Causes

By Mayo Clinic Staff

Numbness is caused by damage, irritation or pressure on the nerves. A single nerve branch or several nerves may be affected. Examples include a slipped disk in the back or carpal tunnel syndrome in the wrist. Certain diseases, such as diabetes, or toxins such as chemotherapy or alcohol can damage longer, more sensitive nerve fibers. These include the nerve fibers that go to the feet.

Numbness commonly affects nerves outside of the brain and spinal cord. When these nerves are affected, it can cause a lack of feeling in the arms, legs, hands and feet.

Numbness alone or numbness associated with pain or other unpleasant sensations isn't usually due to life-threatening conditions. At times, it may be associated with conditions such as stroke or tumor.

Your healthcare professional needs detailed information about your symptoms to diagnose the cause of your numbness. Several types of tests may be needed to confirm the cause before treatment can begin.

Possible causes of numbness include:

Brain and nervous system conditions

  1. Acoustic neuroma (vestibular schwannoma)
  2. Brain aneurysm
  3. Brain AVM (arteriovenous malformation)
  4. Brain tumor
  5. Guillain-Barre syndrome — a condition in which the body's immune system attacks the nerves
  6. Herniated disk
  7. Paraneoplastic syndromes of the nervous system
  8. Peripheral nerve injuries
  9. Peripheral neuropathy
  10. Spinal cord injury
  11. Spinal cord tumor
  12. Stroke
  13. Transient ischemic attack (TIA)
  14. Transverse myelitis

Trauma or overuse injuries

  1. Brachial plexus injury
  2. Carpal tunnel syndrome
  3. Frostbite

Chronic conditions

  1. Alcohol use disorder
  2. Amyloidosis
  3. Charcot-Marie-Tooth disease
  4. Diabetes
  5. Fabry's disease
  6. Multiple sclerosis
  7. Porphyria
  8. Raynaud's disease
  9. Sjogren's syndrome

Infectious diseases

  1. Leprosy
  2. Lyme disease
  3. Shingles
  4. Syphilis

Treatment side effects

  1. Chemotherapy or HIV drugs

Other causes

  1. Heavy metal exposure
  2. Thoracic aortic aneurysm
  3. Vasculitis
  4. Vitamin B-12 deficiency

Causes shown here are commonly associated with this symptom. Work with your doctor or other health care professional for an accurate diagnosis.

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Oct. 31, 2025

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  3. Acute flaccid myelitis (AFM)
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  5. Aneurysms
  6. Anti-seizure medications: Relief from nerve pain
  7. Arteriosclerosis / atherosclerosis
  8. Arteriovenous malformation
  9. Astrocytoma
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  45. Heart-healthy diet: 8 steps to prevent heart disease
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  49. Infographic: Multiple Myeloma
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  100. Spinal cord injury
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  103. Strategies to prevent heart disease
  104. Syringomyelia
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  106. Transient ischemic attack (TIA)
  107. Transverse myelitis
  108. Traumatic brain injury
  109. Vasculitis
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  112. Vitamin deficiency anemia
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