Cytochrome P450 (CYP450) tests

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Sept. 20, 2024
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  1. Bousman CA, et al. Review and consensus on pharmacogenomic testing in psychiatry. Pharmacopsychiatry. 2021; doi:10.1055/a-1288-1061.
  2. Arnone D, et al. Effectiveness of pharmacogenomic tests including CYP2D6 and CYP2C19 genomic variants for guiding the treatment of depressive disorders: Systemic review and meta-analysis of randomised controlled trials. Neuroscience and Biobehavioral Review. 2023; doi:10.1016/j.neubiorev.2022.104965.
  3. Zanardi R, et al. Pharmacogenetic-guided treatment of depression: Real-world clinical applications, challenges, and perspectives. Clinical Pharmacology and Therapeutics. 2021; doi:10.1002/cpt.2315.
  4. Xu L, et al. Effect of pharmacogenomic testing on the clinical treatment of patients with depressive disorder: A randomized clinical trial. Journal of Affective Disorders. 2024; doi:10.1016/j.jad.2024.05.063.
  5. McPherson RA, ed. Pharmacogenomics and personalized medicine. In: Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed Aug. 15, 2024.
  6. Tantisira K, et al. Overview of pharmacogenomics. https://www.uptodate.com/contents/search. Accessed Aug. 15, 2024.
  7. Cytochrome P450 2D6 comprehensive cascade. Mayo Clinic Laboratories. https://www.mayocliniclabs.com/test-catalog/overview/610045#Clinical-and-Interpretive. Accessed Aug. 15, 2024.
  8. Cytochrome P450 2C19 genotype. Mayo Clinic Laboratories. https://www.mayocliniclabs.com/test-catalog/overview/610043#Clinical-and-Interpretive. Accessed Aug. 15, 2024.
  9. Cytochrome P450 2C9 genotype. Mayo Clinic Laboratories. https://www.mayocliniclabs.com/test-catalog/overview/610044#Clinical-and-Interpretive. Accessed Aug. 15, 2024.
  10. Table of pharmacogenetic associations. U.S. Food and Drug Administration. https://www.fda.gov/medical-devices/precision-medicine/table-pharmacogenetic-associations. Accessed Aug. 15, 2024.
  11. Bousman CA, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A genotypes and serotonin reuptake inhibitor antidepressants. Clinical Pharmacology and Therapeutics 2023; doi:10.1002/cpt.2903.
  12. Kung S (expert opinion). Mayo Clinic. Aug. 23, 2024.

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Cytochrome P450 (CYP450) tests