Primary biliary cholangitis

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Displaying 1-1 out of 1 doctors available

Last Name Initial: H

  1. Denise M. Harnois, D.O.

    Denise M. Harnois, D.O.

    1. Transplant Hepatologist
    1. Jacksonville, FL
    Areas of focus:

    Liver transplant, Post-transplant long-term care, Pre-transplant evaluation, Nonalcoholic fatty liver disease, Cirrhosi...s, Liver problems, Primary sclerosing cholangitis, Cholangiocarcinoma, Liver cancer, Alcoholic hepatitis, Hepatocellular carcinoma, Hepatopulmonary syndrome, Primary biliary cholangitis

Research

Mayo Clinic has been conducting research on primary biliary cholangitis for more than 40 years, and many treatments for the disease have been studied at Mayo Clinic. Mayo Clinic was one of the first centers to study ursodeoxycholic acid (UDCA) as a treatment option. Researchers are currently studying new medications — including applying a combination of therapies — for people with only a partial response to UDCA.

The Mayo Clinic research team has made many contributions to understanding the genetics of primary biliary cholangitis. They've helped find several gene variations that seem to make people more likely to develop the disease. Their discoveries are the first step toward developing targeted treatments and potentially curing the disease.

Also, researchers at Mayo Clinic have found that first-degree relatives — parents, siblings or children — of people with primary biliary cholangitis are more likely to have a protein in their blood that indicates the presence of the disease. Doctors call this a biomarker. The finding suggests that a simple blood test could help doctors detect the disease early in first-degree relatives so that treatment can begin before it causes irreversible liver damage.

Basic research related to primary biliary cholangitis and other liver diseases is conducted in the following Mayo Clinic laboratories:

Publications

See a list of publications about primary biliary cholangitis by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

Research Profiles

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By Mayo Clinic Staff

Primary biliary cholangitis care at Mayo Clinic

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Diagnosis & treatmentCare at Mayo Clinic
Nov. 14, 2023
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Living with primary biliary cholangitis?

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Primary biliary cholangitis

Research: It's all about patients

[MUSIC PLAYING]

Joseph Sirven, M.D., Professor of Neurology, Mayo Clinic: Mayo's mission is about the patient. The patient comes first. So the mission and research here is to advance how we can best help the patient, how to make sure the patient comes first in care. So in many ways, it's a cycle. It can start with as simple as an idea worked on in a laboratory, brought to the patient bedside, and if everything goes right — and let's say it's helpful or beneficial — then brought on as a standard approach. And I think that is one of the unique characteristics of Mayo's approach to research — that patient-centeredness — that really helps to put it in its own spotlight.