搜索医生

Leigh G. Griffiths, Ph.D., MRCVS

  1. Veterinary Surgeon

出版物

  1. Deng J, Wu J, Chen X, Sarrafian TL, Varela CE, Whyte W, Guo CF, Roche ET, Griffiths LG, Yuk H, Nabzdyk CS, Zhao X. A bioadhesive pacing lead for atraumatic cardiac monitoring and stimulation in rodent and porcine models. Sci Transl Med. 2024 Jun 19; 16 (752):eado9003 Epub 2024 June 19
    View PubMed
  2. Wu J, Deng J, Theocharidis G, Sarrafian TL, Griffiths LG, Bronson RT, Veves A, Chen J, Yuk H, Zhao X. Adhesive anti-fibrotic interfaces on diverse organs. Nature. 2024 Jun; 630 (8016):360-367 Epub 2024 May 22
    View PubMed
  3. Panicker AJ, Prokop LJ, Hacke K, Jaramillo A, Griffiths LG. Outcome-based Risk Assessment of Non-HLA Antibodies in Heart Transplantation: A Systematic Review. J Heart Lung Transplant. 2024 May 23 [Epub ahead of print]
    View PubMed
  4. Somasekhar L, Griffiths LG. Current Challenges and Future Promise for Use of Extracellular Matrix Scaffold to Achieve the Whole Organ Tissue Engineering Moonshot. Stem Cells Transl Med. 2023 Sep 15; 12 (9):588-602
    View PubMed
  5. Shortreed NA, Panicker AJ, Mangalaparthi KK, Zhong J, Pandey A, Griffiths LG. Optimization of a high-throughput shotgun immunoproteomics pipeline for antigen identification. J Proteomics. 2023 Jun 15; 281:104906 Epub 2023 Apr 13
    View PubMed
  6. Fayyaz AU, Sabbah MS, Dasari S, Griffiths LG, DuBrock HM, Wang Y, Charlesworth MC, Borlaug BA, Jenkins SM, Edwards WD, Redfield MM. Histologic and proteomic remodeling of the pulmonary veins and arteries in a porcine model of chronic pulmonary venous hypertension. Cardiovasc Res. 2023 Mar 17; 119 (1):268-282
    View PubMed
  7. Gates KV, Panicker AJ, Biendarra-Tiegs SM, Vetr NG, Lopera Higuita M, Nelson TJ, Pereira NL, Griffiths LG. Shotgun Immunoproteomics for Identification of Nonhuman Leukocyte Antigens Associated With Cellular Dysfunction in Heart Transplant Rejection. Transplantation. 2022 Jul 1; 106 (7):1376-1389 Epub 2021 Dec 17
    View PubMed
  8. Wu J, Yuk H, Sarrafian TL, Guo CF, Griffiths LG, Nabzdyk CS, Zhao X. An off-the-shelf bioadhesive patch for sutureless repair of gastrointestinal defects. Sci Transl Med. 2022 Feb 2; 14 (630):eabh2857 Epub 2022 Feb 02
    View PubMed
  9. Vogl BJ, Niemi NR, Griffiths LG, Alkhouli MA, Hatoum H. Impact of calcific aortic valve disease on valve mechanics. Biomech Model Mechanobiol. 2022 Feb; 21 (1):55-77 Epub 2021 Oct 23
    View PubMed
  10. Lopera Higuita M, Shortreed NA, Dasari S, Griffiths LG. Basement Membrane of Tissue Engineered Extracellular Matrix Scaffolds Modulates Rapid Human Endothelial Cell Recellularization and Promote Quiescent Behavior After Monolayer Formation. Front Bioeng Biotechnol. 2022; 10:903907 Epub 2022 Aug 02
    View PubMed
  11. Lopera Higuita M, Lopera Giraldo JF, Sarrafian TL, Griffiths LG. Tissue engineered bovine saphenous vein extracellular matrix scaffolds produced via antigen removal achieve high in vivo patency rates. Acta Biomater. 2021 Oct 15; 134:144-159 Epub 2021 June 27
    View PubMed
  12. Yuk H, Wu J, Sarrafian TL, Mao X, Varela CE, Roche ET, Griffiths LG, Nabzdyk CS, Zhao X. Rapid and coagulation-independent haemostatic sealing by a paste inspired by barnacle glue. Nat Biomed Eng. 2021 Oct; 5 (10):1131-1142 Epub 2021 Aug 09
