High cholesterol

Diagnosis

Diagnosis involves the steps that your healthcare professional takes to find out if you have high cholesterol. You receive a blood test to check cholesterol levels. You might hear the blood test called a lipid panel or a lipid profile. The results of the test usually show your:

• Total cholesterol.
• Low-density lipoprotein (LDL) cholesterol.
• High-density lipoprotein (HDL) cholesterol.
• Triglycerides.

In general, you can't have food or liquids other than water for around 9 to 12 hours before the test. This is called fasting. Some cholesterol tests don't require fasting, so follow your healthcare professional's instructions.

Interpreting the numbers

In the United States, cholesterol levels are measured in milligrams (mg) of cholesterol per deciliter (dL) of blood. In Canada and many European countries, cholesterol levels are measured in millimoles per liter (mmol/L). To interpret your test results, use these general guidelines.

Total cholesterol (U.S. and some other countries)	Total cholesterol* (Canada and most of Europe)	Results
*Canadian and European guidelines differ slightly from U.S. guidelines. These conversions are based on U.S. guidelines.
Below 200 mg/dL	Below 5.2 mmol/L	Desirable
200-239 mg/dL	5.2-6.2 mmol/L	Borderline high
240 mg/dL and above	Above 6.2 mmol/L	High

LDL cholesterol (U.S. and some other countries)	LDL cholesterol* (Canada and most of Europe)	Results
*Canadian and European guidelines differ slightly from U.S. guidelines. These conversions are based on U.S. guidelines.
Below 70 mg/dL	Below 1.8 mmol/L	Desirable for people who have coronary artery disease or other forms of atherosclerosis. Optimal for people at high risk or very high risk of coronary artery disease or other forms of atherosclerosis. In some people the desired value could be below 55 mg/dL.
Below 100 mg/dL	Below 2.6 mmol/L	Optimal for healthy people without coronary artery disease or other forms of atherosclerosis.
100-129 mg/dL	2.6-3.3 mmol/L	Near optimal for people who do not have coronary artery disease or other forms of atherosclerosis. High if there is coronary artery disease or other forms of atherosclerosis.
130-159 mg/dL	3.4-4.1 mmol/L	Borderline high for people who do not have coronary artery disease or other forms of atherosclerosis. High if there is coronary artery disease or other forms of atherosclerosis.
160-189 mg/dL	4.1-4.9 mmol/L	High for people who do not have coronary artery disease. Very high if there is coronary artery disease or other forms of atherosclerosis.
190 mg/dL and above	Above 4.9 mmol/L	Very high.

HDL cholesterol (U.S. and some other countries)	HDL cholesterol* (Canada and most of Europe)	Results
*Canadian and European guidelines differ slightly from U.S. guidelines. These conversions are based on U.S. guidelines.
Below 40 mg/dL, men	Below 1.0 mmol/L, men	Low
Below 50 mg/dL, women	Below 1.3 mmol/L, women
40-59 mg/dL, men	1-1.5 mmol/L, men	Better
50-59 mg/dL, women	1.3-1.5 mmol/L, women
60 mg/dL and above	Above 1.5 mmol/L	Best

Triglycerides (U.S. and some other countries)	Triglycerides* (Canada and most of Europe)	Results
*Canadian and European guidelines differ slightly from U.S. guidelines. These conversions are based on U.S. guidelines.
Below 150 mg/dL	Below 1.7 mmol/L	Desirable
150-199 mg/dL	1.7-2.2 mmol/L	Borderline high
200-499 mg/dL	2.3-5.6 mmol/L	High
500 mg/dL and above	Above 5.6 mmol/L	Very high

Children and cholesterol testing

The American Heart Association recommends that children get checked, also called screened, for high cholesterol once between ages 9 and 11. Screening may start earlier if a child has a family history of high cholesterol, heart attack or stroke. Screening also may start earlier if a child has conditions such as diabetes or obesity. The next cholesterol screening is recommended between ages 17 and 21.

Treatment

Treatment choices to reach ideal cholesterol and triglyceride levels should be tailored to meet your needs. Talk with your healthcare professional about what levels are best for you.

Treatment for high cholesterol can include medicine. Together with healthy lifestyle changes, medicine can lower the risk of heart attacks and strokes.

You may benefit from one or more medicines. It depends on things such as your risk factors, age, health and possible medicine side effects. Your healthcare professional helps choose the right treatments for you.

Common cholesterol medicines include:

Statins

Statins block a substance that the liver needs to make cholesterol. This causes the liver to make less cholesterol and to remove cholesterol from the blood.

Statin choices include:

• Atorvastatin (Lipitor).
• Fluvastatin (Lescol XL).
• Lovastatin (Altoprev).
• Pitavastatin (Livalo, Zypitamag).
• Pravastatin.
• Rosuvastatin (Crestor).
• Simvastatin (Zocor).

