Proper Use

Drug information provided by: Merative, Micromedex®

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine comes with a patient information leaflet and patient instructions . Read and follow the instructions carefully. Ask your doctor if you have any questions.

For children who are unable to swallow the tablets, your pharmacist will mix this medicine as a liquid suspension. Shake the bottle of suspension well before each use.

To use the Entresto® Sprinkle oral pellets:

• The Entresto® Sprinkle contains oral pellets inside of a capsule. The capsule must be opened and the pellets sprinkled on soft food (including applesauce, yogurt, or pudding). Do not swallow the empty capsule shells. Do not chew or crush the oral pellets.
• In a small bowl or cup, place 1 to 2 teaspoonfuls of soft food.
• Hold the capsule upright, with the colored cap on top, over the soft food. Gently pinch the middle of the capsule and pull slightly on the top with your other hand to separate the 2 ends of the capsule. Be careful not to spill the contents while opening the capsule.
• Empty all of the pellets onto the food. Check the capsule to make sure that you did not miss any oral pellets. Tap the capsule to remove any remaining oral pellets.
• Give or take the mixture right away.

Dosing

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

• For heart failure:
  • For oral dosage form (tablets):
    • Adults—At first, one tablet 2 times a day. Each tablet contains 49 milligrams (mg) sacubitril and 51 mg valsartan. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 97 mg sacubitril and 103 mg valsartan 2 times a day.
    • Children 1 year of age and older weighing 40 kilograms (kg) or more—Dose is based on body weight and must be determined by your doctor.
      • Weighing 50 kilograms (kg) or more—At first, one tablet 2 times a day. Each tablet contains 49 milligrams (mg) sacubitril and 51 mg valsartan. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 97 mg sacubitril and 103 mg valsartan 2 times a day.
      • Weighing 40 kg to less than 50 kg—At first, one tablet 2 times a day. Each tablet contains 24 mg sacubitril and 26 mg valsartan. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 72 mg sacubitril and 78 mg valsartan 2 times a day.
      • Weighing less than 40 kg—Use of oral liquid or oral pellets is recommended.
    • Children younger than 1 year of age—Use and dose must be determined by your doctor.
  • For oral dosage form (pellets):
    • Children 1 year of age and older weighing less than 50 kilograms (kg)—Dose is based on body weight and must be determined by your doctor.
      • Weighing 34 kilograms (kg) to less than 50 kg—At first, 2 capsules 2 times a day. Each capsule contains 15 milligrams (mg) sacubitril and 16 mg valsartan. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 60 mg sacubitril and 64 mg valsartan 2 times a day.
      • Weighing 26 kg to less than 34 kg—At first, 4 capsules 2 times a day. Each capsule contains 6 mg sacubitril and 6 mg valsartan. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 45 mg sacubitril and 48 mg valsartan 2 times a day.
      • Weighing 19 kg to less than 26 kg—At first, 3 capsules 2 times a day. Each capsule contains 6 mg sacubitril and 6 mg valsartan. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 30 mg sacubitril and 32 mg valsartan 2 times a day.
      • Weighing 13 kg to less than 19 kg—At first, 2 capsules 2 times a day. Each capsule contains 6 mg sacubitril and 6 mg valsartan. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 24 mg sacubitril and 24 mg valsartan 2 times a day.
      • Weighing less than 13 kg—Use of oral liquid is recommended.
    • Children younger than 1 year of age—Use and dose must be determined by your doctor.
  • For oral dosage form (suspension):
    • Children younger than 1 year of age weighing less than 13 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. At first, 1.6 mg per kilogram (mg/kg) of body weight 2 times a day. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 3.1 mg/kg of body weight 2 times a day.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

You may store the mixed oral liquid at room temperature for up to 15 days. Do not refrigerate.

• Before Using
• Precautions

Portions of this document last updated: July 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.

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