搜索医生

Frank V. Brozovich, M.D., Ph.D.

  1. Cardiologist
预约门诊

出版物

  1. Han YS, Pakkam M, Fogarty MJ, Sieck GC, Brozovich FV. Alterations in cardiac contractile and regulatory proteins contribute to age-related cardiac dysfunction in male rats. Physiol Rep. 2024 Aug; 12 (16):e70012
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  2. Han YS, Bandi R, Fogarty MJ, Sieck GC, Brozovich FV. Aging related decreases in NM myosin expression and contractility in a resistance vessel. Front Physiol. 2024; 15:1411420 Epub 2024 May 14
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  3. Larson KF, Malik A, Brozovich FV. Aging and Heart Failure with Preserved Ejection Fraction. Compr Physiol. 2022 Aug 11; 12 (4):3813-3822
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  4. Brozovich FV, Han YS, Arteaga GM, Sharain K, Sieck GC. Changes in Cardiac and Vascular Contractile Protein in a Rat Model of Heart Failure with Preserved Ejection Fraction. FASEB J. 2022 May; 36 Suppl 1
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  5. Zhu J, Angelov S, Alp Yildirim I, Wei H, Hu JH, Majesky MW, Brozovich FV, Kim F, Dichek DA. Loss of Transforming Growth Factor Beta Signaling in Aortic Smooth Muscle Cells Causes Endothelial Dysfunction and Aortic Hypercontractility. Arterioscler Thromb Vasc Biol. 2021 Jun; 41 (6):1956-1971 Epub 2021 Apr 15
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  6. Bos JM, Hebl VB, Oberg AL, Sun Z, Herman DS, Teekakirikul P, Seidman JG, Seidman CE, Dos Remedios CG, Maleszewski JJ, Schaff HV, Dearani JA, Noseworthy PA, Friedman PA, Ommen SR, Brozovich FV, Ackerman MJ. Marked Up-Regulation of ACE2 in Hearts of Patients With Obstructive Hypertrophic Cardiomyopathy: Implications for SARS-CoV-2-Mediated COVID-19. Mayo Clin Proc. 2020 Jul; 95 (7):1354-1368 Epub 2020 Apr 28
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  7. Lyle MA, Alabdaljabar MS, Han YS, Brozovich FV. The vasculature in HFpEF vs HFrEF: differences in contractile protein expression produce distinct phenotypes. Heliyon. 2020 Jan; 6 (1):e03129 Epub 2019 Dec 30
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  8. Li EA, Xi W, Han YS, Brozovich FV. Phosphodiesterase expression in the normal and failing heart. Arch Biochem Biophys. 2019 Feb 15; 662:160-168 Epub 2018 Dec 11
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  9. Lyle MA, Brozovich FV. HFpEF, a Disease of the Vasculature: A Closer Look at the Other Half. Mayo Clin Proc. 2018 Sep; 93 (9):1305-1314 Epub 2018 July 29
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  10. Lyle MA, Davis JP, Brozovich FV. Regulation of Pulmonary Vascular Smooth Muscle Contractility in Pulmonary Arterial Hypertension: Implications for Therapy. Front Physiol. 2017; 8:614 Epub 2017 Aug 23
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  11. Brozovich FV, Nicholson CJ, Degen CV, Gao YZ, Aggarwal M, Morgan KG. Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders. Pharmacol Rev. 2016 Apr; 68 (2):476-532
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  12. Lin S, Brozovich FV. MYPT1 isoforms expressed in HEK293T cells are differentially phosphorylated after GTPgammaS treatment. J Smooth Muscle Res. 2016; 52 (0):66-77
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  13. Degen CV, Bishu K, Zakeri R, Ogut O, Redfield MM, Brozovich FV. The emperor's new clothes: PDE5 and the heart. PLoS One. 2015; 10 (3):e0118664 Epub 2015 Mar 06
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  14. Yuen SL, Ogut O, Brozovich FV. Differential phosphorylation of LZ+/LZ- MYPT1 isoforms regulates MLC phosphatase activity. Arch Biochem Biophys. 2014 Nov 15; 562:37-42. Epub 2014 Aug 26.
