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William L. Hasler, M.D.

预约门诊

出版物

  1. Takakura W, Surjanhata B, Nguyen LAB, Parkman HP, Rao SSC, McCallum RW, Schulman M, Wo JM, Sarosiek I, Moshiree B, Kuo B, Hasler WL, Lee AA. Predicting Response to Neuromodulators or Prokinetics in Patients With Suspected Gastroparesis Using Machine Learning: The "BMI, Infectious Prodrome, Delayed GES, and No Diabetes" Model. Clin Transl Gastroenterol. 2024 Sep 1; 15 (9):e1 Epub 2024 Sept 01
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  2. Hasler WL, Alshaarawy O, Venkatesan T. Cannabis use patterns and association with hyperemesis: A comprehensive review. Neurogastroenterol Motil. 2024 Aug 20; e14895 [Epub ahead of print]
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  3. Takakura W, Surjanhata B, Nguyen LAB, Parkman HP, Rao SS, McCallum RW, Schulman MD, Wo JM, Sarosiek I, Moshiree B, Kuo B, Hasler WL, Lee AA. Predicting Response to Neuromodulators or Prokinetics in Patients with Suspected Gastroparesis Using Machine Learning: the "BIDnD" Model. Clin Transl Gastroenterol. 2024 Jul 1 Epub 2024 July 01
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  4. Hasler WL, Li BUK, Levinthal DJ, Venkatesan T. Cyclic vomiting syndrome: Future clinical and research priorities for: Special supplement/proceedings of 3rd international symposium. Neurogastroenterol Motil. 2024 May 22; e14825 [Epub ahead of print]
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  5. Hasler WL, Lee AA, Moshiree B, Surjanhata BC, Rao S, Parkman HP, Nguyen LA, Sarosiek I, Wo JM, Schulman MI, McCallum RW, Kuo B. Benefits of Prokinetics, Gastroparesis Diet, or Neuromodulators Alone or in Combination for Symptoms of Gastroparesis. Clin Gastroenterol Hepatol. 2024 Apr; 22 (4):867-877.e12 Epub 2023 Oct 30
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  6. Hasler WL. Gastric Alimetry: A Reset of the Field of Gastric Electrophysiologic Testing for Nausea and Other Symptoms? Am J Gastroenterol 2024 Feb 1; 119 (2):249-250 Epub 2023 Oct 19
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  7. Kassim G, Hasler WL. The role of functional lumen imaging probe (flip) before submucosal tunnel myotomy. Techniques and Innovations in Gastrointestinal Endoscopy. 2024; 26 (1):68-79
  8. Jue TL, Hasler WL. The impact of pyloric directed therapy for gastroparesis. Foregut. 2024; 4 (2):191-9
  9. Arca KN, Cai J, Wang F, Kassim G, Hasler WL, Batheja MJ. Migraine and Gastroparesis. Curr Neurol Neurosci Rep. 2022 Dec; 22(12):813-821. Epub 2022 Nov 12.
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  10. Hasler WL, Grabauskas G, Singh P, Owyang C. Mast cell mediation of visceral sensation and permeability in irritable bowel syndrome. Neurogastroenterol Motil. 2022 Jul; 34 (7):e14339 Epub 2022 Mar 21
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  11. Parkman HP, Sharkey E, McCallum RW, Hasler WL, Koch KL, Sarosiek I, Abell TL, Kuo B, Shulman RJ, Grover M, Farrugia G, Schey R, Tonascia J, Hamilton F, Pasricha PJ, NIH/NIDDK Gastroparesis Consortium. Constipation in Patients With Symptoms of Gastroparesis: Analysis of Symptoms and Gastrointestinal Transit. Clin Gastroenterol Hepatol. 2022 Mar; 20 (3):546-558.e5 Epub 2020 Oct 28
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  12. Baker JR, Chey WD, Watts L, Armstrong M, Collins K, Lee AA, Dupati A, Menees S, Saad RJ, Harer K, Hasler WL. How the North American Consensus Protocol Affects the Performance of Glucose Breath Testing for Bacterial Overgrowth Versus a Traditional Method. Am J Gastroenterol. 2021 Apr; 116 (4):780-787
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  13. Vosoughi K, Ichkhanian Y, Benias P, Miller L, Aadam AA, Triggs JR, Law R, Hasler W, Bowers N, Chaves D, Ponte-Neto AM, Draganov P, Yang D, El Halabi M, Sanaei O, Brewer Gutierrez OI, Bulat RS, Pandolfino J, Khashab M. Gastric per-oral endoscopic myotomy (G-POEM) for refractory gastroparesis: results from an international prospective trial. Gut. 2021 Mar 19 [Epub ahead of print]
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  14. Dolan RD, Baker J, Harer K, Lee A, Hasler W, Saad R, Schulman AR. Small Intestinal Bacterial Overgrowth: Clinical Presentation in Patients with Roux-en-Y Gastric Bypass. Obes Surg. 2021 Feb; 31 (2):564-569 Epub 2020 Oct 12
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  15. Augustijns P, Vertzoni M, Reppas C, Langguth P, Lennernas H, Abrahamsson B, Hasler WL, Baker JR, Vanuytsel T, Tack J, Corsetti M, Bermejo M, Paixao P, Amidon GL, Hens B. Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications. Eur J Pharm Sci. 2020 Dec 1; 155:105517 Epub 2020 Aug 18
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  16. Watts LS, Baker JR, Lee AA, Harer K, Bowers N, Law R, Hasler WL. Impact of gastric per-oral endoscopic myotomy on static and dynamic pyloric function in gastroparesis patients. Neurogastroenterol Motil. 2020 Nov; 32 (11):e13892 Epub 2020 June 15
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  17. Lee AA, Rao K, Parkman HP, McCallum RW, Sarosiek I, Nguyen LA, Wo JM, Schulman MI, Moshiree B, Rao S, Kuo B, Hasler WL. Baseline Predictors of Longitudinal Changes in Symptom Severity and Quality of Life in Patients With Suspected Gastroparesis. Clin Gastroenterol Hepatol. 2020 Sep 21 Epub 2020 Sept 21
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  18. Hasler WL. Targeting Treatment of Gastroparesis: Use of Clinical Tests to Guide Treatments. Gastroenterol Clin North Am. 2020 Sep; 49 (3):519-538
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  19. Nguyen L, Wilson LA, Miriel L, Pasricha PJ, Kuo B, Hasler WL, McCallum RW, Sarosiek I, Koch KL, Snape WJ, Farrugia G, Grover M, Clarke J, Parkman HP, Tonascia J, Hamilton F, Abell TL, NIDDK Gastroparesis Clinical Research Consortium (GpCRC). Autonomic function in gastroparesis and chronic unexplained nausea and vomiting: Relationship with etiology, gastric emptying, and symptom severity. Neurogastroenterol Motil. 2020 Aug; 32 (8):e13810 Epub 2020 Feb 15
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  20. Parkman HP, Sharkey EP, Nguyen LA, Yates KP, Abell TL, Hasler WL, Snape W, Clarke J, Schey R, Koch KL, Kuo B, McCallum RW, Sarosiek I, Grover M, Farrugia G, Tonascia J, Pasricha PJ, Frank A. Hamilton for the NIH Gastroparesis Consortium. Marijuana Use in Patients with Symptoms of Gastroparesis: Prevalence, Patient Characteristics, and Perceived Benefit. Dig Dis Sci. 2020 Aug; 65(8):2311-2320. Epub 2019 Nov 22.
