Before Using
Drug information provided by: Merative, Micromedex®
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of triprolidine, pseudoephedrine, and codeine combination in children.
Triprolidine, pseudoephedrine, and codeine combination should not be used to relieve pain after surgery removal of tonsils or adenoids in children. Severe breathing problems and deaths have been reported in some children who received codeine after tonsil or adenoid surgery.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of triprolidine, pseudoephedrine, and codeine combination in the elderly.
Breastfeeding
Codeine
Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.
Pseudoephedrine
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Triprolidine
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
-
Dihydroergotamine
-
Furazolidone
-
Iproniazid
-
Isocarboxazid
-
Linezolid
-
Mavorixafor
-
Methylene Blue
-
Moclobemide
-
Nalmefene
-
Naltrexone
-
Nialamide
-
Ozanimod
-
Phenelzine
-
Procarbazine
-
Rasagiline
-
Safinamide
-
Samidorphan
-
Selegiline
-
Tranylcypromine
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
-
Abametapir
-
Abiraterone Acetate
-
Acepromazine
-
Aclidinium
-
Alfentanil
-
Almotriptan
-
Alosetron
-
Alprazolam
-
Amantadine
-
Amifampridine
-
Amiloride
-
Amineptine
-
Amiodarone
-
Amitriptyline
-
Amitriptylinoxide
-
Amobarbital
-
Amoxapine
-
Amphetamine
-
Amprenavir
-
Anileridine
-
Apalutamide
-
Aprepitant
-
Aripiprazole
-
Aripiprazole Lauroxil
-
Armodafinil
-
Asenapine
-
Atazanavir
-
Atropine
-
Avacopan
-
Baclofen
-
Belladonna
-
Belzutifan
-
Bemetizide
-
Bendroflumethiazide
-
Benperidol
-
Bentazepam
-
Benzhydrocodone
-
Benzphetamine
-
Benzthiazide
-
Benztropine
-
Berotralstat
-
Biperiden
-
Boceprevir
-
Bosentan
-
Bromazepam
-
Bromopride
-
Brompheniramine
-
Bumetanide
-
Buprenorphine
-
Bupropion
-
Buspirone
-
Butabarbital
-
Butalbital
-
Butorphanol
-
Calcium Oxybate
-
Cannabidiol
-
Cannabis
-
Canrenoate
-
Canrenone
-
Carbamazepine
-
Carbinoxamine
-
Carisoprodol
-
Carphenazine
-
Celecoxib
-
Cenobamate
-
Ceritinib
-
Cetirizine
-
Chloral Hydrate
-
Chlordiazepoxide
-
Chlorothiazide
-
Chlorpheniramine
-
Chlorpromazine
-
Chlorthalidone
-
Chlorzoxazone
-
Cilostazol
-
Cimetidine
-
Cinacalcet
-
Ciprofloxacin
-
Citalopram
-
Clarithromycin
-
Clemastine
-
Clidinium
-
Clobazam
-
Clofazimine
-
Clomipramine
-
Clonazepam
-
Clopamide
-
Clopidogrel
-
Clorazepate
-
Cloxazolam
-
Clozapine
-
Cobicistat
-
Cocaine
-
Conivaptan
-
Crizotinib
-
Cyclobenzaprine
-
Cyclopenthiazide
-
Cyclopentolate
-
Cyclosporine
-
Cyclothiazide
-
Cyproheptadine
-
Dabrafenib
-
Dantrolene
-
Daridorexant
-
Darifenacin
-
Darunavir
-
Delavirdine
-
Delorazepam
-
Desipramine
-
Desmopressin
-
Desvenlafaxine
-
Dexamethasone
-
Dexmedetomidine
-
Dextroamphetamine
-
Dextromethorphan
-
Dezocine
-
