, Wold LE, Josephs KA, Ahlskog JE. High school football and risk of neurodegeneration: a community-based study. Mayo Clin Proc. 2012 Apr; 87 (4):335-40
    View PubMed
  383. Graff-Radford J, Josephs KA. Primary progressive aphasia and transient global amnesia. Arch Neurol. 2012 Mar; 69 (3):401-4
    View PubMed
  384. Whitwell JL, Weigand SD, Boeve BF, Senjem ML, Gunter JL, DeJesus-Hernandez M, Rutherford NJ, Baker M, Knopman DS, Wszolek ZK, Parisi JE, Dickson DW, Petersen RC, Rademakers R, Jack CR Jr, Josephs KA. Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics. Brain. 2012 Mar; 135 (Pt 3):794-806
    View PubMed
  385. Boeve BF, Boylan KB, Graff-Radford NR, DeJesus-Hernandez M, Knopman DS, Pedraza O, Vemuri P, Jones D, Lowe V, Murray ME, Dickson DW, Josephs KA, Rush BK, Machulda MM, Fields JA, Ferman TJ, Baker M, Rutherford NJ, Adamson J, Wszolek ZK, Adeli A, Savica R, Boot B, Kuntz KM, Gavrilova R, Reeves A, Whitwell J, Kantarci K, Jack CR Jr, Parisi JE, Lucas JA, Petersen RC, Rademakers R. Characterization of frontotemporal dementia and/or amyotrophic lateral sclerosis associated with the GGGGCC repeat expansion in C9ORF72. Brain. 2012 Mar; 135 (Pt 3):765-83
    View PubMed
  386. Whitwell JL, Xu J, Mandrekar JN, Gunter JL, Jack CR Jr, Josephs KA. Rates of brain atrophy and clinical decline over 6 and 12-month intervals in PSP: determining sample size for treatment trials. Parkinsonism Relat Disord. 2012 Mar; 18 (3):252-6 Epub 2011 Nov 13
    View PubMed
  387. Mateen FJ, Josephs KA, Parisi JE, Drubach DA, Caselli RJ, Kantarci K, Jack C Jr, Boeve BF. Steroid-responsive encephalopathy subsequently associated with Alzheimer's disease pathology: a case series. Neurocase. 2012 Feb; 18: (1)1-12.
    View PubMed
  388. Whitwell JL, Josephs KA. Neuroimaging in frontotemporal lobar degeneration--predicting molecular pathology. Nat Rev Neurol. 2012 Jan 31; 8 (3):131-42
    View PubMed
  389. Coon EA, Whitwell JL, Parisi JE, Dickson DW, Josephs KA. Right temporal variant frontotemporal dementia with motor neuron disease. J Clin Neurosci. 2012 Jan; 19 (1):85-91 Epub 2011 Nov 02
    View PubMed
  390. Hassan A, Parisi JE, Josephs KA. Autopsy-proven progressive supranuclear palsy presenting as behavioral variant frontotemporal dementia. Neurocase. 2012; 18 (6):478-88 Epub 2011 Dec 20
    View PubMed
  391. Savica R, Kumar N, Ahlskog JE, Josephs KA, Matsumoto JY, McKeon A. Parkinsonism and dropped head: dystonia, myopathy or both? Parkinsonism Relat Disord. 2012 Jan; 18(1):30-4. Epub 2011 Aug 27.
    View PubMed
  392. Graff-Radford J, Whitwell JL, Geda YE, Josephs KA. Clinical and imaging features of Othello's syndrome. Eur J Neurol. 2012 Jan; 19 (1):38-46 Epub 2011 Apr 25
    View PubMed
  393. Murray ME, DeJesus-Hernandez M, Rutherford NJ, Baker M, Duara R, Graff-Radford NR, Wszolek ZK, Ferman TJ, Josephs KA, Boylan KB, Rademakers R, Dickson DW. Clinical and neuropathologic heterogeneity of c9FTD/ALS associated with hexanucleotide repeat expansion in C9ORF72. Acta Neuropathol. 2011 Dec; 122 (6):673-90 Epub 2011 Nov 15
    View PubMed
  394. Graff-Radford J, Whitwell JL, Trenerry MR, Ahlskog JE, Jensen MD, Jack CR Jr, Josephs KA. Focal brain atrophy in gastric bypass patients with cognitive complaints. J Clin Neurosci. 2011 Dec; 18 (12):1671-6 Epub 2011 Nov 15
    View PubMed
  395. Hassan A, Whitwell JL, Josephs KA. The corticobasal syndrome-Alzheimer's disease conundrum. Expert Rev Neurother. 2011 Nov; 11 (11):1569-78
    View PubMed
  396. Kouri N, Murray ME, Hassan A, Rademakers R, Uitti RJ, Boeve BF, Graff-Radford NR, Wszolek ZK, Litvan I, Josephs KA, Dickson DW. Neuropathological features of corticobasal degeneration presenting as corticobasal syndrome or Richardson syndrome. Brain. 2011 Nov; 134 (Pt 11):3264-75 Epub 2011 Sept 20
    View PubMed
  397. Dickson DW, Kouri N, Murray ME, Josephs KA. Neuropathology of frontotemporal lobar degeneration-tau (FTLD-tau). J Mol Neurosci. 2011 Nov; 45 (3):384-9 Epub 2011 July 01
    View PubMed
  398. Whitwell JL, Jack CR Jr, Parisi JE, Knopman DS, Boeve BF, Petersen RC, Dickson DW, Josephs KA. Imaging signatures of molecular pathology in behavioral variant frontotemporal dementia. J Mol Neurosci. 2011 Nov; 45 (3):372-8 Epub 2011 May 10
    View PubMed
  399. Kocerha J, Kouri N, Baker M, Finch N, DeJesus-Hernandez M, Gonzalez J, Chidamparam K, Josephs KA, Boeve BF, Graff-Radford NR, Crook J, Dickson DW, Rademakers R. Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations. BMC Genomics. 2011 Oct 27; 12:527
    View PubMed
  400. DeJesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ, Nicholson AM, Finch NA, Flynn H, Adamson J, Kouri N, Wojtas A, Sengdy P, Hsiung GY, Karydas A, Seeley WW, Josephs KA, Coppola G, Geschwind DH, Wszolek ZK, Feldman H, Knopman DS, Petersen RC, Miller BL, Dickson DW, Boylan KB, Graff-Radford NR, Rademakers R. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron. 2011 Oct 20; 72 (2):245-56 Epub 2011 Sept 21
    View PubMed
  401. Mateen FJ, Josephs KA, Trenerry MR, Felmlee-Devine MD, Weaver AL, Carone M, White RD. Long-term cognitive outcomes following out-of-hospital cardiac arrest: a population-based study. Neurology. 2011 Oct 11; 77(15):1438-45. Epub 2011 Sep 14.
    View PubMed
  402. Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, van Swieten JC, Seelaar H, Dopper EG, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini ML, Rosen H, Prioleau-Latham CE, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor MN, Warren JD, Fox NC, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow TW, Manes F, Grafman J, Cappa SF, Freedman M, Grossman M, Miller BL. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain. 2011 Sep; 134(Pt 9):2456-77. Epub 2011 Aug 02.