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  21. Vosoughi K, Ichkhanian Y, Jacques J, Aadam AA, Benias PC, Law R, Hasler WL, Canakis A, Ragi O, Triggs J, Bowers N, Brewer Gutierrez OI, Kumbhari V, Kalloo AN, Bulat RS, Pandolfino JE, Khashab MA. Role of endoscopic functional luminal imaging probe in predicting the outcome of gastric peroral endoscopic pyloromyotomy (with video). Gastrointest Endosc. 2020 Jun; 91 (6):1289-1299 Epub 2020 Feb 06
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  22. Maurer AH, Abell T, Bennett P, Diaz JR, Harris LA, Hasler W, Iagaru A, Koch KL, McCallum RW, Parkman HP, Rao SSC, Tulchinsky M. Appropriate Use Criteria for Gastrointestinal Transit Scintigraphy. J Nucl Med. 2020 Mar; 61 (3):11N-17N
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  23. Harer KN, Hasler WL. Functional Dyspepsia: A Review of the Symptoms, Evaluation, and Treatment Options. Gastroenterol Hepatol (N Y). 2020 Feb; 16 (2):66-74
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  24. Koch KL, Hasler WL, Van Natta M, Calles-Escandon J, Grover M, Pasricha PJ, Snape WJ, Parkman HP, Abell TL, McCallum RW, Nguyen LA, Sarosiek I, Farrugia G, Tonascia J, Lee L, Miriel L, Hamilton F, NIDDK Gastroparesis Clinical Research Consortium. Satiety testing in diabetic gastroparesis: Effects of insulin pump therapy with continuous glucose monitoring on upper gastrointestinal symptoms and gastric myoelectrical activity. Neurogastroenterol Motil. 2020 Jan; 32 (1):e13720 Epub 2019 Oct 01
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  25. Heissam K, Abrehart N, Hoad CL, Wright J, Menys A, Murray K, Glover PM, Hebbard G, Gowland PA, Baker J, Hasler WL, Spiller RC, Corsetti M, Brasseur JG, Hens B, Shedden K, Dickens J, Mudie DM, Amidon GE, Amidon GL, Marciani L. Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants. PLoS One. 2020; 15 (11):e0241441 Epub 2020 Nov 11
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  26. Abell TL, Yamada G, McCallum RW, Van Natta ML, Tonascia J, Parkman HP, Koch KL, Sarosiek I, Farrugia G, Grover M, Hasler W, Nguyen L, Snape W, Kuo B, Shulman R, Hamilton FA, Pasricha PJ. Effectiveness of gastric electrical stimulation in gastroparesis: Results from a large prospectively collected database of national gastroparesis registries. Neurogastroenterol Motil. 2019 Dec; 31 (12):e13714 Epub 2019 Oct 04
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  27. Yu A, Koenigsknecht MJ, Hens B, Baker JR, Wen B, Jackson TL, Pai MP, Hasler W, Amidon GL, Sun D. Mechanistic Deconvolution of Oral Absorption Model with Dynamic Gastrointestinal Fluid to Predict Regional Rate and Extent of GI Drug Dissolution. AAPS J. 2019 Nov 11; 22 (1):3
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  28. Parkman HP, Wilson LA, Farrugia G, Koch KL, Hasler WL, Nguyen LA, Abell TL, Snape W, Clarke J, Kuo B, McCallum RW, Sarosiek I, Grover M, Miriel L, Tonascia J, Hamilton FA, Pasricha PJ, NIDDK Gastroparesis Clinical Research Consortium (GpCRC). Delayed Gastric Emptying Associates With Diabetic Complications in Diabetic Patients With Symptoms of Gastroparesis. Am J Gastroenterol. 2019 Nov; 114 (11):1778-1794
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  29. Hasler WL, Rao SSC, McCallum RW, Krause RA, Nguyen LA, Schulman MI, Lee AA, Moshiree B, Wo JM, Parkman HP, Sarosiek I, Wilding GE, Kuo B. Influence of Gastric Emptying and Gut Transit Testing on Clinical Management Decisions in Suspected Gastroparesis. Clin Transl Gastroenterol. 2019 Oct; 10 (10):e00084
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  30. Parkman HP, Wilson LA, Hasler WL, McCallum RW, Sarosiek I, Koch KL, Abell TL, Schey R, Kuo B, Snape WJ, Nguyen L, Farrugia G, Grover M, Clarke J, Miriel L, Tonascia J, Hamilton F, Pasricha PJ. Abdominal Pain in Patients with Gastroparesis: Associations with Gastroparesis Symptoms, Etiology of Gastroparesis, Gastric Emptying, Somatization, and Quality of Life. Dig Dis Sci. 2019 Aug; 64(8):2242-2255. Epub 2019 Mar 09.
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  31. Lee AA, Rao S, Nguyen LA, Moshiree B, Sarosiek I, Schulman MI, Wo JM, Parkman HP, Wilding GE, McCallum RW, Hasler WL, Kuo B. Validation of Diagnostic and Performance Characteristics of the Wireless Motility Capsule in Patients With Suspected Gastroparesis. Clin Gastroenterol Hepatol. 2019 Aug; 17 (9):1770-1779.e2 Epub 2018 Dec 14
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  32. Parkman HP, Yamada G, Van Natta ML, Yates K, Hasler WL, Sarosiek I, Grover M, Schey R, Abell TL, Koch KL, Kuo B, Clarke J, Farrugia G, Nguyen L, Snape WJ, Miriel L, Tonascia J, Hamilton F, Pasricha PJ, McCallum RW. Ethnic, Racial, and Sex Differences in Etiology, Symptoms, Treatment, and Symptom Outcomes of Patients With Gastroparesis. Clin Gastroenterol Hepatol. 2019 Jul; 17(8):1489-1499.e8. Epub 2018 Nov 04.
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  33. Hasler WL, Wilson LA, Nguyen LA, Snape WJ, Abell TL, Koch KL, McCallum RW, Pasricha PJ, Sarosiek I, Farrugia G, Grover M, Lee LA, Miriel L, Tonascia J, Hamilton FA, Parkman HP, Gastroparesis Clinical Research Consortium. Opioid Use and Potency Are Associated With Clinical Features, Quality of Life, and Use of Resources in Patients With Gastroparesis. Clin Gastroenterol Hepatol. 2019 Jun; 17(7):1285-1294.e1. Epub 2018 Oct 13.
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  34. Hasler WL, Levinthal DJ, Tarbell SE, Adams KA, Li BUK, Issenman RM, Sarosiek I, Jaradeh SS, Sharaf RN, Sultan S, Venkatesan T. Cyclic vomiting syndrome: Pathophysiology, comorbidities, and future research directions. Neurogastroenterol Motil. 2019 Jun; 31 Suppl 2:e13607
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  35. Venkatesan T, Levinthal DJ, Li BUK, Tarbell SE, Adams KA, Issenman RM, Sarosiek I, Jaradeh SS, Sharaf RN, Sultan S, Stave CD, Monte AA, Hasler WL. Role of chronic cannabis use: Cyclic vomiting syndrome vs cannabinoid hyperemesis syndrome. Neurogastroenterol Motil. 2019 Jun; 31 Suppl 2:e13606
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  36. Sharaf RN, Venkatesan T, Shah R, Levinthal DJ, Tarbell SE, Jaradeh SS, Hasler WL, Issenman RM, Adams KA, Sarosiek I, Stave CD, Li BUK, Sultan S. Management of cyclic vomiting syndrome in adults: Evidence review. Neurogastroenterol Motil. 2019 Jun; 31 Suppl 2:e13605
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  37. Venkatesan T, Levinthal DJ, Tarbell SE, Jaradeh SS, Hasler WL, Issenman RM, Adams KA, Sarosiek I, Stave CD, Sharaf RN, Sultan S, Li BUK. Guidelines on management of cyclic vomiting syndrome in adults by the American Neurogastroenterology and Motility Society and the Cyclic Vomiting Syndrome Association. Neurogastroenterol Motil. 2019 Jun; 31 Suppl 2:e13604
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  38. Seekatz AM, Schnizlein MK, Koenigsknecht MJ, Baker JR, Hasler WL, Bleske BE, Young VB, Sun D. Spatial and Temporal Analysis of the Stomach and Small-Intestinal Microbiota in Fasted Healthy Humans. mSphere. 2019 Mar 13; 4 (2)
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  39. Lee A, Baker J, Hasler WL. GI Motility Testing: Stomach, Small Bowel, and Colon. J Clin Gastroenterol. 2019 Mar; 53 (3):159-169
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  40. Baker JR, Dickens JR, Koenigsknecht M, Frances A, Lee AA, Shedden KA, Brasseur JG, Amidon GL, Sun D, Hasler WL. Propagation Characteristics of Fasting Duodeno-Jejunal Contractions in Healthy Controls Measured by Clustered Closely-spaced Manometric Sensors. J Neurogastroenterol Motil. 2019 Jan 31; 25 (1):100-112
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  41. Bermejo M, Paixao P, Hens B, Tsume Y, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Dickens J, Shedden K, Wen B, Wysocki J, Lobenberg R, Lee A, Frances A, Amidon GE, Yu A, Salehi N, Talattof A, Benninghoff G, Sun D, Kuminek G, Cavanagh KL, Rodriguez-Hornedo N, Amidon GL. Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 1: Fasted State Conditions. Mol Pharm. 2018 Dec 3; 15 (12):5454-5467 Epub 2018 Nov 12
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  42. Paixao P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, Salehi N, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Wysocki J, Wen B, Lee A, Frances A, Amidon GE, Yu A, Benninghoff G, Lobenberg R, Talattof A, Sun D, Amidon GL. Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State. Mol Pharm. 2018 Dec 3; 15 (12):5468-5478 Epub 2018 Nov 12
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  43. Hens B, Sinko PD, Job N, Dean M, Al-Gousous J, Salehi N, Ziff RM, Tsume Y, Bermejo M, Paixao P, Brasseur JG, Yu A, Talattof A, Benninghoff G, Langguth P, Lennernas H, Hasler WL, Marciani L, Dickens J, Shedden K, Sun D, Amidon GE, Amidon GL. Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project. Int J Pharm. 2018 Sep 5; 548 (1):120-127 Epub 2018 June 23
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  44. Lee AA, Hasler WL. G-POEM for Gastroparesis: Is There Pressure to Go with the Flow? Dig Dis Sci 2018 Sep; 63 (9):2165-2167
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  45. Paixao P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, Salehi N, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Wysocki J, Wen B, Lee A, Frances A, Amidon GE, Yu A, Benninghoff G, Lobenberg R, Talattof A, Sun D, Amidon GL. Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach. Eur J Pharm Biopharm. 2018 Aug; 129:162-174 Epub 2018 May 29
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  46. Orthey P, Yu D, Van Natta ML, Ramsey FV, Diaz JR, Bennett PA, Iagaru AH, Fragomeni RS, McCallum RW, Sarosiek I, Hasler WL, Farrugia G, Grover M, Koch KL, Nguyen L, Snape WJ, Abell TL, Pasricha PJ, Tonascia J, Hamilton F, Parkman HP, Maurer AH, NIH Gastroparesis Consortium. Intragastric Meal Distribution During Gastric Emptying Scintigraphy for Assessment of Fundic Accommodation: Correlation with Symptoms of Gastroparesis. J Nucl Med. 2018 Apr; 59(4):691-697. Epub 2017 Sep 28.