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  15. Ichiki T, Schirger JA, Huntley BK, Brozovich FV, Maleszewski JJ, Sandberg SM, Sangaralingham SJ, Park SJ, Burnett JC Jr. Cardiac fibrosis in end-stage human heart failure and the cardiac natriuretic peptide guanylyl cyclase system: regulation and therapeutic implications. J Mol Cell Cardiol. 2014 Oct; 75:199-205 Epub 2014 Aug 09
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  16. Konik EA, Han YS, Brozovich FV. The role of pulmonary vascular contractile protein expression in pulmonary arterial hypertension. J Mol Cell Cardiol. 2013 Dec; 65:147-55. Epub 2013 Oct 23.
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  17. Nowakowski SG, Kolwicz SC, Korte FS, Luo Z, Robinson-Hamm JN, Page JL, Brozovich F, Weiss RS, Tian R, Murry CE, Regnier M. Transgenic overexpression of ribonucleotide reductase improves cardiac performance. Proc Natl Acad Sci U S A. 2013 Apr 9; 110(15):6187-92. Epub 2013 Mar 25.
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  18. Bishu K, Ogut O, Kushwaha S, Mohammed SF, Ohtani T, Xu X, Brozovich FV, Redfield MM. Anti-remodeling effects of rapamycin in experimental heart failure: dose response and interaction with angiotensin receptor blockade. PLoS One. 2013; 8 (12):e81325 Epub 2013 Dec 03
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  19. Han YS, Brozovich FV. Altered reactivity of tertiary mesenteric arteries following acute myocardial ischemia. J Vasc Res. 2013; 50 (2):100-8 Epub 2012 Nov 21
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  20. Bishu K, Hamdani N, Mohammed SF, Kruger M, Ohtani T, Ogut O, Brozovich FV, Burnett JC Jr, Linke WA, Redfield MM. Sildenafil and B-type natriuretic peptide acutely phosphorylate titin and improve diastolic distensibility in vivo. Circulation. 2011 Dec 20; 124 (25):2882-91 Epub 2011 Dec 05
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  21. Yuen S, Ogut O, Brozovich FV. MYPT1 protein isoforms are differentially phosphorylated by protein kinase G. J Biol Chem. 2011 Oct 28; 286 (43):37274-9 Epub 2011 Sept 02
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  22. Guvenc B, Ustunel C, Ozturk N, Brozovich FV. A dynamic approach reveals non-muscle myosin influences the overall smooth muscle cross-bridge cycling rate. FEBS Lett. 2010 Jul 2; 584(13):2862-6. Epub 2010 May 04.
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  23. Yuen SL, Ogut O, Brozovich FV. Nonmuscle myosin is regulated during smooth muscle contraction. Am J Physiol Heart Circ Physiol. 2009 Jul; 297 (1):H191-9 Epub 2009 May 08
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  24. Ararat E, Brozovich FV. Losartan decreases p42/44 MAPK signaling and preserves LZ+ MYPT1 expression. PLoS One. 2009; 4 (4):e5144 Epub 2009 Apr 09
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  25. Ogut O, Brozovich FV. The potential role of MLC phosphatase and MAPK signalling in the pathogenesis of vascular dysfunction in heart failure. J Cell Mol Med. 2008 Dec; 12 (6A):2158-64
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  26. Chen FC, Brozovich FV. Gene expression profiles of vascular smooth muscle show differential expression of mitogen-activated protein kinase pathways during captopril therapy of heart failure. J Vasc Res. 2008; 45(5):445-54. Epub 2008 Apr 16.
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  27. Ogut O, Yuen SL, Brozovich FV. Regulation of the smooth muscle contractile phenotype by nonmuscle myosin. J Muscle Res Cell Motil. 2007; 28 (7-8):409-14 Epub 2008 Mar 18
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  28. Given AM, Ogut O, Brozovich FV. MYPT1 mutants demonstrate the importance of aa 888-928 for the interaction with PKGIalpha. Am J Physiol Cell Physiol. 2007 Jan; 292 (1):C432-9 Epub 2006 July 26
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  29. Babu GJ, Celia G, Rhee AY, Yamamura H, Takahashi K, Brozovich FV, Osol G, Periasamy M. Effects of h1-calponin ablation on the contractile properties of bladder versus vascular smooth muscle in mice lacking SM-B myosin. J Physiol. 2006 Dec 15; 577(Pt 3):1033-42. Epub 2006 Sep 14.