    View PubMed
  403. Whitwell JL, Avula R, Master A, Vemuri P, Senjem ML, Jones DT, Jack CR Jr, Josephs KA. Disrupted thalamocortical connectivity in PSP: a resting-state fMRI, DTI, and VBM study. Parkinsonism Relat Disord. 2011 Sep; 17 (8):599-605 Epub 2011 June 12
    View PubMed
  404. Whitwell JL, Jack CR Jr, Przybelski SA, Parisi JE, Senjem ML, Boeve BF, Knopman DS, Petersen RC, Dickson DW, Josephs KA. Temporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis. Neurobiol Aging. 2011 Sep; 32 (9):1531-41 Epub 2009 Nov 14
    View PubMed
  405. Savica R, Rabinstein AA, Josephs KA. Ifosfamide associated myoclonus-encephalopathy syndrome. J Neurol. 2011 Sep; 258 (9):1729-31 Epub 2011 Mar 12
    View PubMed
  406. Whitwell JL, Josephs KA, Avula R, Tosakulwong N, Weigand SD, Senjem ML, Vemuri P, Jones DT, Gunter JL, Baker M, Wszolek ZK, Knopman DS, Rademakers R, Petersen RC, Boeve BF, Jack CR Jr. Altered functional connectivity in asymptomatic MAPT subjects: a comparison to bvFTD. Neurology. 2011 Aug 30; 77 (9):866-74 Epub 2011 Aug 17
    View PubMed
  407. Savica R, Matsumoto JY, Josephs KA, Ahlskog JE, Stead M, Lee KH, Klassen BT. Deep brain stimulation in benign tremulous parkinsonism. Arch Neurol. 2011 Aug; 68 (8):1033-6
    View PubMed
  408. Josephs KA, Hodges JR, Snowden JS, Mackenzie IR, Neumann M, Mann DM, Dickson DW. Neuropathological background of phenotypical variability in frontotemporal dementia. Acta Neuropathol. 2011 Aug; 122 (2):137-53 Epub 2011 May 26
    View PubMed
  409. Whitwell JL, Weigand SD, Gunter JL, Boeve BF, Rademakers R, Baker M, Knopman DS, Wszolek ZK, Petersen RC, Jack CR Jr, Josephs KA. Trajectories of brain and hippocampal atrophy in FTD with mutations in MAPT or GRN. Neurology. 2011 Jul 26; 77 (4):393-8 Epub 2011 July 13
    View PubMed
  410. Whitwell JL, Master AV, Avula R, Kantarci K, Eggers SD, Edmonson HA, Jack CR Jr, Josephs KA. Clinical correlates of white matter tract degeneration in progressive supranuclear palsy. Arch Neurol. 2011 Jun; 68 (6):753-60
    View PubMed
  411. Cornelius JR, Pittock SJ, McKeon A, Lennon VA, Aston PA, Josephs KA, Tippmann-Peikert M, Silber MH. Sleep manifestations of voltage-gated potassium channel complex autoimmunity. Arch Neurol. 2011 Jun; 68 (6):733-8
    View PubMed
  412. Coon EA, Sorenson EJ, Whitwell JL, Knopman DS, Josephs KA. Predicting survival in frontotemporal dementia with motor neuron disease. Neurology. 2011 May 31; 76 (22):1886-93
    View PubMed
  413. Li X, Lapid MI, Burton MC, Josephs KA. Psychoses as the presenting manifestation of Creutzfeldt-Jakob disease in an elderly male. Gen Hosp Psychiatry. 2011 May-Jun; 33(3):302.e7-9. Epub 2011 Mar 24.
    View PubMed
  414. Hassan A, Bower JH, Kumar N, Matsumoto JY, Fealey RD, Josephs KA, Ahlskog JE. Dopamine agonist-triggered pathological behaviors: surveillance in the PD clinic reveals high frequencies. Parkinsonism Relat Disord. 2011 May; 17 (4):260-4 Epub 2011 Feb 09
    View PubMed
  415. Frigerio R, Fujishiro H, Ahn TB, Josephs KA, Maraganore DM, DelleDonne A, Parisi JE, Klos KJ, Boeve BF, Dickson DW, Ahlskog JE. Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies? Neurobiol Aging. 2011 May; 32 (5):857-63 Epub 2009 June 26
    View PubMed
  416. Kouri N, Whitwell JL, Josephs KA, Rademakers R, Dickson DW. Corticobasal degeneration: a pathologically distinct 4R tauopathy. Nat Rev Neurol. 2011 May; 7 (5):263-72 Epub 2011 Apr 12
    View PubMed
  417. Wicklund MR, Mokri B, Drubach DA, Boeve BF, Parisi JE, Josephs KA. Frontotemporal brain sagging syndrome: an SIH-like presentation mimicking FTD. Neurology. 2011 Apr 19; 76 (16):1377-82
    View PubMed
  418. Vemuri P, Simon G, Kantarci K, Whitwell JL, Senjem ML, Przybelski SA, Gunter JL, Josephs KA, Knopman DS, Boeve BF, Ferman TJ, Dickson DW, Parisi JE, Petersen RC, Jack CR Jr. Antemortem differential diagnosis of dementia pathology using structural MRI: Differential-STAND. Neuroimage. 2011 Mar 15; 55 (2):522-31 Epub 2010 Dec 31
    View PubMed
  419. Claassen DO, Lowe VJ, Peller PJ, Petersen RC, Josephs KA. Amyloid and glucose imaging in dementia with Lewy bodies and multiple systems atrophy. Parkinsonism Relat Disord. 2011 Mar; 17(3):160-5. Epub 2010 Dec 31.
    View PubMed
  420. Passov V, Gavrilova RH, Strand E, Cerhan JH, Josephs KA. Sporadic corticobasal syndrome with progranulin mutation presenting as progressive apraxic agraphia. Arch Neurol. 2011 Mar; 68 (3):376-80
    View PubMed
  421. Josephs KA, Whitwell JL, Eggers SD, Senjem ML, Jack CR Jr. Gray matter correlates of behavioral severity in progressive supranuclear palsy. Mov Disord. 2011 Feb 15; 26(3):493-8. Epub 2011 Jan 12.
    View PubMed
  422. Josephs KA Jr, Whitwell JL, Weigand SD, Senjem ML, Boeve BF, Knopman DS, Smith GE, Ivnik RJ, Jack CR Jr, Petersen RC. Predicting functional decline in behavioural variant frontotemporal dementia. Brain. 2011 Feb; 134 (Pt 2):432-48 Epub 2011 Jan 20
    View PubMed
  423. Tomiyasu A, Nakamura M, Ichiba M, Ueno S, Saiki S, Morimoto M, Kobal J, Kageyama Y, Inui T, Wakabayashi K, Yamada T, Kanemori Y, Jung HH, Tanaka H, Orimo S, Afawi Z, Blatt I, Aasly J, Ujike H, Babovic-Vuksanovic D, Josephs KA, Tohge R, Rodrigues GR, Dupre N, Yamada H, Yokochi F, Kotschet K, Takei T, Rudzinska M, Szczudlik A, Penco S, Fujiwara M, Tojo K, Sano A. Novel pathogenic mutations and copy number variations in the VPS13A Gene in patients with chorea-acanthocytosis. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2011; 156(5):620-31.
  424. Hassan A, Bower JH, Kumar N, Matsumoto JY, Fealey RD, Josephs KA, Ahlskog JE. Corrigendum to "Dopamine agonist-triggered pathological behaviors: Surveillance in the PD clinic reveals high frequencies" [Parkinsonism Relat Disord 17 (2011) 260-264]. Parkinsonism Relat Disord. 2011; 17(6):499.