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  47. Hasler WL, May KP, Wilson LA, Van Natta M, Parkman HP, Pasricha PJ, Koch KL, Abell TL, McCallum RW, Nguyen LA, Snape WJ, Sarosiek I, Clarke JO, Farrugia G, Calles-Escandon J, Grover M, Tonascia J, Lee LA, Miriel L, Hamilton FA, NIDDK Gastroparesis Clinical Research Consortium (GpCRC). Relating gastric scintigraphy and symptoms to motility capsule transit and pressure findings in suspected gastroparesis. Neurogastroenterol Motil. 2018 Feb; 30 (2) Epub 2017 Sept 05
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  48. Farmer AD, Wegeberg AL, Brock B, Hobson AR, Mohammed SD, Scott SM, Bruckner-Holt CE, Semler JR, Hasler WL, Hellstrom PM, Drewes AM, Brock C. Regional gastrointestinal contractility parameters using the wireless motility capsule: inter-observer reproducibility and influence of age, gender and study country. Aliment Pharmacol Ther. 2018 Feb; 47 (3):391-400 Epub 2017 Dec 06
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  49. Pasricha PJ, Yates KP, Sarosiek I, McCallum RW, Abell TL, Koch KL, Nguyen LAB, Snape WJ, Hasler WL, Clarke JO, Dhalla S, Stein EM, Lee LA, Miriel LA, Van Natta ML, Grover M, Farrugia G, Tonascia J, Hamilton FA, Parkman HP, NIDDK Gastroparesis Clinical Research Consortium (GpCRC). Aprepitant Has Mixed Effects on Nausea and Reduces Other Symptoms in Patients With Gastroparesis and Related Disorders. Gastroenterology. 2018 Jan; 154 (1):65-76.e11 Epub 2017 Oct 28
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  50. Siraj ES, Homko C, Wilson LA, May P, Rao AD, Calles J, Farrugia G, Hasler WL, Koch KL, Nguyen L, Snape WJ, Abell TL, Sarosiek I, McCallum RW, Pasricha PJ, Clarke J, Tonascia J, Hamilton F, Parkman HP. Islet Cell Associated Autoantibodies and C-Peptide Levels in Patients with Diabetes and Symptoms of Gastroparesis. Front Endocrinol (Lausanne). 2018; 9:32. Epub 2018 Feb 13.
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  51. Calles-Escandón J, Koch KL, Hasler WL, Van Natta ML, Pasricha PJ, Tonascia J, Parkman HP, Hamilton F, Herman WH, Basina M, Buckingham B, Earle K, Kirkeby K, Hairston K, Bright T, Rothberg AE, Kraftson AT, Siraj ES, Subauste A, Lee LA, Abell TL, McCallum RW, Sarosiek I, Nguyen L, Fass R, Snape WJ, Vaughn IA, Miriel LA, Farrugia G, NIDDK Gastroparesis Clinical Research Consortium (GpCRC). Glucose sensor-augmented continuous subcutaneous insulin infusion in patients with diabetic gastroparesis: An open-label pilot prospective study. PLoS One. 2018; 13(4):e0194759. Epub 2018 Apr 13.
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  52. Hens B, Tsume Y, Bermejo M, Paixao P, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Dickens J, Shedden K, Wen B, Wysocki J, Loebenberg R, Lee A, Frances A, Amidon G, Yu A, Benninghoff G, Salehi N, Talattof A, Sun D, Amidon GL. Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs. Mol Pharm. 2017 Dec 4; 14 (12):4281-4294 Epub 2017 Aug 04
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  53. Koenigsknecht MJ, Baker JR, Wen B, Frances A, Zhang H, Yu A, Zhao T, Tsume Y, Pai MP, Bleske BE, Zhang X, Lionberger R, Lee A, Amidon GL, Hasler WL, Sun D. In Vivo Dissolution and Systemic Absorption of Immediate Release Ibuprofen in Human Gastrointestinal Tract under Fed and Fasted Conditions. Mol Pharm. 2017 Dec 4; 14 (12):4295-4304 Epub 2017 Oct 05
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  54. Lee AA, Hasler WL. Diabetes and the Stomach. Curr Treat Options Gastroenterol. 2017 Dec; 15 (4):441-459
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  55. Yu A, Jackson T, Tsume Y, Koenigsknecht M, Wysocki J, Marciani L, Amidon GL, Frances A, Baker JR, Hasler W, Wen B, Pai A, Sun D. Mechanistic Fluid Transport Model to Estimate Gastrointestinal Fluid Volume and Its Dynamic Change Over Time. AAPS J. 2017 Nov; 19 (6):1682-1690 Epub 2017 Oct 04
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  56. Pasricha PJ, Camilleri M, Hasler WL, Parkman HP. White Paper AGA: Gastroparesis: Clinical and Regulatory Insights for Clinical Trials. Clin Gastroenterol Hepatol. 2017 Aug; 15 (8):1184-1190 Epub 2017 Apr 12
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  57. Grover M, Bernard CE, Pasricha PJ, Parkman HP, Gibbons SJ, Tonascia J, Koch KL, McCallum RW, Sarosiek I, Hasler WL, Nguyen LAB, Abell TL, Snape WJ, Kendrick ML, Kellogg TA, McKenzie TJ, Hamilton FA, Farrugia G, NIDDK Gastroparesis Clinical Research Consortium (GpCRC). Diabetic and idiopathic gastroparesis is associated with loss of CD206-positive macrophages in the gastric antrum. Neurogastroenterol Motil. 2017 Jun; 29(6). Epub 2017 Jan 09.
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  58. Parkman HP, Hallinan EK, Hasler WL, Farrugia G, Koch KL, Nguyen L, Snape WJ, Abell TL, McCallum RW, Sarosiek I, Pasricha PJ, Clarke J, Miriel L, Tonascia J, Hamilton F, NIDDK Gastroparesis Clinical Research Consortium (GpCRC). Early satiety and postprandial fullness in gastroparesis correlate with gastroparesis severity, gastric emptying, and water load testing. Neurogastroenterol Motil. 2017 Apr; 29(4). Epub 2016 Oct 25.