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  30. El-Toukhy A, Given AM, Ogut O, Brozovich FV. PHI-1 interacts with the catalytic subunit of myosin light chain phosphatase to produce a Ca(2+) independent increase in MLC(20) phosphorylation and force in avian smooth muscle. FEBS Lett. 2006 Oct 16; 580 (24):5779-84 Epub 2006 Sept 27
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  31. Sadek H, Gilkeson RC, Hoit BD, Brozovich FV. Images in cardiovascular medicine. Case of anomalous right superior vena cava. Circulation. 2006 Oct 10; 114(15):e532-3.
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  32. Rhee AY, Ogut O, Brozovich FV. Nonmuscle myosin, force maintenance, and the tonic contractile phenotype in smooth muscle. Pflugers Arch. 2006 Sep; 452(6):766-74. Epub 2006 May 10.
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  33. Chen FC, Ogut O, Rhee AY, Hoit BD, Brozovich FV. Captopril prevents myosin light chain phosphatase isoform switching to preserve normal cGMP-mediated vasodilatation. J Mol Cell Cardiol. 2006 Sep; 41(3):488-95. Epub 2006 Jul 03.
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  34. Johnson MT, Zhang S, Gilkeson R, Ameduri R, Siwik E, Patel CR, Chebotarev O, Kenton AB, Bowles KR, Towbin JA, Robin NH, Brozovich F, Hoit BD. Intrafamilial variability of noncompaction of the ventricular myocardium. Am Heart J. 2006 May; 151(5):1012.e7-14.
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  35. El-Touhky A, Given AM, Cochard A, Brozovich FV. PHI-1 induced enhancement of myosin phosphorylation in chicken smooth muscle. FEBS Lett. 2005 Aug 15; 579(20):4271-7.
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  36. Karim SM, Rhee AY, Given AM, Faulx MD, Hoit BD, Brozovich FV. Vascular reactivity in heart failure: role of myosin light chain phosphatase. Circ Res. 2004 Sep 17; 95(6):612-8 Epub 2004 Aug 19.
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  37. Huang QQ, Fisher SA, Brozovich FV. Unzipping the role of myosin light chain phosphatase in smooth muscle cell relaxation. J Biol Chem. 2004 Jan 2; 279(1):597-603. Epub 2003 Oct 06.
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  38. Karagiannis P, Babu GJ, Periasamy M, Brozovich FV. Myosin heavy chain isoform expression regulates shortening velocity in smooth muscle: studies using an SMB KO mouse line.[erratum appears in J Muscle Res Cell Motil. 2004;25(7):581 Note: Periasamy, M [added]]. J Muscle Res Cell Motil. 2004; 25(2):149-58.
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  39. Ogut O, Brozovich FV. Creatine phosphate consumption and the actomyosin crossbridge cycle in cardiac muscles. Circ Res. 2003 Jul 11; 93(1):54-60 Epub 2003 Jun 5.
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  40. Ogut O, Brozovich FV. Regulation of force in vascular smooth muscle. J Mol Cell Cardiol. 2003 Apr; 35(4):347-55.
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  41. Karagiannis P, Babu GJ, Periasamy M, Brozovich FV. The smooth muscle myosin seven amino acid heavy chain insert's kinetic role in the crossbridge cycle for mouse bladder. J Physiol (Lond). 2003 Mar 1; 547: (Pt 2)463-73.
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  42. Rhee AY, Brozovich FV. Force maintenance in smooth muscle: analysis using sinusoidal perturbations. Arch Biochem Biophys. 2003 Feb 1; 410(1):25-38.
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  43. Karagiannis P, Brozovich FV. The kinetic properties of smooth muscle: how a little extra weight makes myosin faster. J Muscle Res Cell Motil. 2003; 24(2-3):157-63.