  425. Whitwell JL, Jack CR Jr, Parisi JE, Senjem ML, Knopman DS, Boeve BF, Rademakers R, Baker M, Petersen RC, Dickson DW, Josephs KA. Does TDP-43 type confer a distinct pattern of atrophy in frontotemporal lobar degeneration? Neurology. 2010 Dec 14; 75 (24):2212-20
    View PubMed
  426. Graff-Radford J, Ahlskog JE, Bower JH, Josephs KA. Dopamine agonists and Othello's syndrome. Parkinsonism Relat Disord. 2010 Dec; 16 (10):680-2 Epub 2010 Sept 09
    View PubMed
  427. Whitwell JL, Jack CR Jr, Boeve BF, Parisi JE, Ahlskog JE, Drubach DA, Senjem ML, Knopman DS, Petersen RC, Dickson DW, Josephs KA. Imaging correlates of pathology in corticobasal syndrome. Neurology. 2010 Nov 23; 75 (21):1879-87
    View PubMed
  428. Josephs KA. Dementia and the TAR DNA binding protein 43. Clin Pharmacol Ther. 2010 Oct; 88: (4)555-8.
    View PubMed
  429. Flanagan EP, McKeon A, Lennon VA, Boeve BF, Trenerry MR, Tan KM, Drubach DA, Josephs KA, Britton JW, Mandrekar JN, Lowe V, Parisi JE, Pittock SJ. Autoimmune dementia: clinical course and predictors of immunotherapy response. Mayo Clin Proc. 2010 Oct; 85 (10):881-97
    View PubMed
  430. Claassen DO, Josephs KA, Ahlskog JE, Silber MH, Tippmann-Peikert M, Boeve BF. REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century. Neurology. 2010 Aug 10; 75 (6):494-9 Epub 2010 July 28
    View PubMed
  431. Dickson DW, Ahmed Z, Algom AA, Tsuboi Y, Josephs KA. Neuropathology of variants of progressive supranuclear palsy. Curr Opin Neurol. 2010 Aug; 23 (4):394-400
    View PubMed
  432. Josephs KA, Whitwell JL, Boeve BF, Knopman DS, Petersen RC, Hu WT, Parisi JE, Dickson DW, Jack CR Jr. Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease. Mov Disord. 2010 Jul 15; 25 (9):1246-52
    View PubMed
  433. Josephs KA, Whitwell JL, Parisi JE, Petersen RC, Boeve BF, Jack CR Jr, Dickson DW. Caudate atrophy on MRI is a characteristic feature of FTLD-FUS. Eur J Neurol. 2010 Jul; 17 (7):969-75 Epub 2010 Mar 03
    View PubMed
  434. Urwin H, Josephs KA, Rohrer JD, Mackenzie IR, Neumann M, Authier A, Seelaar H, Van Swieten JC, Brown JM, Johannsen P, Nielsen JE, Holm IE, Dickson DW, Rademakers R, Graff-Radford NR, Parisi JE, Petersen RC, Hatanpaa KJ, White CL 3rd, Weiner MF, Geser F, Van Deerlin VM, Trojanowski JQ, Miller BL, Seeley WW, van der Zee J, Kumar-Singh S, Engelborghs S, De Deyn PP, Van Broeckhoven C, Bigio EH, Deng HX, Halliday GM, Kril JJ, Munoz DG, Mann DM, Pickering-Brown SM, Doodeman V, Adamson G, Ghazi-Noori S, Fisher EM, Holton JL, Revesz T, Rossor MN, Collinge J, Mead S, Isaacs AM, FReJA Consortium. FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration. Acta Neuropathol. 2010 Jul; 120 (1):33-41 Epub 2010 May 20
    View PubMed
  435. Josephs KA, Duffy JR, Fossett TR, Strand EA, Claassen DO, Whitwell JL, Peller PJ. Fluorodeoxyglucose F18 positron emission tomography in progressive apraxia of speech and primary progressive aphasia variants. Arch Neurol. 2010 May; 67: (5)596-605.
    View PubMed
  436. Whitwell JL, Avula R, Senjem ML, Kantarci K, Weigand SD, Samikoglu A, Edmonson HA, Vemuri P, Knopman DS, Boeve BF, Petersen RC, Josephs KA, Jack CR Jr. Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia. Neurology. 2010 Apr 20; 74 (16):1279-87
    View PubMed
  437. Gendron TF, Josephs KA, Petrucelli L. Review: transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration. Neuropathol Appl Neurobiol. 2010 Apr; 36 (2):97-112 Epub 2010 Feb 19
    View PubMed
  438. Hassan A, Whitwell JL, Boeve BF, Jack CR Jr, Parisi JE, Dickson DW, Josephs KA. Symmetric corticobasal degeneration (S-CBD). Parkinsonism Relat Disord. 2010 Mar; 16 (3):208-14 Epub 2009 Dec 16
    View PubMed
  439. Claassen DO, Josephs KA, Peller PJ. The stripe of primary lateral sclerosis: focal primary motor cortex hypometabolism seen on fluorodeoxyglucose F18 positron emission tomography. Arch Neurol. 2010 Jan; 67: (1)122-5.
    View PubMed
  440. Dickson DW, Fujishiro H, Orr C, DelleDonne A, Josephs KA, Frigerio R, Burnett M, Parisi JE, Klos KJ, Ahlskog JE. Neuropathology of non-motor features of Parkinson disease. Parkinsonism Relat Disord. 2009 Dec; 15 Suppl 3:S1-5
    View PubMed
  441. Josephs KA, Whitwell JL, Knopman DS, Boeve BF, Vemuri P, Senjem ML, Parisi JE, Ivnik RJ, Dickson DW, Petersen RC, Jack CR Jr. Two distinct subtypes of right temporal variant frontotemporal dementia. Neurology. 2009 Nov 3; 73 (18):1443-50
    View PubMed
  442. Whitwell JL, Przybelski SA, Weigand SD, Ivnik RJ, Vemuri P, Gunter JL, Senjem ML, Shiung MM, Boeve BF, Knopman DS, Parisi JE, Dickson DW, Petersen RC, Jack CR Jr, Josephs KA. Distinct anatomical subtypes of the behavioural variant of frontotemporal dementia: a cluster analysis study. Brain. 2009 Nov; 132 (Pt 11):2932-46 Epub 2009 Sept 17
    View PubMed
  443. Hu WT, Seelaar H, Josephs KA, Knopman DS, Boeve BF, Sorenson EJ, McCluskey L, Elman L, Schelhaas HJ, Parisi JE, Kuesters B, Lee VM, Trojanowski JQ, Petersen RC, van Swieten JC, Grossman M. Survival profiles of patients with frontotemporal dementia and motor neuron disease. Arch Neurol. 2009 Nov; 66 (11):1359-64
    View PubMed
  444. Cobb SA, Wider C, Ross OA, Mata IF, Adler CH, Rajput A, Rajput AH, Wu RM, Hauser R, Josephs KA, Carr J, Gwinn K, Heckman MG, Aasly JO, Lynch T, Uitti RJ, Wszolek ZK, Kapatos G, Farrer MJ. GCH1 in early-onset Parkinson's disease. Mov Disord. 2009 Oct 30; 24 (14):2070-5
    View PubMed
  445. Cobb SA, Wider C, Ross OA, Mata IF, Adler CH, Rajput A, Rajput AH, Wu RM, Hauser R, Josephs KA, Carr J, Gwinn K, Heckman MG, Aasly JO, Lynch T, Uitti RJ, Wszolek ZK, Kapatos G, Farrer MJ. GCH1 in darly-onset Parkinson's disease. Mov Disord. 2009 Oct 30; 24(14):2070-5.