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  59. Yu A, Baker JR, Fioritto AF, Wang Y, Luo R, Li S, Wen B, Bly M, Tsume Y, Koenigsknecht MJ, Zhang X, Lionberger R, Amidon GL, Hasler WL, Sun D. Measurement of in vivo Gastrointestinal Release and Dissolution of Three Locally Acting Mesalamine Formulations in Regions of the Human Gastrointestinal Tract. Mol Pharm. 2017 Feb 6; 14 (2):345-358 Epub 2016 Dec 23
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  60. Dahl JU, Gray MJ, Bazopoulou D, Beaufay F, Lempart J, Koenigsknecht MJ, Wang Y, Baker JR, Hasler WL, Young VB, Sun D, Jakob U. The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation. Nat Microbiol. 2017 Jan 23; 2:16267
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  61. Gibbons SJ, Grover M, Choi KM, Wadhwa A, Zubair A, Wilson LA, Wu Y, Abell TL, Hasler WL, Koch KL, McCallum RW, Nguyen LAB, Parkman HP, Sarosiek I, Snape WJ, Tonascia J, Hamilton FA, Pasricha PJ, Farrugia G. Repeat polymorphisms in the Homo sapiens heme oxygenase-1 gene in diabetic and idiopathic gastroparesis. PLoS One. 2017; 12 (11):e0187772 Epub 2017 Nov 21
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  62. Hasler WL, Li BU, Koch KL, Parkman HP, Kovacic K, McCallum RW. Methodologic considerations for studies of chronic nausea and vomiting in adults and children. Auton Neurosci. 2017 Jan; 202:28-39 Epub 2016 Aug 03
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  63. Lee AA, Hasler WL. Case study: wireless motility capsule impacts management for patients with suspected functional GI disorders. GI Fellow Adv. 2017; 7:1-4.
  64. Parkman HP, Hallinan EK, Hasler WL, Farrugia G, Koch KL, Calles J, Snape WJ, Abell TL, Sarosiek I, McCallum RW, Nguyen L, Pasricha PJ, Clarke J, Miriel L, Lee L, Tonascia J, Hamilton F, NIDDK Gastroparesis Clinical Research Consortium (GpCRC). Nausea and vomiting in gastroparesis: similarities and differences in idiopathic and diabetic gastroparesis. Neurogastroenterol Motil. 2016 Dec; 28(12):1902-1914. Epub 2016 Jun 27.
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  65. Hasler WL. Newest Drugs for Chronic Unexplained Nausea and Vomiting. Curr Treat Options Gastroenterol. 2016 Dec; 14 (4):371-385
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  66. Lee AA, Hasler WL. Opioids and GI Motility-Friend or Foe? Curr Treat Options Gastroenterol. 2016 Dec; 14 (4):478-494
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  67. Coleski R, Baker JR, Hasler WL. Endoscopic Gastric Food Retention in Relation to Scintigraphic Gastric Emptying Delays and Clinical Factors. Dig Dis Sci. 2016 Sep; 61 (9):2593-601 Epub 2016 May 19
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  68. Koch KL, Hasler WL, Yates KP, Parkman HP, Pasricha PJ, Calles-Escandon J, Snape WJ, Abell TL, McCallum RW, Nguyen LA, Sarosiek I, Farrugia G, Tonascia J, Lee L, Miriel L, Hamilton F, NIDDK Gastroparesis Clinical Research Consortium (GpCRC). Baseline features and differences in 48 week clinical outcomes in patients with gastroparesis and type 1 vs type 2 diabetes. Neurogastroenterol Motil. 2016 Jul; 28(7):1001-15. Epub 2016 Mar 06.
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  69. Drossman DA, Hasler WL. Rome IV-Functional GI Disorders: Disorders of Gut-Brain Interaction. Gastroenterology 2016 May; 150 (6):1257-61
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  70. Stanghellini V, Chan FK, Hasler WL, Malagelada JR, Suzuki H, Tack J, Talley NJ. Gastroduodenal Disorders. Gastroenterology. 2016 May; 150 (6):1380-92
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  71. Pasricha PJ, Yates KP, Nguyen L, Clarke J, Abell TL, Farrugia G, Hasler WL, Koch KL, Snape WJ, McCallum RW, Sarosiek I, Tonascia J, Miriel LA, Lee L, Hamilton F, Parkman HP. Outcomes and Factors Associated With Reduced Symptoms in Patients With Gastroparesis. Gastroenterology. 2015 Dec; 149(7):1762-1774.e4. Epub 2015 Aug 21.
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  72. Wang YT, Mohammed SD, Farmer AD, Wang D, Zarate N, Hobson AR, Hellstrom PM, Semler JR, Kuo B, Rao SS, Hasler WL, Camilleri M, Scott SM. Regional gastrointestinal transit and pH studied in 215 healthy volunteers using the wireless motility capsule: influence of age, gender, study country and testing protocol. Aliment Pharmacol Ther. 2015 Sep; 42 (6):761-72 Epub 2015 July 29
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  73. Hasler WL, Koch KL. Amitriptyline for Functional Dyspepsia: Importance of Symptom Profile and Making a Case for Gastric Emptying Testing. Gastroenterology 2015 Aug; 149 (2):270-2 Epub 2015 June 25
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  74. Hasler WL. Symptomatic management for gastroparesis: antiemetics, analgesics, and symptom modulators. Gastroenterol Clin North Am. 2015 Mar; 44 (1):113-26 Epub 2014 Dec 26
    View PubMed
  75. Coleski R, Wilding GE, Semler JR, Hasler WL. Blunting of Colon Contractions in Diabetics with Gastroparesis Quantified by Wireless Motility Capsule Methods. PLoS One. 2015; 10 (10):e0141183 Epub 2015 Oct 28
    View PubMed
  76. Bernard CE, Gibbons SJ, Mann IS, Froschauer L, Parkman HP, Harbison S, Abell TL, Snape WJ, Hasler WL, McCallum RW, Sarosiek I, Nguyen LA, Koch KL, Tonascia J, Hamilton FA, Kendrick ML, Shen KR, Pasricha PJ, Farrugia G, NIDDK Gastroparesis Clinical Research Consortium (GpCRC). Association of low numbers of CD206-positive cells with loss of ICC in the gastric body of patients with diabetic gastroparesis. Neurogastroenterol Motil. 2014 Sep; 26(9):1275-84. Epub 2014 Jul 13.
    View PubMed
  77. Hasler WL. The use of SmartPill for gastric monitoring. Expert Rev Gastroenterol Hepatol. 2014 Aug; 8 (6):587-600 Epub 2014 May 31
    View PubMed
  78. Hasler WL. Emerging drugs for the treatment of gastroparesis. Expert Opin Emerg Drugs. 2014 Jun; 19 (2):261-79 Epub 2014 Mar 26
    View PubMed
  79. Parkman HP, Van Natta ML, Abell TL, McCallum RW, Sarosiek I, Nguyen L, Snape WJ, Koch KL, Hasler WL, Farrugia G, Lee L, Unalp-Arida A, Tonascia J, Hamilton F, Pasricha PJ. Effect of nortriptyline on symptoms of idiopathic gastroparesis: the NORIG randomized clinical trial. JAMA. 2013 Dec 25; 310(24):2640-9.
    View PubMed
  80. Hasler WL, Owyang C. Challenges of managing pain in constipation-predominant IBS: clinical perspectives on antinociceptive actions of linaclotide. Gastroenterology 2013 Dec; 145 (6):1196-9
    View PubMed
  81. Hasler WL. Geography lessons: scrutinizing state-by-state differences in inpatient gastroparesis care. Dig Dis Sci 2013 Oct; 58 (10):2743-5
    View PubMed
  82. Hasler WL, Wilson LA, Parkman HP, Koch KL, Abell TL, Nguyen L, Pasricha PJ, Snape WJ, McCallum RW, Sarosiek I, Farrugia G, Calles J, Lee L, Tonascia J, Unalp-Arida A, Hamilton F. Factors related to abdominal pain in gastroparesis: contrast to patients with predominant nausea and vomiting. Neurogastroenterol Motil. 2013 May; 25(5):427-38, e300-1. Epub 2013 Feb 17.
    View PubMed
  83. Parkman HP, Yates K, Hasler WL, Nguyen L, Pasricha PJ, Snape WJ, Farrugia G, Koch KL, Calles J, Abell TL, Sarosiek I, McCallum RW, Lee L, Unalp-Arida A, Tonascia J, Hamilton F. Cholecystectomy and clinical presentations of gastroparesis. Dig Dis Sci. 2013 Apr; 58(4):1062-73. Epub 2013 Mar 02.
