Neurology and Neurosurgery

Below are current clinical trials.

129 studies in Neurology and Neurosurgery
(open studies only).

Filter this list of studies by location, status and more.

1. Evaluating Optic Nerve Disease with OCT Angiography

   Rochester, Minn.

   The purpose of this study is to determine if optical coherence tomography (OCT) angiography is able to distinguish different causes of optic neuropathy.

2. Resting State Connectivity in Adolescents with Postural Orthostatic Tachycardia Syndrome and Chronic Pain

   Rochester, Minn.

   The purposes of this study are to compare the functional connectivity in adolescent patients with Postural Orthostatic Tachycardia Syndrome (POTS) both with and without chronic pain, to those with chronic pain alone, to that of healthy controls; to evaluate whether there is a change in functional connectivity following participation in an intensive rehabilitation-oriented program previously demonstrated to have excellent outcomes with regard to functional recovery and symptom control; and to correlate outcomes using standardized symptom and function rating scales to imaging findings.

3. A Registry of Biospecimens for Patients with Central Nervous Systems Inflammatory Disease

   Rochester, Minn.

   The purpose of the study is to learn more about inflammatory diseases of the central nervous system (CNS) by collecting patient information, blood sample (which contain a person’s genes, DNA) and other available tissue samples.

4. A Study to Evaluate Biomarker Target Stimulation

   Rochester, Minn.

   The purpose of this study is to understand how electrical stimulation of the brain can modulate and suppress interictal epileptiform activity as a step on the path to developing new therapies for epilepsy.

5. A Study to Evaluate Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease

   Jacksonville, Fla., Rochester, Minn.

   The purpose of this study is to investigate how abrupt loss of ovarian hormones following bilateral oophorectomy affects overall aging, physical performance, and cognitive function, including the risk for Alzheimer’s disease in women who had this procedure performed prior to natural menopause for benign conditions.

6. A Study to Evaluate the Feasibility of Intraoperative Microdialysis (tissue sampling) during Neurosurgery for Central Nervous System Malignancies

   Rochester, Minn.

   Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies

7. Acute Modulation of Stereotyped High-Frequency Oscillations

   Rochester, Minn.

   The purpose of this study is to do data collection of EEG findings to determine whether new types analysis of intracranial EEG can add different and possibly useful information to standard types of analysis of intracranial EEG. Intracranial EEG data will be collected intraoperatively and postoperatively during routine clinical monitoring, and will be analyzed by researchers for functional brain mapping and the investigation of high frequency oscillations (HFO's), for the purpose of identifying functional and epileptogenic brain areas.  

8. A Study Of Acute Stimulation For The Modulation Of Epileptic Events With A Closed-Loop Brain Interchange System In Drug Resistant Epilepsy

   Rochester, Minn.

   The purpose of this study is to investigate the feasibility of detecting and modulating pathological high-frequency oscillations (HFOs) generated by the seizure onset zone (SOZ) of drug-resistant epilepsy patients using CorTec's Brain Interchange Evaluation Kit (manual provided as supplementary material).

9. A Study Of Vagus Nerve Stimulation (VNS) With Mobility Training For Gait Recovery After Chronic Ischemic Stroke

   Rochester, Minn.

   The purpose of this study is to evaluate the safety, feasibility, and efficacy of vagus nerve stimulation (VNS) paired with mobility training to improve lower extremity function and gait in individuals with chronic ischemic stroke.

10. Adipose-Derived Mesenchymal Stem Cells (AMSCs) For Recurrent Glioblastoma

    Jacksonville, Fla.

    This study aims to evaluate the safety of local delivery of AMSCs for recurrent GBM by noting the incidence of adverse events, as well as radiological and clinical progression.

    To assess the preliminary efficacy of local delivery of AMSCs for recurrent GBM by comparing the clinical, survival, progression, and radiographic outcomes from patients enrolled in our study to historical controls from our institution.