    View PubMed
  13. Xing Q, Parvizi M, Lopera Higuita M, Griffiths LG. Basement membrane proteins modulate cell migration on bovine pericardium extracellular matrix scaffold. Sci Rep. 2021 Feb 25; 11 (1):4607
    View PubMed
  14. Shaik TA, Alfonso-Garcia A, Zhou X, Arnold KM, Haudenschild AK, Krafft C, Griffiths LG, Popp J, Marcu L. FLIm-Guided Raman Imaging to Study Cross-Linking and Calcification of Bovine Pericardium. Anal Chem. 2020 Aug 4; 92 (15):10659-10667 Epub 2020 July 14
    View PubMed
  15. Lopera Higuita M, Griffiths LG. Antigen removal process preserves function of small diameter venous valved conduits, whereas SDS-decellularization results in significant valvular insufficiency. Acta Biomater. 2020 Apr 15; 107:115-128 Epub 2020 Mar 07
    View PubMed
  16. Lopera Higuita M, Griffiths LG. Small Diameter Xenogeneic Extracellular Matrix Scaffolds for Vascular Applications. Tissue Eng Part B Rev. 2020 Feb; 26 (1):26-45 Epub 2019 Nov 27
    View PubMed
  17. Shklover J, McMasters J, Alfonso-Garcia A, Higuita ML, Panitch A, Marcu L, Griffiths L. Bovine pericardial extracellular matrix niche modulates human aortic endothelial cell phenotype and function. Sci Rep. 2019 Nov 13; 9 (1):16688
    View PubMed
  18. Li C, Alfonso-Garcia A, McMasters J, Bec J, Weyers B, Uyesaka L, Griffiths L, Panitch A, Marcu L. Simultaneous intraluminal imaging of tissue autofluorescence and eGFP-labeled cells in engineered vascular grafts inside a bioreactor. Methods Appl Fluoresc. 2019 Sep 20; 7 (4):044003 Epub 2019 Sept 20
    View PubMed
  19. Gates KV, Xing Q, Griffiths LG. Immunoproteomic Identification of Noncarbohydrate Antigens Eliciting Graft-Specific Adaptive Immune Responses in Patients with Bovine Pericardial Bioprosthetic Heart Valves. Proteomics Clin Appl. 2019 Jul; 13 (4):e1800129 Epub 2018 Dec 19
    View PubMed
  20. Dalgliesh AJ, Parvizi M, Noble C, Griffiths LG. Effect of cyclic deformation on xenogeneic heart valve biomaterials. PLoS One. 2019; 14 (6):e0214656 Epub 2019 June 13
    View PubMed
  21. Li C, Shklover J, Parvizi M, Sherlock BE, Alfonso Garcia A, Haudenschild AK, Griffiths LG, Marcu L. Label-Free Assessment of Collagenase Digestion on Bovine Pericardium Properties by Fluorescence Lifetime Imaging. Ann Biomed Eng. 2018 Nov; 46 (11):1870-1881 Epub 2018 July 12
    View PubMed
  22. Dalgliesh AJ, Parvizi M, Lopera-Higuita M, Shklover J, Griffiths LG. Graft-specific immune tolerance is determined by residual antigenicity of xenogeneic extracellular matrix scaffolds. Acta Biomater. 2018 Oct 1; 79:253-264 Epub 2018 Aug 18
    View PubMed
  23. Alfonso-Garcia A, Shklover J, Sherlock BE, Panitch A, Griffiths LG, Marcu L. Fiber-based fluorescence lifetime imaging of recellularization processes on vascular tissue constructs. J Biophotonics. 2018 Sep; 11 (9):e201700391 Epub 2018 June 08
    View PubMed
  24. Gates KV, Griffiths LG. Chronic graft-specific cell-mediated immune response toward candidate xenogeneic biomaterial. Immunol Res. 2018 Apr; 66 (2):288-298
    View PubMed
