Ibrutinib (Oral Route)

Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

1. Back pain
2. bladder pain
3. bloating or swelling of the face, arms, hands, lower legs, or feet
4. bloody or black, tarry stools
5. bloody or cloudy urine
6. blurred vision
7. body aches or pain
8. chest pain or tightness
9. chills
10. confusion
11. cough
12. decreased frequency or amount of urine
13. difficult, burning, or painful urination
14. dizziness or lightheadedness
15. drowsiness
16. dry mouth
17. fainting
18. fast or irregular heartbeat
19. fever
20. frequent urge to urinate
21. headache
22. hoarseness
23. increased thirst
24. irregular heartbeat
25. itching
26. loss of appetite
27. lower back or side pain
28. nausea
29. rapid weight gain
30. seizures
31. severe headache
32. severe stomach pain
33. sore throat
34. tingling of the hands or feet
35. trouble breathing
36. ulcers, sores, or white spots in the mouth
37. unusual bleeding or bruising
38. unusual tiredness or weakness
39. unusual weight gain or loss
40. vomiting
41. vomiting of blood or material that looks like coffee grounds
42. wrinkled skin

Less common

1. Persistent non-healing sore
2. pink skin growth
3. reddish skin patch or irritated area
4. shiny skin bump
5. white, yellow or waxy scar-like area on the skin

Incidence not known

1. Blistering, peeling, or loosening of the skin
2. dark urine
3. diarrhea
4. dilated neck veins
5. difficulty swallowing
6. general feeling of tiredness or weakness
7. hives, skin rash
8. joint pain, stiffness, or swelling
9. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
10. light-colored stools
11. muscle pain
12. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
13. red skin lesions, often with a purple center
14. red, irritated eyes
15. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

1. Belching
2. decreased appetite
3. difficulty having a bowel movement
4. heartburn or indigestion
5. indigestion
6. lack or loss of strength
7. muscle stiffness or spasms
8. small red or purple spots on the skin
9. stomach discomfort, upset, or pain
10. swelling or inflammation of the mouth

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

• Precautions

Portions of this document last updated: July 01, 2024

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