    View PubMed
  84. Rao SSC, Hasler WL. Can high-resolution anorectal manometry shed new light on defecatory disorders? Gastroenterology 2013 Feb; 144 (2):263-265 Epub 2012 Dec 20
    View PubMed
  85. Hasler WL. Gastroparesis. Curr Opin Gastroenterol. 2012 Nov; 28 (6):621-8
    View PubMed
  86. Faussone-Pellegrini MS, Grover M, Pasricha PJ, Bernard CE, Lurken MS, Smyrk TC, Parkman HP, Abell TL, Snape WJ, Hasler WL, Unalp-Arida A, Nguyen L, Koch KL, Calles J, Lee L, Tonascia J, Hamilton FA, Farrugia G, NIDDK Gastroparesis Clinical Research Consortium (GpCRC). Ultrastructural differences between diabetic and idiopathic gastroparesis. J Cell Mol Med. 2012 Jul; 16(7):1573-81.
    View PubMed
  87. Grover M, Bernard CE, Pasricha PJ, Lurken MS, Faussone-Pellegrini MS, Smyrk TC, Parkman HP, Abell TL, Snape WJ, Hasler WL, McCallum RW, Nguyen L, Koch KL, Calles J, Lee L, Tonascia J, Ünalp-Arida A, Hamilton FA, Farrugia G, NIDDK Gastroparesis Clinical Research Consortium (GpCRC). Clinical-histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium. Neurogastroenterol Motil. 2012 Jun; 24(6):531-9, e249. Epub 2012 Feb 17.
    View PubMed
  88. Fisher LR, Hasler WL. New vision in video capsule endoscopy: current status and future directions. Nat Rev Gastroenterol Hepatol. 2012 May 8; 9 (7):392-405 Epub 2012 May 08
    View PubMed
  89. Hasler WL. Gastric emptying testing is not needed to manage presumed gastroparesis or functional dyspepsia. AGA Perspectives. 2012.
  90. Parkman HP, Yates K, Hasler WL, Nguyen L, Pasricha PJ, Snape WJ, Farrugia G, Koch KL, Calles J, Abell TL, McCallum RW, Lee L, Unalp-Arida A, Tonascia J, Hamilton F, National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium. Similarities and differences between diabetic and idiopathic gastroparesis. Clin Gastroenterol Hepatol. 2011 Dec; 9(12):1056-64; quiz e133-4. Epub 2011 Aug 24.
    View PubMed
  91. Saad RJ, Hasler WL. A technical review and clinical assessment of the wireless motility capsule. Gastroenterol Hepatol (N Y). 2011 Dec; 7 (12):795-804
    View PubMed
  92. Kuo B, Maneerattanaporn M, Lee AA, Baker JR, Wiener SM, Chey WD, Wilding GE, Hasler WL. Generalized transit delay on wireless motility capsule testing in patients with clinical suspicion of gastroparesis, small intestinal dysmotility, or slow transit constipation. Dig Dis Sci. 2011 Oct; 56 (10):2928-38 Epub 2011 May 31
    View PubMed
  93. Parkman HP, Yates KP, Hasler WL, Nguyan L, Pasricha PJ, Snape WJ, Farrugia G, Calles J, Koch KL, Abell TL, McCallum RW, Petito D, Parrish CR, Duffy F, Lee L, Unalp-Arida A, Tonascia J, Hamilton F, NIDDK Gastroparesis Clinical Research Consortium. Dietary intake and nutritional deficiencies in patients with diabetic or idiopathic gastroparesis. Gastroenterology. 2011 Aug; 141 (2):486-98, 498.e1-7 Epub 2011 Apr 28
    View PubMed
  94. Hasler WL, Wilson LA, Parkman HP, Nguyen L, Abell TL, Koch KL, Pasricha PJ, Snape WJ, Farrugia G, Lee L, Tonascia J, Unalp-Arida A, Hamilton F, NIDDK Gastroparesis Clinical Research Consortium (GpCRC). Bloating in gastroparesis: severity, impact, and associated factors. Am J Gastroenterol. 2011 Aug; 106(8):1492-502. Epub 2011 Apr 12.
    View PubMed
  95. Hasler WL. Gastroparesis: pathogenesis, diagnosis and management. Nat Rev Gastroenterol Hepatol. 2011 Jul 19; 8 (8):438-53 Epub 2011 July 19
    View PubMed
  96. Pasricha PJ, Colvin R, Yates K, Hasler WL, Abell TL, Unalp-Arida A, Nguyen L, Farrugia G, Koch KL, Parkman HP, Snape WJ, Lee L, Tonascia J, Hamilton F. Characteristics of patients with chronic unexplained nausea and vomiting and normal gastric emptying. Clin Gastroenterol Hepatol. 2011 Jul; 9(7):567-76.e1-4. Epub 2011 Mar 11.
    View PubMed
  97. Grover M, Farrugia G, Lurken MS, Bernard CE, Faussone-Pellegrini MS, Smyrk TC, Parkman HP, Abell TL, Snape WJ, Hasler WL, Ünalp-Arida A, Nguyen L, Koch KL, Calles J, Lee L, Tonascia J, Hamilton FA, Pasricha PJ, NIDDK Gastroparesis Clinical Research Consortium. Cellular changes in diabetic and idiopathic gastroparesis. Gastroenterology. 2011 May; 140(5):1575-85.e8. Epub 2011 Feb 04.
    View PubMed
  98. Hasler WL. Traditional thoughts on the pathophysiology of irritable bowel syndrome. Gastroenterol Clin North Am. 2011 Mar; 40 (1):21-43
    View PubMed
  99. Parkman HP, Yates K, Hasler WL, Nguyen L, Pasricha PJ, Snape WJ, Farrugia G, Koch KL, Abell TL, McCallum RW, Lee L, Unalp-Arida A, Tonascia J, Hamilton F, National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium. Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity. Gastroenterology. 2011 Jan; 140(1):101-15. Epub 2010 Oct 20.
    View PubMed
  100. Rao SS, Camilleri M, Hasler WL, Maurer AH, Parkman HP, Saad R, Scott MS, Simren M, Soffer E, Szarka L. Evaluation of gastrointestinal transit in clinical practice: position paper of the American and European Neurogastroenterology and Motility Societies. Neurogastroenterol Motil. 2011 Jan; 23(1):8-23.
    View PubMed
  101. Hasler WL, Parkman HP, Wilson LA, Pasricha PJ, Koch KL, Abell TL, Snape WJ, Farrugia G, Lee L, Tonascia J, Unalp-Arida A, Hamilton F, NIDDK Gastroparesis Clinical Research Consortium. Psychological dysfunction is associated with symptom severity but not disease etiology or degree of gastric retention in patients with gastroparesis. Am J Gastroenterol. 2010 Nov; 105(11):2357-67. Epub 2010 Jun 29.
    View PubMed
  102. Camilleri M, Thorne NK, Ringel Y, Hasler WL, Kuo B, Esfandyari T, Gupta A, Scott SM, McCallum RW, Parkman HP, Soffer E, Wilding GE, Semler JR, Rao SS. Wireless pH-motility capsule for colonic transit: prospective comparison with radiopaque markers in chronic constipation. Neurogastroenterol Motil. 2010 Aug; 22 (8):874-82, e233 Epub 2010 May 11
    View PubMed
  103. Kloetzer L, Chey WD, McCallum RW, Koch KL, Wo JM, Sitrin M, Katz LA, Lackner JM, Parkman HP, Wilding GE, Semler JR, Hasler WL, Kuo B. Motility of the antroduodenum in healthy and gastroparetics characterized by wireless motility capsule. Neurogastroenterol Motil. 2010 May; 22 (5):527-33, e117 Epub 2010 Jan 29
    View PubMed
  104. Parkman HP, Camilleri M, Farrugia G, McCallum RW, Bharucha AE, Mayer EA, Tack JF, Spiller R, Horowitz M, Vinik AI, Galligan JJ, Pasricha PJ, Kuo B, Szarka LA, Marciani L, Jones K, Parrish CR, Sandroni P, Abell T, Ordog T, Hasler W, Koch KL, Sanders K, Norton NJ, Hamilton F. Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting. Neurogastroenterol Motil. 2010 Feb; 22(2):113-33. Epub 2009 Dec 09.
