Esthesioneuroblastoma care at Mayo Clinic

At Mayo Clinic, doctors from different specialties work together to provide expert care designed for you.

Your Mayo Clinic care team

At Mayo Clinic, ear, nose and throat doctors, known as otolaryngologists, work as part of a team to care for people with esthesioneuroblastoma. The team includes other experts, such as radiation oncologists, medical oncologists, neurosurgeons, radiologists and pathologists. Other professionals are included as needed.

Accurate diagnosis

Mayo Clinic offers rapid, coordinated diagnostic testing and assessments that are done by a team of skilled doctors who specialize in nasal and sinus tumors, including esthesioneuroblastoma.

Diagnosing esthesioneuroblastoma is hard. That's because it's rare and can look like other cancers that occur in the head, neck or nose. Mayo Clinic pathologists use the latest advances in molecular pathologic study to accurately diagnose esthesioneuroblastoma and determine how aggressive it is, known as a tumor grade.

Advanced treatment options

Mayo Clinic head and neck surgeons and neurosurgeons are leaders in performing esthesioneuroblastoma surgeries. Generally, a neurosurgeon and a head and neck surgeon work as a team to remove the cancer safely and completely.

At Mayo Clinic, you can expect:

  • Skilled surgeons trained in the latest techniques. Surgeons have access to the latest ways to improve outcomes and help with healing. Esthesioneuroblastoma surgery can often be performed using minimally invasive surgery to get to the cancer through the nose. Esthesioneuroblastoma surgery is often done by doctors in the Comprehensive Skull Base Clinic.
  • Prompt tissue analysis. Pathologists examine the edges, known as margins, of tissue that is removed during surgery. Examining the tissue during the surgery helps surgeons know that as much of the cancer is removed as possible.
  • Carefully planned radiation treatments. Esthesioneuroblastoma sits near many vital structures in the head, such as the brain and the eyes. Radiation beams must be aimed perfectly to reach the cancer cells and spare the healthy tissue nearby. Mayo Clinic offers many advanced forms of radiation therapy that allow for precise delivery of radiation, including proton therapy and intensity-modulated radiation therapy (IMRT).

Expertise and rankings

Mayo Clinic doctors are recognized as experts in caring for people with esthesioneuroblastoma for the following reasons:

  • Collaboration to provide the best care. Treating esthesioneuroblastoma requires careful teamwork from experts. These include ear, nose and throat specialists, neurosurgeons, and radiation oncologists. Your care team works together to provide you with a treatment plan made to meet your needs.
  • Experience with rare cancers. Mayo Clinic doctors are respected for their broad experience in diagnosing and treating rare cancers such as esthesioneuroblastoma. Each year, Mayo Clinic doctors care for more than 200 people with cancer that affects the inside of the nose, including esthesioneuroblastoma.
  • Comprehensive cancer center. Mayo Clinic Comprehensive Cancer Center meets the strict standards for a National Cancer Institute comprehensive cancer center. These standards recognize scientific excellence and a multispecialty approach focused on cancer prevention, diagnosis and treatment.

Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Jacksonville, Florida, and Mayo Clinic in Phoenix/Scottsdale, Arizona, are ranked among the Best Hospitals for cancer care by U.S. News & World Report. Mayo Clinic Children's Center in Rochester is ranked the No. 1 hospital in Minnesota, and the five-state region of Iowa, Minnesota, North Dakota, South Dakota and Wisconsin, according to U.S. News & World Report's 2024–2025 "Best Children's Hospitals" rankings.

Mayo Clinic Children's

Highly skilled pediatric experts diagnose and treat all types of conditions in children. As a team, we work together to find answers, set goals and develop a treatment plan tailored to your child's needs.

Learn more about Mayo Clinic Children's.

Locations, travel and lodging

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

For more information on visiting Mayo Clinic, choose your location below:

Costs and insurance

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.

In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Learn more about appointments at Mayo Clinic.

Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.

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Mayo Clinic in Arizona, Florida and Minnesota

Mayo Clinic Health System

March 07, 2025

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