  25. Hegyi B, Bossuyt J, Griffiths LG, Shimkunas R, Coulibaly Z, Jian Z, Grimsrud KN, Sondergaard CS, Ginsburg KS, Chiamvimonvat N, Belardinelli L, Varro A, Papp JG, Pollesello P, Levijoki J, Izu LT, Boyd WD, Banyasz T, Bers DM, Chen-Izu Y. Complex electrophysiological remodeling in postinfarction ischemic heart failure. Proc Natl Acad Sci U S A. 2018 Mar 27; 115 (13):E3036-E3044 Epub 2018 Mar 12
    View PubMed
  26. Dalgliesh AJ, Liu ZZ, Griffiths LG. Magnesium Presence Prevents Removal of Antigenic Nuclear-Associated Proteins from Bovine Pericardium for Heart Valve Engineering. Tissue Eng Part A. 2017 Jul; 23 (13-14):609-621 Epub 2017 Mar 10
    View PubMed
  27. Gates KV, Dalgliesh AJ, Griffiths LG. Antigenicity of Bovine Pericardium Determined by a Novel Immunoproteomic Approach. Sci Rep. 2017 May 26; 7 (1):2446
    View PubMed
  28. Lake-Bakaar GA, Griffiths LG, Kittleson MD. Balloon Valvuloplasty of Tricuspid Stenosis: A Retrospective Study of 5 Labrador Retriever Dogs. J Vet Intern Med. 2017 Mar; 31 (2):311-315 Epub 2017 Feb 21
    View PubMed
  29. Gates KV, Pereira NL, Griffiths LG. Cardiac Non-Human Leukocyte Antigen Identification: Techniques and Troubles. Front Immunol. 2017; 8:1332 Epub 2017 Oct 18
    View PubMed
  30. Liu ZZ, Wong ML, Griffiths LG. Effect of bovine pericardial extracellular matrix scaffold niche on seeded human mesenchymal stem cell function. Sci Rep. 2016 Nov 15; 6:37089.
    View PubMed
  31. Papalamprou A, Chang CW, Vapniarsky N, Clark A, Walker N, Griffiths LG. Xenogeneic cardiac extracellular matrix scaffolds with or without seeded mesenchymal stem cells exhibit distinct in vivo immunosuppressive and regenerative properties. Acta Biomater. 2016 Jul 18;
    View PubMed
  32. Wong ML, Wong JL, Horn RM, Sannajust KC, Rice DA, Griffiths LG. Effect of Urea and Thiourea on Generation of Xenogeneic Extracellular Matrix Scaffolds for Tissue Engineering. Tissue Eng Part C Methods. 2016 Jul; 22: (7)700-7.
    View PubMed
  33. Silverman S, Sanchez-Migallon Guzman D, Stern J, Gustavsen KA, Griffiths LG. Standardization of the two-dimensional transcoelomic echocardiographic examination in the central bearded dragon (Pogona vitticeps). J Vet Cardiol. 2016 Jun; 18: (2)168-78.
    View PubMed
  34. Wong ML, Wong JL, Vapniarsky N, Griffiths LG. In vivo xenogeneic scaffold fate is determined by residual antigenicity and extracellular matrix preservation. Biomaterials. 2016 Jun; 92:1-12.
    View PubMed
  35. Papalamprou A, Griffiths LG. Cardiac Extracellular Matrix Scaffold Generated Using Sarcomeric Disassembly and Antigen Removal. Ann Biomed Eng. 2016 Apr; 44: (4)1047-60.
    View PubMed
  36. Chang CW, Dalgliesh AJ, Lopez JE, Griffiths LG. Cardiac extracellular matrix proteomics: Challenges, techniques, and clinical implications. Proteomics Clin Appl. 2016 Jan; 10: (1)39-50.
    View PubMed
  37. Bozorgmanesh R, Magdesian KG, Estell KE, Stern JA, Swain EA, Griffiths LG. Atrial Fibrillation in Eight New World Camelids. J Vet Intern Med. 2016 Jan-Feb; 30: (1)335-8.
    View PubMed
  38. Chang CW, Petrie T, Clark A, Lin X, Sondergaard CS, Griffiths LG. Mesenchymal Stem Cell Seeding of Porcine Small Intestinal Submucosal Extracellular Matrix for Cardiovascular Applications. PLoS One. 2016; 11: (4)e0153412.
