Familial adenomatous polyposis care at Mayo Clinic
Your Mayo Clinic care team
- Experience. Mayo Clinic specialists are experienced in all aspects of treating FAP, including genetic screening and counseling, as well as colorectal surgery.
- Compassionate care. If you're at risk of FAP, Mayo Clinic specialists take time to discuss your options with you. Pediatric specialists closely monitor at-risk children.
- New ideas. Mayo Clinic researchers are investigating new screening methods and surgery options for the disease. You have access to the expertise of Mayo's clinician-researchers.
Mayo Clinic in Rochester, Minnesota, ranks No. 1 for digestive disorders in the U.S. News & World Report Best Hospitals rankings. Mayo Clinic in Phoenix/Scottsdale, Arizona, and Mayo Clinic in Jacksonville, Florida, are ranked among the Best Hospitals for digestive disorders by U.S. News & World Report. Mayo Clinic Children's Center in Rochester is ranked the No. 1 hospital in Minnesota, and the five-state region of Iowa, Minnesota, North Dakota, South Dakota and Wisconsin, according to U.S. News & World Report's 2024–2025 "Best Children's Hospitals" rankings.
Advanced diagnosis and treatment
Familial cancer syndromes (cancers that are hereditary) are rare, and it's important to seek evaluation from doctors familiar with your cancer. Mayo Clinic's highly trained specialists are experienced in the diagnosis and treatment of all familial cancer syndromes.
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Genetic testing. Mayo Clinic's Familial Cancer Program is staffed by experts from several fields who work together to ensure you receive exactly the care you need. Professionals who work in the Familial Cancer Program include specialists in genetic counseling and doctors with expertise in hereditary cancer syndromes.
At Mayo Clinic, you have access to the latest screening methods, including genetic testing, to determine if you have FAP. Genetics counselors discuss the pros and cons of testing with you, including the psychological and medical implications and confidentiality issues. If you choose genetic testing, your counselor and your doctor discuss the results with you.
At Mayo, at-risk children who have the defective gene or whose genetic status isn't known are screened every year starting at age 10. At-risk children who don't have the defective gene are screened periodically starting at age 15.
The Molecular Genetics Laboratory uses the latest techniques to detect specific mutations in the APC gene associated with FAP. If the initial genetic test is negative, Mayo scientists can sequence other genes, including the MUTYH gene. The MUTYH gene is an important cause of MUTYH-associated polyposis.
The Colon Cancer Family Registry uses biospecimens and data from thousands of families to identify colorectal cancer susceptibility genes, analyze gene interactions in causes of colorectal cancer, and translate research findings to better colorectal cancer prevention and treatment.
Faculty members of the colon cancer registry are extensively published in the areas of colorectal cancer risk factors such as alcohol use, molecular biomarkers for colorectal cancer, whole-genome sequencing, gall bladder removal (cholecystectomy), germline mutations and genomic testing for cancer susceptibility.
- Minimally invasive colorectal surgery. At Mayo Clinic, colorectal surgeons use minimally invasive (laparoscopic) techniques whenever possible.
Nationally recognized expertise
Mayo Clinic in Rochester, Minnesota, has been recognized as the best gastroenterology and GI surgery hospital in the nation by U.S. News & World Report in every year since 1990 when the rankings were first established.
Mayo Clinic in Rochester, Minnesota, ranks No. 1 for digestive disorders in the U.S. News & World Report Best Hospitals rankings. Mayo Clinic in Phoenix/Scottsdale, Arizona, and Mayo Clinic in Jacksonville, Florida, are ranked among the Best Hospitals for digestive disorders by U.S. News & World Report. Mayo Clinic Children's Center in Rochester is ranked the No. 1 hospital in Minnesota, and the five-state region of Iowa, Minnesota, North Dakota, South Dakota and Wisconsin, according to U.S. News & World Report's 2024–2025 "Best Children's Hospitals" rankings.
Mayo specialists also have extensive experience in the diagnosis and treatment of every kind of cancer. The Mayo Clinic Comprehensive Cancer Center meets strict standards for a National Cancer Institute comprehensive cancer center, which recognizes scientific excellence and a multidisciplinary approach to cancer prevention, diagnosis and treatment.
Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Jacksonville, Florida, and Mayo Clinic in Phoenix/Scottsdale, Arizona, are ranked among the Best Hospitals for cancer care by U.S. News & World Report. Mayo Clinic Children's Center in Rochester is ranked the No. 1 hospital in Minnesota, and the five-state region of Iowa, Minnesota, North Dakota, South Dakota and Wisconsin, according to U.S. News & World Report's 2024–2025 "Best Children's Hospitals" rankings.
Expertise and rankings
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Experience. Each year Mayo Clinic doctors treat thousands of people who have colon polyps, including those with familial adenomatous polyposis.
At Mayo Clinic's three campuses (Arizona, Florida and Minnesota) combined, colorectal surgeons see more than 11,000 people each year, making the practice among the largest in the world.
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Surgical expertise. Mayo Clinic in Rochester, Minnesota, has been recognized as the best gastroenterology and GI surgery hospital in the nation by U.S. News & World Report every year since 1990 when the rankings were first established.
Mayo Clinic in Rochester, Minnesota, ranks No. 1 for digestive disorders in the U.S. News & World Report Best Hospitals rankings. Mayo Clinic in Phoenix/Scottsdale, Arizona, and Mayo Clinic in Jacksonville, Florida, are ranked among the Best Hospitals for digestive disorders by U.S. News & World Report. Mayo Clinic Children's Center in Rochester is ranked the No. 1 hospital in Minnesota, and the five-state region of Iowa, Minnesota, North Dakota, South Dakota and Wisconsin, according to U.S. News & World Report's 2024–2025 "Best Children's Hospitals" rankings.
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Cancer expertise. Mayo specialists have extensive experience in the diagnosis and treatment of every kind of cancer The Mayo Clinic Comprehensive Cancer Center meets the strict standards for a National Cancer Institute comprehensive cancer center, which recognize scientific excellence and a multidisciplinary approach to cancer prevention, diagnosis and treatment.
Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Phoenix/Scottsdale, Arizona, and Mayo Clinic in Jacksonville, Fla., are ranked among the Best Hospitals for cancer by U.S. News & World Report.
Learn more about Mayo Clinic's gastroenterology and hepatology and colon and rectal surgery expertise and rankings.
Locations, travel and lodging
Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.
For more information on visiting Mayo Clinic, choose your location below:
Costs and insurance
Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.
In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.
Learn more about appointments at Mayo Clinic.
Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.