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  1. Study of Orally Administered AG-120 in Subjects with Advanced Hematologic Malignancies with an IDH1 Mutation - Mayo Clinic

    About this study. The purpose of this Phase I, multicenter study is to evaluate the safety, pharmacokinetics, pharmacodynamics and clinical activity of ...

  2. First-in-Human Study of FLX925 in Subjects with Relapsed or Refractory Acute Myeloid Leukemia - Mayo Clinic

    About this study. This first-in-human clinical trial is a Phase 1/1b, open-label, sequential-group, dose-escalation and cohort expansion study evaluating ...

  3. A Study to Evaluate Enfortumab Vedotin to Treat Metastatic Squamous Cell Carcinoma of the Penis - Mayo Clinic

    The purpose of this study is to estimate the best response of enfortumab vedotin treatment for patients with metastatic squamous cell carcinoma of the penis ( ...

  4. A Study of SC‑004 in Subjects With Advanced Solid Tumors - Mayo Clinic

    Part A (dose regimen finding) will allow definition of the maximum tolerated dose (MTD) through dose escalation and possible dose interval modification. In Part ...

  5. A Study to Evaluate the Safety and Effectiveness of Antithrombotics to Treat Hospitalized COVID-19 Patients - Mayo Clinic

    About this study. This is a randomized, open label, adaptive platform trial to compare the effectiveness of antithrombotic strategies for prevention of ...

  6. Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab With a Safety Lead-in of Encorafenib + Binimetinib + Cetuximab in Patients With BRAF V600E-mutant Metastatic Colorectal Cancer - Mayo Clinic

    Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan ...

  7. Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial - Mayo Clinic

    A transient ischemic attack (TIA) is a transient episode of neurological dysfunction caused by focal brain, spinal cord, or retinal ischemia, without acute ...

  8. Carfilzomib and Dexamethasone in Treating Patients With Multiple Myeloma Who Previously Underwent a Stem Cell Transplant - Mayo Clinic

    Carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Immunosuppressive therapy, such as dexamethasone, may ...

  9. Phase II Study Evaluating Combination Chemotherapy + Radiotherapy (RT) with Avelumab in Muscle Invasive Bladder Cancer - Mayo Clinic

    The purpose of this study is to evaluate the complete response rate of concurrent chemotherapy radiation treatment combined with avelumab for patients with ...

  10. Vardenafil Inhaled for Pulmonary Arterial Hypertension PRN Phase 2B Study - Mayo Clinic

    The purpose of this study is to evaluate the effects of RT234 on exercise parameters assessed by a specialized exercise test (Cardiopulmonary Exercise Test or ...