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  44. MacFarland SM, Jin JP, Brozovich FV. Troponin T isoforms modulate calcium dependence of the kinetics of the cross-bridge cycle: studies using a transgenic mouse line. Arch Biochem Biophys. 2002 Sep 15; 405(2):241-6.
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  45. Richards CT, Ogut O, Brozovich FV. Agonist-induced force enhancement: the role of isoforms and phosphorylation of the myosin-targeting subunit of myosin light chain phosphatase. J Biol Chem. 2002 Feb 8; 277(6):4422-7. Epub 2001 Nov 28.
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  46. Khatri JJ, Joyce KM, Brozovich FV, Fisher SA. Role of myosin phosphatase isoforms in cGMP-mediated smooth muscle relaxation. J Biol Chem. 2001 Oct 5; 276(40):37250-7. Epub 2001 Aug 02.
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  47. Ogut O, Brozovich FV. Determinants of the contractile properties in the embryonic chicken gizzard and aorta. Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1722-32.
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  48. Smith PG, Roy C, Fisher S, Huang QQ, Brozovich F. Selected contribution: mechanical strain increases force production and calcium sensitivity in cultured airway smooth muscle cells. J Appl Physiol. 2000 Nov; 89(5):2092-8.
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  49. Rhee AY, Brozovich FV. The smooth muscle cross-bridge cycle studied using sinusoidal length perturbations. Biophys J. 2000 Sep; 79(3):1511-23.
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  50. Facemire C, Brozovich FV, Jin JP. The maximal velocity of vascular smooth muscle shortening is independent of the expression of calponin. J Muscle Res Cell Motil. 2000 May; 21(4):367-73.
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  51. Huang QQ, Fisher SA, Brozovich FV. Forced expression of essential myosin light chain isoforms demonstrates their role in smooth muscle force production. J Biol Chem. 1999 Dec 3; 274(49):35095-8.
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  52. Huang QQ, Brozovich FV, Jin JP. Fast skeletal muscle troponin T increases the cooperativity of transgenic mouse cardiac muscle contraction. J Physiol (Lond). 1999 Oct 1; 520 Pt 1: 231-42.
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  53. Smith PG, Roy C, Dreger J, Brozovich F. Mechanical strain increases velocity and extent of shortening in cultured airway smooth muscle cells. Am J Physiol. 1999 Aug; 277(2 Pt 1):L343-8.
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  54. Shue GH, Brozovich FV. The frequency response of smooth muscle stiffness during Ca2+-activated contraction. Biophys J. 1999 May; 76(5):2361-9.
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  55. Konstantakos AK, Gilkeson RC, Brozovich FV, Lee JH. Massive pericardial hematoma simulating constrictive pericarditis: a complication of radiofrequency catheter ablation. J Thorac Cardiovasc Surg. 1998 Mar; 115(3):726-7.
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  56. Fisher SA, Ikebe M, Brozovich F. Endothelin-1 alters the contractile phenotype of cultured embryonic smooth muscle cells. Circ Res. 1997 Jun; 80(6):885-93.
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  57. Ikebe M, Brozovich FV. Protein kinase C increases force and slows relaxation in smooth muscle: evidence for regulation of the myosin light chain phosphatase. Biochem Biophys Res Commun. 1996 Aug 14; 225(2):370-6.
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  58. Brozovich FV. Mechanical changes after histamine activation of intact single vascular smooth muscle cells. Arch Biochem Biophys. 1996 Jun 1; 330(1):125-8.
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  59. Egelhoff TT, Naismith TV, Brozovich FV. Myosin-based cortical tension in Dictyostelium resolved into heavy and light chain-regulated components. J Muscle Res Cell Motil. 1996 Apr; 17(2):269-74.
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  60. Tokui T, Brozovich F, Ando S, Ikebe M. Enhancement of smooth muscle contraction with protein phosphatase inhibitor 1: activation of inhibitor 1 by cGMP-dependent protein kinase. Biochem Biophys Res Commun. 1996 Mar 27; 220(3):777-83.
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  61. Brozovich FV. PKC regulates agonist-induced force enhancement in single alpha-toxin-permeabilized vascular smooth muscle cells. Am J Physiol. 1995 May; 268(5 Pt 1):C1202-6.