  446. Whitwell JL, Jack CR Jr, Boeve BF, Senjem ML, Baker M, Ivnik RJ, Knopman DS, Wszolek ZK, Petersen RC, Rademakers R, Josephs KA. Atrophy patterns in IVS10+16, IVS10+3, N279K, S305N, P301L, and V337M MAPT mutations. Neurology. 2009 Sep 29; 73 (13):1058-65
    View PubMed
  447. Frigerio R, Fujishiro H, Maraganore DM, Klos KJ, DelleDonne A, Heckman MG, Crook JE, Josephs KA, Parisi JE, Boeve BF, Dickson DW, Ahlskog JE. Comparison of risk factor profiles in incidental Lewy body disease and Parkinson disease. Arch Neurol. 2009 Sep; 66 (9):1114-9
    View PubMed
  448. Josephs KA, Stroh A, Dugger B, Dickson DW. Evaluation of subcortical pathology and clinical correlations in FTLD-U subtypes. Acta Neuropathol. 2009 Sep; 118 (3):349-58 Epub 2009 May 20
    View PubMed
  449. Hu WT, Rippon GW, Boeve BF, Knopman DS, Petersen RC, Parisi JE, Josephs KA. Alzheimer's disease and corticobasal degeneration presenting as corticobasal syndrome. Mov Disord. 2009 Jul 15; 24 (9):1375-9
    View PubMed
  450. Mateen FJ, Josephs KA. The clinical spectrum of stereotypies in frontotemporal lobar degeneration. Mov Disord. 2009 Jun 15; 24 (8):1237-40
    View PubMed
  451. Vilarino-Guell C, Wider C, Soto-Ortolaza AI, Cobb SA, Kachergus JM, Keeling BH, Dachsel JC, Hulihan MM, Dickson DW, Wszolek ZK, Uitti RJ, Graff-Radford NR, Boeve BF, Josephs KA, Miller B, Boylan KB, Gwinn K, Adler CH, Aasly JO, Hentati F, Destee A, Krygowska-Wajs A, Chartier-Harlin MC, Ross OA, Rademakers R, Farrer MJ. Characterization of DCTN1 genetic variability in neurodegeneration. Neurology. 2009 Jun 9; 72 (23):2024-8
    View PubMed
  452. Kelley BJ, Haidar W, Boeve BF, Baker M, Graff-Radford NR, Krefft T, Frank AR, Jack CR Jr, Shiung M, Knopman DS, Josephs KA, Parashos SA, Rademakers R, Hutton M, Pickering-Brown S, Adamson J, Kuntz KM, Dickson DW, Parisi JE, Smith GE, Ivnik RJ, Petersen RC. Prominent phenotypic variability associated with mutations in Progranulin. Neurobiol Aging. 2009 May; 30 (5):739-51 Epub 2007 Oct 18
    View PubMed
  453. Whitwell JL, Jack CR Jr, Boeve BF, Senjem ML, Baker M, Rademakers R, Ivnik RJ, Knopman DS, Wszolek ZK, Petersen RC, Josephs KA. Voxel-based morphometry patterns of atrophy in FTLD with mutations in MAPT or PGRN. Neurology. 2009 Mar 3; 72 (9):813-20
    View PubMed
  454. Kelley BJ, Boeve BF, Josephs KA. Rapidly progressive young-onset dementia. Cogn Behav Neurol. 2009 Mar; 22 (1):22-7
    View PubMed
  455. Josephs KA, Ahlskog JE, Parisi JE, Boeve BF, Crum BA, Giannini C, Petersen RC. Rapidly progressive neurodegenerative dementias. Arch Neurol. 2009 Feb; 66 (2):201-7
    View PubMed
  456. McKeon A, Ahlskog JE, Bower JH, Josephs KA, Matsumoto JY. Psychogenic tremor: long-term prognosis in patients with electrophysiologically confirmed disease. Mov Disord. 2009 Jan 15; 24(1):72-6.
    View PubMed
  457. Whitwell JL, Jack CR Jr, Senjem ML, Parisi JE, Boeve BF, Knopman DS, Dickson DW, Petersen RC, Josephs KA. MRI correlates of protein deposition and disease severity in postmortem frontotemporal lobar degeneration. Neurodegener Dis. 2009; 6 (3):106-17 Epub 2009 Mar 19
    View PubMed
  458. Kelley BJ, Boeve BF, Josephs KA. Cognitive and noncognitive neurological features of young-onset dementia. Dement Geriatr Cogn Disord. 2009; 27 (6):564-71 Epub 2009 July 11
    View PubMed
  459. Whitwell JL, Josephs KA. Imaging in familial frontotemporal lobar degeneration with mutations in MAPT or PGRN. European Neurological Journal. 2009; 1:25-31.
  460. Cooper AD, Josephs KA. Photophobia, visual hallucinations, and REM sleep behavior disorder in progressive supranuclear palsy and corticobasal degeneration: a prospective study. Parkinsonism Relat Disord. 2009 Jan; 15(1):59-61. Epub 2008 Mar 06.
    View PubMed
  461. Yurchenko A, Lapid MI, Josephs KA. Frontotemporal dementia in older adults: Diagnostic and therapeutic challenges. Clinical Geriatrics. 2009; 17(1):26-31.
  462. Rademakers R, Eriksen JL, Baker M, Robinson T, Ahmed Z, Lincoln SJ, Finch N, Rutherford NJ, Crook RJ, Josephs KA, Boeve BF, Knopman DS, Petersen RC, Parisi JE, Caselli RJ, Wszolek ZK, Uitti RJ, Feldman H, Hutton ML, Mackenzie IR, Graff-Radford NR, Dickson DW. Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. Hum Mol Genet. 2008 Dec 1; 17 (23):3631-42 Epub 2008 Aug 21
    View PubMed
  463. Josephs KA, Duffy JR. Apraxia of speech and nonfluent aphasia: a new clinical marker for corticobasal degeneration and progressive supranuclear palsy. Curr Opin Neurol. 2008 Dec; 21 (6):688-92
    View PubMed
  464. Josephs KA, Whitwell JL, Jack CR Jr. Anatomic correlates of stereotypies in frontotemporal lobar degeneration. Neurobiol Aging. 2008 Dec; 29 (12):1859-63 Epub 2007 June 14
    View PubMed
  465. Czarnecki K, Duffy JR, Nehl CR, Cross SA, Molano JR, Jack CR Jr, Shiung MM, Josephs KA, Boeve BF. Very early semantic dementia with progressive temporal lobe atrophy: an 8-year longitudinal study. Arch Neurol. 2008 Dec; 65 (12):1659-63
    View PubMed
  466. Josephs KA, Whitwell JL, Vemuri P, Senjem ML, Boeve BF, Knopman DS, Smith GE, Ivnik RJ, Petersen RC, Jack CR Jr. The anatomic correlate of prosopagnosia in semantic dementia. Neurology. 2008 Nov 11; 71 (20):1628-33
    View PubMed
  467. Kelley BJ, Boeve BF, Josephs KA. Young-onset dementia: demographic and etiologic characteristics of 235 patients. Arch Neurol. 2008 Nov; 65 (11):1502-8
    View PubMed
  468. Whitwell JL, Josephs KA, Murray ME, Kantarci K, Przybelski SA, Weigand SD, Vemuri P, Senjem ML, Parisi JE, Knopman DS, Boeve BF, Petersen RC, Dickson DW, Jack CR Jr. MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study. Neurology. 2008 Sep 2; 71 (10):743-9
    View PubMed
  469. Fujishiro H, Ahn TB, Frigerio R, DelleDonne A, Josephs KA, Parisi JE, Eric Ahlskog J, Dickson DW. Glial cytoplasmic inclusions in neurologically normal elderly: prodromal multiple system atrophy? Acta Neuropathol. 2008 Sep; 116 (3):269-75 Epub 2008 June 14
    View PubMed
  470. Claassen DO, Parisi JE, Giannini C, Boeve BF, Dickson DW, Josephs KA. Frontotemporal dementia mimicking dementia with Lewy bodies. Cogn Behav Neurol. 2008 Sep; 21 (3):157-63
    View PubMed
  471. Vemuri P, Whitwell JL, Kantarci K, Josephs KA, Parisi JE, Shiung MS, Knopman DS, Boeve BF, Petersen RC, Dickson DW, Jack CR Jr. Antemortem MRI based STructural Abnormality iNDex (STAND)-scores correlate with postmortem Braak neurofibrillary tangle stage. Neuroimage. 2008 Aug 15; 42 (2):559-67 Epub 2008 May 20
    View PubMed
  472. Hu WT, Josephs KA, Knopman DS, Boeve BF, Dickson DW, Petersen RC, Parisi JE. Temporal lobar predominance of TDP-43 neuronal cytoplasmic inclusions in Alzheimer disease. Acta Neuropathol. 2008 Aug; 116 (2):215-20 Epub 2008 July 01
    View PubMed
  473. Josephs KA, Lin WL, Ahmed Z, Stroh DA, Graff-Radford NR, Dickson DW. Frontotemporal lobar degeneration with ubiquitin-positive, but TDP-43-negative inclusions. Acta Neuropathol. 2008 Aug; 116 (2):159-67 Epub 2008 June 14
    View PubMed
  474. DelleDonne A, Klos KJ, Fujishiro H, Ahmed Z, Parisi JE, Josephs KA, Frigerio R, Burnett M, Wszolek ZK, Uitti RJ, Ahlskog JE, Dickson DW. Incidental Lewy body disease and preclinical Parkinson disease. Arch Neurol. 2008 Aug; 65 (8):1074-80
    View PubMed
  475. Milone M, Brunetti-Pierri N, Tang LY, Kumar N, Mezei MM, Josephs K, Powell S, Simpson E, Wong LJ. Sensory ataxic neuropathy with ophthalmoparesis caused by POLG mutations. Neuromuscul Disord. 2008 Aug; 18 (8):626-32 Epub 2008 June 27
    View PubMed
  476. Kantarci K, Knopman DS, Dickson DW, Parisi JE, Whitwell JL, Weigand SD, Josephs KA, Boeve BF, Petersen RC, Jack CR Jr. Alzheimer disease: postmortem neuropathologic correlates of antemortem 1H MR spectroscopy metabolite measurements. Radiology. 2008 Jul; 248 (1):210-20
    View PubMed
  477. Josephs KA. Frontotemporal dementia and related disorders: deciphering the enigma. Ann Neurol. 2008 Jul; 64 (1):4-14
    View PubMed
  478. Fujishiro H, Frigerio R, Burnett M, Klos KJ, Josephs KA, Delledonne A, Parisi JE, Ahlskog JE, Dickson DW. Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease. Mov Disord. 2008 Jun 15; 23 (8):1085-92
    View PubMed
  479. Wider C, Uitti RJ, Wszolek ZK, Fang JY, Josephs KA, Baker MC, Rademakers R, Hutton ML, Dickson DW. Progranulin gene mutation with an unusual clinical and neuropathologic presentation. Mov Disord. 2008 Jun 15; 23 (8):1168-73
    View PubMed
  480. Josephs KA, Whitwell JL, Knopman DS, Hu WT, Stroh DA, Baker M, Rademakers R, Boeve BF, Parisi JE, Smith GE, Ivnik RJ, Petersen RC, Jack CR Jr, Dickson DW. Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype. Neurology. 2008 May 6; 70 (19 Pt 2):1850-7 Epub 2008 Apr 09
    View PubMed
  481. Josephs KA. Review of Frontotemporal dementia syndromes. Journal of Neurology, Neurosurgery & Psychiatry. 2008 May; 79(5):614.