    View PubMed
  39. Jung SW, Sun W, Griffiths LG, Kittleson MD. Atrial Fibrillation as a Prognostic Indicator in Medium to Large-Sized Dogs with Myxomatous Mitral Valvular Degeneration and Congestive Heart Failure. J Vet Intern Med. 2016 Jan-Feb; 30: (1)51-7.
    View PubMed
  40. Kol A, Arzi B, Athanasiou KA, Farmer DL, Nolta JA, Rebhun RB, Chen X, Griffiths LG, Verstraete FJ, Murphy CJ, Borjesson DL. Companion animals: Translational scientist's new best friends. Sci Transl Med. 2015 Oct 7; 7: (308)308ps21.
    View PubMed
  41. Lake-Bakaar GA, Singh MK, Kass PH, Griffiths LG. Effect of pimobendan on the incidence of arrhythmias in small breed dogs with myxomatous mitral valve degeneration. J Vet Cardiol. 2015 Jun; 17: (2)120-8.
    View PubMed
  42. Hanes DW, Wong ML, Jenny Chang CW, Humphrey S, Grayson JK, Boyd WD, Griffiths LG. Embolization of the first diagonal branch of the left anterior descending coronary artery as a porcine model of chronic trans-mural myocardial infarction. J Transl Med. 2015; 13:187.
    View PubMed
  43. Soicher MA, Christiansen BA, Stover SM, Leach JK, Yellowley CE, Griffiths LG, Fyhrie DP. Remineralized bone matrix as a scaffold for bone tissue engineering. J Biomed Mater Res A. 2014 Dec; 102: (12)4480-90.
    View PubMed
  44. Fatakdawala H, Griffiths LG, Humphrey S, Marcu L. Time-resolved fluorescence spectroscopy and ultrasound backscatter microscopy for nondestructive evaluation of vascular grafts. J Biomed Opt. 2014 Aug; 19: (8)080503.
    View PubMed
  45. Cissell DD, Hu JC, Griffiths LG, Athanasiou KA. Antigen removal for the production of biomechanically functional, xenogeneic tissue grafts. J Biomech. 2014 Jun 27; 47: (9)1987-96.
    View PubMed
  46. Wong ML, Griffiths LG. Immunogenicity in xenogeneic scaffold generation: antigen removal vs. decellularization. Acta Biomater. 2014 May; 10: (5)1806-16.
    View PubMed
  47. Wong ML, Wong JL, Athanasiou KA, Griffiths LG. Stepwise solubilization-based antigen removal for xenogeneic scaffold generation in tissue engineering. Acta Biomater. 2013 May; 9: (5)6492-501.
    View PubMed
  48. Lake-Bakaar GA, Johnson EG, Griffiths LG. Aortic thrombosis in dogs: 31 cases (2000-2010). J Am Vet Med Assoc. 2012 Oct 1; 241: (7)910-5.
    View PubMed
  49. Singh MK, Kittleson MD, Kass PH, Griffiths LG. Occlusion devices and approaches in canine patent ductus arteriosus: comparison of outcomes. J Vet Intern Med. 2012 Jan-Feb; 26: (1)85-92.
    View PubMed
  50. Jung S, Orvalho J, Griffiths LG. Aortopulmonary window characterized with two- and three-dimensional echocardiogram in a dog. J Vet Cardiol. 2012; 14: (2)371-5.
    View PubMed
  51. Wong ML, Leach JK, Athanasiou KA, Griffiths LG. The role of protein solubilization in antigen removal from xenogeneic tissue for heart valve tissue engineering. Biomaterials. 2011 Nov; 32: (32)8129-38.
    View PubMed
  52. Arai S, Griffiths LG, Mama K, Hackett TB, Monnet E, Boon JA, Carter L, Orton EC. Bioprosthesis valve replacement in dogs with congenital tricuspid valve dysplasia: technique and outcome. J Vet Cardiol. 2011 Jun; 13: (2)91-9.