Cholesterol absorption inhibitors

The small intestine absorbs the cholesterol from food and releases it into the bloodstream. The medicine ezetimibe (Zetia) helps lower the amount of cholesterol absorbed from food. Your healthcare professional may prescribe ezetimibe with a statin.

Bempedoic acid

Bempedoic acid (Nexletol) works in much the same way as statins. Your healthcare professional may prescribe it if statins cause serious side effects for you. Adding bempedoic acid to a statin can help lower LDL. A pill that contains both bempedoic acid and ezetimibe, called Nexlizet, also is available.

Bile acid sequestrants

The liver uses cholesterol to make bile acids. The body needs these substances for digestion. Bile acid sequestrants bind to bile acids. This prompts the liver to use extra cholesterol to make more bile acids. In turn, that lowers the level of cholesterol in the blood.

Bile acid sequestrants include cholestyramine (Prevalite), colesevelam (Welchol) and colestipol (Colestid).

PCSK9 inhibitors

These medicines can help the liver absorb more LDL cholesterol. This lowers the amount of cholesterol in the blood. Alirocumab (Praluent), evolocumab (Repatha) or inclisiran (Leqvio) might be used for people who have a genetic condition that causes very high levels of LDL. These medicines also may be used in people with a history of heart disease when statins or other cholesterol medicines don’t do enough to lower cholesterol levels. PCSK9 inhibitors are given as a shot under the skin.

Medicines for high triglycerides

If you also have high triglycerides, your healthcare professional may prescribe:

• Fibrates. The medicines fenofibrate (Lipofen) and gemfibrozil (Lopid) speed the removal of triglycerides from the blood. They also help lower LDL cholesterol. Using a fibrate with a statin can raise the risk of statin side effects.
• Niacin. Niacin limits the liver's ability to make LDL cholesterol. But niacin doesn't provide more benefits than a statin. Niacin also has been linked with liver damage and strokes. Most healthcare professionals now recommend it only for people who can't take statins.
• Omega-3 fatty acids. Omega-3 fatty acids can help lower triglycerides. They are available with or without a prescription. If you choose to take supplements without a prescription, talk with your healthcare professional first. Omega-3 fatty acids may affect other medicines that you take. The effectiveness and cost of omega-3 fatty acids varies.

Medicine side effects

Let your healthcare professional know if your cholesterol medicine causes side effects. For instance, side effects of statins can include:

• Muscle pains.
• Muscle damage (very rare).
• Increased blood sugar.

If you decide to take cholesterol medicine, your healthcare professional may recommend liver function tests. These tests help check the medicine's effect on your liver.

Children and cholesterol treatment

Most often, making changes to diet and exercise is the first treatment for children age 2 and older who have high cholesterol. Children age 10 and older who have very high cholesterol levels might be prescribed cholesterol-lowering drugs such as statins.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Lifestyle and home remedies

Lifestyle changes are important if you have high cholesterol. Try to make the following healthy changes:

• Lose extra weight. Losing weight can help lower cholesterol.
• Eat a heart-healthy diet. Focus on plant-based foods. These include fruits, vegetables and whole grains. Limit added sugar and sodium. Also limit saturated fats and trans fats. Healthy fat, found in olive and canola oils, is a better option. Avocados, nuts and oily fish are other sources of healthy fat.
• Be active in your daily life and exercise regularly. Talk with your healthcare professional if you're not active already. Work up to at least 30 minutes of exercise five times a week.
• Don't smoke. If you smoke, you can ask your healthcare professional to help you quit.
• Limit alcohol or don't drink it. Limit alcohol to no more than up to one drink a day for women and up to two for men.
• Manage stress. Activities such as exercise and meditation can help.
• Get enough sleep. It's ideal for adults to get about 7 to 9 hours of sleep each night.

Preparing for your appointment

If you're an adult who hasn't had regular cholesterol level checks, make an appointment with your healthcare professional. Here's some information to help you get ready for your appointment.

What you can do

When you make the appointment, ask if there's anything you need to do in advance. For a cholesterol test, you'll likely have to stop eating and drinking about 9 to 12 hours before the test. You may be able to have water if your healthcare team says it's OK.

Make a list of:

• Your symptoms, if any.
• Key personal information, including a family history of high cholesterol, coronary artery disease, strokes, high blood pressure or diabetes.
• All medicines, vitamins or supplements you take, including doses.
• Questions to ask your healthcare professional.

For high cholesterol, some basic questions to ask your healthcare professional include:

• What tests do I need?
• What's the best treatment?
• How often do I need a cholesterol test?
• Are there brochures or other printed material that I can have? What websites do you recommend?

Feel free to ask other questions.

What to expect from your doctor

Your healthcare team is likely to ask you questions such as:

• What's your diet like?
• How much exercise do you get?
• How much alcohol do you drink?
• Do you smoke? Are you or were you around other smokers?
• When was your last cholesterol test? What were the results?