    View PubMed
  105. Sarosiek I, Selover KH, Katz LA, Semler JR, Wilding GE, Lackner JM, Sitrin MD, Kuo B, Chey WD, Hasler WL, Koch KL, Parkman HP, Sarosiek J, McCallum RW. The assessment of regional gut transit times in healthy controls and patients with gastroparesis using wireless motility technology. Aliment Pharmacol Ther. 2010 Jan 15; 31 (2):313-22 Epub 2009 Oct 08
    View PubMed
  106. Hasler WL, Saad RJ, Rao SS, Wilding GE, Parkman HP, Koch KL, McCallum RW, Kuo B, Sarosiek I, Sitrin MD, Semler JR, Chey WD. Heightened colon motor activity measured by a wireless capsule in patients with constipation: relation to colon transit and IBS. Am J Physiol Gastrointest Liver Physiol. 2009 Dec; 297 (6):G1107-14 Epub 2009 Oct 01
    View PubMed
  107. Coleski R, Anderson MA, Hasler WL. Factors associated with symptom response to pyloric injection of botulinum toxin in a large series of gastroparesis patients. Dig Dis Sci. 2009 Dec; 54 (12):2634-42
    View PubMed
  108. Hasler WL. Serotonin and the GI tract. Curr Gastroenterol Rep. 2009 Oct; 11 (5):383-91
    View PubMed
  109. Rao SS, Kuo B, McCallum RW, Chey WD, DiBaise JK, Hasler WL, Koch KL, Lackner JM, Miller C, Saad R, Semler JR, Sitrin MD, Wilding GE, Parkman HP. Investigation of colonic and whole-gut transit with wireless motility capsule and radiopaque markers in constipation. Clin Gastroenterol Hepatol. 2009 May; 7 (5):537-44
    View PubMed
  110. Coleski R, Hasler WL. Coupling and propagation of normal and dysrhythmic gastric slow waves during acute hyperglycaemia in healthy humans. Neurogastroenterol Motil. 2009 May; 21 (5):492-9, e1-2 Epub 2009 Feb 25
    View PubMed
  111. Hasler WL. Methods of gastric electrical stimulation and pacing: a review of their benefits and mechanisms of action in gastroparesis and obesity. Neurogastroenterol Motil. 2009 Mar; 21 (3):229-43
    View PubMed
  112. Camilleri M, Bharucha AE, di Lorenzo C, Hasler WL, Prather CM, Rao SS, Wald A. American Neurogastroenterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice. Neurogastroenterol Motil. 2008 Dec; 20(12):1269-82.
    View PubMed
  113. Hasler WL, Coleski R, Chey WD, Koch KL, McCallum RW, Wo JM, Kuo B, Sitrin MD, Katz LA, Hwang J, Semler JR, Parkman HP. Differences in intragastric pH in diabetic vs. idiopathic gastroparesis: relation to degree of gastric retention. Am J Physiol Gastrointest Liver Physiol. 2008 Jun; 294 (6):G1384-91 Epub 2008 Apr 10
    View PubMed
  114. Hasler WL. Management of gastroparesis. Expert Rev Gastroenterol Hepatol. 2008 Jun; 2 (3):411-23
    View PubMed
  115. Abell TL, Adams KA, Boles RG, Bousvaros A, Chong SK, Fleisher DR, Hasler WL, Hyman PE, Issenman RM, Li BU, Linder SL, Mayer EA, McCallum RW, Olden K, Parkman HP, Rudolph CD, Tache Y, Tarbell S, Vakil N. Cyclic vomiting syndrome in adults. Neurogastroenterol Motil. 2008 Apr; 20 (4):269-84
    View PubMed
  116. Abell TL, Camilleri M, Donohoe K, Hasler WL, Lin HC, Maurer AH, McCallum RW, Nowak T, Nusynowitz ML, Parkman HP, Shreve P, Szarka LA, Snape WJ Jr, Ziessman HA, American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. Am J Gastroenterol 2008 Mar; 103 (3):753-63 Epub 2007 Nov 19
    View PubMed
  117. Abell TL, Camilleri M, Donohoe K, Hasler WL, Lin HC, Maurer AH, McCallum RW, Nowak T, Nusynowitz ML, Parkman HP, Shreve P, Szarka LA, Snape WJ Jr, Ziessman HA, American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. J Nucl Med Technol. 2008 Mar; 36 (1):44-54 Epub 2008 Feb 20
    View PubMed
  118. Kuo B, McCallum RW, Koch KL, Sitrin MD, Wo JM, Chey WD, Hasler WL, Lackner JM, Katz LA, Semler JR, Wilding GE, Parkman HP. Comparison of gastric emptying of a nondigestible capsule to a radio-labelled meal in healthy and gastroparetic subjects. Aliment Pharmacol Ther. 2008 Jan 15; 27 (2):186-96 Epub 2007 Oct 28
    View PubMed
  119. Hasler WL. Gastroparesis: symptoms, evaluation, and treatment. Gastroenterol Clin North Am. 2007 Sep; 36 (3):619-47, ix
    View PubMed
  120. Hasler WL. Type 1 diabetes and gastroparesis: diagnosis and treatment. Curr Gastroenterol Rep. 2007 Aug; 9 (4):261-9
    View PubMed
  121. Hasler WL. Irritable bowel syndrome and bloating. Best Pract Res Clin Gastroenterol. 2007; 21 (4):689-707
    View PubMed
  122. Hasler WL. Gas and Bloating. Gastroenterol Hepatol (N Y). 2006 Sep; 2 (9):654-662
    View PubMed
  123. Gonlachanvit S, Coleski R, Owyang C, Hasler WL. Nutrient modulation of intestinal gas dynamics in healthy humans: dependence on caloric content and meal consistency. Am J Physiol Gastrointest Liver Physiol. 2006 Sep; 291 (3):G389-95
    View PubMed
  124. Coleski R, Owyang C, Hasler WL. Modulation of intestinal gas dynamics in healthy human volunteers by the 5-HT receptor agonist tegaserod. Am J Gastroenterol. 2006 Aug; 101 (8):1858-65 Epub 2006 June 30
    View PubMed
  125. Hasler WL. Searching for the bitter truth: insights into receptors for taste. Gastroenterology. 2006 Feb; 130 (2):611-2
    View PubMed
  126. Abell TL, Bernstein RK, Cutts T, Farrugia G, Forster J, Hasler WL, McCallum RW, Olden KW, Parkman HP, Parrish CR, Pasricha PJ, Prather CM, Soffer EE, Twillman R, Vinik AI. Treatment of gastroparesis: a multidisciplinary review—the American Motility Society Task Force on Gastroparesis. Neurogastroenterol Motil. 2006; 18:263-83.
  127. Hasler WL. Non-pharmacologic and OTC therapies for chronic constipation. Johns Hopkins Med J. 2006.
  128. Hasler WL. Fecal flora in irritable bowel syndrome: characterization using molecular methods. Gastroenterology. 2005 Aug; 129 (2):759-61
    View PubMed
  129. Hasler WL. Nausea, gastroparesis, and aerophagia. J Clin Gastroenterol. 2005 May-Jun; 39 (5 Suppl 3):S223-9
    View PubMed
  130. Hasler WL. Preventing postoperative nausea and vomiting: a comprehensive comparison of treatments. Gastroenterology. 2005 Feb; 128 (2):509-10; author reply 510-1
    View PubMed
  131. Parkman HP, Hasler WL, Fisher RS. American Gastroenterological Association Technical review on the diagnosis and treatment of gastroparesis. Rev Gastroenterol Mexico. 2005; 70:325-60.
  132. Coleski R, Gonlachanvit S, Owyang C, Hasler WL. Selective reversal of hyperglycemia-evoked gastric myoelectric dysrhythmias by nitrergic stimulation in healthy humans. J Pharmacol Exp Ther. 2005 Jan; 312 (1):103-11 Epub 2004 Oct 19
    View PubMed
  133. Gonlachanvit S, Coleski R, Owyang C, Hasler W. Inhibitory actions of a high fibre diet on intestinal gas transit in healthy volunteers. Gut. 2004 Nov; 53 (11):1577-82
    View PubMed
  134. Parkman HP, Hasler WL, Fisher RS, American Gastroenterological Association. American Gastroenterological Association medical position statement: diagnosis and treatment of gastroparesis. Gastroenterology. 2004 Nov; 127 (5):1589-91
    View PubMed
  135. Parkman HP, Hasler WL, Fisher RS, American Gastroenterological Association. American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis. Gastroenterology. 2004 Nov; 127 (5):1592-622
    View PubMed
  136. Coleski R, Hasler WL. Directed endoscopic mucosal mapping of normal and dysrhythmic gastric slow waves in healthy humans. Neurogastroenterol Motil. 2004 Oct; 16 (5):557-65
    View PubMed
  137. Hasler WL, Schoenfeld P. Safety profile of tegaserod, a 5-HT4 receptor agonist for constipation-predominant irritable bowel syndrome. Drug Safety. 2004; 27:619-31.