  482. Josephs KA, Whitwell JL, Parisi JE, Knopman DS, Boeve BF, Geda YE, Jack CR Jr, Petersen RC, Dickson DW. Argyrophilic grains: a distinct disease or an additive pathology? Neurobiol Aging. 2008 Apr; 29 (4):566-73 Epub 2006 Dec 26
    View PubMed
  483. Dickson DW, Fujishiro H, DelleDonne A, Menke J, Ahmed Z, Klos KJ, Josephs KA, Frigerio R, Burnett M, Parisi JE, Ahlskog JE. Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease. Acta Neuropathol. 2008 Apr; 115 (4):437-44 Epub 2008 Feb 09
    View PubMed
  484. Keegan BM, Giannini C, Parisi JE, Lucchinetti CF, Boeve BF, Josephs KA. Sporadic adult-onset leukoencephalopathy with neuroaxonal spheroids mimicking cerebral MS. Neurology. 2008 Mar 25; 70(13 Pt 2):1128-33. Epub 2008 Feb 20.
    View PubMed
  485. Czarnecki K, Kumar N, Josephs KA. Parkinsonism and tardive antecollis in frontotemporal dementia--increased sensitivity to newer antipsychotics? Eur J Neurol. 2008 Feb; 15 (2):199-201
    View PubMed
  486. Ahmed Z, Josephs KA, Gonzalez J, DelleDonne A, Dickson DW. Clinical and neuropathologic features of progressive supranuclear palsy with severe pallido-nigro-luysial degeneration and axonal dystrophy. Brain. 2008 Feb; 131(Pt 2):460-72. Epub 2007 Dec 24.
    View PubMed
  487. Josephs KA, Whitwell JL, Dickson DW, Boeve BF, Knopman DS, Petersen RC, Parisi JE, Jack CR Jr. Voxel-based morphometry in autopsy proven PSP and CBD. Neurobiol Aging. 2008 Feb; 29 (2):280-9 Epub 2006 Nov 13
    View PubMed
  488. Whitwell JL, Jack CR Jr, Pankratz VS, Parisi JE, Knopman DS, Boeve BF, Petersen RC, Dickson DW, Josephs KA. Rates of brain atrophy over time in autopsy-proven frontotemporal dementia and Alzheimer disease. Neuroimage. 2008 Feb 1; 39 (3):1034-40 Epub 2007 Oct 10
    View PubMed
  489. Josephs KA, Whitwell JL, Ahmed Z, Shiung MM, Weigand SD, Knopman DS, Boeve BF, Parisi JE, Petersen RC, Dickson DW, Jack CR Jr. Beta-amyloid burden is not associated with rates of brain atrophy. Ann Neurol. 2008 Feb; 63 (2):204-12
    View PubMed
  490. Josephs KA. Clinical aspects of TDP-43 proteinopathy, neurofilament inclusion body disease and dementias lacking distinctive proteinopathy. Handb Clin Neurol. 2008; 89:377-82
    View PubMed
  491. Josephs KA, Whitwell JL, Duffy JR, Vanvoorst WA, Strand EA, Hu WT, Boeve BF, Graff-Radford NR, Parisi JE, Knopman DS, Dickson DW, Jack CR Jr, Petersen RC. Progressive aphasia secondary to Alzheimer disease vs FTLD pathology. Neurology. 2008 Jan 1; 70 (1):25-34
    View PubMed
  492. Boeve BF, Josephs KA, Drubach DA. Current and future management of the corticobasal syndrome and corticobasal degeneration. Handb Clin Neurol. 2008; 89:533-48.
    View PubMed
  493. McKeon A, Josephs KA, Klos KJ, Hecksel K, Bower JH, Michael Bostwick J, Eric Ahlskog J. Unusual compulsive behaviors primarily related to dopamine agonist therapy in Parkinson's disease and multiple system atrophy. Parkinsonism Relat Disord. 2007 Dec; 13(8):516-9. Epub 2007 Jun 04.
    View PubMed
  494. Josephs KA. Capgras syndrome and its relationship to neurodegenerative disease. Arch Neurol. 2007 Dec; 64(12):1762-6.
    View PubMed
  495. Geschwind MD, Josephs KA, Parisi JE, Keegan BM. A 54-year-old man with slowness of movement and confusion. Neurology. 2007 Nov 6; 69(19):1881-7.
    View PubMed
  496. Hu WT, Mandrekar JN, Parisi JE, Knopman DS, Boeve BF, Petersen RC, Hutton M, Dickson DW, Josephs KA. Clinical features of pathologic subtypes of behavioral--variant frontotemporal dementia. Arch Neurol. 2007 Nov; 64 (11):1611-6
    View PubMed
  497. Josephs KA, Dickson DW. Hippocampal sclerosis in tau-negative frontotemporal lobar degeneration. Neurobiol Aging. 2007 Nov; 28(11):1718-22. Epub 2006 Aug 22.
    View PubMed
  498. Josephs KA, Dickson DW. Frontotemporal lobar degeneration with upper motor neuron disease/ primary lateral sclerosis. Neurology. 2007 Oct 30; 69(18):1800-1.
    View PubMed
  499. Rascovsky K, Hodges JR, Kipps CM, Johnson JK, Seeley WW, Mendez MF, Knopman D, Kertesz A, Mesulam M, Salmon DP, Galasko D, Chow TW, Decarli C, Hillis A, Josephs K, Kramer JH, Weintraub S, Grossman M, Gorno-Tempini ML, Miller BM. Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directions. Alzheimer Dis Assoc Disord. 2007 Oct-Dec; 21(4):S14-8.
