Proper Use

Drug information provided by: Merative, Micromedex®

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. Also, it is important to keep the amount of medicine in your body at a steady level. To help keep the amount constant, this medicine must be used on a regular schedule.

Take this medicine with food.

To use the oral pellets:

  • Mix the medicine on a small amount of soft food (eg, peanut butter, chocolate hazelnut spread, cream cheese, thick jam, or Greek yogurt) with little amount of water that will stick to a spoon and should be swallowed without chewing.
  • Swallow the mixture within 15 minutes after preparation. Do not crush or chew it.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For hepatitis C virus infection that has been previously treated with other medicines:
      • Adults and children 12 years of age and older or weighing 45 kilograms (kg) or more—3 tablets (total dose of 300 milligrams [mg] glecaprevir and 120 mg pibrentasvir) once a day for 8 to 16 weeks in patients without cirrhosis and 12 to 16 weeks for patients with cirrhosis. Each tablet contains 100 mg glecaprevir and 40 mg pibrentasvir.
      • Children 3 to younger than 12 years of age weighing less than 45 kg—Use of oral pellets is recommended.
      • Children younger than 3 years of age or weighing less than 45 kg—Use and dose must be determined by your doctor.
    • For hepatitis C virus infection that has not been treated with other medicines:
      • Adults and children 12 years of age and older or weighing 45 kilograms (kg) or more—3 tablets (total dose of 300 milligrams [mg] glecaprevir and 120 mg pibrentasvir) once a day for 8 weeks. Each tablet contains 100 mg glecaprevir and 40 mg pibrentasvir.
      • Children 3 to younger than 12 years of age weighing less than 45 kg—Use of oral pellets is recommended.
      • Children younger than 3 years of age or weighing less than 45 kg—Use and dose must be determined by your doctor.
    • For patients receiving a kidney or liver transplant:
      • Adults and children 12 years of age and older or weighing 45 kilograms (kg) or more—3 tablets (total dose of 300 milligrams [mg] glecaprevir and 120 mg pibrentasvir) once a day for 12 or 16 weeks. Each tablet contains 100 mg glecaprevir and 40 mg pibrentasvir.
      • Children 3 to younger than 12 years of age weighing less than 45 kg—Use of oral pellets is recommended.
      • Children younger than 3 years of age or weighing less than 45 kg—Use and dose must be determined by your doctor.
  • For oral dosage form (pellets):
    • For hepatitis C virus infection that has been previously treated with other medicines:
      • Children 3 to younger than 12 years of age weighing less than 45 kg—Dose is base on weight and must be determined by your doctor.
        • Weighing 30 to less than 45 kg—5 packets (total dose of 250 mg glecaprevir and 100 mg pibrentasvir once a day for 8 to 16 weeks in patients without cirrhosis and 12 to 16 weeks for patients with cirrhosis. Each packet contains 50 mg glecaprevir and 20 mg pibrentasvir.
        • Weighing 20 to less than 30 kg—4 packets (total dose of 200 mg glecaprevir and 80 mg pibrentasvir once a day for 8 to 16 weeks in patients without cirrhosis and 12 to 16 weeks for patients with cirrhosis. Each packet contains 50 mg glecaprevir and 20 mg pibrentasvir.
        • Weighing less than 20 kg—3 packets (total dose of 150 mg glecaprevir and 60 mg pibrentasvir once a day for 8 to 16 weeks in patients without cirrhosis and 12 to 16 weeks for patients with cirrhosis. Each packet contains 50 mg glecaprevir and 20 mg pibrentasvir.
      • Children younger than 3 years of age or weighing less than 45 kg—Use and dose must be determined by your doctor.
    • For hepatitis C virus infection that has not been treated with other medicines:
      • Children 3 to younger than 12 years of age weighing less than 45 kg—Dose is base on weight and must be determined by your doctor.
        • Weighing 30 to less than 45 kg—5 packets (total dose of 250 mg glecaprevir and 100 mg pibrentasvir once a day for 8 weeks. Each packet contains 50 mg glecaprevir and 20 mg pibrentasvir.
        • Weighing 20 to less than 30 kg—4 packets (total dose of 200 mg glecaprevir and 80 mg pibrentasvir once a day for 8 weeks. Each packet contains 50 mg glecaprevir and 20 mg pibrentasvir.
        • Weighing less than 20 kg—3 packets (total dose of 150 mg glecaprevir and 60 mg pibrentasvir once a day for 8 weeks. Each packet contains 50 mg glecaprevir and 20 mg pibrentasvir.
      • Children younger than 3 years of age or weighing less than 45 kg—Use and dose must be determined by your doctor.
    • For patients receiving a kidney or liver transplant:
      • Children 3 to younger than 12 years of age weighing less than 45 kg—Dose is base on weight and must be determined by your doctor.
        • Weighing 30 to less than 45 kg—5 packets (total dose of 250 mg glecaprevir and 100 mg pibrentasvir once a day for 12 to 16 weeks. Each packet contains 50 mg glecaprevir and 20 mg pibrentasvir.
        • Weighing 20 to less than 30 kg—4 packets (total dose of 200 mg glecaprevir and 80 mg pibrentasvir once a day for 12 to 16 weeks. Each packet contains 50 mg glecaprevir and 20 mg pibrentasvir.
        • Weighing less than 20 kg—3 packets (total dose of 150 mg glecaprevir and 60 mg pibrentasvir once a day for 12 to 16 weeks. Each packet contains 50 mg glecaprevir and 20 mg pibrentasvir.
      • Children younger than 3 years of age or weighing less than 45 kg—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss a dose and it is less than 18 hours from your usual time, take the missed dose as soon as possible, and then go back to your regular schedule.

If you miss a dose and it is more than 18 hours from your usual time, skip the missed dose and take your next dose at your regular schedule.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep this medicine in its original container until you are ready to use it. Throw away any unused medicine. Do not store and reuse any leftover mixture.

Portions of this document last updated: July 01, 2024

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