    View PubMed
  53. Griffiths LG, Fransioli JR, Chigerwe M. Echocardiographic assessment of interventricular and intraventricular mechanical synchrony in normal dogs. J Vet Cardiol. 2011 Jun; 13: (2)115-26.
    View PubMed
  54. Jung S, Griffiths LG. ECG of the Month. Atrial fibrillation. J Am Vet Med Assoc. 2011 May 15; 238: (10)1258-60.
    View PubMed
  55. Blossom JE, Bright JM, Griffiths LG. Transvenous occlusion of patent ductus arteriosus in 56 consecutive dogs. J Vet Cardiol. 2010 Aug; 12: (2)75-84.
    View PubMed
  56. Griffiths LG. Surgery for cardiac disease in small animals: current techniques. Vet Clin North Am Small Anim Pract. 2010 Jul; 40: (4)605-22.
    View PubMed
  57. Griffiths LG, Choe L, Lee KH, Reardon KF, Orton EC. Protein extraction and 2-DE of water- and lipid-soluble proteins from bovine pericardium, a low-cellularity tissue. Electrophoresis. 2008 Nov; 29: (22)4508-15.
    View PubMed
  58. Griffiths LG, Choe LH, Reardon KF, Dow SW, Christopher Orton E. Immunoproteomic identification of bovine pericardium xenoantigens. Biomaterials. 2008 Sep; 29: (26)3514-20.
    View PubMed
  59. Griffiths LG, Bright JM, Chan KC. Transcatheter intravascular stent placement to relieve supravalvular pulmonic stenosis. J Vet Cardiol. 2006 Nov; 8: (2)145-55.
    View PubMed
  60. Goncalves AC, Griffiths LG, Anthony RV, Orton EC. Decellularization of bovine pericardium for tissue-engineering by targeted removal of xenoantigens. J Heart Valve Dis. 2005 Mar; 14: (2)212-7.
    View PubMed
  61. Griffiths LG, Orton EC, Boon JA. Evaluation of techniques and outcomes of mitral valve repair in dogs. J Am Vet Med Assoc. 2004 Jun 15; 224: (12)1941-5.
    View PubMed
  62. Griffiths LG, Sullivan M, O'Neill T, Reid SW. Ultrasonography versus radiography for detection of fluid in the canine tympanic bulla. Vet Radiol Ultrasound. 2003 Mar-Apr; 44: (2)210-3.
    View PubMed
  63. Doust R, Griffiths LG, Sullivan M. Evaluation of once daily treatment with cyclosporine for anal furunculosis in dogs. Vet Rec. 2003 Feb 22; 152: (8)225-9.
    View PubMed
  64. Griffiths LG, Sullivan M, Reid SW. A comparison of the effects of unilateral thyroarytenoid lateralization versus cricoarytenoid laryngoplasty on the area of the rima glottidis and clinical outcome in dogs with laryngeal paralysis. Vet Surg. 2001 Jul-Aug; 30: (4)359-65.
    View PubMed
  65. Griffiths LG, Sullivan M. Bilateral overlapping mucosal single-pedicle flaps for correction of soft palate defects. J Am Anim Hosp Assoc. 2001 Mar-Apr; 37: (2)183-6.
    View PubMed
  66. Ridyard AE, Corcoran BM, Tasker S, Willis R, Welsh EM, Demetriou JL, Griffiths LG. Spontaneous laryngeal paralysis in four white-coated German shepherd dogs. J Small Anim Pract. 2000 Dec; 41: (12)558-61.
    View PubMed
  67. Griffiths LG, Tiruneh R, Sullivan M, Reid SW. Oropharyngeal penetrating injuries in 50 dogs: a retrospective study. Vet Surg. 2000 Sep-Oct; 29: (5)383-8.
    View PubMed
  68. Griffiths LG, Sullivan M, Borland WW. Cyclosporin as the sole treatment for anal furunculosis: preliminary results. J Small Anim Pract. 1999 Dec; 40: (12)569-72.
    View PubMed
  69. Griffiths LG, Sullivan M, Lerche P. Intrathoracic tracheal avulsion and pseudodiverticulum following pneumomediastinum in a cat. Vet Rec. 1998 Jun 20; 142: (25)693-6.
    View PubMed
PST-20325811