    View PubMed
  500. Hu WT, Parisi JE, Knopman DS, Boeve BF, Dickson DW, Ahlskog JE, Petersen RC, Josephs KA. Clinical features and survival of 3R and 4R tauopathies presenting as behavioral variant frontotemporal dementia. Alzheimer Dis Assoc Disord. 2007 Oct-Dec; 21(4):S39-43.
    View PubMed
  501. Rademakers R, Baker M, Gass J, Adamson J, Huey ED, Momeni P, Spina S, Coppola G, Karydas AM, Stewart H, Johnson N, Hsiung GY, Kelley B, Kuntz K, Steinbart E, Wood EM, Yu CE, Josephs K, Sorenson E, Womack KB, Weintraub S, Pickering-Brown SM, Schofield PR, Brooks WS, Van Deerlin VM, Snowden J, Clark CM, Kertesz A, Boylan K, Ghetti B, Neary D, Schellenberg GD, Beach TG, Mesulam M, Mann D, Grafman J, Mackenzie IR, Feldman H, Bird T, Petersen R, Knopman D, Boeve B, Geschwind DH, Miller B, Wszolek Z, Lippa C, Bigio EH, Dickson D, Graff-Radford N, Hutton M. Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C-->T (Arg493X) mutation: an international initiative. Lancet Neurol. 2007 Oct; 6 (10):857-68
    View PubMed
  502. McKeon A, Pittock SJ, Glass GA, Josephs KA, Bower JH, Lennon VA, Ahlskog JE. Whole-body tremulousness: isolated generalized polymyoclonus. Arch Neurol. 2007 Sep; 64 (9):1318-22
    View PubMed
  503. Josephs KA. Frontotemporal lobar degeneration. Neurol Clin. 2007 Aug; 25 (3):683-96, vi
    View PubMed
  504. Whitwell JL, Jack CR Jr, Kantarci K, Weigand SD, Boeve BF, Knopman DS, Drubach DA, Tang-Wai DF, Petersen RC, Josephs KA. Imaging correlates of posterior cortical atrophy. Neurobiol Aging. 2007 Jul; 28 (7):1051-61 Epub 2006 June 23
    View PubMed
  505. Dickson DW, Josephs KA, Amador-Ortiz C. TDP-43 in differential diagnosis of motor neuron disorders. Acta Neuropathol. 2007 Jul; 114: (1)71-9.
    View PubMed
  506. Whitwell JL, Jack CR Jr, Parisi JE, Knopman DS, Boeve BF, Petersen RC, Ferman TJ, Dickson DW, Josephs KA. Rates of cerebral atrophy differ in different degenerative pathologies. Brain. 2007 Apr; 130 (Pt 4):1148-58 Epub 2007 Mar 08
    View PubMed
  507. Frigerrio R, Glass G, Klos K, Ahlskog J. Do Incidental Lewy Body Disease (ILBD) and Parkinson's disease (PD) Have Similar Risk Factor Profiles? An Exploratory Study. Neurology. 2007 Mar 20; 68(Suppl 1):A259.
  508. Whitwell JL, Jack CR Jr, Baker M, Rademakers R, Adamson J, Boeve BF, Knopman DS, Parisi JF, Petersen RC, Dickson DW, Hutton ML, Josephs KA. Voxel-based morphometry in frontotemporal lobar degeneration with ubiquitin-positive inclusions with and without progranulin mutations. Arch Neurol. 2007 Mar; 64 (3):371-6
    View PubMed
  509. Whitwell JL, Weigand SD, Shiung MM, Boeve BF, Ferman TJ, Smith GE, Knopman DS, Petersen RC, Benarroch EE, Josephs KA, Jack CR Jr. Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer's disease. Brain. 2007 Mar; 130 (Pt 3):708-19 Epub 2007 Jan 31
    View PubMed
  510. Josephs KA, Ahmed Z, Katsuse O, Parisi JF, Boeve BF, Knopman DS, Petersen RC, Davies P, Duara R, Graff-Radford NR, Uitti RJ, Rademakers R, Adamson J, Baker M, Hutton ML, Dickson DW. Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations. J Neuropathol Exp Neurol. 2007 Feb; 66 (2):142-51
    View PubMed
  511. Miller BL, Josephs KA, Parisi JE, Keegan BM. A 34-year-old man with progressive behavioral and language disturbance. Neurology. 2007 Jan 2; 68(1):68-74.
    View PubMed
  512. Whitwell JL, Josephs KA. Voxel-based morphometry and its application to movement disorders. Parkinsonism Relat Disord. 2007; 13 Suppl 3:S406-16.
    View PubMed
  513. Klos KJ, Ahlskog JE, Kumar N, Cambern S, Butz J, Burritt M, Fealey RD, Cowl CT, Parisi JE, Josephs KA. Brain metal concentrations in chronic liver failure patients with pallidal T1 MRI hyperintensity. Neurology. 2006 Dec 12; 67(11):1984-9.
    View PubMed
  514. Boeve BF, Baker M, Dickson DW, Parisi JE, Giannini C, Josephs KA, Hutton M, Pickering-Brown SM, Rademakers R, Tang-Wai D, Jack CR Jr, Kantarci K, Shiung MM, Golde T, Smith GE, Geda YE, Knopman DS, Petersen RC. Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study. Brain. 2006 Nov; 129 (Pt 11):3103-14 Epub 2006 Oct 09
    View PubMed
  515. Josephs KA, Whitwell JL, Jack CR, Parisi JE, Dickson DW. Frontotemporal lobar degeneration without lobar atrophy. Arch Neurol. 2006 Nov; 63 (11):1632-8
    View PubMed
  516. Gass J, Cannon A, Mackenzie IR, Boeve B, Baker M, Adamson J, Crook R, Melquist S, Kuntz K, Petersen R, Josephs K, Pickering-Brown SM, Graff-Radford N, Uitti R, Dickson D, Wszolek Z, Gonzalez J, Beach TG, Bigio E, Johnson N, Weintraub S, Mesulam M, White CL 3rd, Woodruff B, Caselli R, Hsiung GY, Feldman H, Knopman D, Hutton M, Rademakers R. Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration. Hum Mol Genet. 2006 Oct 15; 15 (20):2988-3001 Epub 2006 Sept 01
    View PubMed
  517. Barnes J, Whitwell JL, Frost C, Josephs KA, Rossor M, Fox NC. Measurements of the amygdala and hippocampus in pathologically confirmed Alzheimer disease and frontotemporal lobar degeneration. Arch Neurol. 2006 Oct; 63(10):1434-9.
    View PubMed
  518. Klos KJ, Chandler M, Kumar N, Ahlskog JE, Josephs KA. Neuropsychological profiles of manganese neurotoxicity. Eur J Neurol. 2006 Oct; 13(10):1139-41.
    View PubMed
  519. Josephs KA, Whitwell JL, Boeve BF, Knopman DS, Tang-Wai DF, Drubach DA, Jack CR Jr, Petersen RC. Visual hallucinations in posterior cortical atrophy. Arch Neurol. 2006 Oct; 63 (10):1427-32
    View PubMed
  520. Hu WT, Murray JA, Greenaway MC, Parisi JE, Josephs KA. Cognitive impairment and celiac disease. Arch Neurol. 2006 Oct; 63(10):1440-6.
    View PubMed
  521. Baba Y, Putzke JD, Tsuboi Y, Josephs KA, Thomas N, Wszolek ZK, Dickson DW. Effect of MAPT and APOE on prognosis of progressive supranuclear palsy. Neurosci Lett. 2006 Sep 11; 405(1-2):116-9. Epub 2006 Jul 12.
    View PubMed
  522. Glass GA, Josephs KA, Ahlskog JE. Respiratory insufficiency as the primary presenting symptom of multiple-system atrophy. Arch Neurol. 2006 Jul; 63(7):978-81.