  138. Hasler WL. Impaired thalamic T-type calcium channel function: a possible mechanism for visceral hyperalgesia and functional abdominal pain (Selected Summaries). Gastroenterology. 2004.
  139. Gonlachanvit S, Chen YH, Hasler WL, Sun WM, Owyang C. Ginger reduces hyperglycemia-evoked gastric dysrhythmias in healthy humans: possible role of endogenous prostaglandins. J Pharmacol Exp Ther. 2003 Dec; 307 (3):1098-103 Epub 2003 Oct 08
    View PubMed
  140. Hasler WL, Chey WD. Nausea and vomiting. Gastroenterology. 2003 Dec; 125 (6):1860-7
    View PubMed
  141. Hasler WL. Lactulose breath testing, bacterial overgrowth, and IBS: just a lot of hot air? Gastroenterology. 2003 Dec; 125 (6):1898-900; discussion 1900
    View PubMed
  142. Hasler WL. Gastric neurostimulation for gastroparesis: time to pick up the pace. Gastroenterology. 2003 Sep; 125 (3):979-81; discussion 981
    View PubMed
  143. Hasler WL. Pharmacotherapy for intestinal motor and sensory disorders. Gastroenterol Clin North Am. 2003 Jun; 32 (2):707-32, viii-ix
    View PubMed
  144. Parkman HP, Hasler WL, Barnett JL, Eaker EY, American Motility Society Clinical GI Motility Testing Task Force. Electrogastrography: a document prepared by the gastric section of the American Motility Society Clinical GI Motility Testing Task Force. Neurogastroenterol Motil. 2003 Apr; 15 (2):89-102
    View PubMed
  145. Hasler WL, Schoenfeld P. Systematic review: Abdominal and pelvic surgery in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 2003 Apr; 17 (8):997-1005
    View PubMed
  146. Lien HC, Sun WM, Chen YH, Kim H, Hasler W, Owyang C. Effects of ginger on motion sickness and gastric slow-wave dysrhythmias induced by circular vection. Am J Physiol Gastrointest Liver Physiol. 2003 Mar; 284 (3):G481-9
    View PubMed
  147. Hasler WL. The irritable bowel syndrome during pregnancy. Gastroenterol Clin North Am. 2003 Mar; 32 (1):385-406, viii
    View PubMed
  148. Hasler WL. The stomach and weight reduction: the role of ghrelin. Gastroenterology. 2003 Feb; 124 (2):575-7
    View PubMed
  149. Hasler WL. Is constipation caused by a loss of colonic interstitial cells of Cajal? (Selected Summaries). Gastroenterology. 2003; 125:979-81.
  150. Hasler WL. Baclofen effects on esophageal function: a possible therapy for GERD? Gastroenterology. 2002 Nov; 123 (5):1736-7
    View PubMed
  151. Hasler WL. The irritable bowel syndrome. Med Clin North Am. 2002 Nov; 86 (6):1525-51
    View PubMed
  152. Bjornsson ES, Chey WD, Hooper F, Woods ML, Owyang C, Hasler WL. Impaired gastrocolonic response and peristaltic reflex in slow-transit constipation: role of 5-HT(3) pathways. Am J Physiol Gastrointest Liver Physiol. 2002 Aug; 283 (2):G400-7
    View PubMed
  153. Owyang C, Hasler WL. Physiology and pathophysiology of the interstitial cells of Cajal: from bench to bedside. VI. Pathogenesis and therapeutic approaches to human gastric dysrhythmias. Am J Physiol Gastrointest Liver Physiol. 2002 Jul; 283 (1):G8-15
    View PubMed
  154. Hasler WL. Dumping Syndrome. Curr Treat Options Gastroenterol. 2002 Apr; 5 (2):139-145
    View PubMed
  155. Hasler WL. Air apparent: abnormal gas retention and perception in IBS. (Selected Summaries) Gastroenterology. 2002; 122:576-8.
  156. Hasler WL. Celiac sprue as a possible cause of symptoms in presumed irritable bowel syndrome (Selected Summaries). Gastroenterology. 2002; 122:2086-7.
  157. Sun WM, Hasler WL, Lien HC, Montague J, Owyang C. Nizatidine enhances the gastrocolonic response and the colonic peristaltic reflex in humans. J Pharmacol Exp Ther. 2001 Oct; 299 (1):159-63
    View PubMed
  158. Hasler WL. Augmented Visceral Perception. Curr Treat Options Gastroenterol. 2001 Aug; 4 (4):339-349
    View PubMed
  159. Ladabaum U, Minoshima S, Hasler WL, Cross D, Chey WD, Owyang C. Gastric distention correlates with activation of multiple cortical and subcortical regions. Gastroenterology. 2001 Feb; 120 (2):369-76
    View PubMed
  160. Ladabaum U, Brown MB, Pan W, Owyang C, Hasler WL. Effects of nutrients and serotonin 5-HT3 antagonism on symptoms evoked by distal gastric distension in humans. Am J Physiol Gastrointest Liver Physiol. 2001 Feb; 280 (2):G201-8
    View PubMed
  161. Hasler WL. Are things looking up for the treatment of gastroparesis? Sildenafil in animal models of diabetic gastropathy. Gastroenterology. 2001 Feb; 120 (2):576-8
    View PubMed
  162. Quigley EM, Hasler WL, Parkman HP. AGA technical review on nausea and vomiting. Gastroenterology. 2001 Jan; 120 (1):263-86
    View PubMed
  163. Hasler WL. Persistent colonic inflammation in post-infectious IBS: symptom cause or curiosity? (Selected Summaries) Gastroenterology. 2001; 121:493-4.
  164. Hasler WL. The benefits of dietary fiber on glycemic control in type 2 diabetes: relevance to gastroenterologists. Gastroenterology. 2000 Oct; 119 (4):1168-70
    View PubMed
  165. Hasler WL. 5-HT(3) antagonist therapy of bulimia nervosa: a peripherally active agent for a central nervous system eating disorder? Gastroenterology. 2000 Jul; 119 (1):271-2
    View PubMed
  166. Hasler WL. Neostigmine for acute colonic pseudo-obstruction: new use for an old drug? Gastroenterology. 2000 Feb; 118 (2):443-4
