Proper Use

Drug information provided by: Merative, Micromedex®

For patients using mifepristone tablets for termination of pregnancy:

  • It is very important that you understand the requirements of the Mifepristone REMS program, and become familiar with the Mifepristone medication guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the medication guide if you do not have one
  • Treatment requires 1 tablet of mifepristone and 4 tablets of a medicine called misoprostol.
  • Day One: One 200 milligram (mg) tablet of mifepristone in a single oral dose.
  • 24 to 48 hours after taking mifepristone tablet: Four 200 microgram (mcg) tablets (total dose 800 mcg) of misoprostol. Two 200 mcg tablets are placed in each cheek pouch for 30 minutes. Swallow any remaining pieces with water or other liquid.
  • This medicine must be taken within 24 to 48 hours after mifepristone; no sooner than 24 hours and no later than 48 hours.
  • Most women will expel the pregnancy within 2 to 24 hours of taking misoprostol.
  • You must follow up with your doctor 7 to 14 days after the day one dose of mifepristone. Your doctor will check to make sure you are no longer pregnant. It is very important that you go to your follow-up appointment. Call your doctor if you are not able to make your appointment.
  • This medicine will cause you to bleed and have cramps for about 2 weeks.
  • It is sometimes necessary to have a surgical abortion to completely end the pregnancy. You may also need to have surgery if there is any tissue left in your uterus after treatment with mifepristone.

For patients using mifepristone tablets to control high blood sugar:

  • Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.
  • This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.
  • Swallow the tablet whole. Do not split, crush, or chew it. Take this medicine with food.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For termination of pregnancy (70 days or less) taken together with misoprostol:
      • Adults and pregnant females age 17 and younger—200 milligrams (mg) as a single dose on Day 1. Followed by 800 micrograms (mcg) (four-200 mcg tablets) of misoprostol 24 to 48 hours later taken as a single dose placed in the cheeks for 30 minutes.
      • Children—Use is not recommended.
    • For treatment of hyperglycemia in patients with Cushing's syndrome:
      • Adults—At first, 300 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 1200 mg per day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

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Portions of this document last updated: Aug. 01, 2024

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