    View PubMed
  523. Josephs KA, Duffy JR, Strand EA, Whitwell JL, Layton KF, Parisi JE, Hauser MF, Witte RJ, Boeve BF, Knopman DS, Dickson DW, Jack CR Jr, Petersen RC. Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech. Brain. 2006 Jun; 129 (Pt 6):1385-98 Epub 2006 Apr 13
    View PubMed
  524. Cannon A, Baker M, Boeve B, Josephs K, Knopman D, Petersen R, Parisi J, Dickison D, Adamson J, Snowden J, Neary D, Mann D, Hutton M, Pickering-Brown SM. CHMP2B mutations are not a common cause of frontotemporal lobar degeneration. Neurosci Lett. 2006 May 1; 398 (1-2):83-4 Epub 2006 Jan 23
    View PubMed
  525. Klos KJ, Ahlskog JE, Josephs KA, Apaydin H, Parisi JE, Boeve BF, DeLucia MW, Dickson DW. Alpha-synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals. Neurology. 2006 Apr 11; 66(7):1100-2.
    View PubMed
  526. Ozawa T, Healy DG, Abou-Sleiman PM, Ahmadi KR, Quinn N, Lees AJ, Shaw K, Wullner U, Berciano J, Moller JC, Kamm C, Burk K, Josephs KA, Barone P, Tolosa E, Goldstein DB, Wenning G, Geser F, Holton JL, Gasser T, Revesz T, Wood NW, European MSA study group. The alpha-synuclein gene in multiple system atrophy. J Neurol Neurosurg Psychiatry. 2006 Apr; 77(4):464-7.
    View PubMed
  527. Josephs KA, Parisi JE, Knopman DS, Boeve BF, Petersen RC, Dickson DW. Clinically undetected motor neuron disease in pathologically proven frontotemporal lobar degeneration with motor neuron disease. Arch Neurol. 2006 Apr; 63(4):506-12.
    View PubMed
  528. Josephs KA, Katsuse O, Beccano-Kelly DA, Lin WL, Uitti RJ, Fujino Y, Boeve BF, Hutton ML, Baker MC, Dickson DW. Atypical progressive supranuclear palsy with corticospinal tract degeneration. J Neuropathol Exp Neurol. 2006 Apr; 65 (4):396-405
    View PubMed
  529. Murali HR, Josephs KA, Wijdicks EF. Guillain-Barre syndrome in an immunocompromised patient and coccidioidomycosis infection. Rev Neurol Dis. 2006 Spring; 3(2):82-4.
    View PubMed
  530. Josephs KA, Mandrekar JN, Dickson DW. The relationship between histopathological features of progressive supranuclear palsy and disease duration. Parkinsonism Relat Disord. 2006 Mar; 12(2):109-12. Epub 2005 Dec 06.
    View PubMed
  531. Josephs KA, Matsumoto JY, Ahlskog JE. Benign tremulous parkinsonism. Arch Neurol. 2006 Mar; 63(3):354-7.
    View PubMed
  532. Crum BA, Josephs KA. Varied electrophysiologic patterns in spinocerebellar ataxia type 2. Eur J Neurol. 2006 Feb; 13(2):194-7.
    View PubMed
  533. Josephs KA, Petersen RC, Knopman DS, Boeve BF, Whitwell JL, Duffy JR, Parisi JE, Dickson DW. Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP. Neurology. 2006 Jan 10; 66 (1):41-8
    View PubMed
  534. Whitwell JL, Jack CR Jr, Senjem ML, Josephs KA. Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration. Neurology. 2006 Jan 10; 66 (1):102-4
    View PubMed
  535. Josephs KA, Whitwell JL, Boeve BF, Shiung MM, Gunter JL, Parisi JE, Dickson DW, Jack CR. Rates of cerebral atrophy in autopsy-confirmed progressive supranuclear palsy. Ann Neurol. 2006 Jan; 59(1):200-3.
    View PubMed
  536. Ridha B, Josephs KA. Young-onset dementia: a practical approach to diagnosis. Neurologist. 2006 Jan; 12(1):2-13.
    View PubMed
  537. Shamim A, Siddiqui BK, Josephs KA. The corticobasal syndrome triggered by central pontine myelinolysis. Eur J Neurol. 2006 Jan; 13(1):82-4.
    View PubMed
  538. Klos KJ, Josephs KA, Parisi JE, Dickson DW. Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease. Mov Disord. 2005 Nov; 20(11):1515-20.
    View PubMed
  539. Klos KJ, Bower JH, Josephs KA, Matsumoto JY, Ahlskog JE. Pathological hypersexuality predominantly linked to adjuvant dopamine agonist therapy in Parkinson's disease and multiple system atrophy. Parkinsonism Relat Disord. 2005 Sep; 11 (6):381-6
    View PubMed
  540. Dodd ML, Klos KJ, Bower JH, Geda YE, Josephs KA, Ahlskog JE. Pathological gambling caused by drugs used to treat Parkinson disease. Arch Neurol. 2005 Sep; 62 (9):1377-81 Epub 2005 July 11
    View PubMed
  541. Klos KJ, Ahlskog JE, Josephs KA, Fealey RD, Cowl CT, Kumar N. Neurologic spectrum of chronic liver failure and basal ganglia T1 hyperintensity on magnetic resonance imaging: probable manganese neurotoxicity. Arch Neurol. 2005 Sep; 62(9):1385-90.
    View PubMed
  542. Whitwell JL, Josephs KA, Rossor MN, Stevens JM, Revesz T, Holton JL, Al-Sarraj S, Godbolt AK, Fox NC, Warren JD. Magnetic resonance imaging signatures of tissue pathology in frontotemporal dementia. Arch Neurol. 2005 Sep; 62(9):1402-8.
    View PubMed
  543. Josephs KA, Knopman DS, Whitwell JL, Boeve BF, Parisi JE, Petersen RC, Dickson DW. Survival in two variants of tau-negative frontotemporal lobar degeneration: FTLD-U vs FTLD-MND. Neurology. 2005 Aug 23; 65(4):645-7.
    View PubMed
  544. Ridha BH, Josephs KA, Rossor MN. Delusions and hallucinations in dementia with Lewy bodies: Worsening with memantine. Neurology. 2005 Aug 9; 65(3):481-2.
    View PubMed
  545. Tsuboi Y, Josephs KA, Boeve BF, Litvan I, Caselli RJ, Caviness JN, Uitti RJ, Bott AD, Dickson DW. Increased tau burden in the cortices of progressive supranuclear palsy presenting with corticobasal syndrome. Mov Disord. 2005 Aug; 20(8):982-8.
    View PubMed
  546. Josephs KA, Boeve BF, Duffy JR, Smith GE, Knopman DS, Parisi JE, Petersen RC, Dickson DW. Atypical progressive supranuclear palsy underlying progressive apraxia of speech and nonfluent aphasia. Neurocase. 2005 Aug; 11 (4):283-96
    View PubMed
  547. Hu WT, Josephs KA, Ahlskog JE, Shin C, Boeve BF, Witte RJ. MRI correlates of alien leg-like phenomenon in corticobasal degeneration. Mov Disord. 2005 Jul; 20(7):870-3.
    View PubMed
  548. Godbolt AK, Josephs KA, Revesz T, Warrington EK, Lantos P, King A, Fox NC, Al Sarraj S, Holton J, Cipolotti L, Khan MN, Rossor MN. Sporadic and familial dementia with ubiquitin-positive tau-negative inclusions - Clinical features of one histopathological abnormality underlying frontotemporal lobar degeneration. Arch Neurol. 2005 Jul; 62(7):1097-101.
    View PubMed
  549. Josephs KA, Ahlskog JE, Klos KJ, Kumar N, Fealey RD, Trenerry MR, Cowl CT. Neurologic manifestations in welders with pallidal MRI T1 hyperintensity. Neurology. 2005 Jun 28; 64(12):2033-9. Epub 2005 May 11.
    View PubMed
  550. Rippon GA, Boeve BF, Parisi JE, Dickson DW, Ivnik RI, Jack CR, Hutton M, Baker M, Josephs KA, Knopman DS, Petersen RC. Late-onset frontotemporal dementia associated with progressive supranuclear palsy/argyrophilic grain disease/Alzheimer's disease pathology. Neurocase. 2005 Jun; 11(3):204-11.