Diacetylmorphine
-
Diazepam
-
Diazoxide
-
Dibenzepin
-
Dichloralphenazone
-
Dicloxacillin
-
Dicyclomine
-
Difenoxin
-
Dihydrocodeine
-
Diltiazem
-
Dimenhydrinate
-
Diphenhydramine
-
Diphenoxylate
-
Dipyrone
-
Dolasetron
-
Donepezil
-
Doxepin
-
Doxylamine
-
Dronedarone
-
Droperidol
-
Duloxetine
-
Duvelisib
-
Efavirenz
-
Elagolix
-
Eletriptan
-
Eliglustat
-
Enflurane
-
Enzalutamide
-
Eplerenone
-
Erythromycin
-
Escitalopram
-
Esketamine
-
Eslicarbazepine Acetate
-
Estazolam
-
Eszopiclone
-
Ethacrynic Acid
-
Ethchlorvynol
-
Ethopropazine
-
Ethylmorphine
-
Etozolin
-
Etravirine
-
Fedratinib
-
Fenfluramine
-
Fentanyl
-
Fesoterodine
-
Fexinidazole
-
Flavoxate
-
Flecainide
-
Flibanserin
-
Fluconazole
-
Flunitrazepam
-
Fluoxetine
-
Fluphenazine
-
Flurazepam
-
Fluspirilene
-
Fluvoxamine
-
Fosamprenavir
-
Fosaprepitant
-
Fosnetupitant
-
Fosphenytoin
-
Fospropofol
-
Frovatriptan
-
Furosemide
-
Gabapentin
-
Gabapentin Enacarbil
-
Gepirone
-
Glycopyrrolate
-
Glycopyrronium Tosylate
-
Granisetron
-
Guanethidine
-
Halazepam
-
Haloperidol
-
Halothane
-
Hexobarbital
-
Homatropine
-
Hydrochlorothiazide
-
Hydrocodone
-
Hydroflumethiazide
-
Hydromorphone
-
Hydroxytryptophan
-
Hydroxyzine
-
Hyoscyamine
-
Idelalisib
-
Imatinib
-
Imipramine
-
Indapamide
-
Indinavir
-
Iobenguane I 123
-
Iobenguane I 131
-
Ipratropium
-
Isoflurane
-
Itraconazole
-
Ivacaftor
-
Ivosidenib
-
Ketamine
-
Ketazolam
-
Ketobemidone
-
Ketoconazole
-
Lacosamide
-
Larotrectinib
-
Lasmiditan
-
Lemborexant
-
Lenacapavir
-
Lesinurad
-
Letermovir
-
Levocetirizine
-
Levomilnacipran
-
Levorphanol
-
Lisdexamfetamine
-
Lithium
-
Lofepramine
-
Lofexidine
-
Lomitapide
-
Lonafarnib
-
Loprazolam
-
Lorazepam
-
Lorcaserin
-
Lorlatinib
-
Lormetazepam
-
Loxapine
-
Lumacaftor
-
Magnesium Oxybate
-
Maribavir
-
Mavacamten
-
Meclizine
-
Medazepam
-
Melitracen
-
Melperone
-
Mepenzolate
-
Meperidine
-
Mephobarbital
-
Meprobamate
-
Meptazinol
-
Mesoridazine
-
Metaclazepam
-
Metaxalone
-
Methadone
-
Methamphetamine
-
Methdilazine
-
Methocarbamol
-
Methohexital
-
Methotrimeprazine
-
Methyclothiazide
-
Methyldopa
-
Methylprednisolone
-
Metoclopramide
-
Metolazone
-
Midazolam
-
Midodrine
-
Mifepristone
-
Milnacipran
-
Mirtazapine
-
Mitotane
-
Mobocertinib
-
Modafinil
-
Molindone
-
Moricizine
-
Morphine
-
Morphine Sulfate Liposome
-
Nafcillin
-
Nalbuphine
-
Naratriptan
-
Nefazodone
-
Nelfinavir
-
Netupitant
-
Nevirapine
-
Nicomorphine
-
Nilotinib
-
Nitrazepam
-
Nitrous Oxide
-
Nordazepam
-
Nortriptyline
-
Olanzapine
-
Oliceridine
-
Omaveloxolone
-
Ondansetron
-
Opipramol
-
Opium
-
Opium Alkaloids
-
Orphenadrine
-
Oxazepam
-
Oxcarbazepine
-
Oxitropium Bromide
-
Oxybutynin
-
Oxycodone
-
Oxymorphone
-
Palbociclib
-
Palonosetron
-
Papaveretum
-
Paregoric
-
Paritaprevir
-
Paroxetine
-
Pentazocine
-
Pentobarbital
-
Perampanel
-
Perazine
-
Periciazine