    View PubMed
  167. Hasler WL. Understanding Emesis. (Dissecting Room) Lancet. 2000; 356:1120.
  168. Hasler WL. Garlic breath explained: why brushing your teeth won't help. Gastroenterology. 1999 Nov; 117 (5):1248-50
    View PubMed
  169. Jednak MA, Shadigian EM, Kim MS, Woods ML, Hooper FG, Owyang C, Hasler WL. Protein meals reduce nausea and gastric slow wave dysrhythmic activity in first trimester pregnancy. Am J Physiol. 1999 Oct; 277 (4):G855-61
    View PubMed
  170. Hasler WL. The problem of delayed emesis after cancer chemotherapy: a possible new treatment. Gastroenterology. 1999 Sep; 117 (3):737-8
    View PubMed
  171. Hasler WL. Serotonin receptor physiology: relation to emesis. Dig Dis Sci. 1999 Aug; 44 (8 Suppl):108S-113S
    View PubMed
  172. Hasler WL. New insights into the pathogenesis of rumination: what's coming up next. Gastroenterology. 1999 Apr; 116 (4):1006-8
    View PubMed
  173. Ladabaum U, Hasler WL. Motility of the small intestine. Curr Opin Gastroenterol. 1999 Mar; 15 (2):125-31
    View PubMed
  174. Ladabaum U, Hasler WL. Novel approaches to the treatment of nausea and vomiting. Dig Dis. 1999; 17 (3):125-32
    View PubMed
  175. Hasler WL. The expanding spectrum of clinical uses for botulinum toxin: healing of chronic anal fissures. Gastroenterology. 1999 Jan; 116 (1):221-3
    View PubMed
  176. Chey WD, Fisher L, Barnett J, Delvalle J, Elta GH, Hasler WL, Nostrant T, Palaniappan J, Scheiman J. Low- versus high-dose azithromycin triple therapy for Helicobacter pylori infection. Aliment Pharmacol Ther. 1998 Dec; 12 (12):1263-7
    View PubMed
  177. Hasler WL. Visceral analgesia: an emerging concept for managing functional gastrointestinal disease. Gastroenterology. 1998 Oct; 115 (4):1023-4
    View PubMed
  178. Camilleri M, Hasler WL, Parkman HP, Quigley EM, Soffer E. Measurement of gastrointestinal motility in the GI laboratory. Gastroenterology. 1998 Sep; 115 (3):747-62
    View PubMed
  179. Gorelick AB, Koshy SS, Hooper FG, Bennett TC, Chey WD, Hasler WL. Differential effects of amitriptyline on perception of somatic and visceral stimulation in healthy humans. Am J Physiol. 1998 Sep; 275 (3):G460-6
    View PubMed
  180. Ladabaum U, Koshy SS, Woods ML, Hooper FG, Owyang C, Hasler WL. Differential symptomatic and electrogastrographic effects of distal and proximal human gastric distension. Am J Physiol. 1998 Sep; 275 (3):G418-24
    View PubMed
  181. Bjornsson ES, Chey WD, Ladabaum U, Woods ML, Hooper FG, Owyang C, Hasler WL. Differential 5-HT3 mediation of human gastrocolonic response and colonic peristaltic reflex. Am J Physiol. 1998 Sep; 275 (3):G498-505
    View PubMed
  182. Hasler WL. In search of the cause of idiopathic intestinal pseudo-obstruction: is there a viral etiology? Gastroenterology. 1998 Aug; 115 (2):498-500
    View PubMed
  183. Hasler WL. Pancreatic enzymes and colonic strictures with cystic fibrosis: a case-control study. Gastroenterology. 1998 Mar; 114 (3):609-11; discussion 611-2
    View PubMed
  184. Chey WD, Fisher L, Elta GH, Barnett JL, Nostrant T, DelValle J, Hasler WL, Scheiman JM. Bismuth subsalicylate instead of metronidazole with lansoprazole and clarithromycin for Helicobacter pylori infection: a randomized trial. Am J Gastroenterol. 1997 Sep; 92 (9):1483-6
    View PubMed
  185. Kim MS, Chey WD, Owyang C, Hasler WL. Role of plasma vasopressin as a mediator of nausea and gastric slow wave dysrhythmias in motion sickness. Am J Physiol. 1997 Apr; 272 (4 Pt 1):G853-62
    View PubMed
  186. Hasler WL, Owyang C. Gastrointestinal motor disturbances in diabetes mellitus. Mediguide to Diabetes. 1997; 3:1-8.
  187. Hasler WL, Soudah HC, Owyang C. Mechanisms by which octreotide ameliorates symptoms in the dumping syndrome. J Pharmacol Exp Ther. 1996 Jun; 277 (3):1359-65
    View PubMed
  188. Walsh JW, Hasler WL, Nugent CE, Owyang C. Progesterone and estrogen are potential mediators of gastric slow-wave dysrhythmias in nausea of pregnancy. Am J Physiol. 1996 Mar; 270 (3 Pt 1):G506-14
    View PubMed
  189. Kohagen KR, Kim MS, McDonnell WM, Chey WD, Owyang C, Hasler WL. Nicotine effects on prostaglandin-dependent gastric slow wave rhythmicity and antral motility in nonsmokers and smokers. Gastroenterology. 1996 Jan; 110 (1):3-11
    View PubMed
  190. Hasler WL, Owyang C. Therapeutic approaches to pain resulting from visceral afferent pathway dysfunction. Regulatory Peptide Letter. 1996; 7:27-31.
  191. Hasler WL. Pharmacologic correction of visceral afferent dysfunction in irritable bowel syndrome. Regulatory Peptide Letter. 1996; 7:insert.
  192. Chey WD, Beydoun A, Roberts DJ, Hasler WL, Owyang C. Octreotide reduces perception of rectal electrical stimulation by spinal afferent pathway inhibition. Am J Physiol. 1995 Dec; 269 (6 Pt 1):G821-6
    View PubMed
  193. Chey WD, Kim M, Hasler WL, Owyang C. Hyperglycemia alters perception of rectal distention and blunts the rectoanal inhibitory reflex in healthy volunteers. Gastroenterology. 1995 Jun; 108 (6):1700-8
    View PubMed
  194. Hasler WL, Kurosawa S, Takahashi T, Feng H, Gaginella TS, Owyang C. Bradykinin acting on B2 receptors contracts colon circular muscle cells by IP3 generation and adenylate cyclase inhibition. J Pharmacol Exp Ther. 1995 Apr; 273 (1):344-50
    View PubMed
  195. Hasler WL, Kim MS, Chey WD, Stevenson V, Stein B, Owyang C. Central cholinergic and alpha-adrenergic mediation of gastric slow wave dysrhythmias evoked during motion sickness. Am J Physiol. 1995 Apr; 268 (4 Pt 1):G539-47
    View PubMed
  196. Hasler WL, Soudah HC, Dulai G, Owyang C. Mediation of hyperglycemia-evoked gastric slow-wave dysrhythmias by endogenous prostaglandins. Gastroenterology. 1995 Mar; 108 (3):727-36
    View PubMed
  197. Sims MA, Hasler WL, Chey WD, Kim MS, Owyang C. Hyperglycemia inhibits mechanoreceptor-mediated gastrocolonic responses and colonic peristaltic reflexes in healthy humans. Gastroenterology. 1995 Feb; 108 (2):350-9
    View PubMed
  198. Hasler WL. Irritable bowel syndrome. Current Opinion in Gastroenterology. 1995; 11:16-21.
  199. Hasler WL, Owyang C. Pathophysiology and treatment of diabetic gastroparesis: importance of gastric slow wave dysrhythmias. Regulatory Peptide Letter. 1995; 6:27-31.
  200. Hasler WL. A possible pathogenic role for defective nitric oxide release in infantile hypertrophic pyloric stenosis. Regulatory Peptide Letter. 1995; 6:insert.
  201. Hasler WL, Soudah HC, Owyang C. Somatostatin analog inhibits afferent response to rectal distention in diarrhea-predominant irritable bowel patients. J Pharmacol Exp Ther. 1994 Mar; 268 (3):1206-11
    View PubMed
  202. Bologna SD, Hasler WL, Owyang C. Down-regulation of motilin receptors on rabbit colon myocytes by chronic oral erythromycin. J Pharmacol Exp Ther. 1993 Aug; 266 (2):852-6
    View PubMed
  203. Hasler WL, Soudah HC, Owyang C. A somatostatin analogue inhibits afferent pathways mediating perception of rectal distention. Gastroenterology. 1993 May; 104 (5):1390-7
    View PubMed
  204. Roberts DJ, Hasler WL, Owyang C. GABA mediation of the dual effects of somatostatin on guinea pig ileal myenteric cholinergic transmission. Am J Physiol. 1993 May; 264 (5 Pt 1):G953-60
    View PubMed
  205. Chey WD, Hasler WL, Bockenstedt PL. Angiodysplasia and von Willebrand's disease type IIB treated with estrogen/progesterone therapy. Am J Hematol. 1992 Dec; 41 (4):276-9
    View PubMed
  206. Soudah HC, Lu Y, Hasler WL, Owyang C. Cholecystokinin at physiological levels evokes pancreatic enzyme secretion via a cholinergic pathway. Am J Physiol. 1992 Jul; 263 (1 Pt 1):G102-7
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  207. Hasler WL, Heldsinger A, Chung OY. Erythromycin contracts rabbit colon myocytes via occupation of motilin receptors. Am J Physiol. 1992 Jan; 262 (1 Pt 1):G50-5
    View PubMed
  208. Hasler WL, Heldsinger A, Owyang C. Cisapride acts on muscarinic (glandular M2) receptors to induce contraction of isolated gastric myocytes: mediation via a calcium-phosphoinositide pathway. J Pharmacol Exp Ther. 1991 Dec; 259 (3):1294-300
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  209. Soudah HC, Hasler WL, Owyang C. Effect of octreotide on intestinal motility and bacterial overgrowth in scleroderma. N Engl J Med. 1991 Nov 21; 325 (21):1461-7
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  210. Kurosawa S, Hasler WL, Torres G, Wiley JW, Owyang C. Characterization of receptors mediating the effects of dopamine on gastric smooth muscle. Gastroenterology. 1991 May; 100 (5 Pt 1):1224-31
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  211. Hasler WL, Kurosawa S, Chung OY. Regional cholinergic differences between distal and proximal colonic myenteric plexus. Am J Physiol. 1990 Mar; 258 (3 Pt 1):G404-10
    View PubMed
  212. Hasler W, Owyang C. Peptide hormone regulation of the electrical activity of the stomach. The Regulatory Peptide Letter. 1990; 2:6-12.
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