    View PubMed
  551. Matthews BR, Jones LK, Saad DA, Aksamit AJ, Josephs KA. Cerebellar ataxia and central nervous system whipple disease. Arch Neurol. 2005 Apr; 62(4):618-20.
    View PubMed
  552. Josephs KA, Uchikado H, McComb RD, Bashir R, Wszolek Z, Swanson J, Matsumoto J, Shaw G, Dickson DW. Extending the clinicopathological spectrum of neurofilament inclusion disease. Acta Neuropathol (Berl). 2005 Apr; 109: (4)427-32.
    View PubMed
  553. Knopman DS, Boeve BF, Parisi JE, Dickson DW, Smith GE, Ivnik RJ, Josephs KA, Petersen RC. Antemortem diagnosis of frontotemporal lobar degeneration. Ann Neurol. 2005 Apr; 57 (4):480-8
    View PubMed
  554. Stead M, Josephs KA. Successful treatment of status migrainosus after electroconvulsive therapy with dihydroergotamine. Headache. 2005 Apr; 45(4):378-80.
    View PubMed
  555. Janseen JC, Schott JM, Cipolotti L, Fox NC, Scahill RI, Josephs KA, Stevens JM, Rossor MN. Mapping the onset and progression of atrophy in familial frontotemporal lobar degeneration. J Neurol Neurosurg Psychiatry. 2005 Feb; 76(2):162-8.
  556. Josephs KA, Matsumoto JY, Lindor NM. Heterozygous Niemann-Pick disease type C presenting with tremor. Neurology. 2004 Dec 14; 63 (11):2189-90
    View PubMed
  557. Josephs KA, Tang-Wai DF, Edland SD, Knopman DS, Dickson DW, Parisi JE, Petersen RC, Jack CR, Boeve BF. Correlation between antemortem magnetic resonance Imaging findings and pathologically confirmed corticobasal degeneration. Arch Neurol. 2004 Dec; 61(12):1881-4.
    View PubMed
  558. Paviour DC, Lees AJ, Josephs KA, Ozawa T, Ganguly M, Strand C, Godbolt A, Howard RS, Revesz T, Holton JL. Frontotemporal lobar degeneration with ubiquitin-only-immunoreactive neuronal changes: broadening the clinical picture to include progressive supranuclear palsy. Brain. 2004 Nov; 127(Part 11):2441-51.
    View PubMed
  559. Josephs KA, Silber MH, Fealey RD, Nippoldt TB, Auger RG, Vernino S. Neurophysiologic studies in Morvan syndrome. J Clin Neurophysiol. 2004 Nov-Dec; 21 (6):440-5
    View PubMed
  560. Ozawa T, Paviour D, Quinn NP, Josephs KA, Sangha H, Kliford L, Healy DG, Wood NW, Lees AJ, Holton JL, Rvesz T. The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations. Brain. 2004 Oct 27; Epub ahead of print.
  561. Josephs KA, Tsuboi Y, Cookson N, Watt H, Dickson DW. Apolipoprotein E epsilon 4 is a determinant for Alzheimer-type pathologic features in tauopathies, synucleinopathies, and frontotemporal degeneration. Arch Neurol. 2004 Oct; 61(10):1579-84.
    View PubMed
  562. Josephs KA, Holton JL, Rossor MN, Godbolt AK, Ozawa T, Strand K, Khan N, Al-Sarraj S, Revesz T. Frontotemporal lobar degeneration and ubiquitin immunohistochemistry. Neuropathol Appl Neurobiol. 2004 Aug; 30 (4):369-73
    View PubMed
  563. Josephs KA, Rubino FA, Dickson DW. Nonvasculitic autoimmune inflammatory meningoencephalitis. Neuropathology. 2004 Jun; 24 (2):149-52
    View PubMed
  564. Josephs KA, Tsuboi Y, Dickson DW. Creutzfeldt-Jakob disease presenting as progressive supranuclear palsy. Eur J Neurol. 2004 May; 11(5):343-6.
    View PubMed
  565. Josephs KA, Rossor MN. Alien Hand Syndrome. Practical Neurology. 2004; 4(1):44-55.
  566. Whitwell JL, Warren JD, Josephs KA, Godbolt AK, Revesz T, Fox NC, Rossor MN. Voxel-based morphometry in tau-positive and tau-negative frontotemporal lobar degenerations. Neurodegener Dis. 2004; 1(4-5):225-30.
    View PubMed
  567. Josephs KA, Jones AG, Dickson DW. Hippocampal sclerosis and ubiquitin-positive inclusions in dementia lacking distinctive histopathology. Dem and Geriatric Cog Dis. 2004; 17(4):342-5.
    View PubMed
  568. Tang-Wai DF, Josephs KA. Diagnosis and Management of Dementia in Parkinson's Disease. Geriatrics and Aging. 2004; 7(10):49-54.
  569. Tang-Wai DF, Josephs KA, Boeve BF, Dickson DW, Parisi JE, Petersen RC. Pathologically confirmed corticobasal degeneration presenting with visuospatial dysfunction. Neurology. 2003 Oct 28; 61 (8):1134-5
    View PubMed
  570. Josephs KA, Holton JL, Rossor MN, Braendgaard H, Ozawa T, Fox NC, Petersen RC, Pearl GS, Ganguly M, Rosa P, Laursen H, Parisi JE, Waldemar G, Quinn NP, Dickson DW, Revesz T. Neurofilament inclusion body disease: a new proteinopathy? Brain. 2003 Oct; 126 (Pt 10):2291-303 Epub 2003 July 22
    View PubMed
  571. Josephs KA, Dickson DW. Diagnostic accuracy of progressive supranuclear palsy in the Society for Progressive Supranuclear Palsy brain bank. Mov Disord. 2003 Sep; 18 (9):1018-26
    View PubMed
  572. Tsuboi Y, Slowinski J, Josephs KA, Honer WG, Wszolek ZK, Dickson DW. Atrophy of superior cerebellar peduncle in progressive supranuclear palsy. Neurology. 2003 Jun 10; 60(11):1766-9.
    View PubMed
  573. Josephs KA, Tang Wai DF, Parisi JE. Hippocampal sclerosis in a case of Alzheimer's disease-like dementia with late onset intractable epilepsy. Eur J Neurol. 2003 May; 10(3):333-4.
    View PubMed
  574. Josephs KA, Van Gerpen MW, Van Gerpen JA. Adult onset Niemann-Pick disease type C presenting with psychosis. J Neurol Neurosurg Psychiatry. 2003 Apr; 74 (4):528-9
    View PubMed
  575. Tsuboi Y, Josephs KA, Cookson N, Dickson DW. APOE E4 is a determinant for Alzheimer type pathology in progressive supranuclear palsy. Neurology. 2003 Jan 28; 60 (2):240-5
    View PubMed
  576. Josephs KA, Ishizawa T, Tsuboi Y, Cookson N, Dickson DW. A clinicopathological study of vascular progressive supranuclear palsy: a multi-infarct disorder presenting as progressive supranuclear palsy. Arch Neurol. 2002 Oct; 59 (10):1597-601
    View PubMed
  577. Josephs KA, Parisi JE, Dickson DW. Alpha-synuclein studies are negative in postencephalic parkinsonism of von Economo. Neurology. 2002 Aug 27; 59 (4):645-6
    View PubMed
  578. Travis LH, Josephs KA, Bower JH. 25-year-old woman with incoordination and decreased balance. Mayo Clin Proc. 2001 May; 76(5):551-4.
    View PubMed
  579. Flemming KD, Josephs K, Wijdicks EF. Enlarging vertebrobasilar dolichoectasia with subarachnoid hemorrhage heralded by recurrent ischemia. Case illustration. J Neurosurg. 2000 Mar; 92: (3)504.
    View PubMed
PST-20223124