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  62. Brozovich FV, Yamakawa M. Thin filament regulation of force activation is not essential in single vascular smooth muscle cells. Am J Physiol. 1995 Jan; 268(1 Pt 1):C237-42.
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  63. Brozovich FV, Yamakawa M. Agonist activation modulates cross-bridge states in single vascular smooth muscle cells. Am J Physiol. 1993 Jan; 264(1 Pt 1):C103-8.
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  64. Brozovich FV, Morganroth J, Gottlieb NB, Gottlieb RS. Effect of angiotensin converting enzyme inhibition on the incidence of restenosis after percutaneous transluminal coronary angioplasty. Cathet Cardiovasc Diagn. 1991 Aug; 23(4):263-7.
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  65. Morganroth J, Brozovich FV, McDonald JT, Jacobs RA. Variability of the QT measurement in healthy men, with implications for selection of an abnormal QT value to predict drug toxicity and proarrhythmia. Am J Cardiol. 1991 Apr 1; 67(8):774-6.
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  66. Brozovich FV. Strategies for preventing post-PTCA restenosis. Cardio Intervention. 1991; 1:32-7.
  67. Brozovich FV, Walsh MP, Morgan KG. Regulation of force in skinned, single cells of ferret aortic smooth muscle. Pflugers Arch. 1990 Aug; 416(6):742-9.
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  68. Brozovich FV, Morgan KG. Stimulus-specific changes in mechanical properties of vascular smooth muscle. Am J Physiol. 1989 Nov; 257(5 Pt 2):H1573-80.
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  69. Perreault CL, Brozovich FV, Ransil BJ, Morgan JP. Effects of MCI-154 on Ca2+ activation of skinned human myocardium. Eur J Pharmacol. 1989 Jun 20; 165(2-3):305-8.
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  70. Brozovich FV, Yates LD, Gordon AM. Muscle force and stiffness during activation and relaxation. Implications for the actomyosin ATPase. J Gen Physiol. 1988 Mar; 91(3):399-420.
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  71. Pollack GH, Tirosh R, Brozovich FV, Lacktis JW, Jacobson RC, Tameyasu T. Stepwise shortening: evidence and implications. Adv Exp Med Biol. 1984; 170:765-86.
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  72. De Lisa JA, Brozovich FV. Volume conduction in electromyography: experimental and theoretical review. Electromyogr Clin Neurophysiol. 1983 Nov-Dec; 23(7):651-73.
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  73. Brozovich FV, Pollack GH. Muscle contraction generates discrete sound bursts. Biophys J. 1983 Jan; 41(1):35-40.
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  74. Halar EM, Graf RJ, Halter JB, Brozovich FV, Soine TL. Diabetic neuropathy: a clinical, laboratory and electrodiagnostic study. Arch Phys Med Rehabil. 1982 Jul; 63(7):298-303.
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  75. Halar EM, DeLisa JA, Brozovich FV. Peroneal nerve conduction velocity: the importance of temperature correction. Arch Phys Med Rehabil. 1981 Sep; 62(9):439-43.
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  76. Graf RJ, Halter JB, Pfeifer MA, Halar E, Brozovich F, Porte D Jr. Glycemic control and nerve conduction abnormalities in non-insulin-dependent diabetic subjects. Ann Intern Med. 1981 Mar; 94(3):307-11.
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  77. Halar EM, DeLisa JA, Brozovich FV. Nerve conduction velocity: relationship of skin, subcutaneous and intramuscular temperatures. Arch Phys Med Rehabil. 1980 May; 61(5):199-203.
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  78. Halar EM, Brozovich FV, Milutinovic J, Inouye VL, Becker VM. H-reflex latency in uremic neuropathy: correlation with NCV and clinical findings. Arch Phys Med Rehabil. 1979 Apr; 60(4):174-7.
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  79. DeLisa JA, Brozovich FV. Volume conduction in electromyography. AAEE Mini-Monograph. 1979; 10.
  80. Halar EM, Stolov WC, Venkatesh B, Brozovich FV, Harley JD. Gastrocnemius muscle belly and tendon length in stroke patients and able-bodied persons. Arch Phys Med Rehabil. 1978 Oct; 59(10):476-84.
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PST-20223943