Cardiovascular Diseases and Cardiac Surgery

Below are current clinical trials.

64 studies in Cardiovascular Diseases and Cardiac Surgery
(open studies only).

Filter this list of studies by location, status and more.

1. A Study of the Impact of Cardiac Rehabilitation after Myectomy Procedure for Hypertrophic Cardiomyopathy

   Rochester, Minn.

   The purpose of this study is to describe the clinical impact of cardiac rehabilitation in patients who have undergone myectomy for hypertrophic cardiomyopathy.  Compare the clinical outcomes of patients who have attended cardiac rehab with those who have not attended after myectomy for hypertrophic cardiomyopathy. 

2. A Study to Assess Measurements in Cardiomyopathy Patients Using Software for Multi-level Reconstruction of Three Dimensional Transesophageal Echocardiography (TEE) or Transthoracic Echocardiography (TTE) Images

   Rochester, Minn.

   The purpose of this study is to utilize three dimensional (3D) transesophageal echocardiography (TEE) or 3D transthoracic echocardiography (TTE) to measure various mitral chordal, annular, and leaflet measurements and LV size to better understand the mechanism of regurgitation in patients with FMR.

3. COVID-19 (Coronavirus) Pandemic on Health and Healthcare

   Rochester, Minn.

   The purpose of this study is to identify correlates of healthcare-seeking behavior in patients with ACS and CHF and its association with psychosocial and health outcomes.

4. A Study to Assess Virtual Reality As Anesthesia Adjunct During Electrophysiology Lab Procedures

   Jacksonville, Fla.

   The purpose of this study is to evaluate the use of virtual reality (VR) technology as adjunct to routine anesthesia care for patients undergoing electrophysiology (EP) procedures.

5. Analysis of Outcomes of Left Cardiac Sympathetic Denervation in Arrhythmia Syndromes and Cardiomyopathies

   Rochester, Minn.

   The purpose of this study is to collect and review the Mayo Clinic experience with left cardiac sympathetic denervation (LCSD) in patients with heritable arrhythmias syndromes or refractory ventricular arrhythmias beginning in 2000.

6. Hypoplastic Left Heart Syndrome: Validating Functional Parameters and Novel Echocardiographic Imaging Strategies for Evaluation of Functionally Single Right Ventricular Performance using Previously Recorded Studies

   Rochester, Minn.

   The purpose of this study is to validate novel echocardiographic parameters and algorithms to quantitatively evaluate right ventricular function in patients with Hypoplastic Left Heart Syndrome (HLHS) by applying these methods to previously acquired echocardiographic examinations. 

7. A Study to Assess Frailty and Its Impact on Patients with Pulmonary Hypertension

   Rochester, Minn.

   The purpose of this study is to evaluate the prevalence and effect of frailty in patients referred to pulmonary hypertension (PH) clinic at our institution.

8. A Study to Evaluate Breathing Muscle Training in Cardiac Rehab

   Rochester, Minn.

   We are currently enrolling both healthy volunteers and people who have been diagnosed with heart failure to participate in our research study.  The purpose of this study is to better understand the relationship between exercise, breathing, blood flow and blood pressure.  This study includes two study visits if you are a healthy or heart failure volunteer.    All testing will be performed at our testing center at St. Mary’s Hospital located in Rochester, MN. 

   On the first study visit, the research activities will be discussed and all questions will be answered. Once written consent is provided and the participant is enrolled, lung function and exercise capacity will be measured.

   The second study visit includes two separate breathing muscle workouts (a light and moderate workload) each followed by 10 min of light to moderate cycling exercise. In addition, two breathing tests will also be performed. During this visit, blood is drawn during exercise.

   If you are a patient at Mayo Clinic, who is currently enrolled or will be enrolling in a cardiac rehabilitation exercise program, you will have the option to complete four study visits.  Your first two study visits as described above will be completed at the beginning of cardiac rehabilitation and then we will ask you to return to complete those same two study visits following the completion of your cardiac rehabilitation program.

   Remuneration and parking reimbursement are provided.

9. Spontaneous Coronary Artery Dissection: Case Review

   Rochester, Minn.

   Spontaneous coronary artery dissection (SCAD) is uncommon but important cause of acute coronary syndrome and sudden cardiac death. There is very little data exists in regards to patient clinical characteristics, risk factors, treatment and outcomes. Our objective is to prospectively assess long term outcomes. 

10. Patient-Specific Induced Pluripotent Stem Cell Models for Heritable Channelopathies and Cardiomyopathies

    Rochester, Minn.

    The purpose of this study is to derive and characterize patient-specific disease models for sudden death-predisposing heritable channelopathies and cardiomyopathies using iPS-cell technology.  It is hoped that the molecular, cellular, and electrophysiological phenotypes of these in-vitro disease models will further elucidate the pathophysiologic mechanisms underlying these sudden death-associated conditions.