Lupus nephritis

Diagnosis

Tests to diagnose lupus nephritis include:

• Blood and urine tests. Besides the usual blood and urine tests, urine collected over 24 hours might be tested. These tests measure how well the kidneys are working.
• Kidney biopsy. A small section of kidney tissue is removed and sent to a lab. This test diagnoses lupus nephritis. It also can help show how bad the disease is. There can be more than one biopsy over time.

Treatment

There's no cure for lupus nephritis. Treatment aims to:

• Reduce symptoms or make symptoms go away, called remission.
• Keep the disease from getting worse.
• Keep symptoms from coming back.
• Keep kidneys working well enough to not need a machine to filter waste from blood, called dialysis, or a kidney transplant.

Supportive treatments

In general, these treatments might help people with kidney disease:

• Diet changes. Limiting the amount of protein and salt in the diet can help the kidneys work better.
• Blood pressure medicines. Medicines called angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) can help control blood pressure. These medicines also keep protein from leaking from the kidneys into the urine. Medicines called diuretics help get rid of fluid.

Medicines

Treating severe lupus nephritis might need medicines that slow or stop the immune system from attacking healthy cells. Medicines often are used together. Sometimes certain medicines used at first are switched to prevent toxic effects.

Medicines to treat lupus nephritis might include:

• Steroids, such as prednisone (Rayos).
• Cyclosporine (Gengraf, Neoral, Sandimmune).
• Voclosporin (Lupkynis).
• Tacrolimus (Astagraf, Envarsus, Prograf).
• Cyclophosphamide (Cytoxan).
• Azathioprine (Azasan, Imuran).
• Mycophenolate (CellCept).
• Rituximab (Rituxan).
• Belimumab (Benlysta).

Ongoing clinical trials are testing new treatments for lupus nephritis.

Treatment options for kidney failure

For people who progress to kidney failure, treatment options include:

• Dialysis. Dialysis helps remove fluid and waste from the body, maintain the right balance of minerals in the blood, and manage blood pressure by filtering the blood through a machine.
• Kidney transplant. If kidneys stop working, a kidney from a donor, called a transplant, might be needed.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.