Overview By Mayo Clinic Staff Print Epithelioid sarcoma is a rare type of cancer that starts as a growth of cells in the soft tissue. It can happen anywhere on the body. It often starts under the skin on the finger, hand, forearm, knee or lower leg. Epithelioid sarcoma can happen at any age. It most often affects teenagers and young to middle-aged adults. Epithelioid sarcoma tends to grow slowly. It can come back after treatment. Epithelioid sarcoma is a type of cancer called a soft tissue sarcoma. These cancers happen in the body's connective tissues. There are many types of soft tissue sarcoma. Soft tissue sarcomas, including epithelioid sarcoma, are not common. It is best to seek care at a cancer center that has experience treating people with sarcoma. Request an appointment Diagnosis & treatment Jan. 17, 2025 Print Share on: FacebookTwitter Living with epithelioid sarcoma? Connect with others like you for support and answers to your questions in the Sarcoma support group on Mayo Clinic Connect, a patient community. Sarcoma Discussions Does anyone have chondrosarcoma? 23 Replies Sat, Jan 18, 2025 chevron-right How do you, as a parent, deal with the anger? Son has sarcoma 9 Replies Sat, Jan 18, 2025 chevron-right GNET Sarcoma-Gastrointestinal Neuroectodermal Tumors 15 Replies Thu, Jan 16, 2025 chevron-right See more discussions Show references Goldblum JR, et al. Other malignant soft tissue tumors, including those of uncertain type. In: Enzinger and Weiss's Soft Tissue Tumors. 7th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Jan. 5, 2023. Schuetze SM, et al. Uncommon sarcoma subtypes. https://www.uptodate.com/contents/search. Accessed Jan. 5, 2023. Sarcomas, soft tissue — Introduction. Cancer.Net. https://www.cancer.net/cancer-types/sarcoma/view-all. Accessed Jan. 5, 2023. Soft tissue sarcoma. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1464. Accessed Dec. 20, 2024. Meissner M, et al. Pharmacotherapeutic strategies for epithelioid sarcoma: Are we any closer to a non-surgical cure? Expert Opinion on Pharmacotherapy. 2023; doi:10.1080/14656566.2023.2224500. Gounder M, et al. Tazemetostat in advanced epithelioid sarcoma with loss of INI1/SMARCB1: An international, open-label, phase 2 basket study. The Lancet Oncology. 2020; doi:10.1016/s1470-2045(20)30451-4. Related Products & Services A Book: Mayo Clinic Family Health Book Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Epithelioid sarcomaSymptoms&causesDiagnosis&treatmentDoctors&departments Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship Policy Opportunities Ad Choices Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. NEW: Listen to Health Matters Podcast - Mayo Clinic PressNEW: Listen to Health Matters PodcastMayo Clinic on Incontinence - Mayo Clinic PressMayo Clinic on IncontinenceThe Essential Diabetes Book - Mayo Clinic PressThe Essential Diabetes BookMayo Clinic on Hearing and Balance - Mayo Clinic PressMayo Clinic on Hearing and BalanceFREE Mayo Clinic Diet Assessment - Mayo Clinic PressFREE Mayo Clinic Diet AssessmentMayo Clinic Health Letter - FREE book - Mayo Clinic PressMayo Clinic Health Letter - FREE book CON-20380728 Patient Care & Health Information Diseases & Conditions Epithelioid sarcoma