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  1. A Study to Evaluate the Effectiveness and Safety of Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy (ATTR Amyloidosis with Cardiomyopathy - Mayo Clinic

    The purpose of this study is to evaluate vutrisiran in patients with transthyretin amyloidosis with cardiomyopathy. Participation eligibility. Participant ...

  2. Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Monoclonal Antibody Ch14.18 in Treating Younger Patients with Refractory or Relapsed Neuroblastoma - Mayo Clinic

    Temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as dinutuximab, may find ...

  3. A Study of Neurophysiological and Inflammatory Biomarkers of Seizures and Brain Injury in Children - Mayo Clinic

    The purpose of this study is to connect brain inflammation measured by biomarkers, with data from advanced EEG technology, and clinical outcomes to provide new ...

  4. Efficacy and Safety of Etripamil for the Termination of Spontaneous PSVT. NODE-301 - Mayo Clinic

    The primary objective of this study is to determine whether etripamil nasal spray (NS) 70 mg is superior to placebo at terminating episodes of PSVT in an ...

  5. Can Patients Forecast Their Postoperative Disability after Elective Hand Surgery? - Mayo Clinic

    Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and ...

  6. A Study of the Prevalence and Characteristics of Multiple Sclerosis Related Hypothermia - Mayo Clinic

    About this study · To assess the prevalence of episodic hypothermia among multiple sclerosis (MS) patients evaluated at Mayo Clinic. · To characterize clinical, ...

  7. Safety and Tolerability of GTX-104 Compared With Oral Nimodipine in Patients With aSAH - Mayo Clinic

    The purpose of this study is to deliver nimodipine via IV directly into the bloodstream and to determine if this is as safe and tolerable as oral nimodipine ...

  8. A Study Using Avelumab in Non-Small Cell Lung Cancer that has Progressed - Mayo Clinic

    The purpose of this study is to demonstrate avelumab's overall survival superiority versus docetaxel in patients with programmed death ligand 1 (PD-L1) positive ...

  9. A Study Assessing the Effectiveness and Safety of Alpelisib Plus Fulvestrant in Men and Postmenopausal Women who have Advanced Breast Cancer which Progressed on or after Aromatase Inhibitor Treatment - Mayo Clinic

    ... line of endocrine therapy for metastatic disease; Newly diagnosed advanced breast cancer, then relapsed with documented evidence of progression after one ...

  10. A Study of Comparing Functional Outcomes after Kinematic and Mechanical Alignment in Total Knee Arthroplasty - Mayo Clinic

    The study aim is to conduct a clinical research investigation to compare two alignment techniques used in contemporary total knee arthroplasty by means of a ...