Before Using
Drug information provided by: Merative, Micromedex®
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of glimepiride in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of glimepiride in the elderly. However, elderly patients are more likely to have low blood sugar and age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving glimepiride.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
-
Abiraterone Acetate
-
Alogliptin
-
Aspirin
-
Bexagliflozin
-
Capecitabine
-
Carbamazepine
-
Chloroquine
-
Chlorothiazide
-
Chlorthalidone
-
Ciprofloxacin
-
Delafloxacin
-
Desmopressin
-
Disopyramide
-
Dulaglutide
-
Enoxacin
-
Entacapone
-
Fluconazole
-
Furosemide
-
Gatifloxacin
-
Gemifloxacin
-
Grepafloxacin
-
Hydrochlorothiazide
-
Hydroflumethiazide
-
Hydroxychloroquine
-
Indapamide
-
Insulin
-
Insulin Aspart, Recombinant
-
Insulin Bovine
-
Insulin Degludec
-
Insulin Detemir
-
Insulin Glargine, Recombinant
-
Insulin Glulisine
-
Insulin Lispro, Recombinant
-
Isoniazid
-
Ivacaftor
-
Lanreotide Acetate
-
Levofloxacin
-
Levoketoconazole
-
Liraglutide
-
Lixisenatide
-
Lomefloxacin
-
Mavacamten
-
Metformin
-
Methotrexate
-
Metolazone
-
Metreleptin
-
Miconazole
-
Moxifloxacin
-
Norfloxacin
-
Octreotide Acetate
-
Ofloxacin
-
Pasireotide Diaspartate
-
Phenobarbital
-
Pioglitazone
-
Polythiazide
-
Porfimer
-
Pramlintide
-
Primidone
-
Semaglutide
-
Sitagliptin
-
Somatrogon-ghla
-
Sotagliflozin
-
Sparfloxacin
-
Sparsentan
-
Thioctic Acid
-
Triamterene
-
Trovafloxacin
-
Voriconazole
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
-
Acebutolol
-
Aminolevulinic Acid
-
Atenolol
-
Betaxolol
-
Bisoprolol
-
Bitter Melon
-
Carteolol
-
Carvedilol
-
Celiprolol
-
Colesevelam
-
Esmolol
-
Fenugreek
-
Glecaprevir
-
Glucomannan
-
Guar Gum
-
Isocarboxazid
-
Labetalol
-
Levobunolol
-
Linezolid
-
Methylene Blue
-
Metipranolol
-
Metoprolol
-
Nadolol
-
Nebivolol
-
Oxprenolol
-
Ozanimod
-
Penbutolol
-
Phenelzine
-
Pibrentasvir
-
Pindolol
-
Practolol
-
Procarbazine
-
Propranolol
-
Psyllium
-
Rasagiline
-
Safinamide
-
Saxagliptin
-
Selegiline
-
Sotalol
-
Timolol
-
Tirzepatide
-
Tranylcypromine
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
-
Alcohol, excessive use or
-
Underactive adrenal glands or
-
Underactive pituitary gland or
-
Undernourished condition or
-
Weakened physical condition—These conditions could make you more sensitive to the effects of low blood sugar.
-
Diabetic ketoacidosis (ketones in the blood) or
-
Sulfonamide allergy (antibiotic or stomach medicines, e.g., sulfamethoxazole, sulfasalazine, sulfisoxazole, Azulfidine®, Bactrim®, or Septra®), or history of or
-
Type 1 diabetes—Should not be used in patients with these conditions.
-
Fever or
-
Infection or
-
Surgery or
-
Trauma—These conditions may cause temporary problems with blood sugar control and your doctor may want to treat you temporarily with insulin.
-
Glucose-6-phosphate dehydrogenase (G6PD) deficiency (a hereditary metabolic disorder affecting red blood cells)—May cause hemolytic anemia (blood disorder) in patients with this condition.
-
Heart disease—Use with caution. May make this condition worse.
-
Kidney disease—Use with caution. Higher blood levels of this medicine may occur, which may cause serious problems.
Portions of this document last updated: Aug. 01, 2024
Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.