-
Perphenazine
-
Phenobarbital
-
Phenytoin
-
Pimozide
-
Pinazepam
-
Pipenzolate Bromide
-
Piperacetazine
-
Pipotiazine
-
Pirenzepine
-
Piretanide
-
Piritramide
-
Pitolisant
-
Polythiazide
-
Posaconazole
-
Potassium Oxybate
-
Prazepam
-
Prednisone
-
Pregabalin
-
Primidone
-
Prochlorperazine
-
Procyclidine
-
Promazine
-
Promethazine
-
Propantheline
-
Propiverine
-
Propofol
-
Protriptyline
-
Quazepam
-
Quetiapine
-
Quinethazone
-
Quinidine
-
Quinine
-
Ramelteon
-
Ranitidine
-
Ranolazine
-
Remifentanil
-
Remimazolam
-
Remoxipride
-
Ribociclib
-
Rifabutin
-
Rifampin
-
Rifapentine
-
Ritlecitinib
-
Ritonavir
-
Rizatriptan
-
Rolapitant
-
Ropeginterferon Alfa-2b-njft
-
Saquinavir
-
Schisandra sphenanthera
-
Scopolamine
-
Secobarbital
-
Sertindole
-
Sertraline
-
Sibutramine
-
Sodium Oxybate
-
Solifenacin
-
Spironolactone
-
St John's Wort
-
Stramonium
-
Sufentanil
-
Sulpiride
-
Sumatriptan
-
Suvorexant
-
Tapentadol
-
Telaprevir
-
Telithromycin
-
Telotristat Ethyl
-
Temazepam
-
Terbinafine
-
Terodiline
-
Tetrazepam
-
Thiethylperazine
-
Thiopental
-
Thiopropazate
-
Thioridazine
-
Thiothixene
-
Tianeptine
-
Ticagrelor
-
Tilidine
-
Tiotropium
-
Tipranavir
-
Tizanidine
-
Tolonium Chloride
-
Tolterodine
-
Topiramate
-
Torsemide
-
Tramadol
-
Trazodone
-
Triamterene
-
Triazolam
-
Trichlormethiazide
-
Trifluoperazine
-
Trifluperidol
-
Triflupromazine
-
Trihexyphenidyl
-
Trimeprazine
-
Trimipramine
-
Trofinetide
-
Troleandomycin
-
Tropicamide
-
Trospium
-
Tryptophan
-
Tucatinib
-
Umeclidinium
-
Venlafaxine
-
Verapamil
-
Vilazodone
-
Vonoprazan
-
Voriconazole
-
Vortioxetine
-
Voxelotor
-
Xipamide
-
Zaleplon
-
Zavegepant
-
Ziprasidone
-
Zolmitriptan
-
Zolpidem
-
Zopiclone
-
Zotepine
-
Zuranolone
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
-
Asthma or
-
Breathing problems (eg, obstructive sleep apnea) or
-
Heart or blood vessel disease, severe or
-
Hypertension (high blood pressure), severe or
-
Surgery (eg, surgical removal of adenoid or tonsil), history of—Should not be used in patients with these conditions.
-
Asthma, history of or
-
Brain problems (eg, tumor, increased pressure in the head), history of or
-
Diabetes or
-
Drug dependence, especially with narcotic abuse or dependence, or history of or
-
Enlarged prostate or
-
Gallbladder problems or
-
Glaucoma or history of or
-
Head injury, history of or
-
Heart disease or
-
Heart rhythm problems or
-
Hyperthyroidism (overactive thyroid) or
-
Problems with passing urine or history of or
-
Stomach or bowel problems (eg, ulcers, blockage)—Use with caution. May increase risk for more serious side effects.
-
Kidney disease, severe or
-
Liver disease, severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Portions of this document last updated: Aug. 01, 2024
Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.